31 results about "Miscarriage" patented technology

The invention discloses a preparation method of a medicinal and edible traditional Chinese medicine composition for preventing and treating pregnancy complications. The medicinal and edible traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 24 parts of radix rehmanniae, 12 parts of fructus gardeniae and 9 parts of folium mori. The composition embodies the essence of compatibility of monarch, minister, assistant and guide of a traditional Chinese medicine compound, the radix rehmanniae is used as a monarch drug, the fructus gardeniae is used as a minister drug, the folium mori is used as an assistant drug, and the composition is mainly characterized by nourishing the kidney, containing wood, clearing away fire, calming the liver and lightly dredging upper jiao and exactly conforms to the core pathogenesis of yin deficiency and yang hyperactivity of gestational hypertension. Modern pharmacological experiments prove that the three traditional Chinese medicinal materials all have definite antihypertensive activity, and the action mechanism shows the characteristic of multi-target synergism. The raw materials in the formula are homologous in medicine and food, free of toxic and side effects, mild in medicine property and capable of considering fetal elements, the three medicines all belong to clinical common miscarriage prevention or miscarriage prevention categories, worries about blood breaking and fetal movement are avoided, and the traditional Chinese medicine is suitable for being used in the pregnancy stage. The pharmaceutical composition disclosed by the invention can be used for relieving clinical symptoms of hypertensive patients in pregnancy and improving the outcome of bad pregnancy.

The invention relates to a pharmaceutical composition for treating uterine adhesion and application thereof. The kidney reinforcing and miscarriage preventing pills are used for improving endometrial blood perfusion and increasing the endometrial thickness, the kidney reinforcing and miscarriage preventing pills, aspirin and estrogen play a synergistic treatment role, the postoperative re-adhesion rate is remarkably reduced through combined treatment, and the fertility prognosis of a patient is improved; and the molecular mechanism of a TGF-beta1 pathway and EMT is deeply researched, and by inhibiting excessive activation of the TGF-beta1 signaling pathway, reducing endometrial fibrosis, regulating an epithelial-mesenchymal transition (EMT) process and promoting regeneration of endometrial epithelial cells, endometrial repair is further promoted, multi-target treatment is realized, and the treatment effect is remarkable. A brand-new and efficient treatment scheme is provided for treatment of intrauterine adhesion, an individualized treatment scheme can be formulated according to the specific conditions of patients, the treatment accuracy and effectiveness are improved, and important clinical significance and application value are achieved.

This invention relates to the interdisciplinary field of assisted reproductive technology and artificial intelligence, specifically to a system and method for constructing an embryonic developmental trajectory map that integrates morphological features. By deeply integrating static morphological features with dynamic morphodynamic parameters, a more comprehensive panoramic map of embryonic development with richer information dimensions is constructed, overcoming the one-sidedness of single-dimensional assessment. Automated analysis of the map using an AI model reduces the influence of subjective human factors, enabling the discovery of subtle developmental patterns and potential differences that are difficult to discern with the human eye, significantly improving the accuracy of selecting high-quality embryos. The provided developmental trajectory map allows embryologists to intuitively examine the entire developmental process of the embryo and the performance of each key node, enhancing the interpretability and credibility of the assessment process. Through more scientific embryo selection, it is expected to improve embryo implantation and clinical pregnancy rates, and reduce multiple pregnancy and miscarriage rates.

The invention discloses a high-strength self-lubricating three-layer nested medicine-carrying hollow cervical cerclage band with an auxiliary miscarriage prevention function and a preparation method of the cerclage band, and belongs to the technical field of medical instruments. Degradable polyester monofilaments are woven into a hollow round rope, and the hollow round rope and a medical curved needle are integrated; then carrying out polydopamine-polyethylene glycol double-layer modification on a copper-based metal organic framework (Cu-MOF), and loading active molecules; then mixing the drug-loaded Cu-MOF with collagen natural polymer sol, and uniformly filling the gel into the inner cavity of the round rope and forming a three-dimensional bracket through synchronous drawing type micro-perfusion and light-enzyme synergistic cross-linking; then constructing a transient hydrated lubricating layer on the surface; and finally carrying out ethylene oxide final sterilization to obtain a finished product. The cervical cerclage band device provided by the invention simultaneously provides degradable mechanical support, collagen scaffold induction and long-acting slow release regulation, has a low-friction implantation characteristic, and can be well used for preventing or treating middle and late abortion and premature delivery caused by cervical insufficiency.

