174 results about "Uterine cervix" patented technology

The invention is directed to an intravaginal uterine artery occlusion device for treating uterine disorders such as fibroids, dysfunctional uterine bleeding, postpartum hemorrhage and the like. A occlusion device has a cervical receptacle or cap with an open distal end for receiving the patient's uterine cervix and an elongated shaft having a distal end secured to the closed proximal end of the cervical receptacle and an inner lumen extending to the distal end of the elongated shaft. The patient's uterine cervix is held within the interior of the receptacle by the application of a vacuum to the interior of the receptacle through the inner lumen of the shaft or otherwise, while the leading edge(s) of the cervical receptacle press against the patient's vaginal fornix to occlude an underlying or adjacent uterine artery. At least one blood flow sensor may be provided on the leading edge of the receptacle to aid in locating a uterine artery and to monitor blood flow through the located uterine artery.

Embodiments of the invention provide methods, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and/or late HPV-associated or HPV-specific proteins or antibodies. Detection of HPV DNAs, genomes, and/or oncoproteins by protein chips immunological assays can be used in early clinical screening for HPV infection and general diagnosis for cervical cancer and can be advantageous performed in a multiplexed test. Comparative detection of altered levels of HPV proteins and host proteins can performed in one or more assays. The polypeptides, recombinant proteins, antibodies, nucleic acids, and various detection methods thereof are particularly useful for diagnosing carcinomas of the uterine cervix and those at risk of developing cervical cancer.

A method and device for delivering therapeutic agents to the cervix. The method utilizes a diaphragm with an electrically conductive surface that is placed atraumatically over the outer surface and inner os of the mammalian (animal or human) cervix. The agent is delivered to the diaphragm after which the conductive surface of the diaphragm may be charged by a power source to deliver a electrophoretic field to force the agent deep into cervical tissue and cells. The diaphragm may be used with or without the aid of external or internal leads. A unique intrauterine lead designed in this patent may also be used with the diaphragm to enhance delivery of therapeutic agents.

The invention provides a simulator for training of personnel for immediate postpartum medical treatment, distinctive in that the simulator comprises a representation of an immediate postpartum stage uterus, a cervix, a vagina and a resilience member, the uterus is arranged at an angle to the vagina and the resilience member is arranged for allowing said angle to be straightened out by pressing horizontally forward on the uterus. The invention also provides a simulator for training of personnel for immediate postpartum medical treatment, distinctive in that the simulator comprises a representation of an immediate postpartum stage uterus, a cervix and a vagina, the uterus comprises a transparent top or intermediate layer allowing visual observation, and preferably a removable or foldable non-transparent top layer over the transparent layer.

Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.

A cup-like structure for engaging a cervix of a patient includes a rim, and includes a base defining an aperture through which one or more tubular members of a uterine manipulator may extend into the uterus. The cup-like structure is made from one or more of a polyphthalamide (PPA) material and a polyetheretherketone (PEEK) material. A uterine manipulator including a cup-like structure is also disclosed.

A cervical biopsy instrument that includes a central shaft defining a longitudinal axis and a stop extending laterally from the shaft. The stop typically is formed in substantially the shape of a circle in a plane disposed at substantially right angles to the central axis of the shaft. The instrument also includes an electrode extending from an endocervical portion of the shaft to the stop. The stop may be formed in the shape of a complete circle, or a partial circle. Any free ends are configured to be rounded and extend inwardly toward the shaft or away from the endocervical portion to prevent the presentation of sharp edges or the like which could be caught on irregularities of the uterine cervix. The stop may be affixed to the central shaft along a tangent, or ends of the stop may be affixed to the central shaft. In another embodiment, the stop encircles or partially encircles the shaft, with the shaft extending substantially through the center of the circle. In this embodiment, either one or two electrodes may be provided. Spokes support the stop with respect to the shaft. The spokes may be formed at an acute angle with respect to the shaft to extend away from the shaft toward the endocervical end thereof. These configurations allow the instrument to be rotated in either a clockwise or a counter-clockwise direction about the central axis of the shaft without fear of catching on the uterine cervix. In another aspect of the invention, a marker is provided on the stop to indicate the location of the electrode.

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The invention relates to a cervix brush, comprising a sheath tube, a core pole, a scraper, villus and a guiding head; wherein, the scraper, the guiding head and the sheath tube are formed by integrated injection molding, the guiding head is arranged at the foremost end of the sheath tube, the scraper comprises six plastic strips which can be detached to triangles, the front end of the scraper is connected with the guiding head, the back end of the scraper is connected with the sheath tube and a easy folded groove is arranged between the connection and the scraper, the core pole is axially sleeved in the sheath tube and is slideable, the head of the core pole is fixed in the guiding head, the villus is cultivated at the front ends of the guiding head, the scraper and the sheath tube, the stress on the surface of the cervix from the six scrapers which can be furled and spread is uniform, in particular that the cells at area with high incidence of the cervical cancer from the one third part outside of the cervical canal to the external cervical orifice can be gotten by the cervix brush. The cervix brush has the advantages of small radial direction size, convenient operation and low manufacturing cost.

