63 results about "Pulse field" patented technology

Systems and methods for electroporation are provided. An electroporation system includes a catheter assembly including a first electrode, a second electrode, and a pulse generator coupled to the first and second electrodes. The pulse generator is configured to apply a waveform between the first and second electrodes to perform irreversible electroporation, wherein the waveform includes pulses having a voltage amplitude of 1000 Volts (V) or less and an effective pulse width of 10 microseconds (μs) or more.

The invention discloses a new energy station cable terminal partial discharge signal identification method and system, and the method comprises the following steps: collecting an original signal, carrying out the preprocessing of the original signal, and carrying out the wavelet threshold noise reduction processing, and obtaining a noise reduction signal; performing sliding slicing processing on the denoised one-dimensional long time sequence signal, and inputting the processed signal into the constructed partial discharge identification model to train the model; and inputting the target signal into the trained partial discharge identification model to obtain a time position and a continuous range of a real partial discharge event in the long time sequence signal, thereby realizing effective identification and separation of the partial discharge signal and corona interference of the cable terminal of the new energy field station. Wavelet noise reduction, a time window and one-dimensional convolutional network depth feature recognition are integrally designed, partial discharge signals can be stably recognized in the strong noise and mixed pulse scene of the new energy station cable terminal, and a reliable data basis is provided for insulation state evaluation and operation and maintenance early warning of the new energy station cable terminal.

A medical system may be configured at least to receive a user-selection of a first group of electrodes in a spatial distribution of electrodes; cause, at least in response to the user-selection of the first group of electrodes, a machine-selection of a second group of electrodes in the spatial distribution of electrodes, each electrode in the machine-selected second group of electrodes spaced, according to the spatial distribution, from an electrode in the user-selected first group of electrodes at least by a respective interposed electrode set in the spatial distribution of electrodes; and cause bipolar pulsed field tissue ablation between the user-selected first group of electrodes and the machine-selected second group of electrodes, while omitting at least any electrode of each respective interposed electrode set from causing bipolar pulsed field tissue ablation.

Disclosed are systems and methods for visualization of pulsed field ablation tags. In some implementations, a system includes a device, comprising a processor in communication with one or more sensors and a catheter comprising a plurality of electrodes. In some implementations, the processor is configured to: receive, via the one or more sensors, a position of each of the plurality of electrodes within a three-dimensional environment during a first ablation session; calculate, for the first ablation session, a first implicit function representing an energy field of the first ablation session from the received positions of each of the plurality of electrodes; and present, via a display, a first volumetric representation of the calculated first implicit function.

Waveform characteristics of pulses in a pulse train configured to cause pulsed field tissue ablation may be varied in a manner that improves electromagnetic compatibility while retaining treatment efficacy. Such waveform characteristics may include pulse-to-pulse initiation intervals, inter-pulse delays, pulse on-times, pulse widths, inter-phase delays in the case of biphasic pulses, or a combination thereof. Such waveform characteristics may be varied in a random manner. Variations of waveform characteristics may be bounded by minimum, maximum, or both minimum and maximum differences between various pulses or pulse groups, or between various pulse trains or pulse train groups, for example, to help ensure sufficient stability of treatment signal waveforms while allowing sufficient variability, for example, to improve electromagnetic compatibility.

Described herein is an apparatus and method for predicting Pulsed Field Ablation (PFA) durability. An apparatus may include at least a processor; and a memory communicatively connected to the at least processor, wherein the memory contains instructions configuring the at least processor to receive a training dataset comprising a plurality of example PFA device parameters correlated to a plurality of example PFA outcomes; train a PFA durability machine learning model using the training dataset; receive a PFA device parameter; and generate a PFA durability datum as a function of the PFA device parameter using a trained PFA durability machine learning model.

An electroporation system is provided. The electroporation system includes a catheter comprising a plurality of electrodes; and a pulse generator coupled to the catheter, the pulse generator being configured to generate a waveform delivered using at least one of the plurality of electrodes. The waveform includes a first pulse pattern and a second pulse pattern consecutive to the first pulse pattern, wherein the pulse period defined between the start point of the first pulse pattern and the start point of the second pulse pattern is in the range of 1 millisecond (ms) to 100 ms, such that the waveform contributes to increasing the depth of lesion.