The invention discloses a traditional Chinese medicine composition for treating PCOS pregnancy loss and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20-40 parts of salted semen cuscutae, 20-40 parts of prepared rehmannia root, 10-20 parts of scutellaria baicalensis, 10-20 parts of dogwood, 20-30 parts of astragalus membranaceus, 20-30 parts of bighead atractylodes rhizome, 20-30 parts of white paeony root, 10-20 parts of parasitic loranthus and 10-20 parts of teasel According to the invention, active component groups (mass spectrum identification) and accurate compatibility design (kidney tonifying and miscarriage prevention theory) are defined, so that (1) the PCOS pregnancy rate is obviously increased (52%-80%, experimental verification); (2) synchronously improving reproduction-metabolism-uterus / placenta triple defects (data support such as a < HOMA-IR <->, a < Total T <->, a < Hif1 alpha > <-> and the like); and (3) the blank in the prior art is filled, and an integrated treatment scheme with both embryo protection and placenta function repair is provided. Experimental data, a molecular mechanism and traditional Chinese medicine theories prove the innovativeness and clinical value of the traditional Chinese medicine composition.

The present invention also relates to methods for assessing the risk of pregnancy loss or embryo implantation failure, and to methods for monitoring or evaluating the effectiveness of treatments to reduce the risk of pregnancy loss or embryo implantation failure using specific biomarkers. The present invention also relates to the use of these biomarkers in methods for diagnosing reproductive disorders in individuals, as well as methods for treating reproductive disorders. Furthermore, the biomarkers can further be used in methods for selecting patients for treatment to reduce the risk of embryo implantation failure or miscarriage. The present invention also relates to kits for use in any of the methods described herein.

Methods and devices to control movement of microorganisms, sperm or viruses within a female reproductive system, including methods and devices for preventing infection or pregnancy. Devices may include a cervical barrier that is configured to allow biological fluids to exit the uterus and cervical canal while preventing the ascension of microorganisms, sperm or viruses into the cervical canal and uterus.

The invention relates to a traditional Chinese medicine composition for assisting pregnancy and preventing miscarriage and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 5-30 parts of semen cuscutae, 1-20 parts of herba taxilli, 1-20 parts of radix dipsaci, 1-20 parts of colla corii asini, 1-20 parts of radix codonopsis, 1-20 parts of rhizoma atractylodis macrocephalae, 1-20 parts of poria cocos and 1-15 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition provided by the invention can be used for treating PCOS threatened abortion, and has the comprehensive effects of radically treating, integrally recovering and treating both symptoms and root causes.

The utility model relates to the technical field of fetus protection bedding, in particular to a pregnant woman fetus protection bedding with an adjustable supporting angle, which comprises a backrest and an organ sleeve fixedly arranged below a back cushion, the organ sleeve is fixedly arranged on a base, a base support is arranged in the base, a backrest support is arranged in the backrest, and the back cushion is fixedly arranged on the base. The right side of the backrest support and the right side of the base support are connected to the main shaft through bearings, an air bag set is arranged in the organ sleeve and composed of a plurality of air bags, and air bag air inlets in the air bag set are uniformly arranged and fixed to an air inlet valve on the right side. Pressure borne by the waist and the back of the pregnant woman is gradually increased. The air cushion with the adjustable supporting angle can help the pregnant woman to find a supporting point most suitable for the pregnant woman, the pressure of the waist and the back is effectively relieved, and the proper backrest supporting angle can help the pregnant woman maintain good blood circulation.

The present invention relates to determining the carrier status of Annexin A5 M2 haplotype of parents (both male and female) prior to and / or after pregnancy to minimize the risk of pregnancy complications, including, but not limited to, recurrent pregnancy loss (RPL), infertility, miscarriage, in vitro fertilization (IVF) failure, IUI failure, implantation failure, foetal growth restriction (FGR), small for gestational age (SGA) newborn, intra-uterine foetal death (IUFD), gestational hypertension (GH), pre-eclampsia (PE) and / or venous thromboembolism (VTE). Once M2 carrier status is determined, methods of intervention, including administration of low molecular weight heparin (LMWH) and / or other anti-coagulants can be administered either prior to and / or after pregnancy. Methods of detecting the carrier status as well as method of diagnosing and or predicting prognosis based on the M2 carrier status of a patient and / or couple is also contemplated.

