12 results about "Arterial Intima" patented technology

The invention belongs to the technical field of medicines, and discloses an application of a small molecule compound in preparation of a product for preventing and / or treating pulmonary arterial hypertension and complications thereof. The small molecule compound is 8-[[4-(cyclopropanecarbonyl) piperazine-1-yl] methyl]-1, 3-dimethyl-7-(3-methylbutyl) purine-2, 6-diketone, and the structural formula is as shown in a formula (I): # imgabs0. The small molecule compound and pharmaceutically acceptable salts thereof have a remarkable treatment effect on pulmonary arterial hypertension and complications thereof, and can be used for treating pulmonary arterial hypertension and complications thereof. The effects of preventing and / or treating the pulmonary arterial hypertension include the reduction of right heart hypertrophy, the reduction of right ventricular systolic pressure, right heart enlargement, right heart dysfunction, pulmonary vascular remodeling, pulmonary arterial intima thickness, increase of vascular myelization, pulmonary arterial smooth muscle cell proliferation and migration, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy and the reduction of the right ventricular hypertrophy. The pulmonary arterial intima thickness and the vascular myelization level are improved, pulmonary vascular remodeling is reversed, and pulmonary artery smooth muscle cell proliferation and migration are inhibited.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

The invention relates to the field of animal models, in particular to a construction method and application of an experimental animal plaque model.The construction method includes the steps that after blood flow is blocked through a balloon method, induction is conducted by directly infiltrating a calcium chloride solution into an endarterium, and finally an artery blood vessel calcified plaque model is formed; therefore, an experimental animal model with high efficiency, repeatability, minimally invasive property and pathological correlation is provided for the research of the artery blood vessel calcified plaque.

The invention provides a method, a system, equipment, a medium and a program product for predicting carotid endarterectomy postoperative restenosis, and belongs to the field of intelligent medical treatment. According to the method, it is found for the first time that the perivascular adipose tissue attenuation value data of the to-be-detected sample can be used for predicting carotid endarterectomy restenosis, and if the perivascular adipose tissue attenuation value data of the to-be-detected sample is higher than a threshold value, the carotid endarterectomy restenosis risk of the to-be-detected sample is high; if the attenuation value data of the adipose tissue around the blood vessel of the to-be-detected sample is lower than the threshold value, the risk of restenosis after carotid endarterectomy of the to-be-detected sample is low. The method can be used for assisting operation decision before carotid endarterectomy.

The application relates to the field of biological medicine, in particular to a medicine for preventing intimal hyperplasia and application thereof, and specifically discloses application of a plasmid in preparation of a medicine for preventing intimal hyperplasia through extra-vascular injection, wherein the plasmid is one or more of HGF plasmid, VEGF plasmid and eNOS plasmid, and the plasmid is a naked plasmid. Through the scheme, a medicine of a safe, simple, efficient and local continuous expression gene delivery mode is developed, the medicine is precisely delivered from outside to inside through an extra-vascular injection path, the problems of easy loss of intraluminal medicine and poor targeting of systemic administration are solved, and the treatment effect of the disease is greatly improved.

The invention relates to the technical field of vascular intervention, in particular to a motor catheter assisted carotid endarterectomy system which comprises a motor catheter, a balloon guide catheter, a 45-degree guide catheter, a brain protection umbrella and a peripheral balloon catheter. By means of the combined arrangement of the motor catheter, the balloon guide catheter, the 45-degree guide catheter, the brain protection umbrella and the peripheral balloon catheter, the problem that at present, a patient cannot tolerate general anesthesia or refuse to accept a traditional incision operation, so that carotid endarterectomy cannot be conducted is effectively solved; and meanwhile, the problems of large trauma and long wound healing time of the conventional carotid endarterectomy are solved, and the problem that a combined operating room needs to be built in order to reduce the surgical risk and facilitate the surgical operation at present is perfectly solved.

Disclosed is a deep learning segmentation model training method, comprising: acquiring a three-dimensional vascular image containing a vascular segment of interest; processing the three-dimensional vascular image by means of a deep learning segmentation model to be trained, so as to obtain a tunica media segmentation result image and a tunica intima segmentation result image; determining a loss function according to a tunica media segmentation result label, a tunica intima segmentation result label, the tunica media segmentation result image, and the tunica intima segmentation result image, and updating a parameter of the deep learning segmentation model to be trained so as to obtain a trained deep learning segmentation model, wherein a tunica media segmentor and a tunica intima segmentor of the deep learning segmentation model use a cross-attention mechanism to segment the three-dimensional vascular image to obtain the tunica media segmentation result image and the tunica intima segmentation result image. The described method allows for the accurate segmentation of tunica intimae and tunica mediae of blood vessels. Further disclosed are a deep learning segmentation model training apparatus, a vascular image segmentation method and apparatus, an electronic device, and a readable storage medium.

