1148 results about "Peritoneal membrane" patented technology

A peritoneal dialysis (“PD”) system having an ultrafilter is disclosed herein. In one example, the PD system includes a housing and a PD fluid pump. The PD system also includes a filter comprising an outer chamber, a central portion, a membrane, an inlet connected to the outer chamber, an outlet, a first venting port connected to the outer chamber, and a second venting port connected to the central portion. The first venting port has a valve preventing air flow into the filter via the first venting port. The PD system further includes a pressure sensor and a control unit configured to control the PD fluid pump. The control unit is further configured to determine a pressure inside the filter based on an output from the pressure sensor and determine an integrity status of the membrane based on the pressure inside the filter.

Provided herein is a peritoneal dialysis (“PD”) system comprising a housing and one or more doors comprising elastomeric properties. Each of the one or more doors comprises one or more features configured to couple to one or more features of the housing. Further, each door includes one or more inserts molded between two layers of elastomeric material where the features are coupled to. The doors are configured to cover and thermally insulate one or more PD fluid lines when in a closed configuration. The doors are also configured to transition to an open configuration to provide access to one or more PD fluid lines for treatment.

The invention discloses a peritoneal dialysis anti-blocking high-circulation nursing device for pediatric nephropathy patients, and belongs to the technical field of medical nursing. Comprising the following modules: a multi-mode sensing module for collecting pressure, flow velocity, turbidity, vibration spectrum and temperature data in a catheter in real time; the signal optimization processing module highlights weak features of potential blockage and improves data quality; the feature fusion analysis module is used for comprehensively evaluating the state of the catheter; the AI prediction analysis module is used for predicting the occurrence probability, the position and the possible time window of blockage; the risk early warning and intervention module is used for sending out graded early warning signals according to the prediction result and generating personalized anti-blocking intervention suggestions; the micro-fluidic execution module inhibits formation of initial sediments through a micro-pulse technology and dynamic fluid mechanics adjustment, and effectively reduces the risk of blockage; and the remote medical support module provides visual data visualization and intervention suggestions, supports remote monitoring and emergency intervention, and is seamlessly integrated with a hospital system while ensuring data security.

The invention relates to medical instruments, in particular to a peritoneal dialysis device which comprises a dialysate management unit, a sensor unit, a processor, a storage device, a peritoneal transfer model, an intelligent alarm management unit and a communication unit, and the dialysate management unit is configured to be used for perfusion of dialysate into the abdominal cavity of a patient and drainage of the dialysate from the abdominal cavity of the patient; the sensor unit is configured to be used for monitoring physiological parameters of a patient and dialysate characteristic parameters and receiving symptom information and comfort level scores input by the patient, the storage stores instructions executed by the processor, and the instructions enable the processor to be capable of dynamically adjusting treatment parameters of the dialysate management unit in real time in combination with a pre-trained peritoneal transfer model. The perfusion speed, the drainage speed or the dialysate temperature of the dialysate management unit are dynamically adjusted, so that the comfort level score of the patient is maintained to be above a preset threshold value, treatment parameters can be dynamically adjusted in real time to optimize the treatment effect, peritonitis risks are early warned, and the comfort level of the patient is improved.

A medical treatment system, such as a peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, the peritoneal dialysis system may include a control system that can adjust a volume of fluid infused into a peritoneal cavity to prevent intraperitoneal fluid volume from exceeding a pre-determined amount. The control system can adjust by adding one or more therapy cycles, allowing for fill volumes during each cycle of the one or more therapy cycles to be reduced. The control system may continue to allow the fluid to drain from the peritoneal cavity as completely as possible before starting a next therapy cycle of the one or more therapy cycles. The control system may also adjust a dwell time of the fluid within the peritoneal cavity during the one or more therapy cycles in order to complete a therapy within a scheduled time period. A cycler may also be configured to have a heater control system that monitors both a temperature of a heating tray and a temperature of a bag of dialysis fluid in order to bring a temperature of the dialysis fluid rapidly to a specified temperature, with minimal temperature overshoot.

