37 results about "Endometrial receptivity" patented technology

The invention relates to the technical field of medical informatics, in particular to an intelligent endometrial receptivity evaluation system based on multi-modal fusion. The system comprises a memory and a processor, and the processor executes a computer program stored in the memory so as to realize the following steps: acquiring endometrial thickness, estrogen content, luteal hormone content and pulse index of a reference person and a person to be evaluated; determining the intimal change stability according to the endometrial thickness increase characteristics of the reference person; according to the fluctuation condition of the estrogen content of the reference personnel, the decrease condition of the estrogen content detected in two adjacent times and the change condition of the luteal hormone content, determining the category of the to-be-evaluated personnel; and determining the creep over-frequency expression degree by combining the decreasing condition of the pulse index of the to-be-evaluated person and the uterine contraction condition so as to obtain a comprehensive index. According to the method, the data of different dimensions of the endometrium of the to-be-evaluated person is synthesized to obtain the comprehensive index, and reference data is provided for subsequent evaluation of a doctor.

The invention discloses application of 2-aminoethoxy diphenyl borate (2-APB) in preparation of a medicine for improving endometrial receptivity and treating diseases related to the endometrial receptivity, and belongs to the technical field of biological medicine. A large number of experiments prove that 2-APB specifically activates a TRPM6 channel, enhances calcium ion influx and activates a calcium-dependent CaM-CaMKII-Ecadherin signal axis, so that expression of receptivity markers (such as E-cadherin and ICAM-1) is up-regulated, and endometrial receptivity is improved. The problems of poor targeting property and high toxicity of the traditional calcium ion carrier are solved, and a safe and effective treatment strategy is provided for a patient suffering from repeated implantation failure (RIF).

This invention relates to the field of intelligent information processing technology and discloses an intelligent assessment system for endometrial receptivity based on biosensor data processing. The system acquires signals of multiple types of biomarkers in bodily fluid samples through multi-channel biosensor detection and performs structured preprocessing and quantitative transformation. Based on this, it establishes object-level associations between biosensor data and multi-source information to construct a unified feature data system. Furthermore, it constructs a weighted heterogeneous assessment graph and introduces a manifold stochastic feature modeling mechanism to generate manifold feature data. The manifold features and original features are jointly input into a shared-parameter cyclic Transformer model. Through cyclic inference and consistency constraints, multi-round feature fusion is achieved, outputting the endometrial receptivity assessment result. This invention improves the multi-source data modeling capability and the stability and consistency of the assessment process.

The present application belongs to the field of biological medicine and molecular biology technology, and particularly relates to a marker for predicting the occurrence of repeated implantation failure and application thereof. The present application finds that abnormal lipid peroxidation in uterine epithelium can cause implantation defects, and the lipid peroxidation level of the uterus in patients with repeated implantation failure or repeated spontaneous abortion is enhanced, wherein the content of active aldehyde substance MDA and non-heme iron in serum can be used as a new non-invasive clinical index for predicting RIF patients; further, eliminating uterine lipid ROS to improve endometrial receptivity can be used as a potential new treatment strategy to improve embryo implantation and clinical pregnancy rate, and therefore has good practical application value.

The invention discloses application of rutin hydrate in preventing and treating repeated embryo planting failure, and belongs to the technical field of assisted reproduction. It is found for the first time that CD36 is a key membrane protein for lipid transport and uptake of EECs, rutin hydrate competitively inhibits combination of CD36 and natural ligands of CD36, abnormal lipid excessive uptake is remarkably blocked, lipid accumulation and lipid toxicity damage in cells are effectively relieved, and the effect of inhibiting EECs lipid transport and uptake is achieved. And finally, the endometrial receptivity defect related to RIF is reversed, and the embryo adhesion and implantation capability is remarkably improved. Therefore, rutin hydrate provides a brand new strategy for developing targeted therapy drugs for RIF, especially for lipid metabolism disorder type endometrial receptivity badness, and has remarkable clinical application and transformation prospects.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a sperm-nourishing seed jade decoction and application thereof to improvement of endometrial receptivity, the sperm-nourishing seed jade decoction is composed of 30 g of radix rehmanniae preparata, 15 g of cornus officinalis, 15 g of radix paeoniae alba and 15 g of angelica sinensis, by inhibiting the epithelial-mesenchymal transition (EMT) process, the expression of E-cadherin and beta-catenin is up-regulated, the expression of Vimentin is down-regulated, and the endometrial receptivity is improved. Therefore, the stability and integrity of endometrial epithelium are maintained, intimal thickening, gland hyperplasia and angiogenesis are promoted, and an effective treatment strategy can be provided for infertility caused by thin endometrium.

