377 results about "Peritoneal membrane" patented technology

The invention relates to an automatic peritoneal dialysis machine auxiliary system capable of preventing peritoneal protein from being lost, and belongs to the technical field of peritoneal dialysis. By arranging the auxiliary system comprising a hollow fiber membrane filter, peritoneal drainage liquid is guided into the hollow fiber membrane filter in the drainage stage; the protein is intercepted by utilizing the semi-permeable membrane characteristic, and small molecule metabolic wastes penetrate through the semi-permeable membrane characteristic to form a filtrate rich in the protein; and then the feedback pump speed is dynamically adjusted through a control system based on a signal of a flow sensor, so that the feedback process of the protein liquid is stably synchronized with drainage, liquid injection and staying stages of the automatic peritoneal dialysis machine, online recovery and safe feedback of protein are realized, and the problem that the protein liquid flows back to the treatment cycle of the automatic peritoneal dialysis machine is solved on the premise that the treatment cycle is coordinated with the treatment cycle of the automatic peritoneal dialysis machine. Protein in peritoneal drainage liquid is continuously and selectively recovered and safely returned, so that the problem of protein trophism loss of long-term peritoneal dialysis patients is directly reduced.

The present disclosure relates to a transplantable cell therapy product composition for diabetes mellitus that contains an aggregate of insulin-secreting cells derived from stem cells. In the present disclosure, an NF microwell array membrane was fabricated by applying a molding process to an electrospun, permeable, biodegradable polycaprolactone (PCL) NF membrane and thus allows gases and soluble factors to permeate therethrough. The NF microwell of the present disclosure could provide more nutrients to the iPSC aggregates than conventional impermeable PDMS microwells, thus enhancing survival and differentiation capabilities of the cells. Additionally, the NF membrane was attached singly to the subcutaneous tissue and to the surface of organs such as liver and peritoneum without the need for a fixing material or separate sutures and was integrated with surrounding tissues, resulting in higher insulin secretion than PDMS microwells. Therefore, the present disclosure can be effectively utilized as a composition for the prevention or treatment of diabetes.

The present disclosure generally relates to systems and methods of use for draining cerebrospinal fluid (CSF) from a brain or a spinal canal in a subject, for example, to treat hydrocephalus or other conditions. In some embodiments, the disclosure relates to a device comprising a flow controller positioned within a conduit that allows CSF to flow through the conduit from a first end to a second end. This may allow the CSF to drain, for example, from an intradural space (such as a thecal sac) into, for example, a paraspinal space, paraspinal vein or other venous space, or peritoneal cavity. A variety of methods may be used to hold or anchor the device in place, for example, an expansion apparatus. In some embodiments, the device can be implanted percutaneously at a location along or within a subject's spinal column, thus reducing the need for surgery, general anesthesia, and hospitalizations.

The utility model relates to a peritoneal dialysis tube disinfection device which comprises a disinfection tank and a tank cover detachably connected with the disinfection tank, the tank cover is provided with a tube placing hole allowing a tube body of a peritoneal dialysis tube connected with a human body to penetrate through, so that a first end, far away from the human body, of the peritoneal dialysis tube can vertically enter an inner cavity of a tank body in the disinfection tank in the axial direction under the action of gravity; the bottom face of the inner cavity of the tank body is provided with a limiting step axially aligned with the pipe containing hole, so that the first end can be kept on the limiting step in a clamped connection mode. The disinfection tank is designed for the titanium alloy end of the peritoneal dialysis catheter, so that the end can be ensured to be completely immersed into disinfectant in the disinfection tank under the action of gravity, and the pollution risk of the external environment to the peritoneal dialysis catheter is reduced. In addition, due to the design of the limiting step, it is ensured that the end is kept at the stable position in the disinfection process, the end is prevented from shaking or shifting in the disinfection tank, and the titanium alloy end is prevented from being physically damaged due to collision.

In some examples, a sensor for detecting dextrose includes at least one working electrode including Cu and being configured to electro-oxidize dextrose in an aqueous solution. The sensor further includes at least one counter electrode. In some examples, a system includes a fluid line, a dextrose container, a peritoneal dialysis container, and the sensor. The fluid line is configured to transport water. The dextrose container is configured to introduce dextrose in the fluid line to generate a peritoneal dialysis composition comprising the water and dextrose. The peritoneal dialysis container is downstream of the dextrose container and configured to receive the peritoneal dialysis composition. The sensor may be configured to detect dextrose in the peritoneal dialysis composition.

