24results about "Dialysis" patented technology

This invention discloses a method for preparing a blood purification dialysis membrane and its application, relating to the field of materials preparation technology. The method includes the following steps: S1, dissolving polyacrylonitrile powder in N-N-dimethylformamide solvent to obtain a PAN spinning solution; S2, spinning the PAN spinning solution using electrospinning to obtain a PAN nanofiber membrane; S3, depositing a multi-walled carbon nanotube solution into the interfiber gaps of the PAN nanofiber membrane to obtain a composite PAN nanofiber membrane; S4, subjecting the composite PAN nanofiber membrane to hot-pressing treatment to obtain the blood purification dialysis membrane. By combining electrospinning with multi-walled carbon nanotube deposition and hot-pressing processes, a composite membrane with a gradient pore size structure is constructed. This effectively removes small and medium-sized toxins while selectively retaining large-molecule proteins, solving the technical challenges of wide pore size distribution and difficulty in balancing toxin removal and protein retention in traditional dialysis membranes. It offers the advantages of precise membrane structure control and improved blood purification efficiency.

Provided is a microfluidic dialysis module including an upper plate having an upper flow path through which a first fluid flows therein formed on one surface thereof, and an upper inlet through which the first fluid flows into the upper flow path and an upper outlet through which the first fluid flows out of the upper flow path; a lower plate having a lower flow path through which a second fluid flows therein, and having a plurality of lower inlets through which the second fluid flows into the lower flow path and a plurality of lower outlet through which the second fluid flows out of the lower flow path; a membrane disposed between the one surface of the upper plate and the one surface of the lower plate and formed in a porous membrane structure; and a fixing member coupling the upper plate and the lower plate.

The application discloses a silk fibroin solution purification device and a purification method thereof, which comprises a dialysate storage tank, a dialysis water tank, a finished product storage tank and a PLC control cabinet; a liquid pumping pump, a self-priming pump and a dialysis cavity are installed in the dialysis water tank, a dialysis bag is hung in the dialysis cavity, and the liquid inlet and the liquid outlet of the dialysis bag are connected to the liquid pumping pump and the self-priming pump through liquid inlet electromagnetic valves and liquid outlet electromagnetic valves respectively; the liquid pumping pump is connected to the liquid pumping electromagnetic valve of the dialysate storage tank, and the self-priming pump is connected to the liquid inlet of the finished product storage tank; water inlet electromagnetic valves and water outlet electromagnetic valves are further installed on the dialysis cavity; and the PLC control cabinet is connected to all electromagnetic valves, the liquid pumping pump and the self-priming pump. The application adopts the PLC to monitor information of each module and control a dialysis process, liberates manual work, reduces cost, improves dialysis precision at the same time, ensures purification quality, improves product purity, automatically monitors a dialysis end point, improves consistency of purification, sets a dialysis circulating flow system and improves dialysis efficiency.

The invention relates to a tangential flow filter module (10) having a first carrier plate (12), a second carrier plate (14) and a permeable membrane (16) arranged between the carrier plates, wherein a plurality of first channels (20) is arranged in the first carrier plate (12) on the side thereof facing the membrane (16), said first channels extending in a flow direction (24) from a first common inlet (26) to a first common outlet (28), wherein a cavity having a second outlet is arranged in the second carrier plate (18) on its side facing the membrane, and wherein the cavity is arranged opposite the plurality of first channels with respect to the membrane. The invention also relates to a tangential flow filter arrangement (100) in which a first such tangential flow filter module (10) and a second such tangential flow filter module (10) are stacked in such a way that the second carrier plate of the first tangential flow filter module and the first carrier plate of the second tangential flow filter module are formed by a common carrier plate.

The present disclosure relates to semipermeable membranes comprising a base membrane and a coating with a vinyl polymer derived from vinyl monomers carrying an acid group and grafted onto the surface of the base membrane by radiation induced graft copolymerization (RIGC), thereby introducing a coating carrying negative charges. The coated membranes are especially suitable for blood purification applications as they are characterized by an increased selectivity and excellent blood compatibility and an excellent hemocompatibility due to the careful selection of the vinyl monomers used for the coating process and the introduction of negative charges. The invention also relates to a production process for said coated membranes and to their use in hemodialysis devices and in medical applications such as extracorporeal blood purification.