The invention relates to the technical field of biomedicine, in particular to a group of key biomarkers for predicting endometrial receptivity, including specific microbial strains and metabolites, and a prediction model containing the markers. The method comprises the following steps: collecting a uterine cavity lavage fluid sample, carrying out 16S rRNA gene sequencing and non-targeted metabonomics analysis, and screening out eight key microbial strains and eight key metabolites; based on the markers, the following diagnostic models are constructed: a model only based on eight microbial strains; a model based on only eight metabolites; a combined microorganism and metabolite model; and a clinical data model is further combined. According to the method, a microbiome and metabolome multi-omics conjoint analysis strategy is adopted, strict screening is carried out in combination with LASSO regression, SVM-RFE and other machine learning algorithms, and the obtained biomarker is high in specificity. The constructed model, especially a combined model, shows high prediction precision and good calibration degree through verification of various curves.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating polycystic ovarian syndrome as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from Chinese yam, semen cuscutae, pulp of dogwood fruit, radix glehniae, radix scrophulariae, lily, rhizoma polygonati, tortoise shell, cistanche deserticola, lotus seed and raspberry, has the effects of tonifying kidney and replenishing essence, nourishing yin and blood, replenishing qi and tonifying spleen, and benefiting uterus and accommodating fetus, and is mainly used for treating the polycystic ovarian syndrome. Research results show that the traditional Chinese medicine composition can significantly improve the sex hormone level of a patient with the polycystic ovarian syndrome, increase the endometrial thickness, improve the ovarian function and improve the endometrial receptivity, the ovulation rate and the pregnancy rate. Therefore, the traditional Chinese medicine composition has important clinical significance and wide market application prospects.

The invention belongs to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition for assisting pregnancy and implantation in a test tube and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following medicinal materials: teasel root, parasitic loranthus, semen cuscutae, radix paeoniae alba, liquorice, divaricate saposhnikovia root, roasted rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, ramie root, scutellaria baicalensis, Chinese yam, fructus amomi, coptis chinensis, dogwood, radix rehmanniae preparata, folium mori, bamboo shavings and loofah sponge charcoal. The traditional Chinese medicine composition can regulate spleen and kidney deficiency states, improve ovarian blood flow, improve serum sex hormone level, increase endometrial thickness and vascular endothelial growth factor expression, contribute to endometrial growth, improve endometrial receptivity, assist implantation and development of reproductive embryos and improve pregnancy success rate of patients, and has good application prospects. The traditional Chinese medicine composition has more obvious effect on patients with ovarian reserve function decline, and is worthy of clinical popularization and application.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for improving endometrial receptivity, which is composed of the following components in parts by mass: Xianlingpi 15-25 parts, Cistanche 15-25 parts, Shanyurou 15-25 parts, Rhizoma Rehmanniae Preparata 15-25 parts, Radix Paeoniae Alba 15-25 parts, Atractylodes 15-25 parts, Spatholobus suberectus 15-25 parts, Salvia miltiorrhiza 10-20 parts, Rhizoma Cyperi 10-20 parts. The traditional Chinese medicine composition has the effects of tonifying kidney and generating essence, invigorating spleen and replenishing qi and blood, soothing liver and regulating qi, and activating blood and dredging collaterals, can up-regulate the expression of endometrial hormone receptors ERbeta and PR, enhance endometrial blood perfusion, increase endometrial thickness, improve endometrial receptivity, and thus improve the success rate of embryo implantation.

The invention provides an endometrial receptivity prediction method based on a multi-channel ultrasonic image fusion module. The invention discloses an endometrial receptivity prediction method based on a multi-channel ultrasonic image fusion module. The method comprises the following steps: respectively extracting initial features of three ultrasonic images of blood flow Doppler, a cross section and a longitudinal section; inputting the initial features into a three-channel cross attention module for feature interaction and enhancement of multiple iterations to obtain fusion features; and finally, predicting endometrial receptivity by taking whether pregnancy succeeds or not as an endpoint index (pregnancy probability) based on the fusion features. The endometrial receptivity prediction method based on the multi-channel ultrasonic image fusion module has the advantages that multi-mode ultrasonic images are fused, deep feature interaction is carried out, and accurate endometrial receptivity prediction is achieved.

