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56 results about "Endometrial tissue" patented technology
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Application of pyruvate carboxylase in diagnosis and treatment of endometriosis
InactiveCN120721966AOrganic active ingredientsDisease diagnosisPyruvate carboxylasePharmaceutical drug
The invention discloses pyruvate carboxylase (PC) serving as a biomarker for detecting endometriosis and application of the pyruvate carboxylase (PC) to treatment of the endometriosis. The biomarker can be used for detecting the expression level of PC in an endometrial tissue sample through an immunohistochemical method, and when the IHC score is greater than or equal to 4, a subject is judged to be at a high risk of endometriosis or suffered from the endometriosis. Meanwhile, the invention provides an application of drugs (including specific siRNA, ZY-444, octyl gallate and the like) for inhibiting PC expression in treatment of endometriosis, and a corresponding treatment method. The invention provides a new biomarker, target spot and scheme for detection and treatment of endometriosis, and has important clinical application value.
Owner:HANGZHOU FIRST PEOPLES HOSPITAL
Endometrial tissue spectrum data processing method and equipment based on Raman spectrum
The invention discloses a Raman spectrum-based endometrial tissue spectral data processing method and equipment, and relates to the technical field of data processing. The method comprises the following steps: firstly, calculating a gradient change sequence of to-be-processed spectral data, carrying out continuity verification in combination with wavelength and width, and accurately dividing a Raman characteristic peak interval and a background baseline interval; then, iterative baseline fitting processing based on a Raman peak protection mechanism is adopted, blood fluorescence interference is eliminated, and pure Raman spectrum data is obtained. And further, inputting the pure spectral data into a pre-constructed segmented fusion feature extraction network, extracting local wave band features, fusing the local wave band features with global features, and outputting a data classification result. According to the embodiment of the invention, the problem of difficult feature extraction caused by low signal-to-noise ratio of a bleeding sample and non-uniform background in related technologies can be effectively solved, the integrity of spectrum fingerprint information is ensured while strong fluorescence interference is thoroughly eliminated, and the accuracy of data feature extraction and the robustness of classification and recognition are improved.
Owner:JIANGSU JIYUAN MEDICAL TECH CO LTD
Traditional Chinese medicine prescription efficacy evaluation system for treating intrauterine adhesion
The invention relates to the technical field of medical care information processing, and discloses a traditional Chinese medicine prescription efficacy evaluation system for treating intrauterine adhesion, comprising: a data preprocessing module for acquiring endometrial dynamic response gray time sequence characteristic data before and after a subject takes a prescription; the phase analysis module is used for determining a phase deviation distribution coefficient according to the phase angle distribution of the gray scale data of the reference pixel and the response pixel; the frequency domain inversion module is used for constructing an energy transfer gain spectrum by calculating a power ratio and identifying a characteristic resonant frequency; the evaluation index output module is used for generating an evaluation index for evaluating the viscoelasticity improvement degree of the endometrial tissue according to the deviation value of the characteristic resonant frequency in combination with the variation of the phase deviation distribution coefficient. And the quantitative accuracy of evaluation is improved.
Owner:PEOPLES HOSPITAL AFFILIATED TO FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE (FUJIAN PROVINCIAL PEOPLES HOSPITAL)
CD56 detection method of endometrial tissue and application of CD56 detection method
InactiveCN119985467APreparing sample for investigationMaterial analysis by optical meansStainingDigital analysis
The invention relates to the technical field of biomedical engineering, in particular to an endometrial tissue CD56 detection method and application thereof, and the endometrial tissue CD56 detection method comprises the following steps: S1, obtaining an endometrial tissue sample by adopting a non-invasive or minimally invasive method; s2, carrying out standardization treatment on the collected endometrial tissue sample; s3, performing immunohistochemical staining; s4, performing digital analysis; and S5, judging a result. According to the research, the endometrial tissue is obtained under the endometrial sampler, the expression level of CD56 in the endometrial tissue is detected through immunohistochemistry, and an RSA patient with the too high CD56 level is subjected to immunoregulation treatment, so that the pregnancy outcome is improved, and compared with traditional diagnostic curettage, the endometrial curettage has the advantage of being small in endometrial damage, and the clinical application prospect is broad. Compared with a hysteroscope endometrial biopsy operation, the method has the advantages of being convenient to operate and low in cost.
