95 results about "Endometrial tissue" patented technology

An apparatus and method of use or treatment are disclosed for creating intrauterine adhesions resulting in amenorrhea. In particular, the apparatus relates to an easily deployed intrauterine implant that readily and consistently reduces or eliminates abnormal intrauterine bleeding. In addition, the apparatus is also used as a uterine marker device for visualizing endometrial tissue thickness and potential changes. The method of the present invention serves as a supplement to or a replacement for conventional hysterectomy or ablation / resection procedures used to treat menorrhagia.

An apparatus and method for causing necrosis of tissue and specifically intended for thermal ablation of the uterine cavity to cauterizing the endometrial tissue. The apparatus includes a liquid-tight, liquid filled system having a distal flexible member; a proximal flexible member; and a catheter joining and providing a liquid path between these distal and proximal members. The apparatus further includes a pressurizable pneumatic chamber into which the proximal flexible member is inserted and a means to controllably heat the contents of the pneumatic chamber. The system operates to: first withdraw substantially all of the liquid into the proximal flexible member contained within the pressurizable pneumatic chamber; second to heat this liquid to a temperature such that it can cause tissue necrosis; and third to force the heated liquid from the proximal flexible member into the distal flexible member where it is maintained for a predetermined time and at a predetermined pressure. Where this distal member has been inserted into a uterine cavity or is otherwise is in contact with living tissue, the presence of the heated liquid results in tissue necrosis and cauterization.

Devices and methods of use or treatment are disclosed for creating fibrosis and resulting in amenorrhea. In particular, the device relates to an easily deployed intrauterine implant that readily and consistently reduces or eliminates abnormal intrauterine bleeding. In addition, the device is also used as a uterine marker for visualizing endometrial tissue thickness and potential changes. The methods of the present invention serve as a supplement to or a replacement for conventional treatments and procedures used to treat menorrhagia.

A single device is provided for performing the diagnostic procedures of sonohysterography and endometrial biopsy. The device includes a cervical seal to occlude the cervix and a substance delivery and removal device to deliver and remove a fluid from the uterus. The substance delivery and removal device may also be used to create a vacuum so that suction occurs near side-ports that are used to collect endometrial tissue samples from multiple locations as the device is rotated or moved laterally within the patient. Additionally, the sample may be taken using a cellular collection device.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. A sealing member is deployed in the cervical canal during ablation.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes of the wall.

The present invention is directed toward a device that performs ablation of tissue. The device has a catheter with a shaft through which an ablative agent can travel, a first positioning element attached to the catheter shaft at a first position and a second positioning element attached to the catheter shaft at a second position. The shaft also has ports through which the ablative agent can be released.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes of the wall. An expandable member, such as a balloon, is provided that expands to close the cervical canal during ablation.

An apparatus and method of use or treatment are disclosed for creating intrauterine adhesions resulting in amenorrhea. In particular, the apparatus relates to an easily deployed intrauterine implant that readily and consistently reduces or eliminates abnormal intrauterine bleeding. In addition, the apparatus is also used as a uterine marker device for visualizing endometrial tissue thickness and potential changes. The method of the present invention serves as a supplement to or a replacement for conventional hysterectomy or ablation / resection procedures used to treat menorrhagia.

The invention relates to a medical surgical clamp matched with an endoscope, in particular to a visible surgical clamp with an endoscope sheath used for taking the intrauterine device out from the uterus. The existing visible surgical clamp is used in the birth control surgery, for example in the surgery to take the intrauterine device out from the uterus with the endoscope. Due to the easy bleeding of the endometrium tissue, the lens of the endoscope is easily contaminated to dim the surgery view, and the device is inserted in and taken out repeatedly for flashing, therefore the surgery time is prolonged and the operation is complicated. After the improvement, the groove formed after the side by side arrangement of the endoscope sheath and the drive rod is also fixed with two flush pipes 15 and 17, wherein the open of one flush pipe faces the open of the endoscope sheath 10, and the open of the other flush pipe faces a clamp head 6. A surgical cannula is provided, and the water nozzle on the surgical cannula is communicated with a negative pressure source to absorb and remove the water of flushing. The improved surgical clamp provides clear surgery view, has compact integral structure and convenient operation, and can shorten the surgery time.

