853 results about "Peritoneal membrane" patented technology

A peritoneal dialysis (“PD”) system having an ultrafilter is disclosed herein. In one example, the PD system includes a housing and a PD fluid pump. The PD system also includes a filter comprising an outer chamber, a central portion, a membrane, an inlet connected to the outer chamber, an outlet, a first venting port connected to the outer chamber, and a second venting port connected to the central portion. The first venting port has a valve preventing air flow into the filter via the first venting port. The PD system further includes a pressure sensor and a control unit configured to control the PD fluid pump. The control unit is further configured to determine a pressure inside the filter based on an output from the pressure sensor and determine an integrity status of the membrane based on the pressure inside the filter.

Provided herein is a peritoneal dialysis (“PD”) system comprising a housing and one or more doors comprising elastomeric properties. Each of the one or more doors comprises one or more features configured to couple to one or more features of the housing. Further, each door includes one or more inserts molded between two layers of elastomeric material where the features are coupled to. The doors are configured to cover and thermally insulate one or more PD fluid lines when in a closed configuration. The doors are also configured to transition to an open configuration to provide access to one or more PD fluid lines for treatment.

The invention discloses a peritoneal dialysis anti-blocking high-circulation nursing device for pediatric nephropathy patients, and belongs to the technical field of medical nursing. Comprising the following modules: a multi-mode sensing module for collecting pressure, flow velocity, turbidity, vibration spectrum and temperature data in a catheter in real time; the signal optimization processing module highlights weak features of potential blockage and improves data quality; the feature fusion analysis module is used for comprehensively evaluating the state of the catheter; the AI prediction analysis module is used for predicting the occurrence probability, the position and the possible time window of blockage; the risk early warning and intervention module is used for sending out graded early warning signals according to the prediction result and generating personalized anti-blocking intervention suggestions; the micro-fluidic execution module inhibits formation of initial sediments through a micro-pulse technology and dynamic fluid mechanics adjustment, and effectively reduces the risk of blockage; and the remote medical support module provides visual data visualization and intervention suggestions, supports remote monitoring and emergency intervention, and is seamlessly integrated with a hospital system while ensuring data security.

The invention relates to medical instruments, in particular to a peritoneal dialysis device which comprises a dialysate management unit, a sensor unit, a processor, a storage device, a peritoneal transfer model, an intelligent alarm management unit and a communication unit, and the dialysate management unit is configured to be used for perfusion of dialysate into the abdominal cavity of a patient and drainage of the dialysate from the abdominal cavity of the patient; the sensor unit is configured to be used for monitoring physiological parameters of a patient and dialysate characteristic parameters and receiving symptom information and comfort level scores input by the patient, the storage stores instructions executed by the processor, and the instructions enable the processor to be capable of dynamically adjusting treatment parameters of the dialysate management unit in real time in combination with a pre-trained peritoneal transfer model. The perfusion speed, the drainage speed or the dialysate temperature of the dialysate management unit are dynamically adjusted, so that the comfort level score of the patient is maintained to be above a preset threshold value, treatment parameters can be dynamically adjusted in real time to optimize the treatment effect, peritonitis risks are early warned, and the comfort level of the patient is improved.

In some examples, a system includes a glucose sensor configured to generate a signal indicative of a blood glucose level of a patient, a medical device configured to deliver insulin to the patient, a peritoneal dialysis (PD) device, and control circuitry. The control circuitry is configured to control the PD device to deliver PD therapy to a patient during a PD cycle, determine a blood glucose level of the patient during the PD cycle based on a signal from the glucose sensor, determine that the blood glucose level is greater than or equal to a predetermined blood glucose level threshold, and control the medical device to deliver insulin to the patient in response to determining the blood glucose level is greater than or equal to the predetermined blood glucose level threshold.