A leak detecting apparatus (1) for detecting a leak and determining the size of the leak in a suture repaired site (5) of a hollow organ (3), for example, a stomach, in a cavity (7), for example, the peritoneal cavity of a subject comprises a first insufflator (12) for insufflating the hollow organ (3) with a first gas, and a second insufflator (14) for insufflating the cavity (7) with a second gas. A gas detector (18) is provided for detecting the concentration of the first gas in gases exhausted from the cavity (7) through a communicating conduit (35). A flow meter (25) monitors the flow rate of the first gas to the hollow organ (3). First and second pressure sensors (15) and (16) monitor the static pressure of the first and second gases in the hollow organ (3) and the cavity (7), respectively. The apparatus (1) is operable in a first mode and a second mode. In both the first and second modes of operation a microprocessor (50) controls the second insufflator (14) for maintaining the pressure in the cavity (7) at a relatively low predefined pressure, and the first insufflator (12) for maintaining a constant predefined pressure differential between the pressures in the hollow organ (3) and the cavity (7) of approximately 7 mmHg. In the first mode the microprocessor (50) determines the size of the leak as a function of the pressure differential and the concentration of the first gas in the exhaust gases. In the second mode of operation the microprocessor (50) determines the size of the leak as a function of the pressure differential and the flow rate of the first gas to the hollow organ (3) with the hollow organ (3) sealed apart from the sutured site (5).

A medical fluid system includes a medical fluid pump actuator; a medical fluid carrying set including a flexible sheet; a temperature sensor positioned and arranged to sense a temperature of the medical fluid flowing through the medical fluid carrying set; a pressure sensor positioned and arranged to contact the flexible sheet when the medical fluid carrying set is loaded for operation with the medical fluid pump actuator; and a control unit configured to (i) precondition the flexible sheet for operation with the pressure sensor by causing the medical fluid pump actuator to apply pressure to the flexible sheet and (ii) use an output from the temperature sensor in a compensation algorithm that modifies an output from the pressure sensor.

This utility model relates to the field of packaging and sealing technology, and discloses a peritoneal dialysis fluid packaging and sealing machine, including a support plate. A slide rail is fixedly connected to the upper surface of the support plate, and a slider is fixedly connected to the upper surface of the slide rail. A clamping assembly is provided outside the slider, the clamping assembly including a clamping plate. The clamping plate is disposed outside the slider, and a connecting rod two is fixedly connected to the outer wall of the clamping plate. A fixing post one is rotatably connected to one end of the outer wall of the connecting rod two, and a fixing post two is rotatably connected to one end of the connecting rod two. A connecting rod three is rotatably connected to the outer wall of the fixing post one. In this utility model, the clamping plate stably clamps the packaging bag by driving the gears and connecting rods through a motor. Combined with the sliding of the slider on the slide rail, the packaging bag can be accurately transported to the sealing position, improving the stability of clamping and transporting, ensuring accurate positioning of the packaging bag during the sealing process, reducing sealing deviations caused by displacement, and improving sealing quality.

The present disclosure sets forth an automated peritoneal dialysis (“PD”) system, which enables the re-use of certain disposable components. The APD system includes a sterilization source, such as a steamer or a UV radiation light source that sterilizes a disposable filter. During therapy, the disposable filter is connected to a PD fluid line and to a patient's catheter. Post-therapy, the disposable filter is disconnected from the patient's catheter, but remains connected to the PD fluid line, and the disposable filter undergoes steam or UV radiation sterilization.

1. Name of the product in this design: Disposable kit for peritoneal dialysis devices. 2. Purpose of this design: This product is a disposable kit for peritoneal dialysis devices. 3. The key design points of this product are: Design 1 focuses on the combination of color and shape, and Design 2 focuses on the shape of the product. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Design 1 requests color protection.

A proportioning system includes a solute container filled with dry solutes, a source of water, a container of electrolyte concentrate, a fluid circuit connecting the solute container to the source of water and the container of electrolyte concentrate, the fluid circuit having an empty mixing container, a controller configured to transfer water from the source of water to the solute container through the fluid circuit so as to prepare a solute concentrate solution in the solute container. The controller is configured to transfer fluid from the container of electrolyte concentrate to a mixing container as well as a solute concentrate from the solute container to the mixing container and further adding water to said mixing container to form a medicament therein.