The invention relates to methods for assessing the risk of miscarriage or embryo implantation failure, and also for monitoring or evaluating the effect of a treatment to reduce the risk of miscarriage or embryo implantation failure using specific biomarkers. The invention also relates to the use of these biomarkers in methods of diagnosing a reproductive disorder in an individual, and also to methods of treating a reproductive disorder. In addition, the biomarkers can further be used in methods of selecting patients for treatment to reduce risk of embryo implantation failure or miscarriage. The invention also relates to kits for use in any of the methods described herein.

The invention relates to the technical field of biological medicine, in particular to application of TRIM21 serving as a biomarker in screening or preparing a preparation for reducing ciprofloxacin exposure related abortion risk. The problems that in the prior art, key action links and molecular mechanisms of pregnancy loss caused by exposure of environment or non-therapeutic dose ciprofloxacin are not clear, and objective detection markers capable of prompting risk states in the early stage of pregnancy and relatively standard and repeatable detection methods are lacked are solved. The invention discloses an application of TRIM21 as a biomarker in screening or preparing a preparation for reducing miscarriage risk related to ciprofloxacin exposure, the pregnancy risk caused by ciprofloxacin exposure can be recognized in an early stage by detecting the expression level of TRIM21, and a candidate preparation with a protective effect is further screened. The invention provides a new thought and target for developing a novel medicine for preventing abortion.

The present invention relates to a feed additive for promoting reproduction of pregnant sows, a preparation method thereof and an application thereof. The components of the feed additive for promoting reproduction of pregnant sows include: a fermented Chinese herbal medicine complex, a compound fat powder, ergothioneine, yeast selenium and a carrier material; the raw materials for preparing the compound fat powder include glycerol butyrate, lipoic acid, nicotinamide and a wall material; the fermented Chinese herbal medicine complex is a product obtained by fermenting a Chinese herbal medicine fermentation substrate with a compound bacterium and a compound enzyme. This feed additive solves the problems that pregnant sows in the previous stage have follicular cysts, the quality of oocytes decreases, embryonic development is damaged, resulting in high rates of miscarriage, premature birth, malformation rate, mummy rate, etc. due to oxidative stress and other reasons, thereby significantly improving the reproductive performance of pregnant sows.

The invention discloses a traditional Chinese medicine composition for preventing and treating pregnancy complications as well as a preparation method and application thereof. The composition is composed of medicinal and edible traditional Chinese medicines including radix rehmanniae recen, fructus gardeniae, gastrodia elata, fructus lycii and exocarpium citri rubrum, and mulberry leaves, ramulus uncariae cum uncis and the like can be selectively added. The preparation method comprises the steps of extracting volatile oil by steam distillation, leaching by a solvent, concentrating, mixing and the like, and can be combined with ultrasonic crushing to strengthen extraction. The composition is based on the treatment method of nourishing kidney, containing wood, clearing heat, calming liver, dissolving turbidity and preventing miscarriage in traditional Chinese medicine, has the effects of multi-target synergistic pressure reduction, proteinuria improvement and fetal development promotion aiming at the pathogenesis of yin deficiency and yang hyperactivity in the gestation period, is high in safety and free of fetal toxic and side effects, and is suitable for prevention and treatment of hypertensive diseases in the gestation period such as preeclampsia and the like.

The application provides application of a vitamin-magnesium compound in preparation of a medicine for preventing and treating miscarriage in a pregnant period and an early pregnant period and a preparation, relates to the technical field of biological medicines, and the vitamin-magnesium compound is a magnesium-based coordination chelate with a repairing effect on endometrial tissue. The vitamin-magnesium compound is an organic ligand of the magnesium-based coordination chelate, and the organic matter is any one of vitamin B13, vitamin B3 and vitamin C. The magnesium-based coordination chelate acts on endometrial stromal cells, promotes cell proliferation, and promotes normal implantation of an embryo. The magnesium-based coordination chelate acts on endometrial tissue vascular endothelial cells, promotes cell proliferation, and promotes angiogenesis to meet the nutritional supply of the embryo. The magnesium-based coordination chelate acts on endometrial tissue macrophages, M1 type macrophages are polarized into M2 type macrophages, immune tolerance to the embryo is promoted, and the normal growth and development of the embryo are prevented from being affected by the attack of maternal immune cells.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating repeated planting failure and a preparation method and application thereof. The traditional Chinese medicine composition disclosed by the invention has the effects of removing blood stasis, tonifying kidney and warming meridians by promoting blood circulation, removing blood stasis and tonifying kidney; furthermore, the uterus-warming and kidney-tonifying treatment traditional Chinese medicine composition is used for warming meridians and uterus, tonifying kidney and nourishing blood to improve the intimal receptivity; further, the post-transplantation implantation miscarriage prevention treatment traditional Chinese medicine composition is used for achieving the effects of strengthening heart, assisting embryo, nourishing blood, preventing miscarriage and supporting early pregnancy; the three groups of traditional Chinese medicine components are subjected to progressive three-stage treatment to realize systematic intervention from eliminating evil to strengthening the body resistance and then to miscarriage prevention, so that the embryo implantation rate and the clinical pregnancy rate of a patient with repeated implantation failure are improved.