Trocar components and methods of use are described, wherein the trocar components are configured to provide access to intraperitoneal space via the rectouterine pouch to surgical tools, which optionally include one or more surgical robot members. The surgical tools are optionally 5 mm or more in diameter. In some embodiments, a cannula part has a lumen sized to provide to a plurality of the surgical tools simultaneous transvaginal access to the intraperitoneal space via the rectouterine pouch. In some embodiments, an incision sized to receive a distal aperture of the cannula is created, optionally using one or two dilators. The dilators are sized to create (optionally starting from a puncture by a needle 2 mm in diameter or less) an oblong aperture. In some embodiments, the oblong aperture is at least twice as wide across a long diameter as across a short diameter.An access port for sealing an opening of a natural orifice and supplying access to a body cavity through the natural orifice including: a sealing unit; an unobstructed single lumen cannula extending to the body cavity; a connector connecting the cannula to the sealing unit; an access opening through the sealing unit to the single lumen; a cap including a plurality of cap openings configured to seal between medical instruments inserted into the openings and the access opening.

In some examples, a system includes a glucose sensor configured to generate a signal indicative of a blood glucose level of a patient, a medical device configured to deliver insulin to the patient, a peritoneal dialysis (PD) device, and control circuitry. The control circuitry is configured to control the PD device to deliver PD therapy to a patient during a PD cycle, determine a blood glucose level of the patient during the PD cycle based on a signal from the glucose sensor, determine that the blood glucose level is greater than or equal to a predetermined blood glucose level threshold, and control the medical device to deliver insulin to the patient in response to determining the blood glucose level is greater than or equal to the predetermined blood glucose level threshold.

The invention provides a peritoneal dialysis solution detection data intelligent analysis method based on visual identification, and the method comprises the steps: obtaining a to-be-identified test paper image, carrying out the test paper region segmentation and color correction of the test paper image, and carrying out the brightness equalization processing of a test paper detection region, and obtaining a processed test paper detection region; obtaining a standardized color feature vector of a test paper color development area from the test paper detection area; carrying out mapping matching on the standardized color feature vector and a standard colorimetric database to obtain a colorimetric matching value, carrying out color abnormality identification according to the colorimetric matching value, comparing the color abnormality with a preset abnormal value to obtain a test paper colorimetric analysis result, and carrying out self-adaptive correction on the test paper colorimetric analysis result with abnormality; and constructing a personalized colorimetric model according to the colorimetric matching value in combination with a historical colorimetric matching value, and performing health trend analysis and early warning.

A medical treatment system, such as peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, a peritoneal dialysis system may include patient line state detector for detecting whether a patient line is primed before it is to be connected to the patient. The patient line state detector can also the ability to detect whether a patient line has been properly mounted for priming. Both patient line presence / absence and fill state can be determined using an optical system, e.g., one that employs a single optical sensor.

The invention belongs to the technical field of data management, and discloses a cloud-based peritoneal dialysis data management system and method. The system comprises a cloud data center and a plurality of edge computing gateways, the plurality of edge computing gateways are all in communication connection with the cloud data center, and the cloud data center is in communication connection with a plurality of external query terminals. The method comprises the following steps: receiving a peritoneal dialysis file uploaded by a data acquisition device; performing data analysis on the peritoneal dialysis file to obtain initial peritoneal dialysis data; performing data extraction on the initial peritoneal dialysis data to obtain formatted peritoneal dialysis data; encrypting the formatted peritoneal dialysis data to obtain first encrypted peritoneal dialysis data, and uploading the first encrypted peritoneal dialysis data to a cloud data center for cloud storage. According to the invention, the problems of low data processing efficiency, poor accuracy, large labor cost input, poor data circulation, low data value, difficulty in local storage, large hardware cost input and low data security in the prior art are solved.

Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and / or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and / or degraded within the GI tract.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and / or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

