38 results about "Pulse field" patented technology

The invention discloses a new energy station cable terminal partial discharge signal identification method and system, and the method comprises the following steps: collecting an original signal, carrying out the preprocessing of the original signal, and carrying out the wavelet threshold noise reduction processing, and obtaining a noise reduction signal; performing sliding slicing processing on the denoised one-dimensional long time sequence signal, and inputting the processed signal into the constructed partial discharge identification model to train the model; and inputting the target signal into the trained partial discharge identification model to obtain a time position and a continuous range of a real partial discharge event in the long time sequence signal, thereby realizing effective identification and separation of the partial discharge signal and corona interference of the cable terminal of the new energy field station. Wavelet noise reduction, a time window and one-dimensional convolutional network depth feature recognition are integrally designed, partial discharge signals can be stably recognized in the strong noise and mixed pulse scene of the new energy station cable terminal, and a reliable data basis is provided for insulation state evaluation and operation and maintenance early warning of the new energy station cable terminal.

Waveform characteristics of pulses in a pulse train configured to cause pulsed field tissue ablation may be varied in a manner that improves electromagnetic compatibility while retaining treatment efficacy. Such waveform characteristics may include pulse-to-pulse initiation intervals, inter-pulse delays, pulse on-times, pulse widths, inter-phase delays in the case of biphasic pulses, or a combination thereof. Such waveform characteristics may be varied in a random manner. Variations of waveform characteristics may be bounded by minimum, maximum, or both minimum and maximum differences between various pulses or pulse groups, or between various pulse trains or pulse train groups, for example, to help ensure sufficient stability of treatment signal waveforms while allowing sufficient variability, for example, to improve electromagnetic compatibility.

An electroporation system is provided. The electroporation system includes a catheter comprising a plurality of electrodes; and a pulse generator coupled to the catheter, the pulse generator being configured to generate a waveform delivered using at least one of the plurality of electrodes. The waveform includes a first pulse pattern and a second pulse pattern consecutive to the first pulse pattern, wherein the pulse period defined between the start point of the first pulse pattern and the start point of the second pulse pattern is in the range of 1 millisecond (ms) to 100 ms, such that the waveform contributes to increasing the depth of lesion.

The invention discloses a duodenum mucosa remodeling system based on pulse field ablation and a control method, and the system comprises a multi-modal sensing ablation catheter which is used for collecting multi-modal data related to duodenum ablation through a multi-modal sensor; the multi-sensing data fusion unit is used for extracting key features after preprocessing the multi-modal data, and fusing the key features according to a preset algorithm to obtain a multi-modal feature vector; the real-time tissue feature analysis module is used for recognizing the tissue type of the current ablation point location in real time according to the multi-modal feature vector and analyzing the dynamic change of tissue features; the self-adaptive parameter adjustment engine is used for determining corresponding ablation parameters according to the tissue type of the current ablation point location and the dynamic change of the tissue characteristics; and the motion compensation and prediction system is used for predicting the motion trail of the duodenum in a future preset time period. The problem that in the prior art, a duodenum mucosa remodeling system is poor in remodeling effect is solved.

The improved systems described herein are equipped with one or more pulsed field electroporation (PFE) electrodes configured to induce localized and targeted PFE output at target tissue (e.g., in the ear, nose or throat).

The invention belongs to the technical field of electromagnetic compatibility tests, and relates to an electromagnetic compatibility transient electromagnetic pulse immunity performance evaluation auxiliary device, which comprises at least one set of visual shielding device, at least one set of transient electromagnetic pulse suppression device and an interconnection wire harness, the visual shielding device is used for placing all or part of the auxiliary equipment; and the transient electromagnetic pulse suppression device is connected to the auxiliary equipment and the tested sample through the interconnection wire harness. According to the invention, the visual shielding device is arranged, so that the shielding effectiveness of more than 30 dB can be realized, and the interference of a transient electromagnetic pulse field on auxiliary equipment is effectively reduced; a transient electromagnetic pulse suppression device is arranged, the pulse residual suppression voltage is lower than 296.4 V, and the shielding effectiveness of an external electromagnetic field reaches 60 dB or above; the shielding connecting wire harness is arranged, and the surface transfer impedance is lower than 2 m omega / m within the frequency range of 9 kHz to 3 GHz. According to the device, the transient electromagnetic pulse field is prevented from being coupled and conducted to auxiliary equipment through the wire harness; and transient electromagnetic pulse suppression under a high-speed communication condition is realized.