Owner:WENZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Method for improving yield of endometrial stem cell exosome
PendingCN119614487AIncrease productionhigh speedCell dissociation methodsSkeletal/connective tissue cellsMitomycin CSomatic cell
The invention provides a co-culture system for increasing the yield of endometrial stem cell exosomes and a method for increasing the yield of endometrial stem cell exosomes, firstly, fibroblasts are subjected to mitomycin C pretreatment, so that the cells are stagnated in G1, S and G2 stages of a cell cycle, meanwhile, RNA and protein synthesis continues to be carried out, and the endometrial stem cell exosomes are obtained; the fibroblasts are kept in a non-proliferative but metabolic active state; then, endometrial stem cells extracted from endometrial tissues in the proliferation period and fibroblasts are indirectly co-cultured through a Transwell chamber and are separated through a semi-permeable membrane, and stem cell differentiation caused by inter-cell contact reaction and fusion of the stem cells and somatic cells is eliminated; after co-culture, taking out the endometrial stem cells, putting the endometrial stem cells into a serum-free culture medium special for exosomes for separate culture, harvesting cell supernate, and purifying the exosomes; compared with the endometrial stem cells which are independently cultured in the whole process, the co-culture system disclosed by the invention has the advantages that the amplification speed of the endometrial stem cells and the exosome yield of unit quantity of cells are remarkably improved.
Owner:SHENZHEN RUIPUXUN BIOPHARMACEUTICAL CO LTD
System and method for characterizing magnetic resonance medical scans of pelvic regions
A method and apparatus for analyzing one or more MR images showing a pelvic region to identify features indicative of a region containing endometrial tissue is described. The method comprises the steps of: acquiring one or more quantitative non-contrast MR medical image scans of the pelvic region; determining one or more MR metrics to determine one or more multi-parameter MR maps of the pelvic region; and analyzing the multi-parameter MR map to determine a biomarker indicative of a region of abnormal iron concentration.
Owner:PERSPECTUM LTD
Methods for the treatment of endometriosis
PCT designated stageWO2025162964A1Antibody ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsTunica intimaEndometrioses
Endometriosis is a chronic oestrogen-dependent inflammatory disease characterised by the presence of endometrial tissue outside the uterine cavity. There is currently no cure for endometriosis. Here, the Inventors demonstrated in vivo that targeting CD73 significantly alters the development of endometriosis. These results thus demonstrate the relevance of CD73 as a therapeutic target in endometriosis.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
Methods of generating human endometrial stromal fibroblasts and three-dimensional multi-layered human endometrial tissue compositions
Disclosed herein are methods for obtaining endometrial stromal fibroblast cells from pluripotent stem cells, such as induced pluripotent stem cells. The present disclosure also provides methods of obtaining a three-dimensional, multilayered endometrial tissue composition. Methods of using the cells and tissue compositions in drug screening and therapeutic applications are also provided.
Owner:NORTHWESTERN UNIV
Disposable hysteroscope electric resection specimen collector
ActiveCN222516891Ueasy to separateprevent flow awaySurgeryVaccination/ovulation diagnosticsTissue specimenMechanical engineering
Owner:SHENZHEN NANSHAN DISTRICT SHEKOU PEOPLES HOSPITAL (SHENZHEN QIANHAI SHEKOU FREE TRADE ZONE HOSPITAL)
Methods of treating endometriosis
PCT designated stage expiredWO2024229242A3Microbiological testing/measurementDisease diagnosisEndometriosesPeritoneal membrane
Methods of treating patients with endometriosis are provided. In various embodiments, the treatment methods select specific types of therapies for patients with different stages of endometriosis detected based on cellular compositions, particularly immune cell compositions, in an endometrial tissue, in combination or alternative to conventional imaging or laparoscopy techniques. Further embodiments provide methods for diagnosing or stratifying patients having peritoneal endometriosis. Overall, heterogeneous immune response underlies subtype-specific and patient-specific heterogeneity in endometriosis.
Owner:CEDARS SINAI MEDICAL CENT
Device for treating endometriosis
An electrotherapeutic device can be configured for at least partial insertion into a patient. The device can include a shaft including a proximal portion and a distal portion, a gas-delivery lumen extending between the proximal portion and the distal portion of the shaft, and one or more electrodes located near the distal portion of the shaft. The electrodes can include a plasma activation electrode for generating plasma from gas delivered to the distal portion of the shaft via the gas-delivery lumen, and an ablation electrode for generating electromagnetic ablation energy. The medical device can be used in a method of treating endometriosis including delivering a gas toward an in vivo treatment site within a patient, generating plasma from the gas on or near the in vivo treatment site using a plasma activation electrode, exposing the treatment site to the plasma, and applying electromagnetic ablation energy to treat endometrial tissue.