The invention provides a stem cell culture medium and a method for culturing endometrium stem cells by using the stem cell culture medium. The method comprises the following steps: separately collecting menstrual blood and endometrium tissues, respectively culturing the menstrual blood and endometrium tissues in the stem cell culture medium provided by the invention to respectively obtain menstrual blood adherent cells and endometrium adherent cells, culturing the menstrual blood adherent cells and endometrium adherent cells in a cell culture bottle, collecting the adherent cells by trypsinization, inoculating the adherent cells in a cell coculture dish, and culturing the adherent cells in the stem cell culture medium provided by the invention. The stem cell culture medium has the advantages of simple components, fewer added components and lower cost. After more than 20 generations of in-vitro culture, the cells can not easily have the phenomenon of aging or degeneration, and can maintain the activity and stem property of the stem cells for a long time. The stem cell culture method is simple and effective, the cell proliferation efficiency is high, and the in-vitro culture doubling time is only 20 hours or so. The cells can be stably amplified by 50 generations.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes of the wall.

The invention provides a method of preparing endometrium mesenchymal stem cells from menstrual blood. The method comprises the steps that firstly, a menstruation tampon is placed in the vagina of a woman during the menstrual period of the woman, wherein the menstruation tampon comprises an absorption tampon body which is provided with a water absorption fiber core, the water absorption fiber core is wrappedina gauze absorption layer, and the menstruation tampon is kept in the vagina till menstrual blood and / or deciduous endometrial tissue are adsorbed on the gauze absorption layer; secondly, a pull wire is pulled out to take out the menstruation tampon, the menstrual blood and / or the deciduous endometrial tissue adsorbed on the gauze absorption layer are eluted off with eluant to obtain an eluted product; thirdly, karyocytes are extracted from the eluted product and subjected to cell culture. The method can be conveniently used clinically and can be accepted by menstrual blood donators; moreover, the obtained endometrium mesenchymal stem cells have higher proliferative activity.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. A Hall effect sensor carried by the working end is used to generate a signal that indicates a dimension of the uterine cavity or a frame-open parameter of the working end.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric. Radiofrequency energy is applied for a first interval of time at constant power, the power being sufficient to capacitively couple current across the dielectric to the contacted endometrial tissue. A voltage parameter measured within the first interval, and radiofrequency energy is applied at a constant voltage over a second, treatment interval to ablate endometrial tissue, the constant voltage being related to the recorded voltage.

The invention provides a method for detecting endometrial receptivity through MST1 and phosphorylated MST1. The method comprises the steps that a human endometrial carcinoma cell line Ishikawa and HEK293T cells are kept and cultured in a 10% FBS and mycillin containing double-antibody DMEM / F12 culture solution; an immunoblotting experiment is carried out; co-immunoprecipitation is carried out; immunohistochemistry is carried out; adjustment of MST1 on the transcriptional activity of HOXA10 is analyzed through chromosome co-immunoprecipitation (ChIP) / PCRs; human choriocarcinoma cell (BeWo) sphere adhering experiments are carried out. According to the method, the expression level of MST1 and MST1 phosphorylation modification in endometrial tissue is detected conveniently and fast, and the receptivity state of the endometrium can be directly reflected.

Methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for contraception. Methods and compounds are based on the levels of ebaf in endometrial tissue. Methods for diagnosing endometrial receptivity and bleeding function by screening a biological sample such as an endometrial tissue sample, or bodily fluid for the presence of ebaf. A contraceptive compound containing an effective amount of ebaf and a pharmaceutically acceptable carrier. A diagnostic kit for timing contraception containing reagents for screening a sample for the presence of ebaf. A method of treating endometrial irregularities by down-regulating the expression of ebaf.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes and for conforming to an asymmetric or symmetric shape of the patient's uterine.

A step-shaped endometrial curette is provided. The step-shaped endometrial curette includes a handle, a curetting bar, and a collection cup. The handle is connected to a first end portion of the curetting bar. A second end portion of the curetting bar has a distal end formed with a plurality of mushroom-shaped curetting plates for removing endometrial tissues by scraping. The collection cup is slidably connected between the first end portion and the mushroom-shaped curetting plates and serves to hold the removed endometrial tissues. As the mushroom-shaped curetting plates are arranged stepwise, and the curetting bar is freely flexible to adapt to the internal shape and angles of the uterus, specimens can be taken from inside the uterus without dilatation of the cervix or anesthesia. Besides, the collection cup can collect all the removed endometrial tissues to enable sufficient and thorough pathological examination.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric. Radiofrequency energy is applied for a first interval of time at constant power, the power being sufficient to capacitively couple current across the dielectric to the contacted endometrial tissue. A voltage parameter measured within the first interval, and radiofrequency energy is applied at a constant voltage over a second, treatment interval to ablate endometrial tissue, the constant voltage being related to the recorded voltage.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes of the wall. An expandable member, such as a balloon, is provided that expands to close the cervical canal during ablation.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes and for conforming to an asymmetric or symmetric shape of the patient's cervix. An expandable seal is provided for sealing the cervical canal.