The invention provides a peritoneal dialysis solution detection data intelligent analysis method based on visual identification, and the method comprises the steps: obtaining a to-be-identified test paper image, carrying out the test paper region segmentation and color correction of the test paper image, and carrying out the brightness equalization processing of a test paper detection region, and obtaining a processed test paper detection region; obtaining a standardized color feature vector of a test paper color development area from the test paper detection area; carrying out mapping matching on the standardized color feature vector and a standard colorimetric database to obtain a colorimetric matching value, carrying out color abnormality identification according to the colorimetric matching value, comparing the color abnormality with a preset abnormal value to obtain a test paper colorimetric analysis result, and carrying out self-adaptive correction on the test paper colorimetric analysis result with abnormality; and constructing a personalized colorimetric model according to the colorimetric matching value in combination with a historical colorimetric matching value, and performing health trend analysis and early warning.

A medical treatment system, such as peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, a peritoneal dialysis system may include patient line state detector for detecting whether a patient line is primed before it is to be connected to the patient. The patient line state detector can also the ability to detect whether a patient line has been properly mounted for priming. Both patient line presence / absence and fill state can be determined using an optical system, e.g., one that employs a single optical sensor.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and / or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

The invention discloses a remote intelligent home peritoneal dialysis system, a peritoneal dialysis control method, a terminal and a medium. The system comprises a patient terminal device, a remote server and a mobile terminal. The patient end device is used for collecting and transmitting multi-dimensional data. And the remote server is used for collecting the multi-dimensional data collected by the patient end equipment, analyzing and processing the multi-dimensional data by using an AI model, and outputting early warning information, a prediction result and a treatment scheme. And the mobile terminal is used for acquiring the early warning information, the prediction result and the treatment scheme pushed by the remote server, and generating a visual data board. The remote intelligent home peritoneal dialysis system provided by the invention is beneficial for helping a patient clearly know the health condition of the patient, meanwhile, a doctor can carry out omnibearing monitoring on the patient, and three-in-one integration of all-dimensional monitoring, AI intelligent decision making and doctor-patient closed-loop management is facilitated.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The invention provides an evaluation method for gastric cancer peritoneal metastasis state recognition and PCI score estimation, and the method comprises the steps: receiving a preoperative abdominal enhancement CT image, and carrying out the automatic positioning preprocessing of the peritoneum through resampling, normalization, image enhancement and a region attention mechanism; image omics features are extracted from the region of interest and fused with the depth features of the multi-scale convolutional neural network, and a binary classification model based on a residual network / Transform is constructed to output transition state probability and confidence; pCI scores of all the areas are quantitatively evaluated synchronously through the peritoneal thirteen subareas, and finally a transfer prediction result, a PCI spatial distribution map, a visual heat map and a model interpretation report are integrated to form structured diagnosis output. According to the method, transition state identification and PCI score quantification can be realized, and the problems of single function, weak generalization, low interpretability and the like of a traditional model are solved.

A system and method for monitoring the health of dialysis patients with Raman spectroscopy measurements of one or more target analytes is described. The methods include irradiating one or more fluids of interest with light to produce one or more spectrum and detecting the spectrum with a detector. The fluids of interest are preferably those related to dialysis, including hemodialysis and peritoneal dialysis. In a preferred embodiment, the fluids are irradiated with monochromatic light, and one or more Raman spectra are detected as a result of the irradiation. The fluids may be irradiated within the dialysis tubing itself, or removed from the dialysis tubing and irradiated in a separate chamber. The Raman spectra of one or more target analytes of a dialysis patient may be followed over time or compared to one or more reference spectra, thereby providing information on the health of dialysis patients.

