Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis and its preparation method

An ultrasonic contrast agent, arteriosclerosis technology, applied in echo/ultrasonic imaging agents, preparations for in vivo experiments, pharmaceutical formulations, etc. The method is simple and easy to implement, the clinical dose is reduced, and the cost is low.

Active Publication Date: 2022-04-08
HEILONGJIANG UNIV OF CHINESE MEDICINE +1
View PDF11 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to further enhance the targeted imaging enhancement effect of ultrasound contrast agents, there are more and more studies on targeted ultrasound contrast agents. The existing targeted ultrasound contrast agents often use antigen-antibody, biotin-anti-biotin and other means to achieve target imaging. It has disadvantages such as complex preparation methods, high requirements for storage and transportation conditions, and high cost of use, which limits its application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: A targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis

[0024] 7 parts of hyaluronic acid, 93 parts of soybean lecithin, 40% tert-butanol solution, appropriate amount of perfluoropropane, prepared according to the following steps:

[0025] (1) Add soybean lecithin containing hyaluronic acid to a mixed solution of 8 times the weight of tert-butanol and water, homogenize at 30°C for 4 minutes under a pressure of 100MPa, and then filter and sterilize through a 220nm filter membrane to obtain an emulsion;

[0026] (2) Divide the emulsion obtained in step (1) into vials and vacuum freeze-dry to obtain freeze-dried powder, then slowly fill in perfluoropropane to 55KPa in a vacuum state, and then slowly fill in the mixed gas of perfluoropropane and nitrogen to 1 standard atmospheric pressure, then use a rubber stopper to seal the vial, and the volume ratio of perfluoropropane in the mixed gas is 50%;

[0027] (3) Use the...

Embodiment 2

[0028] Example 2: A targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis

[0029] 3 parts of hyaluronic acid, 4 parts of mannuronic acid, 93 parts of soybean lecithin, 40% tert-butanol solution, appropriate amount of perfluoropropane, prepared according to the following steps:

[0030] (1) Add soybean lecithin containing hyaluronic acid and mannuronic acid to a mixed solution of 8 times the weight of tert-butanol and water, homogenize at 30°C and 100MPa pressure for 4 minutes, then filter and sterilize through a 220nm filter membrane, get lotion;

[0031] (2) Divide the emulsion obtained in step (1) into vials and vacuum freeze-dry to obtain freeze-dried powder, then slowly fill in perfluoropropane to 55KPa in a vacuum state, and then slowly fill in the mixed gas of perfluoropropane and nitrogen to 1 atmospheric pressure, then use a rubber stopper to seal the vial, and the volume ratio of perfluoropropane in the mixed gas is 50%;

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a targeted ultrasound contrast agent for enhancing the ultrasound diagnosis of carotid atherosclerosis and a preparation method thereof. It is prepared from phospholipid and biological inert gas, which realizes the carotid arteriosclerosis targeting of ultrasound contrast agent at low cost and enhances the ultrasound imaging effect of carotid arteriosclerosis.

Description

technical field [0001] The invention belongs to the field of diagnostic reagents, and in particular relates to a targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis and a preparation method thereof. Background technique [0002] Atherosclerosis (Artherosclerosis, AS) refers to the deposition of blood components such as lipids in the arterial intima, the proliferation of smooth muscle cells and the increase of collagen fibers, forming atherosclerotic fat-containing necrotic lesions and sclerosis of the vessel wall. Atherosclerosis is the result of the joint action of multiple factors, and its pathogenesis is complex. Among them, lipid metabolism disorder is the basis of atherosclerosis. It is characterized by the involvement of arterial lesions starting from the intima. Sugar accumulation, hemorrhage and thrombosis, further fibrous tissue hyperplasia and calcium deposition, and gradual degeneration and calcification of the arterial...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
CPCA61K49/221A61K49/223
Inventor 石光煜李丹姜丽丽孟扬张倩尹磊焦洋张雪娇苏德春王丽颖
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com