180 results about "Arterial Intima" patented technology

Post-interventional neointimal hyperplasia in arteries is treated by the application of ultrasonic energy. Usually, an intravascular catheter having an interface surface is positioned at a target site in the artery which has previously been treated. The interface surface is vibrationally excited to apply energy to the arterial wall in a manner which inhibits smooth muscle cell proliferation in the neointimal layer.

Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a device and a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.

Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.

The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a PDE-4 inhibitor, a PDE-5 inhibitor, a compound that elevates cGMP and/or PKG, a stimulator of guanylyl cyclase and/or PKG, a combination of a compound that elevates cGMP, PKG or NO with an antioxidant that decreases ROS, or a compound that increases MMP activity.

A ring for use in anastomosis. Preferably, the ring is integrally formed from metal, and includes a ring portion and tines and docking members that extend from the ring portion. The ring portion and tines are malleable, and preferably also the docking members are malleable. The ring portion and tines are malleable in the sense that once deformed from a first shape into a second shape, they will not relax back into the first shape from the second. To install the ring in a vessel with the ring portion extending around an incision or other orifice, the tines pierce the tissue around the orifice and are curled against an anvil. The action of curling the tines inverts the tissue near the orifice edges to expose the inside surface of the vessel or organ. Other aspects of the invention are a method and apparatus for installing an anastomosis ring in an incision or other orifice in a vessel or other organ, a method and apparatus for precisely aligning two anastomosis rings (each installed in an incision or other orifice of a different organ) and fastening the aligned rings together. The clips can be crimped onto the aligned rings, or they can be spring clips which are sprung onto the aligned rings to clamp the rings together by spring force. Also within the scope of the invention are crimping and spring clips for use in listening together two aligned anastomosis rings. In other embodiments, the invention is a method for performing an anastomosis by installing an anastomosis ring in an orifice in an organ, installing another anastomosis ring in an orifice in another organ, precisely aligning the two installed anastomosis rings, and fastening the aligned rings together.

An intravascular catheter device having a catheter and an ultrasound ablation manifold is proposed for generating cavitations and acoustic jet streams in the blood to ablate atheroma. The ablation manifold has a power transducer and a coupled leaky acoustic cavity. The leaky acoustic cavity contains a first portion of ultrasonic power emission for intra-cavity ablation while allowing a second portion of ultrasonic power emission to leak outside for an extra-cavity ablation. The power transducer and the leaky acoustic cavity are configured to form a confocal resonant cavity. An intervening bird cage is coupled to the resonant cavity for stronger resonance while maintaining ultrasound leakage. A protective shield is mounted around the waist of bird cage to strengthen resonance and to prevent damaging the intima from an otherwise normal incidence of high intensity ultrasound. A microbubble releasing device and micro pump are also included to further increase the ablation efficacy.

A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.

Percutaneous apparatus for forming a bicuspid venous valve from autologous tissue are disclosed. A multilumen catheter is disclosed that includes a delivery shaft positioned on either side of the balloon. When the balloon is inflated within the vein at a treatment location where a bicuspid valve is to be created, the delivery shafts are pressed into the wall of the vein by the inflated balloon so that exit ports in the delivery shafts are at diametrically opposed locations. The delivery shafts may than be used to deliver puncture elements through the exit ports and into the vessel wall to gain access to a subintimal layer of the vein wall. In this manner, the inventive multilumen catheter aids in making properly positioned flaps of venous tissue for creating a bicuspid venous valve from autologous tissue.

A method for assessing cardiac function using an ultrasound imaging catheter system includes positioning an ultrasound catheter so the ultrasound transducer can image a ventricle, obtaining images of the ventricle at two or more times within the cardiac cycle, recognizing an edge of the endocardium, measuring dimensions of the ventricle, calculating a volume or area of the ventricle at the two or more points in the cardiac cycle, and calculating the ejection fraction based upon the difference in volume or area at the two or more times in the cardiac cycle. The method can be used to determine a location for an intervention, such as placement of a pacemaker pacing lead, and may be performed before and after an intervention to assess the impact of the treatment on cardiac function.

A new technique is disclosed for providing an ultrasonic diagnostic apparatus and an ultrasonic diagnostic method, by which it is possible to diagnose vascular endothelial function with high sensitivity through measurement of changes of elastic modulus of vascular wall in the region of tunica intima and tunica media with high precision by using ultrasonic waves in the diagnosis of vascular endothelial reaction after the stopping of avascularization. According to this technique, the apparatus comprises an arithmetic unit 19 for obtaining elastic modulus of a vascular wall 4, and the apparatus is provided with at least one of a calculation data storage unit 20 for storing changes over time of elastic modulus of vascular wall when artery is avascularized and the avascularization is then stopped, or a display unit 21 for displaying changes over time of elastic modulus of the vascular wall.

Described herein are a device and a method for the treatment of varicose veins via laser radiation, and in particular using a holmium laser. The radiation of a laser source (5) is injected in a fiber (3) that can be inserted in the vessel to be treated. The laser source emits a radiation such as to cause a hyalinizing sclerosis with structural modifications both to the fibers of the collagen (shrinkage) and to the extracellular matrix of the median coat of the vein by the photothermal effect, substantially without thermal stress of the morphological component of the tunica media and of the tunica intima.

Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.

The invention relates to a preparation method and application of collagen scaffold composite bone marrow-derived mesenchymal stem cells (BMSCs). The preparation method comprises the steps of preparing single cell suspension after trypsinizing the BMSCs, uniformly dropwise adding the single cell suspension to a collagen scaffold, putting the collagen scaffold into an incubator to be cultured, and adding an L-DMEM complete medium to continue culture, thus obtaining the collagen scaffold composite BMSCs. The preparation method has the advantages that the following defects are overcome: endometria are seriously injured as intrauterine adhesion is mechanically separated by adopting hysteroscopic surgery, intrauterine devices or anti-adhesion materials are put after the surgery and estrogens are given after the surgery to promote intima growth; the problem of intima scars can not be solved; functional intima repair can not be achieved; adhesion is very easy to happen again. As active ingredients for treating serious endometrium injury, the BMSCs are convenient to obtain, secrete growth factors to improve the local microenvironment and immunoregulation, have good biocompatibility, degradability and safety, promote scarred endometrium repair and increase the intima thickness and local blood vessel density.

A medicine coated scaffold for preventing and treating the renarrowing of arteria coronaria after plastic operation features that the tatin kind of medicines which can suppress the growth of new tunia intime and the reproduction of smooth muscle cells is contained in the coated layer of scaffold and can be slowly released to prevent said renarrowing of arteria coronaria. Its advantages are high effect and low cost.

A medical imaging diagnosis apparatus for measuring the composite thickness of the tunica intima (42) and the tunica media (44) of a blood vessel of a subject by acquiring image data on the blood vessel.

In order to improve the accuracy of the IMT measurement of the composite thickness, the medical imaging diagnosis apparatus has extracting means for extracting the tunica intima (42) and the tunica exterma (46) of the blood vessel on the basis of the brightness information of the image data to measure the composite thickness of the tunica intima and the tunica exterma of the vessel in reference to the two extracted regions.

A scaffold with coated medicine layer is composed of scaffold body and medicine layer containing taxol or its derivative, anti-thrombocyte medicine and anti-inflammatory medicine. Its advantages are high effect to durably prevent the new growth of tunica intima, renarrowing and delayed thrombus, and no affection to normal endothelium process.