The present disclosure provides compositions and methods for using oxytocin antagonists such as compounds of substituted pyrrolidine-3-ketoxime derivatives of formula (I) in the treatment of subjects receiving embryo transplantation therapy. The compositions and methods of the present disclosure may be used to administrate an oxytocin antagonist to a subject, including (3Z, 5S)-5-(hydroxymethyl)-1-[(2 '-methyl-1, 1'-biphenyl-4-yl) carbonyl] pyrrolidin-3-one O-methyl oxime, and the like, in particular, to a subject. The present invention relates to a method for improving endometrial receptivity and reducing the likelihood of embryo transfer failure and abortion after, for example, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) embryo transfer procedures. (Formula I)

An electronic system for detecting events related to a pregnancy of a female human, such as ovulation, conception, and miscarriage, comprises a wearable device (1) with a sensor system (100) worn in contact with the skin for measuring one or more physiological parameters. A processor (13, 30, 40) is configured to receive a user entry indicating a time of actual menses, and to determine time windows, for analyzing physiological parameters of the female human, using the time of actual menses. The processor is further configured to detect the pregnancy related events by comparing the physiological parameters, determined and recorded for a first time window, with those determined and recorded for a second time window, to indicate the pregnancy related events when defined detection criteria are met, and to use the user input for pregnancy related events to optimize the detection of these events with machine learning trained algorithms.

A method for managing miscarriage in a female individual suffering from a pregnancy loss, comprising at least: a) obtaining a set of data comprising pregnancy loss data associated with a foetus and / or foetal tissue, said pregnancy loss data comprising at least a βhCG value (IU / L) in said female individual, measured at the time of the determination of the pregnancy loss, b) determining one or more management score based on said set of data comprising at least a first management score predictive of a most suitable type of management of miscarriage to be received by said female individual at the time of the pregnancy loss, for removing the foetus and / or foetal tissue, c) predicting the most suitable type of management of miscarriage to be received by said female individual based on said one or more management score comprising said first management score, and d) removing said foetus and / or foetal material according to said most suitable type of management of miscarriage predicted based on said one or more management score comprising said first management score; wherein said most suitable type of management of miscarriage predicted based on said one or more management score comprising said first management score increases the most the likelihood of occurrence of an ovulation during a period of 6 weeks after said pregnancy loss in said female individual.

The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for promoting the absorption of subchorionic hematoma in the early stage of pregnancy. The traditional Chinese medicine composition includes an oral medicine and an external patch. The external patch is prepared by grinding the following raw materials and mixing them with vinegar: Eucommia ulmoides, Boehmeria nivea root, Psoralea corylifolia, Artemisia argyi charcoal, Cassia obtusifolia, Rheum palmatum, Areca catechu, Foeniculum vulgare, Akebia quinata, Zanthoxylum bungeanum, Eugenia caryophyllata, Cinnamomum cassia, stir-fried Atractylodes macrocephala. The oral medicine is prepared by grinding the following raw materials: Cuscuta chinensis, Taxillus chinensis, Dipsacus asperoides, Colla Corii Asini, Anemarrhena asphodeloides, Phellodendron amurense, Dioscorea opposita, Paeonia lactiflora, Boehmeria nivea root, Eucommia ulmoides, Saposhnikovia divaricata, Cornus officinalis, Angelica sinensis, Rubia cordifolia, Agrimonia pilosa. The traditional Chinese medicine composition of the present invention includes an oral medicine and an external patch. The compatibility of the medicines is scientific and reasonable. The internal administration combined with external application has a significant therapeutic effect on the formation of hematoma caused by the downward aggregation of yin and blood to nourish the fetus after pregnancy, the more exuberant blood heat due to yin blood deficiency, the heat lurking in Chong and Ren meridians, the exuberant yang and blood heat, the overflow of blood due to heat, and the forced abnormal bleeding. It has the functions of stopping bleeding and preventing miscarriage.