Owner:GYRUS ACMI INC
An endometrial stem cell exosome preparation for treating endometrial damage and a preparation method thereof
PendingCN122167574AImmunoglobulins against animals/humansArtificial cell constructsAntiendomysial antibodiesTreatment effect
The application belongs to the technical field of biotechnology and medicine, and specifically discloses a single-domain antibody-exosome compound (Nb-EMX2-Exos) targeting EMX2 as well as a preparation method and application thereof. The compound is prepared by covalently coupling a single-domain antibody (Nb-EMX2) specifically binding to EMX2 protein to the surface of endometrial stem cell-derived exosomes (ESC-Exos). In-vitro experiments show that the compound can specifically recognize and efficiently internalize into damaged endometrial stromal cells with high expression of EMX2, and significantly promote the migration and proliferation of the cells. In-vivo experiments further prove that the compound can precisely target and enrich in damaged endometrial tissue, effectively promote the structural repair (thicken the endometrium and reduce fibrosis) of the endometrium, and completely restore the fertility function. The application provides a novel targeted treatment preparation for solving the problems of poor targeting of natural exosomes and limited treatment effect, and has important application value in the treatment of endometrial injury repair and related infertility.
Owner:GUANGZHOU HEXIU BIOTECHNOLOGY DEVELOPMENT CO LTD
Model construction method based on animal endometrial epithelium organ and application thereof
PendingCN121975720AAnalyze core rulesClose to physiological realityClimate change adaptationMicrobiological testing/measurementBiotechnologyStaining
The invention discloses a model building method based on animal endometrial epithelium organoid and application of the model building method, and relates to the technical field of cell engineering and organoid. According to the method, healthy cow endometrial tissue serves as a raw material, a model is built through the steps of pretreatment, enzymolysis, cell cleaning and screening, seed gum culture, passage, cryopreservation resuscitation and the like, and the model is built through Hamp; e, verifying morphological integrity through dyeing, and detecting E-cadherin expression through IHC dyeing to confirm cell specificity. The animal organ model restores the in-vivo three-dimensional microenvironment and species specificity, overcomes the limitation of traditional two-dimensional culture and mouse models, can accurately simulate the pathological process of endometritis, is applied to research on the pathogenesis of endometritis of dairy cows, can also efficiently screen anti-inflammatory drugs and evaluate the drug effect, and has a wide application prospect. A reliable in-vitro tool is provided for disease prevention and treatment, and healthy development of the dairy cow breeding industry is assisted.
Owner:NINGXIA UNIVERSITY
Use of the SPON2 gene or its protein as a target in the diagnosis or treatment of endometriosis
ActiveCN120700136BOrganic active ingredientsMicrobiological testing/measurementFibrosisTargeted therapy
This invention belongs to the field of biotechnology, and particularly relates to the use of the SPON2 gene or its protein as a target in the diagnosis or treatment of endometriosis. Supported by multi-omics and single-cell level data and tested with clinical samples, this invention, for the first time, elucidates the correlation between SPON2 and endometriosis (EM), revealing that high expression of SPON2 in eutopic and ectopic endometrial fibroblasts in endometriosis patients enhances their proliferation, invasion, and migration abilities. Inhibiting SPON2 gene expression or inhibiting SPON2 protein function reduces the proliferation and invasion abilities of endometrial tissue, as well as lesion migration, invasion, and fibrosis, thus improving the condition of endometriosis. This suggests that the SPON2 gene or its protein can serve as a diagnostic or therapeutic target, providing new ideas and directions for the clinical diagnosis and targeted therapy of endometriosis.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
Compositions and methods for treating endometrial tissue
PendingUS20250288614A1Mammal material medical ingredientsSexual disorderEndometrial cellTunica intima
A method for treating a subject having. or at risk of having. damaged endometrial tissue generally includes administering to the subject an amount of a PEP preparation effective to treat the subject's endometrial tissue. The PEP preparation may be administered therapeutically or prophylactically. In another aspect. a method of promoting proliferation of endometrial cells generally includes contacting the endometrial cells with an amount of a PEP preparation effective to promote proliferation of the endometrial cells. In another aspect. a method of promoting wound closure by endometrial cells generally includes administering to endometrial cells into which a wound has been introduced an amount of a PEP preparation effective to promote closure of the wound.