A power generator is disclosed for generating ablating energy deliverable to a catheter for treatment of heart rhythm disorders. The power generator includes a first output port configured to deliver ablation energy through a first conductive wire of a catheter and a second output port configured to receive a sensing signal from a thermocouple junction formed at a catheter electrode. The generator includes a first power driver for producing waveforms suitable for radiofrequency ablation (RFA) and a second power driver for generating pulsed waveforms suitable for pulsed field ablation (PFA). A switching circuit selectively couples one of the power drivers to the first output port based on a selected ablation modality. A control circuit receives an input indicating the selected modality and controls the switching circuit accordingly. The system enables dual-modality ablation using a shared catheter interface, facilitating seamless transition between RFA and PFA without requiring hardware reconfiguration.

The invention discloses a duodenum mucosa remodeling system based on pulse field ablation and a control method, and the system comprises a multi-modal sensing ablation catheter which is used for collecting multi-modal data related to duodenum ablation through a multi-modal sensor; the multi-sensing data fusion unit is used for extracting key features after preprocessing the multi-modal data, and fusing the key features according to a preset algorithm to obtain a multi-modal feature vector; the real-time tissue feature analysis module is used for recognizing the tissue type of the current ablation point location in real time according to the multi-modal feature vector and analyzing the dynamic change of tissue features; the self-adaptive parameter adjustment engine is used for determining corresponding ablation parameters according to the tissue type of the current ablation point location and the dynamic change of the tissue characteristics; and the motion compensation and prediction system is used for predicting the motion trail of the duodenum in a future preset time period. The problem that in the prior art, a duodenum mucosa remodeling system is poor in remodeling effect is solved.

The improved systems described herein are equipped with one or more pulsed field electroporation (PFE) electrodes configured to induce localized and targeted PFE output at target tissue (e.g., in the ear, nose or throat).

The invention relates to the technical field of pesticide detection, and particularly discloses an intelligent pesticide residue detection method which comprises the following steps: S1, matrix interfering substance identification: weighing a preset mass of a to-be-detected sample, putting the to-be-detected sample into a spectral imaging detection instrument, collecting a diffuse reflection spectrum of the sample through a near infrared spectrometer, and determining the matrix interfering substance in the to-be-detected sample; combining a convolutional neural network model to identify crop types, and synchronously estimating relative proportions of fibers, starch and lipid to obtain matrix components; s2, a pulsed field cooperative dynamic extraction step: according to the identified matrix components, performing differential parameter regulation and control in an ultrasonic-microwave-infrared composite field extraction cavity; when the lipid proportion is larger than a first preset value, microwave and infrared synergistic heating is started to reach 50-60 DEG C, normal hexane saturated acetonitrile extraction is matched, and meanwhile the turbidity of extract liquor is monitored in real time through a camera; according to the technical scheme, aiming at the characteristics of the grain matrix, the problems of insufficient efficiency and serious matrix interference can be solved.

An improved system described herein equipped with one or more Pulsed Field Electroporation (PFE) electrodes configured to cause localized and targeted PFE output at the targeted tissue, for example, in an ear, nose, or throat.

The invention belongs to the technical field of electromagnetic compatibility tests, and relates to an electromagnetic compatibility transient electromagnetic pulse immunity performance evaluation auxiliary device, which comprises at least one set of visual shielding device, at least one set of transient electromagnetic pulse suppression device and an interconnection wire harness, the visual shielding device is used for placing all or part of the auxiliary equipment; and the transient electromagnetic pulse suppression device is connected to the auxiliary equipment and the tested sample through the interconnection wire harness. According to the invention, the visual shielding device is arranged, so that the shielding effectiveness of more than 30 dB can be realized, and the interference of a transient electromagnetic pulse field on auxiliary equipment is effectively reduced; a transient electromagnetic pulse suppression device is arranged, the pulse residual suppression voltage is lower than 296.4 V, and the shielding effectiveness of an external electromagnetic field reaches 60 dB or above; the shielding connecting wire harness is arranged, and the surface transfer impedance is lower than 2 m omega / m within the frequency range of 9 kHz to 3 GHz. According to the device, the transient electromagnetic pulse field is prevented from being coupled and conducted to auxiliary equipment through the wire harness; and transient electromagnetic pulse suppression under a high-speed communication condition is realized.