A device for safely and effectively disinfecting a catheter while it remains implanted in a patient's body is provided. [Solution] Methods and devices for providing therapeutic electromagnetic radiation (EMR) to inactivate infectious agents and / or enhance healthy cell growth in, on, or around a catheter (10) placed in a patient's body cavity. Non-ultraviolet therapeutic EMR is transmitted axially along the lumen of the catheter body and / or along an optical element (14) within the catheter body. Delivery of the therapeutic EMR to specific infected areas and / or areas requiring tissue healing results in inactivation of primary sources of infection in, on, and around the catheter and / or enhancement of healthy cell growth around the catheter through the use of controlled relative intensity and treatment-site-specific dose projection of the therapeutic EMR radially emitted from the optical element. Specific embodiments for urinary catheters and peritoneal dialysis catheters are also disclosed.

The present application relates to the technical field of automatic peritoneal dialysis machine, and particularly relates to a peritoneal dialysis fluid constant-temperature supply and flow self-adaptive regulation and control system; comprising: a liquid supply driving module, a non-contact end heating module, a multi-dimensional signal sensing module and a temperature-pressure coupling multi-state collaborative control module; the present application introduces a non-contact electromagnetic resonance end heating structure and a temperature-pressure coupling multi-state collaborative control algorithm, on the one hand, uses air gap and high-frequency electromagnetic eddy current to realize safe endogenous heat of dialysis fluid in the pipeline, effectively avoids the risk of local thermal deformation and plasticizer precipitation of the pipeline caused by traditional contact heating, improves the biological safety of fluid infusion, constructs a feedforward defense mechanism based on the change rate of end temperature, and through extraction of the dynamic amplitude and static component of the hydraulic waveform, realizes accurate identification of cold stimulation spasm, regular physiological disturbance and pipeline mechanical obstruction, and after diagnosing mechanical obstruction, actively drives the stepping motor to perform reverse backflushing action.

The abdominal wall retractor for the observation hole of the laparoscope comprises a first retraction arm and a second retraction arm, the first retraction arm and the second retraction arm are hinged through a hinged shaft, and the first retraction arm comprises a first retraction arm front section, a first retraction arm middle section and a first retraction arm rear section. The end part of the rear section of the first retraction arm is fixedly connected with a first operation ring; the second retraction arm comprises a second retraction arm front section, a second retraction arm middle section and a second retraction arm rear section, the end part of the second retraction arm rear section is fixedly connected with a second operation ring, and the end part of the first retraction arm front section is movably connected with a first retraction rod and a second retraction rod; and the end part of the front section of the second retracting arm is movably connected with a third retracting rod and a fourth retracting rod. The utility model has the beneficial effects that the abdominal wall of the observation hole and the subcutaneous fat layer can be expanded, and the anterior sheath layer and the peritoneal layer can be better exposed, so that the peritoneal layer and the anterior sheath layer can be better sutured under direct vision, related complications of a puncture hole are avoided, the use is safe and reliable, and the operation time of medical personnel is saved.

The application discloses a Bifidobacterium longum subsp.longum strain for relieving pathological characteristics of mice with chronic kidney disease induced by adenine, and belongs to the technical fields of microorganisms and medicines.The application provides a biomarker combination related to end-stage renal disease of peritoneal dialysis, wherein the corresponding species abundance in the biomarker combination presents significant difference in matched healthy control population and peritoneal dialysis population, can effectively distinguish the end-stage renal disease population of peritoneal dialysis and the healthy population, and has high sensitivity and specificity.The application also provides a Bifidobacterium longum subsp.longum strain CCFM1375 capable of delaying the progression of renal failure, which can be used for preparing products for improving chronic kidney disease.

A peritoneal dialysis (“PD”) system includes a PD fluid pump; a patient line for receiving used PD fluid pumped by the PD fluid pump during a patient drain; a pressure sensor positioned and arranged to sense a negative pressure associated with the PD fluid pumped during the patient drain; and a control unit configured to (i) determine or know a flowrate of the PD fluid pumped during the patient drain, (ii) determine an applied negative pressure at which the PD fluid pump is to pump the PD fluid during the patient drain, the applied pressure based on a pressure drop corresponding to the determined or known flowrate, and (iii) use sensed negative pressure from the pressure sensor to cause the PD fluid pump to pump the PD fluid during the patient drain at the applied negative pressure.