Owner:MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH
Application of Dan'e'fukang in preparation of medicine for treating dysfunctional uterine bleeding
The invention belongs to the technical field of application of traditional Chinese medicines, and particularly relates to application of a Dan'e Fukang preparation in preparation of a medicine for treating dysfunctional uterine bleeding. Pharmacological experiments prove that Dan'e'fukang can shorten the blood coagulation time and bleeding time of mice, and increase the uterine coefficient, estradiol level and progesterone level of rats without ovulation type dysfunctional uterine bleeding and the VEGF protein expression quantity of endometrial tissues of the rats. The Dan'e Fukang provides more medication choices for clinical treatment of dysfunctional uterine bleeding diseases, and has the advantages of good effect, many years of clinical use experience and high safety.
Owner:YUNNAN SHENGKE PHARM CO LTD
Artificial uterine platform and applications thereof
Provided herein include synthetic endometrial tissues and uterus-like structures for assessing embryo implantation and growth in vitro. Provided herein also include methods and devices for making the synthetic endometrial tissues and uterus-like structures and uses thereof to culture embryos (e.g., human embryos). The methods and synthetic endometrial tissues and structures generated herein can be used to culture pre-implantation embryos (e.g., human embryos) to reach a post-implantation stage.
Owner:CALIFORNIA INST OF TECH +1
A medicine for preventing or treating endometrial fibrosis
This invention relates to the pharmaceutical field, specifically to a drug for the prevention or treatment of endometrial fibrosis, comprising poloxamer and spermidine; poloxamer is added to the spermidine solution and swelled at 3-5°C until completely dissolved to form a liquid precursor; the liquid precursor undergoes a phase transition at 35-40°C to form a gel; the liquid precursor is injected into the uterine cavity to reduce the expression of αSMA in the endometrial tissue, inhibit the transformation of stromal cells into myofibroblasts, and promote angiogenesis.
Owner:JILIN UNIVERSITY
Neurotrophic receptor tyrosine kinase (NTRK) inhibitors and methods of use thereof
The present disclosure relates to compounds and pharmaceutical compositions thereof that inhibit one or more members of the neurotrophic receptor tyrosine kinase (NTRK) family (i.e., NTRK1, NTRK2 and / or NTRK3). In another aspect, the disclosure provides a method of treating, preventing and / or ameliorating at least one disease and / or disorder selected from endometrial tissue ectopic, cancer and pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of the disclosure and / or a pharmaceutical composition of the disclosure.
Owner:BAYLOR COLLEGE OF MEDICINE
Application of Danbie Capsules in the Preparation of Products for Treating Endometriosis
This invention belongs to the field of biomedical technology, specifically relating to the application of Danbie capsules in the preparation of products for treating endometriosis. This invention discovers that the combined use of Danbie capsules and progestins has a synergistic effect, with a superior intervention effect on endometrial stromal cells compared to a single component. Furthermore, this invention provides a traditional Chinese medicine-containing serum, the main medicinal components of which are quercetin and luteolin, which can effectively inhibit the growth and migration of endometrial stromal cells and induce apoptosis. This traditional Chinese medicine-containing serum is derived from Danbie capsules. Animal experiments have shown that Danbie capsules can inhibit the expression of AKT1 in endometrial tissue, and cell experiments have shown that the traditional Chinese medicine-containing serum can induce apoptosis of endometrial stromal cells, suggesting that the intervention effect of the traditional Chinese medicine Danbie capsules and its containing serum on endometrial stromal cells is related to AKT1 expression, providing an important insight into the relevant mechanism.
Owner:GUANGZHOU PANGAOSHOU PHARM CO LTD
A hysteroscopic specimen collection device
A hysteroscopic specimen collection device includes a connecting piece and a collection bag. The connecting piece has an operating through hole and a first adhesive layer on its back. The lower end of the connecting piece is connected to the opening side of the collection bag. A first filter and a second filter are installed sequentially from top to bottom inside the collection bag. The first filter is detachably installed inside the collection bag. The diameter of some filter holes in the second filter is smaller than the diameter of some filter holes in the first filter. A fixing plate is provided on the back of the connecting piece or the collection bag to assist in fixing the collection device during use. The first and second filters of this invention facilitate the separation of tissue specimens and distension fluid flowing into the collection bag, enabling specimen collection and separation of specimens of different sizes, such as easily separating uterine fibroid tissue and endometrial tissue. The first adhesive layer and the fixing plate together fix the collection device. The overall structure is simple, convenient, and practical.