The invention discloses an endometrial receptivity detection system and method based on machine learning and a medium, and the method comprises the following steps: collecting a continuous multi-frame uterus ultrasonic image sequence, and executing space registration and time standardization processing; segmenting an endometrial region of interest, and processing to obtain an endometrial form dynamic signal sequence; executing time-frequency transformation and local morphological analysis; generating a space-time resonance feature vector through the space-time form resonance network STMR-Net; performing feature fusion to generate an endometrial receptivity embedding vector; calculating receptivity characteristic distribution, generating an endometrial receptivity index, and judging a receptivity grade result; executing frequency spectrum inversion analysis and key feature mapping to generate a receptivity interpretation graph; and outputting a detection result. According to the method, intelligent detection of dynamic oscillation characteristics of the endometrium is realized by utilizing a machine learning and space-time form resonance analysis method, and the method has the advantages of high quantification, high interpretability and high diagnosis precision.

The invention provides an endometrial receptivity evaluation method, device and equipment, a medium and a program product. The method comprises the following steps: acquiring a fresh embryo transplantation type, clinical data of a patient and a uterus longitudinal section ultrasonic image of an ovum taking day; performing endometrial segmentation on the ultrasonic image to obtain an endometrial region, and determining a peripheral region based on the endometrial region and a transplantation type; extracting radiomics characteristics of the endometrial region and the peripheral region, and extracting clinical characteristics of the clinical data; and inputting the image omics characteristics and the clinical characteristics into an endometrial receptivity multi-modal evaluation model corresponding to the transplantation type to obtain the pregnancy probability output by the multi-modal evaluation model after the fresh embryo transplantation in the current period. According to the method, the device, the equipment, the medium and the program product provided by the invention, real-time analysis is carried out in combination with an artificial intelligence technology, and an evaluation result of the fresh embryo transplantation period can be provided in a short time.

The invention relates to the technical field of hydrogel, in particular to stem cell loaded self-crosslinking hydrogel (HGADOC) with continuous oxygen release and active oxygen removal functions. The stem cell loaded self-crosslinking hydrogel with the continuous oxygen release and active oxygen removal functions is prepared from a self-crosslinking hydrogel matrix (GADO) loaded peroxide liposome and stem cells, wherein the self-crosslinking hydrogel matrix (GADO) is prepared from 1%-4% of a dopamine-hydrazide modified gelatin (Gel-ADH-DA) solution and 0.5%-2% of an oxidized sodium alginate (OSA) solution through a Schiff base reaction. The HGADOC realizes endometrial regeneration by synergistically enhancing the survival and function of umbilical cord mesenchymal stem cells (HUMSC). GADOC can be retained in uterine cavity tissues for a long time, serves as a mechanical barrier and a cell factor repository, continuously releases therapeutic paracrine factors, promotes endometrial regeneration, collagen remodeling and endometrial receptivity, and recovers fertility.

The invention discloses application of circSLC26A4 in preparation of a medicine for promoting endometrial receptivity formation, and belongs to the technical field of biology. Research finds that overexpression circSLC26A4 can up-regulate mRNA and protein expression of an endometrial receptivity marker and improve the adhesion rate of an embryo on an endometrial, and shows that the circSLC26A4 has the application values of improving the endometrial receptivity, promoting embryo implantation and improving the reproductive capacity; in addition, overexpression of circSLC26A4 can also significantly improve the activity and proliferation number of endometrial epithelial cells, reduce the apoptosis rate and enhance the cell migration ability, and shows the application value of circSLC26A4 in the aspect of repairing endometrium. And a theoretical basis and a technical support are provided for developing related reagents or therapeutic drugs by taking circSLC26A4 as a target spot for regulating and controlling endometrial receptivity.

This invention provides the application of lecithin in the preparation of drugs for the prevention and / or treatment of infertility, belonging to the field of biomedical preparation technology. Specifically, it relates to the application of lecithin in the preparation of drugs for the prevention and / or treatment of infertility, recurrent miscarriage, and / or uterine decidualization disorders. The lecithin can effectively reduce TNF-α levels in early pregnancy, improve uterine decidualization disorders, and increase endometrial receptivity, thereby increasing pregnancy rates and providing a new approach for the treatment of infertility and recurrent miscarriage.

The invention provides a method for predicting endometrial receptivity by using a sample obtained in a non-invasive sampling mode, a method for establishing a prediction model by using the sample, the established prediction model, a marker associated with the endometrial receptivity in the sample and a corresponding kit.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating repeated planting failure and a preparation method and application thereof. The traditional Chinese medicine composition disclosed by the invention has the effects of removing blood stasis, tonifying kidney and warming meridians by promoting blood circulation, removing blood stasis and tonifying kidney; furthermore, the uterus-warming and kidney-tonifying treatment traditional Chinese medicine composition is used for warming meridians and uterus, tonifying kidney and nourishing blood to improve the intimal receptivity; further, the post-transplantation implantation miscarriage prevention treatment traditional Chinese medicine composition is used for achieving the effects of strengthening heart, assisting embryo, nourishing blood, preventing miscarriage and supporting early pregnancy; the three groups of traditional Chinese medicine components are subjected to progressive three-stage treatment to realize systematic intervention from eliminating evil to strengthening the body resistance and then to miscarriage prevention, so that the embryo implantation rate and the clinical pregnancy rate of a patient with repeated implantation failure are improved.

