102 results about "Lymphatic system" patented technology

Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.

Embodiments of the present invention are directed to systems, apparatuses, devices and methods for improving, modifying and/or stabilizing pharmacokinetic and/or pharmacodynamic profile of a drug infused into the tissue by a catheter and absorbed into the blood or lymphatic system. In some embodiments, infusion sets provide fluid and electrical connection between a catheter assembly/treatment element and at least one of a fluid source and a second source.

A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.

A microfluidic-based platform with cultured three-dimensional tissues simulates major human physiological systems for rapid evaluation of individual drugs prior to clinical testing or for personalized medical applications. The platform integrates the circulatory and lymphatic systems in a physiologically correct manner. The physiological systems may be simulated in the platform by microfluidic tissue culture devices which accommodate various tissues and provide integrated microvascular and lymphatic systems. Biomimetic nanofiber meshes or microfiber structures may be used to provide the cells with a physiologically relevant substrate. Each device may have an on-board detection system utilizing optical fiber bundles for microarray multiplexing of biomarkers, label-free SERS measurement of drugs, and microendoscopic confocal imaging of cells and tissues.

A method, system and device for enhancing muscle training and performance by accelerating blood flow to the muscles and enhancing flow in the lymphatic system, incorporating mechanical stimulation and in some cases electrical stimulation of the muscle. A muscle recovery apparatus includes: an active compression device and an electrical stimulation device, where the active compression device is configured to be disposed about a user's muscle and to mechanically compress the user's muscle to facilitate muscle recovery, and where the electrical stimulation device is coupled to an inner surface of the active compression device, such that the electrical stimulation device can be placed in contact with the user to electrically stimulate the user's muscle.

The invention relates to a lenalidomide derivative and a use thereof as a medicine, and in particular relates to a compound shown as a formula (I), a solvate, a hydrate, a stereoisomer or pharmaceutically acceptable salt thereof. The invention further relates to a pharmaceutical composition comprising the compound, and the use of the compound in preparing medicines for preventing or treating malignant tumors, in particular malignant tumors in the blood-lymphatic system. Compared with lenalidomide, the compound provided by the invention has a longer half-life period and can be used for preparing long-acting preparations.

An improved apparatus and method of body contouring and skin conditioning for the treatment of conditions such as lymphoedema by producing vibrations in the subcutaneous layers of fat. The apparatus includes a cup which engages the patient's skin surface and a vacuum source which provides suction and a pulsating movement against the skin's surface, mimicking the movement of the lymphatic system and flushing out toxins, fat layers and trapped fluid from the area.

The present invention relates to the field of diagnostic imaging and provides compositions of ultrasound contrast agents, particularly gas-filled microvesicles suspensions, in combination with vital dyes. The compositions of the invention are advantageously used in the visualization of the lymphatic system, particularly for the detection of the sentinel lymph node or nodes of a tumor.

The invention discloses a method for preparing a clinic-level CAR-T cell preparation by minicircle DNA transfection T cells. The method comprises a technology of preparing the clinic-level CAR-T cell preparation by using non-viral minicircle DNA (minicircle DNA, mcDNA) vector to efficiently transfect T cells. The mcDNA transfection technology comprises the design and synthesis of a chimeric antigen receptor (CAR) carried with a target gene, the construction of target gene-CAR parent vector plasmids, the extraction of target gene-CAR-mcDNA vector plasmids, the target gene-CAR-mcDNA vector plasmid transfection T cells, and the clinic-level CAR-T cell preparation prepared by using the mcDNA transfection technology. The invention further discloses a use of the mcDNA transfection technology. The mcDNA transfection technology has the characteristics of high transfection efficiency to mammal T cells, stable expression, stable function, and no effect to cytogene feature. The prepared CAR-T cell preparation has the characteristics of strong targeting property, high killing efficiency and clinic safety. The mcDNA transfection technology can be used for preparing the clinic-level CAR-T cell preparation for treating various solid tumors and blood and lymphatic system tumors.

A compression device for exerting pressure on an arm, shoulder, and/or trunk of a patient in need thereof (for example, a patient with hyperalgia or recovering from surgery in which the lymphatic system is affected), including an arm compression hose, a shoulder part for exerting pressure on the shoulder and trunk area, and a band-shaped fastening means for positioning the shoulder part and exerting pressure on the shoulder part. The arm compression hose exerts a pressure that decreases from a maximum pressure at the wrist or hand to a minimum pressure near the shoulder end of the arm, where the minimum pressure is approximately 70% of the maximum pressure. One or more lining pockets can be constructed on the inner lining of the compression device, where each lining pocket can hold one or more compression pads to increase tissue pressure in one or more body areas in need thereof. The compression pads each can have a shape that approximately conforms to the shape of the body part to which it is applied. The shoulder part can also have a shape that approximately conforms to the contour of the shoulder/trunk area to which it is applied. In addition, compression pants can be prepared with lining pockets for receiving compression pads. In one embodiment, compression pants include one or more donut-shaped pads or equivalents thereof that are placed in one or more lining pockets, each of which surrounds one or more osteoma openings.