A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

A system for visualization of pulsed field ablation tags comprises a device. The device comprises a processor in communication with one or more sensors and a catheter comprising a plurality of electrodes. The processor is configured to receive, via the one or more sensors, a position of each of the plurality of electrodes within a three-dimensional environment during a first ablation session. The processor is configured to calculate, for the first ablation session, a first implicit function representing an energy field of the first ablation session from the received positions of each of the plurality of electrodes. The first implicit function is calculated via a signed distance function based on positions of a pair of adjacent electrodes of the plurality of electrodes during the first ablation session. The processor is configured to present, via a display, a first volumetric representation of the calculated first implicit function.

A method and a pulsed electric field (PEF) ablation instrument are provided. According to one aspect, a method in a PFA generator includes receiving electrical responses for each of at least one non-therapeutic waveform. The process also includes determining an electric field distribution based at least in part on the received electrical responses. The process further includes selecting a non-therapeutic waveform that produces an electric field distribution that satisfies criteria. The process also includes mapping the selected non-therapeutic waveform to an ablative waveform.

To provide an underwater detection device capable of operating an ultrasonic transducer with a target transmission power even when the transmission power is set small, the underwater detection device is provided with: a control circuit configured to set a target pulse width corresponding to a transmission power inputted to the ultrasonic transducer and output a control pulse; a Field Effect Transistor (FET) driver configured to output a first voltage signal corresponding to a pulse width of the control pulse; and a power transistor configured to output a second voltage signal that operates the ultrasonic transducer by inputting the first voltage signal. The control circuit is configured to: correct the target pulse width when less than a predetermined threshold value and output the control pulse having the corrected pulse width, and output the control pulse having the target pulse width when the target pulse width exceeds the threshold value.

The present disclosure provides a medical system for performing pulse field ablation medical procedures. The medical system includes an ablation device configured to generate electrical fields that cause electroporation of tissue of a subject, a sensor array in electrical communication with the ablation device, and a control unit in electrical communication with the ablation device and the sensor array. The ablation device includes at least one set of electrodes. The sensor array includes at least one surface electromyography (sEMG) sensor and at least one inertial measurement unit (IMU) sensor. The control unit configured to generate a pulse waveform, transmit the pulse waveform to the ablation device, determine a muscle contraction level based on signal data from the ablation device and sensor data from the sensor array, and to determine an sEMG threshold based on the sensor data and muscle contraction level.

The present invention relates to a generator (G) for a substantially charge-balanced pulse for application onto at least one electrode pair (101) of a medical device, the generator comprising: a pulse-shaping output stage (POS) for coupling to the at least one electrode pair; an internal pulse generator for applying an internal pulse to the pulse-shaping output stage; wherein the pulse-shaping output stage comprises a transformer (T) and / or a capacitor system (CS) comprising at least one capacitor such that the internal pulse is transformed into a substantially charge-balanced pulse in the at least one electrode pair (I1) when coupled to the pulse-shaping output stage (POS). Further aspects relate to a catheter, a system, a method.

A method for irrigation during pulsed field ablation (PFA) includes operating a pump for delivering irrigation in idle mode, receiving a first user command to deliver a PFA sequence and toggling the pump to active mode. The first PFA sequence is delivered after a pre-defined ramp-up delay, and a timer is preset to be ON for a defined working duration. A second user command to delivery a PFA sequence is received and delivered with no imposed delay while the timer is ON. The timer is reset based on the second user command. The pump is toggled to idle mode after the defined working duration lapses.

A medical system for performing a pulsed field ablation medical procedure is provided. The medical system includes an ablation device configured to generate an electric field that causes electroporation of tissue of a subject; a sensor array in electrical communication with the ablation device; and a control unit in electrical communication with the ablation device and the sensor array. The ablation device includes at least one set of electrodes. The sensor array includes at least one surface electromyography (sEMG) sensor and at least one inertial measurement unit (IMU) sensor. The control unit is configured to generate a pulse waveform; transmitting the pulse waveform to the ablation device; determining a muscle contraction level based on signal data from the ablation device and sensor data from the sensor array; and determining an sEMG threshold based on the sensor data and the muscle contraction level.