A salt ion membrane may be paired with an absorption device to provide advantaged separation processes comprising: introducing a first aqueous salt stream and a mixed feed stream comprising at least one olefin and at least one paraffin to a salt ion membrane under conditions effective to form at least two phases; obtaining an olefin-rich permeate stream and an olefin-lean retentate stream from the salt ion membrane, in which the olefin-rich permeate stream and / or the olefin-lean retentate stream further comprises a salt ion membrane aqueous salt phase; introducing at least a portion of the olefin-lean retentate stream and a second aqueous salt stream to an absorption device under conditions effective to promote olefin extraction; obtaining an olefin-rich aqueous salt stream from the absorption device; and providing at least a portion of the olefin-rich aqueous salt stream as at least a portion of the first aqueous salt stream.

This invention relates to a method for preparing highly active biomass masterbatches using an air separation nitrogen generation coupled with electrolytic hydrogen-rich water biomass extraction device, and its application, belonging to the field of high-value biomass extraction technology. Based on an integrated extraction device, this invention designs a dual-path differentiated extraction process according to the differences in the thermosensitivity of the raw materials: for non-thermally sensitive / highly lignified raw materials, a path of "low-temperature pretreatment with hydrogen-rich water → high-temperature steam explosion cell disruption → rapid nitrogen cooling → low-temperature high-pressure extraction with hydrogen-rich water and nitrogen" is used; for thermosensitive raw materials, a path B of "low-temperature leaching with hydrogen-rich water → low-temperature high-pressure extraction with nitrogen" is used. The entire process achieves self-production of nitrogen and hydrogen-rich water, eliminating the need for external gas and water sources. This invention can scalably prepare various highly active biomass masterbatches such as willow tea thearubigin, whole tea polyphenols / theanine / catechins, corn germ SOD three enzymes, ginsenosides, and bird's nest peptides, with a masterbatch activity retention rate ≥98% and a significantly improved yield; simultaneously, it protects the masterbatch and its applications in food, health products, and cosmetics.

The present disclosure provides an improved filtration membrane suitable for filtration of blood in vivo. The improved filtration membrane is resistant to breakage with minimal areal penalty due to presence of a system of supports on the backside of the membrane. The minimal areal penalty is achieved by using supports that provide a hierarchical scaffolding that comprises ribs of two different heights as disclosed herein.

The present invention relates to a polyurethane casting composition obtained or obtainable by a process comprising the step of reacting a polyol component (A) and an isocyanate component (B) comprising at least one polyisocyanate (IC), wherein the polyol component (A) comprises at least one fat-based polyol (a1); and at least one compound (a2) having at least one unsaturated C-C-bond and at least one hydroxy group and a molecular weight in the range of from 100 to 600 g / mol. The present invention also relates to a process for producing a filter element comprising hollow fibers embedded at their end in a cured polyurethane casting composition comprising embedding hollow fibers in the polyurethane casting composition according to the present invention; curing the polyurethane casting composition at a temperature of at least 10°C to obtain a composite element comprising the hollow fibers embedded in the cured polyurethane composition; and treating the composite element under conditions suitable for sterilization, as well as a filter element comprising hollow fibers embedded at their end in a cured polyurethane casting composition obtained or obtainable according to said process. Furthermore, the present invention relates to the use of the polyurethane casting composition according to the invention for preparing a filter element comprising hollow fibers.

This specification provides a structure for in vitro blood perfusion that can effectively remove reactive oxygen species (ROS) that cause inflammation in the blood, an in vitro blood perfusion tube including the structure and an in vitro blood purification device, a method for preparing the structure, and an in vitro blood purification method using the in vitro blood purification device, wherein the structure for in vitro blood perfusion includes cerium dioxide nanoparticles and a carrier loaded with cerium dioxide nanoparticles.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

The present disclosure is directed to hemodialysis membranes. In particular, the present disclosure relates to hemodialysis membranes comprising uremic metabolites and zwitterionic moieties, and methods of hemodialysis thereof.

The utility model provides a kind of gel dialysis device, it is characterized in that, including reaction bucket, storage rack, dialysis screen and electric mixer, the gel of being wrapped by dialysis membrane bag is located in dialysis screen in the utility model gel dialysis device by the setting of storage rack and dialysis screen, will not be broken by magnetic son or stirring paddle in the process of stirring dialysis;When crosslinking high molecular gel expands to contact with the inner wall of dialysis screen, inner wall will be squeezed, volume no longer grows, dialysis membrane bag clamp will not be opened, avoid the problem of gel swelling to scrap.