A method for predicting the likelihood of occurrence of an ovulation during a period of 6 weeks after the detection of a pregnancy loss in a female individual, said method comprising at least: a) obtaining a set of data comprising pregnancy loss data associated with a foetus and / or foetal tissue, said pregnancy loss data comprising at least a βhCG value (IU / L) in said female individual, measured at the time of the determination of the pregnancy loss, b) determining one or more likelihood score based on said set of data, c) predicting the likelihood of the occurrence of an ovulation in said female individual during a period of 6 weeks after a pregnancy loss based on said one or more likelihood score.

The present disclosure relates to a composition for treating infertility, which includes beta core fragment hCG (βcf hCG) as an active ingredient. The βcf hCG is identified to stimulate endometrial development in early pregnancy, is highly expressed in placental tissue, and is involved in maintaining fetal development in early pregnancy. The composition plays an important role in implantation and maintenance of early pregnancy by increasing the thickness of the endometrium, increasing the expression of genes necessary for uterine development, and promoting the growth of uterine-derived cell line. The composition can be usefully used to treat habitual miscarriage in female infertility, and to increase the success rate of pregnancy by improving the implantation rate of fertilized eggs in the process of in vitro fertilization.

The utility model discloses an abortion tissue observation basin, the abortion tissue observation basin comprises a basin body and a collector, the basin body is provided with a storage part and a hanging part which is formed by outward horizontal extension of the top wall of the storage part, the upper end of the collector is adjustably hung at the opposite front side end of the hanging part, and the collector is arranged in the storage part. The lower end part of the collector is suspended in the collection cavity of the storage part, the collector is of a barrel-shaped structure with an open upper end and a sealed lower end, sieve pores are uniformly distributed in a barrel body of the collector, and the pore diameter of the sieve pores is smaller than the diameter of the pregnancy tissue. The abortion tissue observation basin is simple in structure, discharged urine and blood are filtered into the collection cavity of the containing part through filtration and separation of the collector located at the front side end of the containing part, pregnancy tissue is left in the collector so that observation and detection can be facilitated, and discharged urine and blood can be conveniently collected into the collection cavity relative to the rear side.

The invention relates to methods for assessing the risk of pregnancy loss or embryo implantation failure, and also for monitoring or evaluating the effect of a treatment to reduce the risk of pregnancy loss or embryo implantation failure using specific biomarkers. The invention also relates to the use of these biomarkers in methods of diagnosing a reproductive disorder in an individual, and also to methods of treating a reproductive disorder. In addition, the biomarkers can further be used in methods of selecting patients for treatment to reduce risk of embryo implantation failure or miscarriage. The invention also relates to kits for use in any of the methods described herein.

The utility model discloses a miscarriage fetus removal and specimen taking device, belongs to the technical field of medical equipment, and solves the problems that in the prior art, in the embryo screening process, the smell is unpleasant, nausea and vomiting are easily caused, and the screening time is long. The abortion fetus removal and specimen taking device comprises a bedpan body, a filter part and a partition part, the partition part is arranged in the middle of the bedpan body, and the filter part is arranged at the end, used for containing vagina excrement and urine, of the bedpan body; during use, under the action of the separator, excrement is separated to one side, far away from the filter, of the separator, vagina excrement and urine are separated to the filter, and the filter filters the vagina excrement and urine to obtain specimens. According to the specimen screening device, medical staff can conveniently screen specimens, screening time is greatly shortened, the medical staff can conveniently and directly observe discharged tissues, and discomfort of patients is reduced.

This invention relates to Lactobacillus plantarum ( Lactobacillus plantarum The application of L168 in improving inflammation levels during pregnancy and resisting abortion caused by excessive immune stimulation belongs to the field of microbial application technology. The *Lactobacillus plantarum* (…) Lactobacillus plantarum L168 strain is deposited at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 13660. This invention relates to *Lactobacillus plantarum* (…). Lactobacillus plantarum) L168 effectively inhibits excessive inflammatory responses during pregnancy, reduces the risk of miscarriage caused by immune stimulation, improves the maternal immune microenvironment, and promotes healthy fetal development. As a natural probiotic preparation, it is highly safe and easy to take. It can be widely used in pregnancy health management products, especially in the adjunctive treatment and preventative intervention of high-risk pregnant women, and has significant clinical and commercial value.