The invention discloses a solute replacement system, peritoneal dialysis equipment and medical first-aid equipment, and the solute replacement system comprises an interface pipeline, one end of which is communicated with a human body and which comprises a first channel for outputting waste liquid from the human body and a second channel for inputting new liquid to the human body; the circulating replacement pipeline is communicated with the other end of the interface pipeline and comprises a liquid inlet pipeline which is communicated with the first channel to receive the waste liquid, a new liquid pipeline which is communicated with the second channel to output the new liquid, and a perfusion device which is connected between the liquid inlet pipeline and the new liquid pipeline in series; the perfusion device is used for receiving the waste liquid so as to remove toxins in the waste liquid and then outputting the waste liquid to the new liquid pipeline; the driving device is arranged in the interface pipeline or the circulating replacement pipeline and is used for driving the waste liquid and the new liquid to flow; and the control device is used for executing a CFPD treatment mode to control the driving device to drive the waste liquid and the new liquid to continuously flow.

The invention relates to the technical field of medical information processing, and discloses an AI-based peritoneal dialysis state prediction system, which comprises a data acquisition module used for acquiring medical data of a peritoneal dialysis patient; the data preprocessing module is used for carrying out missing value processing on the collected medical data by adopting KNN interpolation and STL decomposition, and carrying out feature extraction through sliding window analysis to obtain target feature data; the dialysis state prediction module is used for inputting the target feature data into the ResNet-Transformer-GRU model and outputting a dialysis state prediction result; the generation module is used for generating personalized dialysis scheme adjustment suggestions by adopting a multi-target particle swarm optimization algorithm based on the dialysis state prediction result; the visualization module is used for visually displaying the dialysis state prediction result and the personalized dialysis scheme adjustment suggestion to medical staff; through automatic data acquisition, processing and prediction, manual operation of medical staff is reduced, and time and energy are saved.

The invention discloses an optical detection device for rapidly judging peritoneal dialysis outlet infection, and relates to the technical field of medical instruments, and the device comprises a collected image set obtaining module which is used for calling a light source to carry out light emission according to a preset light type sequence and carrying out image collection of different spectrums by using a high-resolution camera and an optical filter wheel, acquiring a collection image set; the multi-scale feature set obtaining module is used for traversing the collected image set to carry out multi-scale feature collection and obtaining a collected image multi-scale feature group set; the interactive iteration feature set obtaining module is used for carrying out intra-group feature interactive iteration to obtain an interactive iteration feature set; and the mapping analysis result obtaining module is used for performing infection mapping analysis based on the interactive iteration feature set to obtain a target mapping analysis result. The technical problems of low infection image recognition accuracy and poor detection result reliability in the prior art are solved, and the technical effect of improving the optical detection result reliability is achieved.

The invention relates to an automatic peritoneal dialysis machine auxiliary system capable of preventing peritoneal protein from being lost, and belongs to the technical field of peritoneal dialysis. By arranging the auxiliary system comprising a hollow fiber membrane filter, peritoneal drainage liquid is guided into the hollow fiber membrane filter in the drainage stage; the protein is intercepted by utilizing the semi-permeable membrane characteristic, and small molecule metabolic wastes penetrate through the semi-permeable membrane characteristic to form a filtrate rich in the protein; and then the feedback pump speed is dynamically adjusted through a control system based on a signal of a flow sensor, so that the feedback process of the protein liquid is stably synchronized with drainage, liquid injection and staying stages of the automatic peritoneal dialysis machine, online recovery and safe feedback of protein are realized, and the problem that the protein liquid flows back to the treatment cycle of the automatic peritoneal dialysis machine is solved on the premise that the treatment cycle is coordinated with the treatment cycle of the automatic peritoneal dialysis machine. Protein in peritoneal drainage liquid is continuously and selectively recovered and safely returned, so that the problem of protein trophism loss of long-term peritoneal dialysis patients is directly reduced.

Systems and methods for infection prevention and treatment in biological conduits using electroporation or pulsed field ablation (PFA). The system includes an elongate member, such as a dialysis catheter, vascular access device, or peritoneal dialysis conduit, with at least one electrode positioned along, within, or around the member. A control unit applies pulsed electric fields to inhibit microbial colonization, disrupt bacterial biofilms, and alter permeability of bacterial or endothelial cells to enhance sterility or fluid exchange. The system may use real-time impedance monitoring, microbial detection, or fluid composition analysis to adjust electroporation parameters. Electroporation may synchronize with dialysis cycles or antimicrobial lock solutions. The method includes automated, clinician-controlled, or sensor-triggered treatments to reduce infections and improve device longevity. The system provides an alternative or augment to antibiotics, reducing the risk of drug-resistant infections while improving the longevity and safety of medical implants.