Disclosed is a pulsed field ablation actuator comprising: (a) an electrode comprising an electrode surface for delivering an electrical current to anatomical tissue; and a deformable insulator selectively covering the electrode surface, the deformable insulator configured to deform when contacted by anatomical tissue to expose the electrode surface. Methods and apparatus for performing electroporation as well as other forms of ablation performed concurrently with electroporation are also disclosed.

A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

A system for visualization of pulsed field ablation tags comprises a device. The device comprises a processor in communication with one or more sensors and a catheter comprising a plurality of electrodes. The processor is configured to receive, via the one or more sensors, a position of each of the plurality of electrodes within a three-dimensional environment during a first ablation session. The processor is configured to calculate, for the first ablation session, a first implicit function representing an energy field of the first ablation session from the received positions of each of the plurality of electrodes. The first implicit function is calculated via a signed distance function based on positions of a pair of adjacent electrodes of the plurality of electrodes during the first ablation session. The processor is configured to present, via a display, a first volumetric representation of the calculated first implicit function.

A method and a pulsed electric field (PEF) ablation instrument are provided. According to one aspect, a method in a PFA generator includes receiving electrical responses for each of at least one non-therapeutic waveform. The process also includes determining an electric field distribution based at least in part on the received electrical responses. The process further includes selecting a non-therapeutic waveform that produces an electric field distribution that satisfies criteria. The process also includes mapping the selected non-therapeutic waveform to an ablative waveform.

To provide an underwater detection device capable of operating an ultrasonic transducer with a target transmission power even when the transmission power is set small, the underwater detection device is provided with: a control circuit configured to set a target pulse width corresponding to a transmission power inputted to the ultrasonic transducer and output a control pulse; a Field Effect Transistor (FET) driver configured to output a first voltage signal corresponding to a pulse width of the control pulse; and a power transistor configured to output a second voltage signal that operates the ultrasonic transducer by inputting the first voltage signal. The control circuit is configured to: correct the target pulse width when less than a predetermined threshold value and output the control pulse having the corrected pulse width, and output the control pulse having the target pulse width when the target pulse width exceeds the threshold value.

The present disclosure provides a medical system for performing pulse field ablation medical procedures. The medical system includes an ablation device configured to generate electrical fields that cause electroporation of tissue of a subject, a sensor array in electrical communication with the ablation device, and a control unit in electrical communication with the ablation device and the sensor array. The ablation device includes at least one set of electrodes. The sensor array includes at least one surface electromyography (sEMG) sensor and at least one inertial measurement unit (IMU) sensor. The control unit configured to generate a pulse waveform, transmit the pulse waveform to the ablation device, determine a muscle contraction level based on signal data from the ablation device and sensor data from the sensor array, and to determine an sEMG threshold based on the sensor data and muscle contraction level.

A power generator is disclosed for generating ablating energy deliverable to a catheter for treatment of heart rhythm disorders. The power generator includes a first output port configured to deliver ablation energy through a first conductive wire of a catheter and a second output port configured to receive a sensing signal from a thermocouple junction formed at a catheter electrode. The generator includes a first power driver for producing waveforms suitable for radiofrequency ablation (RFA) and a second power driver for generating pulsed waveforms suitable for pulsed field ablation (PF A). A switching circuit selectively couples one of the power drivers to the first output port based on a selected ablation modality. A control circuit receives an input indicating the selected modality and controls the switching circuit accordingly. The system enables dual-modality ablation using a shared catheter interface, facilitating seamless transition between RFA and PF A without requiring hardware reconfiguration.

The present invention relates to a generator (G) for a substantially charge-balanced pulse for application onto at least one electrode pair (101) of a medical device, the generator comprising: a pulse-shaping output stage (POS) for coupling to the at least one electrode pair; an internal pulse generator for applying an internal pulse to the pulse-shaping output stage; wherein the pulse-shaping output stage comprises a transformer (T) and / or a capacitor system (CS) comprising at least one capacitor such that the internal pulse is transformed into a substantially charge-balanced pulse in the at least one electrode pair (I1) when coupled to the pulse-shaping output stage (POS). Further aspects relate to a catheter, a system, a method.