A cervical biopsy system for improving the quality and efficiency of cervical biopsies. The cervical biopsy system includes an elongated housing with a handle attached to one end, a punch attached to an opposite end of the housing, a retrieval blade movably positioned within the punch for severing a biopsy tissue, and a trigger member mechanically connected to the retrieval blade for manipulating the retrieval blade within the punch. The punch is inserted into the inner wall of the uterine cervix for cutting around a uniform piece of biopsy tissue. The retrieval blade is manipulated to sever the biopsy tissue from the uterine cervix and the user is able to withdraw the biopsy tissue for medical testing.

Embodiments of the invention provide methods, assays, and kits for detecting HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with pre-malignant and malignant epithelial cell lesions. Detection of HPV DNAs, genomes, and/or oncoproteins by nucleic acid hybridization assays and immunological assays can be used in early clinical screening for HPV infection and diagnosis for cervical cancer. The polypeptides, recombinant proteins, antibodies, nucleic acids, and various detection methods thereof are particularly useful for diagnosing carcinomas of the uterine cervix and those at risk of developing cervical cancer.

The invention relates to the field of medicines, in particular to an angiogenesis inhibitor for inhibiting several matrix metal protein enzyme and inhibiting the transfer of the vascular endothelial cell, which can be applied to preparation and treatment of entity tumor and rheumatoid arthritis. The polypeptide comprises a polypeptide I, polypeptide II, polypeptide III and polypeptide IV (Seq NO.1, Seq NO.2, Seq NO.3, Seq NO.4); The polypeptide can be used for treating entity tumor and rheumatoid arthritis. The four angiogenesis inhibitors can be applied to preparation of medicine for treating tumor, and is characterized in that: the tumor is derived from primary of neck, brain, thyroid gland, esophagus, pancreas, lung, liver, stomach, mammary gland, kidney, colon or rectum, ovary, cervix, uterus, prostate, bladder and testis or secondary cancer, melanoma, hemangioma and sarcoma.

The invention relates to the field of medicines, and in particular relates to an inhibitor of angiogenesis capable of inhibiting matrix metallo-proteinase and migration of vascular endothelial cells. The inhibitor can be used for preventing and treating solid tumor and rheumatoid arthritis. The polypeptide specifically means polypeptide I, polypeptide II, polypeptide III and polypeptide IV (with reference to SeqNO.1, SeqNO.2, SeqNO.3 and SeqNO.4). The polypeptide can be used for treating solid tumor and rheumatoid arthritis. The four inhibitors of angiogenesis can be applied to preparing medicines for treating tumor. The polypeptide is characterized in that tumor is originated from essential or subsequent cancers, melanoma, hemangioma and sarcoma of heat and neck, brain, thyroid, esophagus, pancreas, lung, liver, stomach, breast, kidney, gall bladder, colon or rectum, ovary, cervix uterus, uterus, prostate, bladder and testis.

The present invention provides methods and compositions for detecting cervical cancer in a human. The present invention provides CIP2A as a biomarker detectable in a biological sample from cervix of an individual, an increased expression of same is an indication of cervical cancer in the individual. CIP2A mRNA or protein can both serve as reliable biomarkers. In one embodiment, the present invention provides a combined use of CIP2A with at least one additional biomarker selected from the group consisting of Ki67, TOP2A, MCM2, MCM5, p14^ARF and p16^INK4a, to better serve as a detection means for cervical cancer. The present invention provides a reliable and accurate assay methods and compositions which may be used for detecting cervical cancer in an individual with a high sensitivity and specificity. The present assay provides a novel use of CIP2A as a tool for early detection of cervical cancer in humans.

The invention provides peptides designed to be highly reactive with antibodies from patients infected with oncogenic HPV. Also disclosed is a method for their use in an immunoassay to detect HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with premalignant and malignant epithelial cell lesions. The peptides and the disclosed method are particularly useful for diagnosing carcinomas of the uterine cervix, or pre-stages thereof, or those at risk of development of carcinoma. The detection can be effected on blood samples, or other bodily fluid or tissue, by ascertaining the presence of IgA or IgG antibodies against HPV 16 and/or 18.

A step-shaped endometrial curette is provided. The step-shaped endometrial curette includes a handle, a curetting bar, and a collection cup. The handle is connected to a first end portion of the curetting bar. A second end portion of the curetting bar has a distal end formed with a plurality of mushroom-shaped curetting plates for removing endometrial tissues by scraping. The collection cup is slidably connected between the first end portion and the mushroom-shaped curetting plates and serves to hold the removed endometrial tissues. As the mushroom-shaped curetting plates are arranged stepwise, and the curetting bar is freely flexible to adapt to the internal shape and angles of the uterus, specimens can be taken from inside the uterus without dilatation of the cervix or anesthesia. Besides, the collection cup can collect all the removed endometrial tissues to enable sufficient and thorough pathological examination.

The present invention is directed to a system and method for monitoring the dilatation of the uterine cervix during labor and deliver. The system has a gauge and a monitoring unit. In one embodiment the gauge includes features for convenient attachment to the gloved fingertips of the clinician performing a routine digital probing of the cervix. The monitoring unit includes a sensor to automatically read the measurement of the gauge and a processor to process, record and display the sensor data. This system may be valuable for the assessment of the progress of labor and the early detection of delivery complications.