The invention discloses an intestinal anastomosis operation abdominal cavity film covering structure, and relates to the technical field of intraoperative film covering, the intestinal anastomosis operation abdominal cavity film covering structure comprises an external connection part, an internal expansion part and an adsorption part, through inflation of an outer pipe, transverse branch pipes and vertical branch pipes of a corrugated pipe structure extend, transverse concave bases and vertical concave bases are far away from each other, and meanwhile transverse folding frames and vertical folding frames are unfolded; a pull wire of the negative pressure assembly can be pulled in the unfolding process of the transverse folding frame and the vertical folding frame, so that the fragment connected with the pull wire is pulled up, the fragment forms negative pressure at the peritoneum position through the connecting film, and the lower film is attached to the peritoneum and the unfolding position of an operator; the unfolding effect is achieved through inflation, meanwhile, the prominent effect of adsorbing the covered position is achieved, the intestinal canal incision operation is carried out on the upper side of the upper film, and the pollution of the intestinal canal is received.

The invention relates to the technical field of computers, and discloses an automatic measurement method for ultrasonic diaphragm muscle, computer equipment and a medium, the method comprises the following steps: in response to an ultrasonic demand, selecting an ultrasonic probe and an ultrasonic mode, the ultrasonic probe comprises a high-frequency probe and a low-frequency probe, and the ultrasonic mode comprises a B mode and an M mode; utilizing the selected ultrasonic probe to scan the tested tissue according to an ultrasonic mode, and automatically identifying the diaphragm area; the pleura position and the peritoneum position are automatically positioned in a high-frequency probe B mode, and the diaphragm thickness is calculated; the maximum inspiratory end diaphragm thickness and the calm end-expiratory end diaphragm thickness are automatically measured in the M mode of the low-frequency probe, and the diaphragm thickness fraction is calculated; and automatically measuring the inspiratory end diaphragm position and the expiratory end diaphragm position in the M mode of the low-frequency probe, and calculating the diaphragm movement degree. The diaphragm thickness, the diaphragm thickness score and the diaphragm movement degree are respectively and automatically measured by automatically identifying the diaphragm area and simplifying the operation process of a worker, and the parameter measurement efficiency is improved.

This disclosure relates to systems for medical fluid pumps and related methods. In some implementations, a system includes a system for draining fluid from a peritoneal cavity of a patient comprising a microfluidic pump; a drain bag fluidly coupled to the microfluidic pump; and an inlet line coupled to the drain bag, wherein the microfluidic pump is configured to apply a negative pressure to an interior of the drain bag to draw effluent from a peritoneal cavity of the patient along the inlet line and into the drain bag. In some implementations, a system for performing peritoneal dialysis includes a microfluidic pump; a dual chamber bag fluidly coupled to the microfluidic pump, where the dual chamber bag includes an effluent chamber configured to be fluidly coupled to a peritoneal cavity of a patient; a dialysate chamber; and a flexible membrane separating the effluent chamber from the dialysate chamber.

The invention discloses a peritoneal dialysis system which comprises an abdominal cavity pipeline with the first end communicated with the abdominal cavity of a human body; the semi-permeable membrane assembly comprises a membrane, a first side and a second side, the first side and the second side are separated by the membrane, and the first side is communicated with the second end of the abdominal cavity pipeline so as to receive the abdominal cavity dialysate from the abdominal cavity pipeline and inject the abdominal cavity dialysate into the abdominal cavity of the human body; the external liquid path system comprises an external liquid pipeline communicated with the second side, and the external liquid pipeline comprises a waste liquid outlet for outputting dialysis waste liquid led out from the peritoneal dialysis liquid through the membrane; when the peritoneal dialysis solution is led out, the membrane allows moisture and small molecular solutes in the peritoneal dialysis solution to permeate into the second side and entraps a macromolecular penetrant on the first side so as to maintain the osmotic pressure of the peritoneal dialysis solution.