The subject invention pertains to methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for contraception. Methods and compounds are based on the levels of ebaf in endometrial tissue. Methods for diagnosing endometrial receptivity and bleeding function by screening a biological sample such as an endometrial tissue sample, or bodily fluid for the presence of ebaf. A contraceptive compound containing an effective amount of ebaf and a pharmaceutically acceptable carrier. A diagnostic kit for timing contraception containing reagents for screening a sample for the presence of ebaf. A method of treating endometrial irregularities by down-regulating the expression of ebaf.

The invention discloses a protein extraction and treatment process at different time points (including early, middle and late periods of secretion: LH_2, LH_5, LH_7, LH_9, LH_10 and LH_12, and LH_0 on the day of injection of hCG) in a human endometrial tissue secretion period, and a protein spectrum and a phosphorylation modification mass spectrum are carried out to obtain molecular expression modes at different time points in the secretion period. The molecular expression modes can provide a basis for further knowing the dynamic change of the human endometrial tissue secretion period, and is beneficial to judging an endometrial implantation window period and guiding the embryo transplantation time in an assisted reproduction technology.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes and for conforming to an asymmetric or symmetric shape of the patient's cervix. An expandable seal is provided for sealing the cervical canal.

The invention discloses compound traditional Chinese medicine for treating endometriosis. The compound traditional Chinese medicine comprises, by weight, 8-12 parts of Pollen Typhae, 8-12 parts of trogopterus dung, 1-3 parts of dragon's blood, 12-20 parts of astragali radix, 8-12 parts of dipsacus root, 8-12 parts of roasted myrrh, 8-12 parts of corydalis yanhusuo, and 8-12 parts of szechwan chinaberry fruit. The invention further discloses a preparation method and application of the compound traditional Chinese medicine. The compound traditional Chinese medicine brings the advantages of multi-targeted treating of traditional Chinese medicine into full play. Lab observation of development of ectopic endometrium in a drug inhibited rat endometriosis model shows that the compound traditional Chinese medicine can inhibit development of endometriosis in terms of inhibiting cell proliferation, angiogenesis and invasion in ectopic endometrium tissues, lowering inflammatory cell factor level in peritoneal fluid and the like.

A delivery vehicle for a silver ion source such as silver nitrate and the like, suitable for use in the treatment of menorrhagia, comprises a plurality of physiologically inert beads bearing a tissue cauterizing amount of a silver ion source. Preferably the beads are made of a physiologically inert polymer, ceramic or stainless steel. The silver ion source preferably is silver nitrate and can be substantially pure silver nitrate, or can comprise silver nitrate in combination with a physiologically tolerable binder or a diluent. Suitable binders include physiologically tolerable synthetic polymeric binders, polysaccharide binders, and the like. Diluents can include other salt materials such as potassium nitrate. The beads are useful in treating menorrhagia of a mammalian uterus. The beads can be delivered to the uterus via a catheter, and are distributed throughout the uterine cavity by uterine massage or like expedient. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e.g., by catheter, and the beads recovered from the uterus.

The invention provides application of SMOC2 gene (SPARC related modular calcium binding2, with the Chinese name of secreting modular calcium binding protein 2; smooth muscle related protein 2) in preparation of medicine for detecting or treating endometrial cancer and ovarian cancer. A tissue chip comprising 157 endometrial cancer tissue specimens, 30 normal proliferative phase endometrium tissue specimens and 30 normal secretory phase endometrium tissue specimens is established by utilizing a tissue microarray technology, the expression conditions of SMOC2 in the specimens are detected by utilizing the immunohistochemical technique, the positive expression rate of the SMOC2 in the normal tissue of the endometrium is far lower than the positive expression rate in the endometrial cancer, and the expression intensity is positively correlated to muscular invasion depth of the endometrial cancer and tumor grading of the endometrial cancer. Therefore, the SMOC2 gene can be used for preparing the medicine for detecting or treating endometrial cancer. The medicine is reliable in experimental result and high in repeatability and has good clinical application prospect and good application values and social benefits.

The invention discloses application of a microRNA (micro ribonucleic acid)-miR-145 molecular marker to quickly detecting the survival of embryos of sows. The microRNA molecular marker in endometrial tissues of the sows with low embryo survival numbers is abnormally high in expression and can be secreted in serum via active secretion procedures of tissues, and serum miR-145 is the molecular marker with a function of quickly detecting the survival of the embryos of the sows as discovered by means of large-sample detection on the expression level of the serum miR-145 of the sows with the low embryo survival numbers. The application has the advantages that the embryo survival rates of the sows are predicted, the sows with poor embryo survival can be eliminated as soon as possible, and accordingly economic benefits can be effectively increased for pig raising enterprises.

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an RF ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. A Hall effect sensor carried by the working end is used to generate a signal that indicates a dimension of the uterine cavity or a frame-open parameter of the working end.