Protein separation can be provided based on a High Performance Countercurrent Membrane Purification (HPCMP), which can exploit highly selective diffusive transport across thin walls of a hollow fiber membrane for separation of proteins. Embodiments of an HPCMP system can separate mixtures of multiple proteins (e.g. separate BSA and Mb) or other biological material and provide high yields (e.g. achieving greater than 98% yield of both proteins with purification factors greater than 100-fold, etc.). Embodiments of a HPCMP system can be configured for high resolution separations in the preparation of biopharmaceuticals and natural protein products. Other embodiments can be utilized in other protein separation environments or biological material separation environments.

This utility model relates to the field of working fluid reprocessing, specifically a working fluid purification and regeneration system. It includes an electrical control box, a sterilization module, and a functional regeneration module. Both the sterilization module and the functional regeneration module are electrically connected to the electrical control box. The sterilization module includes a heater, a circulating pump, a dialysis filtration device, a first level gauge, and a filtration purification cartridge for holding the working fluid in use. The functional regeneration module includes a liquid-drawing mixer, a second level gauge, and a functional regeneration cartridge for holding the regenerated fluid. The liquid-drawing mixer is connected to the original fluid cartridge and is equipped with a second flow meter and a water inlet valve. A dispensing valve is installed between the circulating pump and the liquid-drawing mixer, and a return valve is also installed on the circulating pump. This product can achieve impurity and sterilization of the working fluid and concentration adjustment, ensuring the working fluid remains in an effective state and enabling long-term recycling of the working fluid without waste discharge or hazardous waste treatment.

Method for operating a device (100) for extracorporeal blood treatment, - whereby hemodialysis and hemodiafiltration can be performed using the method, and - during hemodiafiltration the following steps are performed: - Pumping blood through one blood side (1a) of a dialyzer (1) using an electric blood pump (2), - Pumping substitute (3) by means of an electric substitute pump (4), and - Adjusting the flow rate of the electric substitution pump (4) such that the current consumption of the electric blood pump (2) remains within predefinable limits.

In accordance with at least one aspect of this disclosure, a method for treating a cancer patient via a blood filtration procedure comprises obtaining blood from a patient having a cancer: wherein the blood has at least one type of circulating tumor cells (CTCs) or at least one type of soluble targets; contacting the blood with a modified membrane to remove the CTCs or the soluble targets; wherein the modified membrane comprises at least one type of ligand composition attached to at least one of its surfaces.

The invention relates to a process for recovering fatty acids and / or nutrients from a feed using a system comprising an electrodialysis bipolar membrane (EDBPM) system, an electrodialysis system (ED) system, and a membrane contactor (MC). The process utilizes an EDBPM system to generate an acidic flow and an alkaline flow. The acidic flow is pumped directly to the feed side of the MC. The ED system is utilized to isolate the hydroxide ions generated by the bipolar membrane of the EDBPM system. The isolated OH- stream is pumped directly to the permeate side of the MC. The invention further relates to a system for recovering fatty acids and / or nutrients from a feed.

The utility model relates to the technical field of ginseng polypeptide production, in particular to a ginseng polypeptide separation and purification device which comprises a shell, a shell cover, a panel and a plurality of dialysis bags, the shell cover is arranged at the opening end of the shell, a feeding port is formed in the shell cover, the panel is arranged on the surface of the feeding port in a covering mode, a plurality of clamping grooves are formed in the panel, and the dialysis bags are arranged in the clamping grooves. Clamping grooves are formed in the shell cover, bag openings of the dialysis bags are inserted into the clamping grooves and are flattened and sealed inwards through the clamping grooves, positioning columns are installed on the sides, located in the clamping grooves, of the panel, positioning rings are installed on the two sides of the openings of the dialysis bags and sleeve the positioning columns, and a pushing mechanism for driving the panel to move and driving the dialysis bags to swing is installed on the shell cover. The bag opening can be flattened and sealed through the clamping groove, and after the positioning ring on the dialysis bag is sleeved on the positioning column, the dialysis bag can be directly hung, so that the dialysis bag can be immersed in deionized water and can be quickly separated in a swinging manner.