The invention discloses a remote intelligent home peritoneal dialysis system, a peritoneal dialysis control method, a terminal and a medium. The system comprises a patient terminal device, a remote server and a mobile terminal. The patient end device is used for collecting and transmitting multi-dimensional data. And the remote server is used for collecting the multi-dimensional data collected by the patient end equipment, analyzing and processing the multi-dimensional data by using an AI model, and outputting early warning information, a prediction result and a treatment scheme. And the mobile terminal is used for acquiring the early warning information, the prediction result and the treatment scheme pushed by the remote server, and generating a visual data board. The remote intelligent home peritoneal dialysis system provided by the invention is beneficial for helping a patient clearly know the health condition of the patient, meanwhile, a doctor can carry out omnibearing monitoring on the patient, and three-in-one integration of all-dimensional monitoring, AI intelligent decision making and doctor-patient closed-loop management is facilitated.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The utility model relates to the technical field of hole pricking sealers, in particular to an abdominal wall hole pricking sealer and a conveyor of the abdominal wall hole pricking sealer. The device comprises a closing disc and a lifting rod, the lower end of the lifting rod is detachably connected with the center of the closing disc, the lifting rod is perpendicular to the upper and lower end faces of the closing disc, and the lifting rod can lift and operate the closing disc; a plurality of barb nails are fixed to the upper end face of the closing disc, a vertically-through locking hole is formed in the center of the closing disc, the lower end of the lifting rod is connected with a locking block, the shape of the locking block is matched with that of the locking hole, the upper end face of the locking block is attached to the lower end face of the closing disc, and the locking block and the locking hole are arranged in a staggered mode in the circumferential direction. According to the utility model, the pricking hole closing operation can be simply and reliably completed, and the difficulty that needle sewing in a small pricking hole is difficult and time-consuming is solved; meanwhile, the stab hole can be in a tension-free state during healing, cutting of a suture line to the thin peritoneum is avoided, the stab hole is prevented from being broken, and the stab hole healing effect is improved.

The invention provides an evaluation method for gastric cancer peritoneal metastasis state recognition and PCI score estimation, and the method comprises the steps: receiving a preoperative abdominal enhancement CT image, and carrying out the automatic positioning preprocessing of the peritoneum through resampling, normalization, image enhancement and a region attention mechanism; image omics features are extracted from the region of interest and fused with the depth features of the multi-scale convolutional neural network, and a binary classification model based on a residual network / Transform is constructed to output transition state probability and confidence; pCI scores of all the areas are quantitatively evaluated synchronously through the peritoneal thirteen subareas, and finally a transfer prediction result, a PCI spatial distribution map, a visual heat map and a model interpretation report are integrated to form structured diagnosis output. According to the method, transition state identification and PCI score quantification can be realized, and the problems of single function, weak generalization, low interpretability and the like of a traditional model are solved.

A combined magnetic and bioabsorbable device for ventral hernia closure and / or tension distribution for maintenance of tissue apposition for healing, while avoiding a long-term footprint of foreign material and precluding materials spanning the interior layer of the abdominal closure where risk to visceral structures exists.

A use of a GPR1 as a target in preparing an endometriosis-related diagnostic and / or therapeutic formulation, relating to the technical field of biomedicine. The present invention provides a use of a GPR1 target as a diagnostic marker in preparing a reagent or kit for diagnosing endometriosis. The endometriosis is selected from one of uterosacral ligament endometriosis, peritoneal endometriosis, rectovaginal endometriosis, deep infiltrating endometriosis, and ovarian endometriosis. The present invention discovers that the expression of the GPR1 is significantly increased in endometriosis tissues and cells, indicating that the GPR1 can be used as a diagnostic marker for endometriosis. It has been discovered in in-vitro and in-vivo models that GPR1 knockout significantly inhibits the abilities of hEM15A cells to proliferate, migrate, and invade and the growth of ectopic foci in animals, indicating that the GPR1 can be used as a new intervention target for clinically treating endometriosis.

The utility model relates to the technical field of hole pricking sealers, in particular to an adduction type abdominal wall hole pricking sealer and a conveyor of the adduction type abdominal wall hole pricking sealer. The device comprises a sealing disc and a lifting rod, the upper end face and the lower end face of the sealing disc are a peritoneum face facing the peritoneum and an abdominal cavity face facing the abdominal cavity respectively, at least two barb nails inclining and falling towards the inner ring are arranged on the peritoneum face of the sealing disc, and the lower end of the lifting rod is clamped to the center of the sealing disc; the upper end and the lower end of the lifting rod extend out of an inner hole of the sleeve respectively, a ratchet wheel is arranged at the lower end of the sleeve and located on the inner circle of the circumference where the barbed nails are located, and when the ratchet wheel rotates, ratchets make contact with the barbed nails and can open the barbed nails towards the outer circle. The barbed nail disclosed by the utility model can tighten and tightly fix a stamp hole which is closed into a linear opening, and has a compression hemostasis effect, so that the stamp hole is outwards in a tension-free state, the closing operation of the stamp hole is simply and reliably completed, the closing precision of the stamp hole is enhanced, the bleeding amount of the stamp hole is reduced, the healing effect of the stamp hole is improved, and the split of the stamp hole is completely eradicated.