The application discloses a peritoneal dialysis prescription dynamic adjustment method and system, relates to the field of data processing, and comprises the following steps: under the authorization condition of a patient, acquiring multi-dimensional data related to current peritoneal dialysis of the patient; integrating the multi-dimensional data into a structured patient state description text; calling a large language model, generating an adjusted peritoneal dialysis prescription based on the patient state description text according to a set frequency by using a peritoneal dialysis prescription prompt word template. The application can significantly improve the accuracy and timeliness of the dialysis prescription.

A dialysis system having motor driven pressure estimation of fluid within a patient line is disclosed. A peritoneal dialysis (“PD”) system includes a fluid pump and a patient line that fluidly couples the fluid pump to an indwelling catheter leading into a patient's peritoneal cavity. The PD system also includes a motor driver that controls a motor of the fluid pump and transmits an output signal that is indicative of a load on the motor. The PD system further includes a machine learning algorithm that associates data related to output signals from motor drivers with known fluid pressures within patient lines. A processor of the PD system transmits an input signal to activate the motor driver, receives the output signal from the motor driver, and estimates a fluid pressure within the patient line by applying the data from the received output signal to the machine learning algorithm.

In accordance with the present disclosure, a method for automatically controlled peritoneal perfusion includes receiving perfusion parameters such as a predefined intra-abdominal volume and inflow rate and circulating a perfusate between a reservoir and a subject's cavity using an inflow pump and an outflow pump. A reservoir volume may be measured by a weight sensor, inflow data may be obtained from a flow-rate sensor and a commanded flow rate may be accessed from the outflow pump. A drainage efficiency of the outflow pump may then be estimated using the reservoir volume, inflow rate, and the commanded outflow rate. A drainage efficiency model may be identified from experimental or operational data to represent efficiency dynamics. Based on this model, a perfusion safety control routine may evaluate a safety barrier function and adjust operation of the inflow and outflow pumps to maintain safety and compliance with the perfusion parameters.

The invention discloses an antibacterial composite periosteum for an oral cavity and a processing technology of the antibacterial composite periosteum, and relates to the technical field of periosteum. The method specifically comprises the following steps: step 1, treating defatted pig peritoneum with a decellularized solution, cleaning and sterilizing to obtain a pig peritoneum decellularized matrix; 2, treating the pig peritoneal decellularized matrix with a glyoxal solution, cleaning, and sterilizing to obtain a pretreated pig peritoneal decellularized matrix; step 3, uniformly coating the surface of the pretreated porcine peritoneal acellular matrix with an antibacterial solution, and performing sterilization, standing and freeze-drying to obtain the antibacterial composite periosteum. Wherein the antibacterial solution is prepared from the following raw material components in concentration: 1 to 2 weight percent of modified chitosan, 0.2 to 0.4 weight percent of amino-terminated polyethylene glycol and 0.01 to 0.05 weight percent of p-toluenesulfonic acid, and a solvent is a PBS (Phosphate Buffer Solution). The antibacterial composite periosteum is good in biocompatibility and has excellent clinical application value in oral surgery.

A peritoneal dialysis (“PD”) system includes a PD machine and a docking station connected to the PD machine via a power cord. The docking station includes a plurality of connectors configured to receive a cable of one or more wired peripheral entity, a transceiver for wireless communication with one or more wireless peripheral entity, and a power supply rated to power the PD machine during a PD treatment that includes batch or inline PD fluid heating.

The utility model discloses a drainage tube pull-out post-operation dressing change component, including support rod and dressing, the support rod includes support section and handle, the dressing is wrapped in the support section, the dressing is bonded with the support section, the dressing includes cotton yarn layer and antibacterial coating. According to the dressing changing assembly after the drainage tube is pulled out, treatment can be conducted according to the recovery condition of a wound, dressing can stretch into the wound or even the peritoneum of the abdominal cavity through the supporting rod, the wound can be better sterilized and killed, and the wound can be better recovered.

A peritoneal dialysis (“PD”) system includes a plurality of PD fluid components, a reusable PD fluid line selectively fluidly communicating with the PD fluid components, a source of PD fluid selectively fluidly communicating with the reusable PD fluid line, a source of anti-scaling fluid selectively fluidly communicating with the reusable PD fluid line, and a control unit configured to (i) operate the plurality of PD fluid components during treatment using PD fluid from the source heated to a treatment temperature, and (ii) circulate unused PD fluid heated to a disinfection temperature in combination with anti-scaling fluid from the source of anti-scaling fluid after treatment for disinfecting the plurality of PD fluid components and the reusable PD fluid line, the anti-scaling fluid provided in an amount configured to lower the pH of the unused PD fluid to a level below which precipitates are formed and above which the pH causes disinfection.