The invention relates to the technical field of medical data processing, in particular to an endometrial receptivity evaluation system based on vagina high-frequency ultrasonic imaging. According to the system, a blood flow pulsation rhythmicity coefficient is extracted through a time sequence ultrasonic echo image, and local microvascular perfusion resistance is generated in combination with brightness characteristics; constructing a vertical growth direction field based on an intimal anatomical contour, introducing direction difference penalty when the transmission cost of adjacent positions is calculated, and constructing an anisotropic resistance network; a supply-demand bipartite graph model is constructed based on the minimum energy consumption principle, an effective blood perfusion path is obtained through global optimal matching solution, and the overall perfusion resistance and the intimal non-perfusion degree are quantitatively output according to the effective blood perfusion path. According to the method, pathological disordered blood flow and physiological effective perfusion can be effectively distinguished, and the specificity and accuracy of endometrial receptivity evaluation are improved.

The present disclosure provides compositions and methods for using oxytocin antagonists such as compounds of substituted pyrrolidine-3-ketoxime derivatives of formula (I) in the treatment of subjects receiving embryo transplantation therapy. The compositions and methods of the present disclosure may be used to administrate an oxytocin antagonist to a subject, including (3Z, 5S)-5-(hydroxymethyl)-1-[(2 '-methyl-1, 1'-biphenyl-4-yl) carbonyl] pyrrolidin-3-one O-methyl oxime, and the like, in particular, to a subject. The present invention relates to a method for improving endometrial receptivity and reducing the likelihood of embryo transfer failure and abortion after, for example, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) embryo transfer procedures. (Formula I)

The invention provides an application of an IGFBP5 (Insulin-like Growth Factor Binding Protein 5) gene in preparation of a medicine for improving endometrial receptivity impairment, and the IGFBP5 gene is used for preparing the medicine for improving the endometrial receptivity impairment. The number of embryo implantation sites can be effectively increased, abnormal proliferation of endometrial epithelial cells is reduced, and the relative expression level of estrogen response genes and progestational hormone response genes is improved. The IGFBP5 gene disclosed by the invention is a key downstream effector molecule of an IL-22-STAT3 signal channel, and the endometrial receptivity can be enhanced by supplementing IGFBP5 protein so as to save embryo implantation failure.

The invention provides application of blood nourishing oral liquid combined with drospirenone ethinylestradiol in clinical symptoms and endometrial receptivity after an induced abortion operation, and belongs to the technical field of biological medicine. According to the application of the blood nourishing oral liquid and the drospirenone ethinylestradiol in preparation of the medicine for improving the clinical symptoms after the induced abortion operation, the result of the embodiment shows that compared with a drospirenone ethinylestradiol single administration group, the combined administration group has the advantages that the vaginal bleeding duration is shorter, the vaginal bleeding amount is smaller, the abdominal pain degree is lower, and the clinical symptoms after the induced abortion operation can be improved. The dominant follicle size, the endometrial thickness, the endometrial volume, the type A endometrial rate, the type III endometrial and the ratio of the endometrial-muscular layer binding band are all higher than those of a control group, and the aneurysm hemodynamic indexes are all lower than those of a single administration group. Therefore, the blood-nourishing oral liquid combined with drospirenone ethinylestradiol can effectively improve postoperative clinical symptoms of patients, promote follicle development and improve endometrial receptivity.

The invention belongs to the technical field of new application of hippocampus multi-penis pills, and provides application of the hippocampus multi-penis pills in preparation of a medicine for improving or treating female infertility. Animal test results show that the hippocampus multi-penis pill has a good treatment effect on premature ovarian failure and endometriosis. Clinical test results show that when the hippocampus multi-penis pill is applied to female infertility patients, the treatment effect is remarkable, and the development of ovarian follicles can be effectively promoted, the endometrial receptivity can be improved, the immune function of the organism can be regulated, and the inflammation can be inhibited. Animal test and clinical test results show that the hippocampus multi-penis pill has a certain application prospect in preparation of medicines for improving or treating female infertility.