Owner:175TH HOSPITAL OF PEOPLES LIBERATION ARMY
Use of vitamin-magnesium complex in preparation of medicine for preventing and treating miscarriage during pregnancy and early pregnancy period and preparation thereof
The application provides application of a vitamin-magnesium compound in preparation of a medicine for preventing and treating miscarriage in a pregnant period and an early pregnant period and a preparation, relates to the technical field of biological medicines, and the vitamin-magnesium compound is a magnesium-based coordination chelate with a repairing effect on endometrial tissue. The vitamin-magnesium compound is an organic ligand of the magnesium-based coordination chelate, and the organic matter is any one of vitamin B13, vitamin B3 and vitamin C. The magnesium-based coordination chelate acts on endometrial stromal cells, promotes cell proliferation, and promotes normal implantation of an embryo. The magnesium-based coordination chelate acts on endometrial tissue vascular endothelial cells, promotes cell proliferation, and promotes angiogenesis to meet the nutritional supply of the embryo. The magnesium-based coordination chelate acts on endometrial tissue macrophages, M1 type macrophages are polarized into M2 type macrophages, immune tolerance to the embryo is promoted, and the normal growth and development of the embryo are prevented from being affected by the attack of maternal immune cells.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
Polypeptide aiuap for preventing, assisting in preventing or treating formation of intrauterine adhesions and application thereof
ActiveCN115703820BSmall molecular weightlow toxicityPeptide/protein ingredientsDepsipeptidesFibrosisTunica intima
The application discloses a polypeptide AIUAP for preventing or assisting in preventing formation of intrauterine adhesion and application thereof. The polypeptide AIUAP for preventing, assisting in preventing or treating formation of intrauterine adhesion has an amino acid sequence of TFGGAPGFPLGSPLSSPVFPR (SEQ ID NO. 1), and is composed of 21 amino acids. The application discloses application of the polypeptide AIUAP in preparation of a medicine for preventing, assisting in preventing or treating intrauterine adhesion. In the research, a method of tandem mass spectrometry is used to screen endogenous polypeptides differentially expressed in intrauterine adhesion tissues and normal proliferative endometrial tissues, and it is found that the polypeptide AIUAP highly expressed in the intrauterine adhesion tissues can inhibit formation of fibrosis. Since the AIUAP has the characteristics of small molecular weight, self-source and small toxicity, the AIUAP can become an important auxiliary medicine for preventing and treating intrauterine adhesion.
Owner:NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
Method for induced differentiation of blood-derived endometrial mesenchymal stem cells into cartilage cells
The invention relates to the technical field of cell differentiation, in particular to a method for induced differentiation of menstrual blood-derived endometrial mesenchymal stem cells into chondrocytes, which comprises an endometrial tissue preservation solution and a novel induction reagent, the endometrial tissue preserving fluid is prepared from 500mL of DMEM / F-12 basal culture medium, penicillin, streptomycin and gentamicin; the novel induction reagent comprises a basic induction reagent, hydroxyapatite, patient serum and articular cavity tissue fluid. In some existing induced differentiation methods, the number, activity and purity of cells cannot meet the requirements of clinical application, compared with the prior art, a novel induction reagent is used, some substances are added on the basis of a basic induction reagent, and an endometrial tissue preservation solution is prepared to prevent bacteria from influencing the cells, so that the method has the advantages of simple operation and low cost. And the number, activity and purity of cartilage cells differentiated by induction are improved, so that the method can meet the requirements of clinical application.
Owner:HENAN ZHONGSAI GUOLAN HEALTH MANAGEMENT GRP CO LTD
Application of pyruvate carboxylase in diagnosis and treatment of endometriosis
ActiveCN121049511AOrganic active ingredientsDisease diagnosisPyruvate carboxylasePharmaceutical drug
The invention discloses pyruvate carboxylase (PC) serving as a biomarker for detecting endometriosis and application of the pyruvate carboxylase (PC) to treatment of the endometriosis. The biomarker can be used for detecting the expression level of PC in an endometrial tissue sample through an immunohistochemical method, and when the IHC score is greater than or equal to 4, a subject is judged to be at a high risk of endometriosis or suffered from the endometriosis. Meanwhile, the invention provides an application of drugs (including specific siRNA, ZY-444, octyl gallate and the like) for inhibiting PC expression in treatment of endometriosis, and a corresponding treatment method. The invention provides a new biomarker, target spot and scheme for detection and treatment of endometriosis, and has important clinical application value.