Dialysis device for performing peritoneal dialysis with at least one control unit, with at least one input unit for inputting one or more values, and with at least one processor, wherein the processor is designed to perform a method for estimating the treatment duration of a peritoneal dialysis treatment, wherein the estimation of the treatment duration is based on an ideal treatment duration, wherein the ideal treatment duration is increased by one or more delay values, characterized in that the delay values ​​depend on one or more patient-specific parameters.where a patient-specific parameter is catheter performance and the catheter performance is taken into account when estimating the infusion time and / or when estimating the outflow time and / or when estimating the duration of the last infusion, and the catheter performance, and in particular an absolute or relative increase thereof, is editable by a user.

The present disclosure sets forth a peritoneal dialysis (“PD”) system, which allows the lowest operating ambient temperature of the PD fluid to be decreased without modifying the heater power or the flow rate during treatment. The system includes a PD machine or cycler. Fresh PD fluid is delivered via a single or dual lumen patient line to the patient and is first heated to a body fluid temperature, e.g., 37° C. Before fill, the PD fluid is preheated by pumping the fresh PD fluid from a solution bag, through the inline heater, into an empty solution bag, and back until the fresh PD fluid is heated to a pre-determined temperature. This allows the initial temperature of the fresh PD fluid in the solution bag to be lower.

The present application relates to the technical field of peritoneal dialysis, in particular to a multi-bag independent control and intelligent circulation system of peritoneal dialysis equipment. The present application determines the correction residual amount based on the basic backflow residual amount and the basic perfusion residual amount adjusted by the flushing effect of the backflow of waste liquid, and the weight change of each drug liquid bag before and after dialysis circulation and the theoretical ultrafiltration amount. The characteristic correction residual amount is determined based on the state parameter difference of each drug liquid bag dialysis cycle and several dialysis cycles before it. The target flushing amount after each drug liquid bag dialysis cycle is determined based on the characteristic correction residual amount and the concentration gradient difference of the adjacent two circulation drug liquids, and the next drug liquid bag output target flushing amount is controlled to flush the pipeline with the drug liquid, and the generated flushing waste liquid is guided to the previous drug liquid bag to start the next drug liquid bag dialysis cycle. The present application realizes dynamic and accurate quantification of pipeline residual, combines physical correction and personalized habit calibration, and improves the pipeline flushing effect.

The invention discloses an anti-drifting peritoneal dialysis pipeline convenient to fix, relates to the technical field of peritoneal dialysis pipelines, and aims to solve the technical problems that a polyester sleeve is insufficient in fixing and anti-traction capacity, and a catheter is prone to shifting and even falling off due to accidental pulling. Comprising a fixing bellyband surrounding the waist and belly, a first dialysis tube arranged at a subcutaneous tunnel section, a fixing mechanism and an auxiliary mechanism. According to the invention, the compressible elastic anchor wing is in a dry and compressed state in the implantation process, rapidly absorbs tissue fluid after implantation to generate hydration expansion and recover an outward expansion form, and is matched with micron-sized pyramid-shaped textures on the surface of the micro-texture biological anchoring area to provide an ideal scaffold for fibroblast attachment and collagen deposition; the catheter can be mechanically interlocked with surrounding abdominal wall fascia and subcutaneous fiber adipose tissue, the initial subcutaneous stability of the dialysis catheter is guaranteed, and the problems that a polyester sleeve is insufficient in fixing and anti-traction capacity, and the catheter is prone to displacement and even disengagement due to accidental pulling are solved.

The utility model is suitable for the technical field of abdominal surgery, and provides an extraperitoneal cavity dilator which comprises an operation end, the bottom of the operation end is in threaded connection with an inflation pipeline, a check valve is installed on the inner wall of the inflation pipeline, and a balloon dilator is arranged at the bottom of the inflation pipeline. The inflation pipeline is of a hollow cylinder structure and comprises a bent section used for bending, a reinforcing layer is arranged at the bottom of the bent section, and the check valve is arranged at the tail end of the reinforcing layer in the same direction. The check valve comprises an air cavity, the air cavity is formed in the middle section of the check valve, an air inlet is formed in one end of the air cavity, an air outlet is formed in the other end of the air cavity, the air inlet is formed in the end close to the bent section, and a check module is installed in the air cavity. According to the device, one-way flowing of gas is ensured through the non-return module, backflow and leakage are avoided, deflation can be achieved through the deflation rod, and operation stability and high adaptability are achieved.