A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

A method and a pulsed electric field (PEF) ablation instrument are provided. According to one aspect, a method in a PFA generator includes receiving electrical responses for each of at least one non-therapeutic waveform. The process also includes determining an electric field distribution based at least in part on the received electrical responses. The process further includes selecting a non-therapeutic waveform that produces an electric field distribution that satisfies criteria. The process also includes mapping the selected non-therapeutic waveform to an ablative waveform.

Methods and apparatus for monitoring and actively reducing leakage currents flowing on patient applied parts used in ablation therapy. In an example, a signal-processing circuit connected between a toroidal-coil sensor and a sleeve-capacitor coupler, both AC-coupled to the catheter cable, applies a Fourier transform and an energy minimization algorithm to the output of the toroidal-coil sensor to determine amplitudes and phases for frequency components of the signal applied to the sleeve-capacitor coupler. A corresponding current coupled through the sleeve-capacitor coupler into the catheter cable counteracts the leakage current to force the total non-therapy electrical current flowing on the patient applied parts to a level that is lower than a fixed threshold value, e.g., selected in accordance with an applicable standard.

The invention relates to the field of medical equipment, and discloses a method for realizing ablation marking by controlling an electric field, which comprises the following steps of: applying an ablation pulse field to an ablation site on target tissue for ablation treatment; after the ablation treatment, acquiring biological impedance change information of the ablation site, and determining the ablation quality grade of the ablation treatment according to the information; according to the determined ablation quality grade, selecting a corresponding non-destructive electrical characteristic coding sequence; the selected electrical feature coding sequence is applied to the ablation site, and a marker associated with an ablation quality level is formed on the site. Informationized and non-thermalized marking is achieved in a pure electric control mode, the mark can bear ablation quality state information, and the technical problem that after pulse field ablation, the position and effect of an ablation site are difficult to identify in real time due to the fact that the ablation site has no obvious change on the macroscopic level of the tissue is solved.

A system for performing electroporation ablation of target tissue in a heart includes a catheter with electrodes, a graphical display, and a controller. The controller generates on the display, a predicted lesion zone on an anatomical map of the heart corresponding to an electric field generated with pulsed electrical signals prior to delivery of the signals to electrodes at a location proximate target tissue. Prior to delivery of the signals to the electrodes, a pre-ablation indicator is generated on the display based on the position of the electrodes at the location. After or concurrently with delivery of the signals at each location, the controller generates an ablation indicator on the anatomical map based on the position of the electrodes at the location, the delivery of the signal, and measured changes in the target tissue.

A catheter with a planar end effector having elongated ablation electrodes configured to provide electrical signals to achieve intravascular resection (IRE) in target tissue is presented. The planar end effector is alignable along the longitudinal axis of the catheter and configured to flex away from the longitudinal axis upon contact with tissue. Bipolar electrical signals can be applied between the elongated ablation electrodes in various combinations to achieve partial invasive ablation (PFA). The end effector may also include diagnostic electrodes configured to receive electrical signals from tissue to map the tissue, paired tissue contact electrodes for determining which portions of the end effector are in contact with the tissue, or reference electrodes configured to measure blood voltage.

A medical device system includes an elongated structure configured to be navigated to an implantation site within a patient, at least one electrode carried on a distal portion of the elongated structure, and processing circuitry. The processing circuitry is configured to cause the at least one electrode, when proximate to the implantation site, to: deliver PF A energy to ablate a first type of tissue at the implantation site; and provide electrical neuromodulation therapy to a second type of tissue at the implantation site.

Methods and devices for carrying out pulsed field ablation are disclosed. Specifically, the instant disclosure includes surgical clamps configured to clamp tissue and determine the distance between repositionable jaws and tailor pulse field ablation energy to the thickness of the clamped tissue, which is indicative of the spacing between the repositionable jaws. Also disclosed are methods of calibrating pulse field ablation devices and methods of using pulse field ablation devices.

A catheter is presented having a planar end effector with elongated ablation electrodes configured to provide electrical signals to achieve IRE in target tissue. The planar end effector can be aligned along a longitudinal axis of a shaft of the catheter and configured to flex away from the longitudinal axis when making contact with tissue. Bipolar electrical signals can be applied between the elongated ablation electrodes in various pair combinations to achieve PFA. The end effector may also include diagnostic electrodes configured to receive electrical signals from tissue to map tissue, pairs of tissue contact electrodes to determine which portions of the end effector are in contact with tissue, or reference electrodes configured to measure blood voltage.

