10 results about "Tissue composition" patented technology

Disclosed herein are methods for obtaining endometrial stromal fibroblast cells from pluripotent stem cells, such as induced pluripotent stem cells. The present disclosure also provides methods of obtaining a three-dimensional, multilayered endometrial tissue composition. Methods of using the cells and tissue compositions in drug screening and therapeutic applications are also provided.

A tissue density assessment apparatus 200 comprises first and second transducer panels 210, 212 (30, 32 fig. 1) spaced apart facing each other. The transducer panels are connected to support arms 206, 208. One of the transducer plates 210, 212 is adjustable relative to the other e.g. by movement of arm 206 relative to fixed arm 208. At least one ultrasound emitter is disposed on the second panel, and at least one ultrasound receiver is disposed on the first panel. A processor determines from the received ultrasound signals a tissue composition / constitution measure of the assessed tissue, and may determine an overall tissue composition / constitution measurement across the entire area of the tissue. An adjustment element 220 may be provided between a panel and the body to reduce air gaps and increase comfort. The element may have a fluid filled bladder 220 and contact plate 222. Preferably a patient is assessed in an upright position (e.g. standing or seated). The apparatus may obtain a measure of an average breast tissue composition / constitution, which can be used to indicate a medical condition, or a risk of a medical condition, e.g cancer.

Disclosed are methods and systems for selecting one or more candidate regions from a tissue for inclusion in a tissue microarray (TMA). Methods involve determining tissue compositions of regions across the tissue and selecting the candidate regions that have desired tissue compositions for inclusion in a TMA. For example, desired tissue compositions can include one or more tissue classes, examples of which include tumor, stroma, immune, necrosis, other tissue, or combinations thereof. Thus, the disclosed method represents an automated process of selecting candidate regions without involving manual input.

A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Several new inventions are detailed with this system, method, and device. While at the core, these inventions may ablate tissue by application of a short duration electric field, the therapy waveform used to apply the electric field is novel and optimized to preserve the intra-cellular content possible across different identified tissues. The optimized pulse biases tissue to an electroporation state and then presents a “hammer pulse” which may be along the same polarity or different polarity. This treatment minimizes thermal effects and is being defined as Pulse Field Immunotherapy (PFI). The antigens are left in situ and taken up by antigen-presenting cells in the periphery allowing the immune system to engage. Additional tissue feedback is obtained through an invention that performs measurements on tissue to determine its composition while the applicator is inserted into normal tissue, followed by diseased tissue. Tissue composition is compared against a library of characterized Tissue Identity Profiles (TIPs), allowing for immediate assessments and therapy to be provided while the patient is undergoing traditional diagnosis.

A fibrous birth tissue composition fabricated from placental tissue is provided. Methods of processing a mammal's placental tissue to form a fibrous birth tissue composition are provided. Regenerative methods are also provided.

An organ tissue composition or constitution assessment apparatus (10) comprises first and second panel elements (16, 18) disposed in spaced apart and facing relationship. One of the first and second panel elements (16, 17) is adjustable relative to the other in distance. At least one ultrasound emitter (32) is disposed on the second panel element (18). At least one ultrasound receiver (30) is disposed on the first panel element (16), such that the emitter and receiver face another. The panel elements are connected to a support structure (12, 14) and preferably in an arrangement which enables assessment of a patient's body part while the patient is in an upright position. The apparatus includes a processing unit (304) which is configured to determine from the received ultrasound signals a tissue composition or constitution measure associated with the organ tissue to be assessed and preferably an overall tissue composition or constitution measurement across the entire area of the organ tissue to be assessed. The preferred embodiment is able to obtain a measure of an average breast tissue composition or constitution, which can be used as indicative of a medical condition or risk of a medical condition, such as cancer, and as a guide to selection of optimum screening procedures.

A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

A fibrous birth tissue composition fabricated from placental tissue is provided. Methods of processing a mammal's placental tissue to form a fibrous birth tissue composition are provided. Regenerative methods are also provided.

A system for assessing cancer includes a memory configured to store one or more images of tissue of a patient, where the one or more images originate from a magnetic resonance imaging (MRI) machine. The system also includes a processor operatively coupled to the memory and configured to determine a composition of the tissue. The processor is also configured to determine, based at least in part on the composition of the tissue, an apparent diffusion constant of the tissue. The processor is also configured to identify a region of cancer based at least in part on the apparent diffusion constant. The processor is further configured to generate a map that identifies the region of cancer in the tissue.