The utility model discloses a peritoneal dialysis connector and a screwing tool thereof, and relates to the field of peritoneal dialysis device structures, and the peritoneal dialysis connector comprises a dialysis bag connector which is used for being installed on a dialysis bag or a connecting pipe of the dialysis bag; the dialysis bag connector can be inserted into the lock cover, a through hole is formed in the lock cover, and a peritoneal dialysis catheter penetrates through the through hole and enters the lock cover to be connected with the dialysis bag connector; the lock cover can be movably connected with the other end of the dialysis bag connector; the outer radial end part of the insertion end, inserted into the lock cover, of the dialysis bag connector is gradually reduced; when the lock cover is connected with the dialysis bag connector, the inner wall of the lock cover can generate locking extrusion force on the joint of the peritoneal dialysis catheter and the dialysis bag connector. The outer diameter of the insertion end, inserted into the lock cover, of the dialysis bag connector is arranged to be of the conical structure gradually decreasing towards the end, and the step structure is arranged to be matched with the lock cover, so that the purposes of improving the installation convenience degree of the connector and avoiding liquid leakage are achieved.

The invention discloses a culture medium for constructing a colorectal cancer peritoneal metastasis micro-tumor cell model and application of the culture medium. The invention relates to the technical field of biology, and provides a culture medium for culturing a micro-tumor model for colorectal cancer peritoneal metastasis. The invention discloses a cholera toxin immunopotentiator, which is composed of an antibacterial and antifungal agent three antibody, HEPES, GlutaMax, a human recombinant protein EGF, a human recombinant protein bFGF, a human recombinant protein HGF, a human recombinant protein Noggin, a human recombinant protein R-spondin 1, a human recombinant protein GDNF, SB202190, A83-01, Primocin, N-acetyl-L-cysteine, nicotinamide, an N2 additive, cholera toxin, B27, ITS-X, Y-27632, Galunissertib and a basal culture medium. The culture medium and the culture method disclosed by the invention can effectively improve the culture success rate of colorectal cancer peritoneal metastasis and focus combination.

Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and / or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and / or degraded within the GI tract.

The invention discloses a movable assistor for peritoneal dialysis, and relates to the technical field of peritoneal dialysis. The movable assistor for peritoneal dialysis comprises a bottom plate, a fixing rod is fixedly arranged on the top face of the bottom plate, the outer wall of the fixing rod is slidably sleeved with a lifting sleeve, a plurality of self-locking wheels are fixedly arranged on the bottom face of the bottom plate, and a lifting mechanism, a dialysis mechanism, a placing mechanism and a fixing mechanism are arranged above the bottom plate. The dialysis mechanism has the technical effects that the dialysis mechanism is composed of the monitoring part and the control part, an automatic monitoring and intelligent control system for the dialysis process is formed, two tray scales of the monitoring part can monitor the weight change of a dialysate container in real time, and the weight information is transmitted to the control calculator through a second data line; the two intelligent flow monitoring valves are installed at the bottom of the connecting pipe and can monitor the flow of dialysate in real time and transmit data through the first data line, and the calculator is controlled to analyze and process the received weight and flow information.