Systems and methods are provided for treating a target tissue. Accordingly, an electrode catheter is positioned in proximity to the target tissue and a dose of energy is delivered. The dose of energy includes a set of pulses at a first frequency. Each pulse has a maximal pulse magnitude and a pulse duration associated with a reference pulse and an energy output that is less than the reference pulse. A pulse waveform of each pulse includes a set of peak intervals at a second frequency and interspersed nadir intervals. The duration of each nadir interval is less than a restitution interval of the target tissue, and the second frequency enhances production of an oxidative reaction. The resultant Maxwell stress substantially equals the Maxwell stress that would be produced by the reference pulse, while the oxidative stress is greater than the oxidative stress producible by the reference pulse.

A method for irrigation during pulsed field ablation (PFA) includes operating a pump for delivering irrigation in idle mode, receiving a first user command to deliver a PFA sequence and toggling the pump to active mode. The first PFA sequence is delivered after a pre-defined ramp-up delay, and a timer is preset to be ON for a defined working duration. A second user command to delivery a PFA sequence is received and delivered with no imposed delay while the timer is ON. The timer is reset based on the second user command. The pump is toggled to idle mode after the defined working duration lapses.

The invention discloses a pulsed field ablation device and a pulsed field ablation control method. The pulsed field ablation device comprises a sleeve, and an impedance detection electrode is arranged at the top end of the sleeve; the deformation supporting body can extend out of the interior of the cannula through deformation and then is unfolded, and a plurality of pulse field ablation electrodes are arranged on the deformation supporting body; the pulse field ablation power supply is used for supplying power to the pulse field ablation electrode; the impedance detection module is used for recording the impedance of the impedance detection electrode; and the switch control module is used for controlling the on-off state of the pulse field ablation power supply according to the magnitude of the impedance detection signal.

The invention discloses a PFA technology-based dual-channel drive intelligent sleep-aiding pillow, which comprises a pillow, the pillow is provided with a high-voltage and low-frequency generation device and a power supply, the power supply supplies power to the high-voltage and low-frequency generation device, and the high-voltage and low-frequency pulse generation device is used for outputting high-voltage and low-frequency pulse signals. More than two groups of electrode pairs are arranged on the high-voltage low-frequency pulse generating device, are arranged on the surface of the pillow and are positioned at the Fengchi acupoint. Compared with the prior art, more than two groups of electrode pairs are arranged at the position of the Fengchi acupoint of the pillow, each group of electrode pairs corresponds to one Fengchi acupoint, and high-voltage and low-frequency pulsed electric field stimulation is applied to the Fengchi acupoints and peripheral nerves through the high-voltage and low-frequency pulse generator, so that nervous excitability is reduced, sleep is induced, and sleep quality is improved.

A medical system for performing a pulsed field ablation medical procedure is provided. The medical system includes an ablation device configured to generate an electric field that causes electroporation of tissue of a subject; a sensor array in electrical communication with the ablation device; and a control unit in electrical communication with the ablation device and the sensor array. The ablation device includes at least one set of electrodes. The sensor array includes at least one surface electromyography (sEMG) sensor and at least one inertial measurement unit (IMU) sensor. The control unit is configured to generate a pulse waveform; transmitting the pulse waveform to the ablation device; determining a muscle contraction level based on signal data from the ablation device and sensor data from the sensor array; and determining an sEMG threshold based on the sensor data and the muscle contraction level.

A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

A method and apparatus for performing a medical ablation procedure. In one example, a medical device includes an ablation waveform generator and an electronic controller. The ablation waveform generator is configured to apply an electrical waveform to a treatment element positionable proximate a treatment site of a patient. The electronic controller is configured to control the ablation waveform generator. The electronic controller is further configured to cause the ablation waveform generator to generate a biphase waveform having an inter-phase delay and an inter-pulse delay greater than the inter-phase delay. The electronic controller is configured to cause the ablation waveform generator to apply the biphasic waveform to the treatment element.