A pulse field ablation system may include a first elongate shaft, a second elongate shaft, one or more electrodes, a wave generator, and a treatment control module. The first elongate shaft may include one or more lumens with a first lumen configured to pass a fluid to treat a thrombus in a vessel of a subject. The second elongate shaft may be configured to extend in a distal direction beyond a distal end of the first shaft. The one or more electrodes may be disposed at a distal portion of the second elongate shaft. The wave generator may be configured to be in electrical communication with the one or more electrodes. The treatment control module may selectively cause the wave generator to deliver energy to an electrode of the one or more electrodes, where the energy may be configured to lyse red blood cells of the thrombus.

The invention relates to the technical field of cell carrier microvesicle transfection, and discloses an electric pulse field accurate control system for physical transfection of cell carrier microvesicles. Comprises: a parameter determination module configured to determine a short-time high-voltage electric pulse application scheme according to physicochemical property parameters of cell carrier microvesicles; the dynamic adjustment module is configured to mix the cells and exogenous contaminants, transfer the cells and the exogenous contaminants to the electrode cup, and dynamically adjust the applied voltage, capacitance and pulse frequency based on the phenomenon of uneven voltage distribution caused by surface tension of liquid in the electrode cup; and the tracking processing module is configured to continuously track electrochemical reaction characteristics in a transfection process, process toxic substances and bubbles generated by the electrochemical reaction, guarantee an electrotransfection effect of cells in a stable field intensity current region, realize accurate control of an electric pulse field and improve the transfection efficiency of the cell carrier microvesicles. The invention provides a breakthrough solution for efficient transfection of the microvesicles.

A medical device may include an electrosurgical hand piece. The electrosurgical hand piece may have a housing with a proximal end, a distal end, and a chamber proximate the proximal end. The chamber may be configured to releasably retain and electrically couple with a power source. The electrosurgical hand piece may also include a treatment delivery element configured to releasably couple to the distal end of the housing. The treatment delivery element may be configured to communicate with the power source and deliver biphasic pulsed field ablation. The medical device may also include a charging element which may charge the power source using inductive charging or near-field (RF) wireless charging.

A medical system may provide at least one high voltage pulse train configured to cause pulsed field ablation of tissue. Each pulse train of the at least one pulse train may include a plurality of biphasic voltage pulses. The plurality of biphasic voltage pulses may include a first biphasic voltage pulse and a second biphasic voltage pulse that sequentially follows the first biphasic voltage pulse. The first biphasic voltage pulse may include a first monophasic voltage pulse followed by a second monophasic voltage pulse, the first monophasic voltage pulse having a first polarity and the second monophasic voltage pulse having a second polarity opposite the first polarity. The second biphasic voltage pulse may include a third monophasic voltage pulse followed by a fourth monophasic voltage pulse, the third monophasic voltage pulse having the second polarity and the fourth monophasic voltage pulse having the first polarity.

[0003] Systems and methods for visualization of pulsed field ablation tags are disclosed. In some implementations, the system includes a device including a processor in communication with one or more sensors and a catheter including a plurality of electrodes. In some implementations, the processor is configured to receive, via the one or more sensors, a position of each of the plurality of electrodes within a three-dimensional environment during a first ablation session, calculate, for the first ablation session, a first implicit function representing an energy field of the first ablation session from the received position of each of the plurality of electrodes, and present, via a display, a first volumetric representation of the calculated first implicit function.

An ablation system includes an ablation generator, catheter, and a closed-loop ablation processor operably coupled thereto. The processor receives baseline tissue properties, such as baseline tissue impedance, tissue thickness, tissue anatomical location, tissue type, catheter-tissue contact force, catheter stability against the tissue, and baseline electrogram signal morphology. The processor also receives waveform parameters for the generator. Using the baseline tissue properties and the waveform parameters, the processor determines whether pulsed field or radiofrequency ablation therapy should be delivered and computes corresponding target ablation metric(s), such as a target ablation index. The processor then commands the generator to deliver ablation therapy to the tissue and monitors lesion formation using intra-therapeutic tissue properties (and waveform parameters) to compute intra-therapeutic ablation metric(s) and comparing the intra-therapeutic ablation metric(s) to the target ablation metric(s). Ablation therapy ceases when the intra-therapeutic ablation metric(s) satisfy the target ablation metric(s).