The invention relates to application of a cGAS-STING signal channel inhibitor in preparation of a product for preventing or treating abdominal adhesion, and belongs to the technical field of biological medicines. The invention finds that peritoneal dialysis causes that a peritoneal mesothelial cell cGAS-STING pathway and downstream protein thereof are activated, inflammatory factors are generated, and the peritoneal mesothelial cell secretes a chemotactic factor CCL2 (MCP-1) participating in macrophage recruitment, so that migration of macrophages can be promoted, and abdominal adhesion is caused. The cGAS-STING signaling pathway inhibitor can be used for relieving the effects, so that the aim of treating abdominal adhesion is fulfilled.

The present belongs to the field of disease therapy, and more specifically to the field of cancer therapy. It relates more specifically to compound activating the peroxisome proliferator-activated gamma receptor (PPARγ) for use in the prevention and / or treatment of cancer involving small peritoneal macrophages (SPM) and large peritoneal macrophages (LPM). It also relates to a pharmaceutical composition comprising at least one compound activating the peroxisome proliferator-activated gamma receptor (PPARγ) for use in the prevention and / or treatment of cancer.

A dialysis-ultrasound system is described that includes an ultrasound therapy device integrated with a catheter to incorporate ultrasound therapy into a dialysis system. The ultrasound device may be or may include a high-intensity focused ultrasound (HIFU) device or peripheral focused ultrasound stimulation (pFUS) device. The ultrasound therapy may target the liver, for example, to treat diabetes. In one example, a system includes a catheter configured to be arranged within the peritoneal cavity of a patient for peritoneal dialysis (PD), and an ultrasound device configured to emit ultrasound waves. The ultrasound device is integrated with the catheter and is arranged on the catheter to be implanted within the peritoneal cavity of the patient to provide ultrasound therapy to a target region of the patient. Other embodiments are described.

A peritoneal dialysis (“PD”) system (10) includes a PD machine (20); a patient line (50) extending from the PD machine (20); a filter set (100) in fluid communication with the patient line (50), the filter set (100) including an air diverting net (112) configured to divert air from PD fluid flowing through the filter set (100); and an air return line (58) positioned to return PD fluid containing air back to the PD machine (20).

The invention discloses application of GPR1 as a target spot in preparation of endometriosis related diagnosis and / or treatment preparations, and belongs to the technical field of biological medicines. The invention provides application of a GPR1 target spot serving as a diagnostic marker in preparation of a reagent or a kit for diagnosing endometriosis. The endometriosis is selected from one of a uterus-sacral ligament type endometriosis, a peritoneal type endometriosis, a rectum-vagina type endometriosis, a deep infiltration type endometriosis and an ovarian type endometriosis. The invention discovers that the expression of GPR1 in endometriosis tissues and cells is obviously increased, which prompts that GPR1 can be used as a diagnostic marker of endometriosis. In-vitro and in-vivo models find that the knockout of GPR1 significantly inhibits the proliferation, migration and invasion ability of hEM15A cells and the growth of ectopic lesions in animals, indicating that GPR1 can be used as a new intervention target for clinical treatment of endometriosis.

Systems and methods are disclosed for peritoneal dialysis. In an illustrative example, a peritoneal dialysis system can include an input lumen that receives a fluid from a first portion of a peritoneal cavity of a patient. The peritoneal dialysis system includes a filter that filters the fluid to produce a filtered fluid and a waste product. The peritoneal dialysis system includes a mixer that adds a predetermined amount of at least one electrolyte to the filtered fluid to produce a dialysate. The peritoneal dialysis system includes a sensor that measures one or more characteristics of the dialysate, and a controller that compares the one or more characteristics to one or more dialysate characteristic thresholds to verify that the dialysate satisfies one or more rules. The peritoneal dialysis system includes an output lumen that provides the dialysate to a second portion of the peritoneal cavity of the patient.