The present application relates to the technical field of medical instruments and particularly to a three-cavity microcatheter. The three-cavity microcatheter comprises: a first tube body, wherein a guide wire cavity is formed in the first tube body; a second tube body; a third tube body, wherein at least one guide wire outlet is formed in a sidewall of the far end of the first tube body, the guide wire outlet is in communication with the guide wire cavity, and a far end part of the second tube body, a far end part of the first tube body, and a far end part of the third tube body are arranged side by side in a flat shape such that, when the three-cavity microcatheter enters an inner space of the tunica vasculosa, the at least one guide wire outlet faces the tunica intima and / or the tunica media; and a positioning mark, wherein the second tube body and / or the third tube body are provided with the positioning mark, and the positioning mark is configured for positioning the guide wire outlet of the first tube body. The solutions provided by the present application enable a directional puncture of the puncture guide wire reentering the true vascular lumen from the subintimal space, increasing the success rate of one-time surgery.

The application provides application of a biomarker in prediction of restenosis after carotid endarterectomy, and belongs to the field of biotechnology. It is found for the first time that the expression level of CCL-8 in perivascular adipose tissue can be used for prediction of restenosis after carotid endarterectomy, and the expression level of CCL-8 in the perivascular adipose tissue has good efficiency in prediction of restenosis after carotid endarterectomy, which is verified by real clinical samples collected by the application.

The present invention relates to the technical field of surgical instruments used in donor organ transplantation. Disclosed is an integrated puncture and perfusion catheter for perfusion of donor abdominal organs for transplantation, comprising: a puncture cylinder, wherein a reservoir is fixedly connected to a puncture end of the puncture cylinder; and further comprising: a puncture and perfusion switching mechanism, wherein the puncture and perfusion switching mechanism is arranged at the center of the puncture cylinder, and is used for freely switching the puncture and perfusion functions of the puncture cylinder at the same position. Through cooperation of provided structures such as a first rack, a second rack, and a guide member, the rotation of a gear disc can be used to control the first rack and the second rack to slide in opposite directions of the puncture cylinder, such that a puncture tip moves backward upon the completion of penetration to provide clearance, thereby avoiding damage to tunica intima caused by retention of the puncture tip, and improving the viability of a harvested organ; and the second rack carries a support tube by means of the guide member to move towards the perfusion position, and the support tube replaces the puncture tip at the puncture position, such that a perfusion pipe is prevented from deviating from a puncture port, thereby minimizing perfusate usage costs.

The invention provides a diabetes mellitus great vasculopathy prediction method and device based on fundus image features, and belongs to the technical field of image processing, and the method comprises the steps: constructing a diabetes mellitus carotid intima middle layer thickness bilateral fundus data set; performing blood vessel segmentation processing on the diabetic carotid intima middle layer thickness bilateral fundus data set by using a semantic segmentation model based on visual stimulation self-adaption to obtain a binocular blood vessel data set; training the carotid intima middle-layer thickness prediction model by using the diabetic carotid intima middle-layer thickness bilateral fundus data set and the binocular blood vessel data set to obtain a trained carotid intima middle-layer thickness prediction model; and performing diabetes mellitus great vasculopathy prediction by using the trained carotid intima middle layer thickness prediction model. According to the method, the pressure of medical resources can be effectively relieved, the cost is reduced, and the detection rate of the great vasculopathy marker of the diabetic patient is increased, so that the application of precise medical treatment in screening of the great vasculopathy of the diabetic patient is promoted.

The utility model discloses a blood diversion device for carotid intimal plaque exfoliation, which comprises a connecting tube and intubation tubes arranged at two ends of the connecting tube, the intubation tubes are fixedly connected with the connecting tube, an annular positioning groove is coaxially arranged on the peripheral surface of each intubation tube, the surface of each annular positioning groove is fixedly connected with an air bag, and the air bag is fixedly connected with the connecting tube. An annular positioning groove is formed in the outer circumferential face of the cannula, an air bag is arranged at the annular positioning groove, a pressurizing cavity is coaxially formed in the cannula, and a connecting hole is formed between the pressurizing cavity and the annular positioning groove, the connecting tube is arranged at the two ends of the connecting tube respectively, the cannula is used for being inserted into a blood vessel, and the annular positioning groove is formed in the outer circumferential face of the cannula and provided with the air bag. The pressurizing cavity is formed in the cannula body, compressed air is contained in the pressurizing cavity, the compressed air is conveyed into the annular positioning groove through the connecting hole, the air bag outside the annular positioning groove is expanded, the cannula body and the blood vessel are fixed, the pressurizing cavity is formed in the cannula body, the size of the device is smaller, and operation is convenient and fast.