The invention belongs to the field of molecule biological medicine, and relates to a magnetic polyacrylic acid-modified nanometer pipe and a method for preparing the same. A multi-wall carbon nanometer pipe is modified by polyacrylonitrile and hydrolyzed under acid condition to obtain a polyacrylic acid-modified water-soluble nanometer pipe containing large quantity of carboxyl groups; by the water-phase chemical co-precipitation method, a magnetic ferroferric oxide-polyacrylic acid-modified multi-wall carbon nanometer pipe composite with the diameter of between 10 and 80nm is prepared, and the composite has good lymphotaxis and strong magnetic response; tests show that a medicine carrier can effectively adsorb chemical treatment medicines to a lymphatic system, slowly release the chemical treatment medicines in a metastasis lymph node of a malignant tumor, has good magnetic field positioning effect and obviously inhibits the proliferation and metastasis of the tumor cell of the lymph node. The invention provides a novel intervention means for lymphatic metastasis of the malignant tumor.

The present invention provides methods for the localized delivery of an agent to the lymphatic system, including localized delivery to a lymphatic capillary bed.

The invention belongs to the field of pharmaceutical preparations, and relates to an active targeting liposome carrier system for in situ tumors and lymphatic metastatic tumors. The carrier system is composed of polypeptides and liposomes whose amino acid sequence is CGNKRTRGC sequence of LyP-1. Wherein the LyP-1 sequence polypeptide is connected by two cysteines through a disulfide bond to form a ring structure. The liposome carrier system can passively drain the liposome into the lymphatic system through subcutaneous interstitial injection or intramuscular injection, and target the tumor metastasis lymph node through the mediated effect of LyP-1. The system can also be administered directly via intravenous injection, targeting tumors in situ and lymphatic metastases through tumor EPR effects and LyP-1-mediated effects. The liposome carrier system of the present invention can be used for targeted delivery of drugs for the diagnosis or treatment of tumors in situ and lymphatic metastases.

The invention discloses a health-preserving ceramic material. The health-preserving ceramic material is prepared from the following raw materials including pumice stones, ophicalcitum, magnet, gypsum rubrum, graystones, ruddle, zeolite, mirabilite, graphite, phlogopitum and medical stone. The invention also discloses a health-preserving ceramic container. According to the invention, eleven traditional Chinese medical mineral substances are mixed and proportioned, and are added to china clay after special processing through goldwater ball-milling; and then, multiple times of high-temperature sintering are conducted for producing the ceramic material and the ceramic container. Therefore, the health-preserving ceramic material and the health-preserving ceramic container have an alkalescent property and are capable of generating negative ions, resolving and converting food such as water and alcohol, promoting nutrient uptake, enhancing the metabolism, and effectively inhibiting and rapidly removing toxins in the lymphatic system and gastrointestinal tracts of human bodies, converting macromolecular water into molecular water, improving water absorption of the human bodies, and enhancing the immunity.

The invention discloses a sugar-free compound meal-replacement enzyme solution and a preparation process thereof. The preparation method comprises the following steps: secondarily fermenting the firstly fermented enzyme stoste and a medical material additive, mixing the modified enzyme solution with the meal-replacement agent, the candida utilis and the glycerin, and performing third fermentation to obtain the compound meal-replacement enzyme solution. The compound meal-replacement enzyme solution prepared by the invention has the half-fast meal replacement function in a short time without side effect, is nutrient and delicious, and has the advantages of tonifying spleen and nourishing stomach, adjusting the internal secretion, activating the immunological lymphatic system, nourishing qi and blood, detoxifying, removing edema and losing weight and has the meal-replacement effect.

The invention discloses a traditional Chinese veterinary medicine capable of promoting animal growth, helping digestion and invigorating the spleen. The traditional Chinese veterinary medicine comprises the following raw materials: Radix Codonopsis, Radix Astragali, Poria cocos, bighead atractylodes rhizome, dried orange peel, Chinese yam and brown sugar. A processing method for the traditional Chinese veterinary medicine comprises the following steps: separately crushing the above raw materials into powder with a pulverizer and uniformly mixing the obtained powder according to a prescription. The traditional Chinese veterinary medicine can adjust the functions of the spleen and the stomach, increase feed intake, promote the development of a lymphatic system, improve the immunity of a peripheral immune system and enhance disease resistance.

The invention discloses a method for preparing a spirulina platensis active protein. The method specifically comprises the following steps: putting algae powder into a phosphate buffer liquid and active polypeptides, and performing multigelation so as to obtain a crude protein liquid; adding ammonium sulfate into the crude protein liquid, and performing salting out; putting salted precipitate into a dialysis bag, and performing dialysis in the phosphate buffer liquid; performing a hydroxyapatite adsorption chromatography method on dialyzate, thereby obtaining a pure active protein product. The method has the beneficial effects that active proteins can be extracted by using the method, the extraction efficiency is improved, the yield of the active proteins is increased, the operation is simple, and no special instrument or equipment is needed; the active proteins prepared by using the method are high in purity, bright in color and rich in nutrition, capable of improving lymphocyte activity, improving body immunity through lymphatic systems, improving disease resistance of bodies, removing free radicals in living bodies and promoting hemocyte regeneration of animals, and has remarkable antitumor activity.