The application discloses a method for increasing the number of early embryo implantation and promoting embryo development. The research result of the application shows that after superovulation, the endometrial receptivity is damaged, the embryo implantation site is increased, but the embryo development is slow, the sizes of the embryos are different, and the number of abnormal embryos is increased. The research of the application finds that neomycin can increase the number of embryo implantation after superovulation, and can significantly promote embryo development and reduce the number of abnormal embryos, thereby providing a new method for the production of livestock, poultry and pets.

The present invention provides a method for determining endometrial receptivity and an application thereof. Specifically, the present invention provides a method for determining endometrial receptivity and markers for determining an endometrial receptivity status. The markers of the present invention could greatly reduce the error rate during the determination of the endometrial receptivity.

The invention discloses a traditional Chinese medicine composition for treating thin endometrial reproductive disorder infertility, which is prepared from the following raw material medicines in parts by weight: 20-30 parts of prepared rehmannia root, 10-15 parts of Chinese angelica, 10-15 parts of raw dogwood, 10-12 parts of parched white peony root, 4-6 parts of glossy privet fruit, 4-6 parts of yerbadetajo herb, 4-6 parts of cortex lycii radicis, 10-12 parts of moutan bark, 4-6 parts of golden cypress, 10-12 parts of raw rehmannia root and 10-15 parts of poria cocos. , 10-20 parts of fried rhizoma atractylodis macrocephalae, 10-15 parts of fried eucommia ulmoides and 10-15 parts of salted radix dipsaci. Compared with an existing medicine for treating thin endometrial type reproductive disorder infertility, the traditional Chinese medicine composition can effectively increase the endometrial thickness and improve the endometrial receptivity of a thin endometrial infertility patient, and is excellent in treatment effect, low in side effect and good in application prospect.

The invention belongs to the technical field of animal models, and particularly relates to a preparation method for constructing a rat embryo implantation failure model based on streptococcus agalactiae. The method comprises the following steps: culturing a streptococcus agalactiae strain with the number of BNCC336970 by using a solid culture medium containing sheep blood, adjusting the concentration of a bacterial solution to 1 * 10 < 8 > CFU / mL, and carrying out vaginal perfusion on an SPF-grade female SD rat every day for 21 days continuously. And after the perfusion is finished, the female mouse is mated with the male mouse at the early oestrus stage, the detected vaginal suppository is marked as the 0.5 th day of pregnancy, the mouse is killed at the 7.5 th day of pregnancy, and the model is evaluated by counting the embryo implantation quantity and detecting the expression level of endometrial tissue receptivity factors MMP9 and VEGF (Vascular Endothelial Growth Factor). A clinical pathogen pathogenic mechanism is simulated through a genital tract infection way for the first time, and the problem of physiological status deviation caused by traditional hormone intervention, immune agonists or genetic engineering methods is solved. The constructed model can stably induce the obvious reduction of the embryo implantation number and the reduction of endometrial receptivity, and provides a standardized tool for the pathological mechanism research of infectious embryo implantation failure and the screening of therapeutic drugs.

Endometrial receptivity status is determined by measuring, in an uterine fluid sample taken from a woman, the amounts of at least three proteins selected among NNMT, LCN2, PGR, SLC26A2, SLC34A2, TCN1, ENPP3, GRN, STC1, DPP4, MPO, CD55, ELANE, MSLN, CTSB, RNASET2, CRISP3, MVP, MMP26, AOC1 and SDCBP2. The EM receptivity status of the woman is determined based on a comparison of the measured amounts of the at least three proteins with respective control amounts.

The application discloses application of circSATB1 in preparation of a medicine for improving the reproductive capacity of sheep, and belongs to the technical field of biological medicine. The nucleotide sequence of the circSATB1 is shown as SEQ ID NO. 1. The application firstly analyzes the sheep seminal plasma extracellular vesicle circRNA expression profile, wherein the expression amount of circSATB1 in the seminal plasma extracellular vesicle is relatively high, overexpression of the circSATB1 can extremely significantly promote the proliferation and migration of endometrial epithelial cells, and significantly inhibit the apoptosis of the endometrial epithelial cells. Interference with the circSATB1 can extremely significantly inhibit the proliferation and migration of the endometrial epithelial cells, and extremely significantly promote the apoptosis of the endometrial epithelial cells. The above results prove the important significance of the circSATB1 in the formation of endometrial receptivity, and provide a new idea for improving the embryo implantation rate of a female animal.

Disclosed herein are methods and compositions for promoting fertility and / or endometrial receptivity in a subject, by providing arachidonic acid triglyceride (AA-TG) to the subject. In some embodiments, compositions are provided to the subject before or during a course of fertility treatment or process of natural conception.