The present application relates to a kind of peritoneal dialysis catheter fixing auxiliary device, including the bottom plate for shielding stoma and the bandage for fixing bottom plate on patient's body, first through-hole for dialysis tube to pass through is opened in the thickness direction on the bottom plate, sleeve is mounted in the first through-hole, one end of the sleeve is communicated with first through-hole, the other end extends downward;Rotary fit has cover plate above the bottom plate, the bottom surface of the cover plate is sealed with the top surface of bottom plate, second through-hole is opened in the thickness direction on the cover plate, the first through-hole is located on the rotation track of second through-hole.This technical solution, by setting sleeve, can avoid stoma healing during interval, without using special dialysis tube daily care tool, effectively reduce the discomfort of patient's daily life, and can adjust the opening and closing state of stoma, facilitate medical staff operation.

The utility model relates to a multifunctional infusion support for peritoneal dialysis, which comprises a support body, the support body comprises a first rod and a second rod, the second rod is telescopically matched with the first rod, the infusion support further comprises a shelving part, the shelving part is connected with the first rod, and a reference body is arranged on the shelving part. By arranging the first rod and the second rod, the height can be freely adjusted according to illness conditions, and the flow speed of dialysate can be conveniently controlled; the peritoneal dialysis waste liquid bag can be conveniently placed through the arrangement of the placing part, stumbling traction is reduced, infection factors are reduced, meanwhile, the brightness of peritoneal dialysis liquid can be identified through the arrangement of the reference body, and the quality of the peritoneal dialysis liquid can be rapidly evaluated.

The present disclosure relates to a transplantable cell therapy product composition for diabetes mellitus that contains an aggregate of insulin-secreting cells derived from stem cells. In the present disclosure, an NF microwell array membrane was fabricated by applying a molding process to an electrospun, permeable, biodegradable polycaprolactone (PCL) NF membrane and thus allows gases and soluble factors to permeate therethrough. The NF microwell of the present disclosure could provide more nutrients to the iPSC aggregates than conventional impermeable PDMS microwells, thus enhancing survival and differentiation capabilities of the cells. Additionally, the NF membrane was attached singly to the subcutaneous tissue and to the surface of organs such as liver and peritoneum without the need for a fixing material or separate sutures and was integrated with surrounding tissues, resulting in higher insulin secretion than PDMS microwells. Therefore, the present disclosure can be effectively utilized as a composition for the prevention or treatment of diabetes.

The invention relates to the technical field of peritoneal dialysis in the nephrology department, and discloses a peritoneal dialysis catheter anti-blocking device in the nephrology department, the peritoneal dialysis catheter anti-blocking device comprises a peritoneal dialysis catheter, an inflow tube and an anti-blocking mechanism are fixedly installed outside the peritoneal dialysis catheter, a rotating shaft is rotatably connected to the interior of a drainage tube, and propeller blades are fixedly installed outside the rotating shaft. An equipment box is fixedly mounted on the right side of the drainage tube, and a micro motor is fixedly mounted in the equipment box. According to the anti-blocking device for the peritoneal dialysis catheter in the nephrology department, when the micro motor drives the rotating shaft to rotate, the propeller blades slowly stir dialysate in the peritoneal dialysis catheter, and a directional vortex is formed; according to the design, liquid flowing is accelerated, protein, blood components and mineral substances are effectively prevented from being adsorbed or precipitated on the tube wall, the problem of blockage caused by standing is solved, meanwhile, the process does not need to depend on drugs, the operation process is simplified, early-stage tiny sediments can be preventively removed, and the catheter is kept unobstructed.

The present disclosure generally relates to systems and methods of use for draining cerebrospinal fluid (CSF) from a brain or a spinal canal in a subject, for example, to treat hydrocephalus or other conditions. In some embodiments, the disclosure relates to a device comprising a flow controller positioned within a conduit that allows CSF to flow through the conduit from a first end to a second end. This may allow the CSF to drain, for example, from an intradural space (such as a thecal sac) into, for example, a paraspinal space, paraspinal vein or other venous space, or peritoneal cavity. A variety of methods may be used to hold or anchor the device in place, for example, an expansion apparatus. In some embodiments, the device can be implanted percutaneously at a location along or within a subject's spinal column, thus reducing the need for surgery, general anesthesia, and hospitalizations.