A system and method for monitoring the health of dialysis patients with Raman spectroscopy measurements of one or more target analytes is described. The methods include irradiating one or more fluids of interest with light to produce one or more spectrum and detecting the spectrum with a detector. The fluids of interest are preferably those related to dialysis, including hemodialysis and peritoneal dialysis. In a preferred embodiment, the fluids are irradiated with monochromatic light, and one or more Raman spectra are detected as a result of the irradiation. The fluids may be irradiated within the dialysis tubing itself, or removed from the dialysis tubing and irradiated in a separate chamber. The Raman spectra of one or more target analytes of a dialysis patient may be followed over time or compared to one or more reference spectra, thereby providing information on the health of dialysis patients.

The invention discloses a solute replacement system, peritoneal dialysis equipment and medical first-aid equipment, and the solute replacement system comprises an interface pipeline, one end of which is communicated with a human body and which comprises a first channel for outputting waste liquid from the human body and a second channel for inputting new liquid to the human body; the circulating replacement pipeline is communicated with the other end of the interface pipeline and comprises a liquid inlet pipeline which is communicated with the first channel to receive the waste liquid, a new liquid pipeline which is communicated with the second channel to output the new liquid, and a perfusion device which is connected between the liquid inlet pipeline and the new liquid pipeline in series; the perfusion device is used for receiving the waste liquid so as to remove toxins in the waste liquid and then outputting the waste liquid to the new liquid pipeline; the driving device is arranged in the interface pipeline or the circulating replacement pipeline and is used for driving the waste liquid and the new liquid to flow; and the control device is used for executing a CFPD treatment mode to control the driving device to drive the waste liquid and the new liquid to continuously flow.

The invention relates to the technical field of medical information processing, and discloses an AI-based peritoneal dialysis state prediction system, which comprises a data acquisition module used for acquiring medical data of a peritoneal dialysis patient; the data preprocessing module is used for carrying out missing value processing on the collected medical data by adopting KNN interpolation and STL decomposition, and carrying out feature extraction through sliding window analysis to obtain target feature data; the dialysis state prediction module is used for inputting the target feature data into the ResNet-Transformer-GRU model and outputting a dialysis state prediction result; the generation module is used for generating personalized dialysis scheme adjustment suggestions by adopting a multi-target particle swarm optimization algorithm based on the dialysis state prediction result; the visualization module is used for visually displaying the dialysis state prediction result and the personalized dialysis scheme adjustment suggestion to medical staff; through automatic data acquisition, processing and prediction, manual operation of medical staff is reduced, and time and energy are saved.

The invention discloses an optical detection device for rapidly judging peritoneal dialysis outlet infection, and relates to the technical field of medical instruments, and the device comprises a collected image set obtaining module which is used for calling a light source to carry out light emission according to a preset light type sequence and carrying out image collection of different spectrums by using a high-resolution camera and an optical filter wheel, acquiring a collection image set; the multi-scale feature set obtaining module is used for traversing the collected image set to carry out multi-scale feature collection and obtaining a collected image multi-scale feature group set; the interactive iteration feature set obtaining module is used for carrying out intra-group feature interactive iteration to obtain an interactive iteration feature set; and the mapping analysis result obtaining module is used for performing infection mapping analysis based on the interactive iteration feature set to obtain a target mapping analysis result. The technical problems of low infection image recognition accuracy and poor detection result reliability in the prior art are solved, and the technical effect of improving the optical detection result reliability is achieved.

The invention relates to an automatic peritoneal dialysis machine auxiliary system capable of preventing peritoneal protein from being lost, and belongs to the technical field of peritoneal dialysis. By arranging the auxiliary system comprising a hollow fiber membrane filter, peritoneal drainage liquid is guided into the hollow fiber membrane filter in the drainage stage; the protein is intercepted by utilizing the semi-permeable membrane characteristic, and small molecule metabolic wastes penetrate through the semi-permeable membrane characteristic to form a filtrate rich in the protein; and then the feedback pump speed is dynamically adjusted through a control system based on a signal of a flow sensor, so that the feedback process of the protein liquid is stably synchronized with drainage, liquid injection and staying stages of the automatic peritoneal dialysis machine, online recovery and safe feedback of protein are realized, and the problem that the protein liquid flows back to the treatment cycle of the automatic peritoneal dialysis machine is solved on the premise that the treatment cycle is coordinated with the treatment cycle of the automatic peritoneal dialysis machine. Protein in peritoneal drainage liquid is continuously and selectively recovered and safely returned, so that the problem of protein trophism loss of long-term peritoneal dialysis patients is directly reduced.