Owner:HANGZHOU FIRST PEOPLES HOSPITAL
Sampling tool and sampling method for endometrial biopsy
PendingCN121926637ASurgical needlesVaccination/ovulation diagnosticsTunica intimaMechanical engineering
The invention relates to the technical field of medical equipment, in particular to a sampling tool for endometrium biopsy and a sampling method.The sampling tool comprises a suction tube, a scraper composed of a plurality of scraping wires is arranged at the far end of the suction tube, and one end of the scraper is inserted into an opening in the far end of the suction tube and connected with the suction tube; a channel for endometrial tissues to enter and exit is arranged between the scraper and the inner wall of the suction tube; the near end of the suction pipe is provided with a pressure adjusting part used for adjusting the pressure intensity in the suction pipe. The scraping wires extend in the axial direction of the suction pipe, the two ends, in the same direction, of the multiple scraping wires are fixedly connected together, and the middles of the multiple scraping wires are spliced to form a hollow ellipsoid structure. The problem that in the suction process of a suction tube in the prior art, in the suction process, a suction inlet is directly covered and blocked by endometrial tissue which is not separated, and contusion is caused to local tissue in a blocked area is solved.
Owner:CHANGSHA MATERNAL & CHILD HEALTH HOSPITAL
A disposable endometrial sampler
This utility model discloses a disposable endometrial sampler, including an outer tube, a negative pressure suction head connected to one end of the outer tube by a thread, and a sampling bottle connected to one end of the outer tube by a thread. The negative pressure suction head and the sampling bottle are sequentially installed inside the outer tube. A core rod is inserted inside the outer tube, and a silicone ring is provided at the end of the core rod inside the outer tube. The core rod pulls the silicone ring to move inside the outer tube, so that endometrial tissue is sucked into the outer tube through the negative pressure suction head. This utility model uses the sampling bottle to directly obtain endometrial tissue inside the outer tube, reducing the loss and contamination of endometrial tissue collected inside the outer tube during the testing and transfer process.
Owner:安徽省宿州市立医院
IGF1-BP coupled lipid nanoparticles as well as preparation method and application thereof
InactiveCN120078905AOrganic active ingredientsPharmaceutical non-active ingredientsNanocarriersMorpholine
The invention relates to IGF1-BP coupled lipid nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. In order to solve the problem that an endometrial nano-carrier and a corresponding targeting drug are still lacked in the existing preeclampsia prevention and treatment, the invention provides a preparation method of IGF1-BP coupled lipid nanoparticles, which comprises the following steps: respectively preparing an organic phase solution and a water phase solution, assembling the lipid nanoparticles by using the organic phase solution and the water phase solution, and preparing the IGF1-BP coupled lipid nanoparticles. And connecting IGF1-BP to the surface of the lipid nanoparticle through a coupling reaction by virtue of an EDC / NHS technology, so as to obtain the IGF1-BP coupled lipid nanoparticle. According to the IGF1-BP coupled lipid nanoparticles provided by the invention, morpholino oligonucleotide for reducing endometrial APOD expression is delivered to endometrial tissues in a targeted manner, so that not only can the symptoms of preeclampsia be relieved during pregnancy, but also prophylactic treatment can be performed on lying-in women with high risk of preeclampsia during prepregnancy.
Owner:SHENZHEN HUARUI MODEL BIOTECHNOLOGY CO LTD
Method for evaluating chronic endometritis of infertility patient based on hysteroscope score
The invention discloses an infertility patient chronic endometritis assessment method based on hysteroscope scoring, and relates to the technical field of medical treatment. The method for evaluating the chronic endometritis of the infertility patient based on the hysteroscope score comprises the following steps: step 1, detecting the uterine cavity of the patient by adopting a hysteroscope examination mode; 2, judging CE specific expression of the patient under a hysteroscope; step 3, carrying out CD138 immunohistochemical detection on endometrial tissues of the patient; step 4, carrying out statistical analysis by adopting software SPSS22.0 and R4.1. 2; compared with the prior art, the CE specificity performance of a patient under the hysteroscope is examined in a hysteroscope examination mode, the hysteroscope scoring system is constructed, observation indexes in the hysteroscope scoring system can be easily mastered after learning, the hyperemia area can be divided according to the uterine cavity six-equal-division method even under the condition that no measuring tool under the hysteroscope exists, and popularization is convenient.
Owner:华科臻致(北京)科技有限公司
Methods and systems for endometrial ablation utilizing radio frequency
Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes of the wall.
Owner:MINERVA SURGICAL INC