The present invention discloses a traditional Chinese medicine composition for nourishing yin, activating blood circulation and preventing miscarriage, including an external plaster and an oral medicine. Among them, the external plaster is made from Taxillus chinensis, Dipsacus asper, Cuscuta chinensis, Codonopsis pilosula, Atractylodes macrocephala, stir-fried Dolichos lablab, Dioscorea opposita, Amomum villosum, Pueraria lobata, Dendrobium officinale, Angelica sinensis, Salvia miltiorrhiza, Paeonia suffruticosa, Ligusticum wallichii, Astragalus membranaceus, Olibanum, Myrrha, Angelica dahurica, Mentha haplocalyx, Glycyrrhiza uralensis, Zanthoxylum bungeanum in specific proportions. The oral medicine is made from Taxillus chinensis, Dipsacus asper, Cuscuta chinensis, Codonopsis pilosula, Atractylodes macrocephala, stir-fried Dolichos lablab, Dioscorea opposita, Amomum villosum, Pueraria lobata, Dendrobium officinale, Angelica sinensis, Salvia miltiorrhiza, Paeonia suffruticosa, Ligusticum wallichii in specific proportions. The present invention treats both the principal and secondary aspects of the disease by oral administration and external application on Yongquan acupoint, Xuehai acupoint and Zusanli acupoint, and has the effects of supplementing qi and nourishing blood, nourishing yin and promoting fluid production, activating blood circulation and removing stasis, and improving uterine blood supply during pregnancy. It is used for symptoms such as vaginal bleeding during pregnancy, five centers fever, dry mouth and throat, slow embryo development, red tongue or dark tongue with petechiae and ecchymoses, scanty tongue coating, thready, slippery and rapid pulse caused by deficiency of both qi and blood, deficiency of kidney yin, and qi stagnation and blood stasis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing or treating early abortion of polycystic ovarian syndrome as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from glossy privet fruit, morinda officinalis, radix rehmanniae preparata, astragalus membranaceus, codonopsis pilosula, Chinese yam, rhizoma atractylodis, radix ophiopogonis, rhizoma anemarrhenae and coptis chinensis, has the effects of tonifying kidney and spleen, clearing heat and drying dampness and harmonizing chong and ren channels, and is mainly used for preventing or treating early abortion of polycystic ovarian syndrome. The traditional Chinese medicine composition disclosed by the invention has a synergistic effect in the aspect of treating early abortion caused by the polycystic ovarian syndrome, systematically deals with complex endocrine metabolism disorder of a patient with the polycystic ovarian syndrome, and provides a brand new treatment strategy for miscarriage prevention. Meanwhile, the novel application of the traditional Chinese medicine composition in preparation of medicines for preventing and treating early abortion of polycystic ovarian syndrome is defined. Therefore, the traditional Chinese medicine composition has important clinical significance and wide market application prospects.

The invention discloses a machine learning-based auxiliary miscarriage prevention decision-making method for a whole pregnancy period after frozen embryo transplantation. The method comprises the following steps: obtaining pregnancy clinical data to construct a feature data set, obtaining a feature data set after initial screening, training and testing an artificial neural network model by using the feature data set after initial screening, performing feature extraction on pregnancy clinical data to be decided by using the artificial neural network model after testing qualification, and determining the pregnancy clinical data to be decided. And according to the pregnancy prediction characteristics, predicting a pregnancy outcome used for assisting a fetus protection decision. An artificial neural network model of the auxiliary miscarriage prevention decision-making method can effectively capture embryo quality, endometrial receptivity and complex nonlinear interaction among beta-hCG through a multi-layer perceptron architecture, so that a clinician is assisted and guided to preferentially select single embryo transplantation, and in addition, the early warning ability for biochemical pregnancy and early abortion is improved, and the early warning ability is improved. A clinical intervention window can be advanced by 5-7 days, an invalid transplantation period is reduced, and the economic cost of a patient is saved in a single period.

The invention relates to methods for assessing the risk of pregnancy loss or embryo implantation failure, and also for monitoring or evaluating the effect of a treatment to reduce the risk of pregnancy loss or embryo implantation failure using specific biomarkers. The invention also relates to the use of these biomarkers in methods of diagnosing a reproductive disorder in an individual, and also to methods of treating a reproductive disorder. In addition, the biomarkers can further be used in methods of selecting patients for treatment to reduce risk of embryo implantation failure or miscarriage. The invention also relates to kits for use in any of the methods described herein.