27 results about "Spinal Nerve Disorders" patented technology

Disclosed are methods for quantification of a perivascular space in a subject's central nervous system. The methods include administering contrast agent into cerebrospinal fluid of the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in the perivascular space within the region of interest.

A plurality of circular RNAs (circRNAs) the expression of which is correlated with brain disorders. The circRNAs are useful for compositions, kits, assays, and methods for the identification, diagnosis, screening, treatment and / or monitoring of brain disorders including psychiatric disorders such as bipolar disorder (BD), schizophrenia (SCZ), depression, Attention-Deficit / Hyperactivity Disorder (ADHD), Obsessive-compulsive disorder (OCD), Anxiety Disorders, etc., and neurodevelopmental disorders such as Autism, Asperger's Syndrome, and other Autism Spectrum Disorders (ASD), pervasive developmental disorders not otherwise specified (PDD-NOS), etc.

This invention discloses an essential oil-based intervention system for the simultaneous treatment of heart and brain function based on dual feedback of eye movement and heart rate variability, belonging to the field of rehabilitation medicine technology. The system includes: a data synchronization acquisition module, which acquires heart rate variability data and eye movement characteristic data and generates a synchronized physiological data stream; a dual feedback joint assessment module, which assesses the patient's real-time physical and mental state level based on the synchronized physiological data stream; a synchronized intervention decision module, which generates essential oil atomization control instructions and eye movement training control instructions in parallel according to the physical and mental state level; and a synchronized intervention execution module, which drives the essential oil atomization unit and the eye movement training unit to execute corresponding intervention actions synchronously at the hardware level on the time axis. This invention achieves integrated and precise intervention of heart and brain function through dual-modal physiological feedback closed loop and synchronized control, effectively solving the problems of brain separation, delayed intervention, and poor coordination in traditional rehabilitation centers, and improving the synchronous rehabilitation effect of cognitive function and autonomic nervous function in stroke patients.

Disclosed are compounds of formula (I) wherein G1 is as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in the treatment of e.g. a neurodegenerative disorder, a movement disorder, or a brain disorder, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy. An exemplary compound is e.g. (2,5-difluoro-4-(6-(((3aR,5s,6aS)-2-((tetrahydro-2H-pyran-4-yl)methyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-λ6-sulfanone (e.g. example 12; compound no. 7) Pharmacological data on the activity of the compounds in an mAChR M4 cell-based assay are provided (e.g. table 2).TABLE 2Human M4Cpd. No.IC50 (nM)Emin (%)*113.44239.62318.5345846575.4361883746.0385607918.43101.821186.231243.42138.63*% ACh maximum at 30 μM.

The present disclosure provides an AI-based clinical decision support system comprising an input module configured to receive clinical information comprising brain scan data, an analysis module configured to parse the clinical information using statistical measures from functional connectivity analysis with counterfactual explanations to identify brain connectivity patterns associated with brain disorders, and an output module configured to present a recommended diagnosis and explanation comprising attribution information identifying connectivity features contributing to the diagnosis. The brain scan data comprises functional magnetic resonance imaging, electroencephalography, and magnetoencephalography data. The statistical measures comprise functional connectivity analysis and graph theory metrics including degree metrics, betweenness centrality measures, and clustering coefficients. The analysis module comprises a functional connectivity engine configured to process brain scan data and generate connectivity features, a feature bank configured to store connectivity features, and modeling backbones configured to analyze connectivity features using machine learning techniques.

The present disclosure describes methods comprising administering N-acetylcysteine (NAC) or a pharmaceutically-acceptable salt or congener thereof. The disclosed methods can be used to treat a brain disorder.

The invention discloses a speech decoding analysis method and system based on electroencephalogram signals and computer equipment, and belongs to the technical field of electroencephalogram signal processing.The speech decoding analysis method comprises the following steps that a corpus is selected as natural stimulation, and the corpus is continuous natural language streaming media; acquiring a multi-channel EEG (electroencephalogram) signal of the subject under natural stimulation; dividing the multi-channel EEG signals into short-time EEG signals corresponding to single words in a corpus based on timestamps; the short-time EEG signals are converted into frequency domain power spectral density, and the power ratio of the short-time EEG signals is calculated based on the power spectral density; words in the corpus are classified based on the power ratio, and language decoding is achieved. According to the method, the power ratio is used as a biomarker, fine decoding of different word classes of words under natural stimulation by short-time EEG signal frequency domain features is realized, and a new perspective is provided for revealing a potential neural mechanism of a brain disorder patient.

An ultrasound neuromodulation system and method, e.g. for treating brain disorders, directs ultrasound transducers to sequentially energise plural candidate target volumes. Physiological responses to

The present invention refers to the biomedical field. Particularly, the present invention refers to an in vitro method for obtaining a cortical brain organoid, a cortical brain organoid obtained or obtainable by said method and its application as a medicament, preferably in a method of treating a brain disorder, condition, or disease.

Provided herein are ibogaine compounds which can be useful for methods of treating a neuropsychiatric disease or neurological disorder, for increasing neural plasticity, or for modulating the function of a serotonin transporter.

The present disclosure describes methods of administering N-acetylcysteine (NAC) via intranasal nose-to-brain administration. The effect of intranasal NAC nose-to-brain administration can be monitored using an analytical technique, for example, magnetic resonance spectroscopy (MRS). In some embodiments, intranasal nose-to-brain NAC can be used to treat a condition, for example, a brain injury.

Provided herein are tetracyclic heterocyclic compounds which can be useful for methods of treating a disease or for increasing neural plasticity. The compounds can also be useful for increasing dendritic spine density.

Provided herein are tetracyclic heterocyclic compounds useful in methods of treating a disease or for increasing neural plasticity. These compounds can also be used to increase dendritic spine density.

Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and / or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.

Aspects of the invention are directed to methods of stimulating or promoting neurogenesis by administering to a subject of a composition comprising a cyclodextrin and a polyethylene glycol to alleviate learning, memory and cognitive deficits present in subjects afflicted with various brain disorders or from neurodegenerative disorder associated with aging.

To provide a round bar sole massager. [Solution] This back massager consists of two round rods 1 and 2 connected by rubber rings 3 and 4, with hollows 5, 6, 7, and 8 at the ends of each of the two round rods for inserting bells and scented sachets. To enhance continuity, it can be used while sitting on a chair or sofa. It improves sitting with your legs spread apart on a chair or sofa, or sitting with your back against the wall, which can cause back pain and knee pain. The appropriate stimulation to the soles of the feet, the scent of the wood, and the relaxing sound of the bells improve sleep quality and alleviate various physical, mental, and brain disorders, such as improving sensitivity to cold. The scented sachets are effective in repelling insects, deodorizing, and repelling dust mites.

The present invention provides compositions, systems, and methods for treating or preventing brain disorder with compositions comprising a prebiotic (e.g., green banana flour) and one or both of Lactobacillus reuteri, and Lactobacillus plantarum. In certain embodiments, the brain disorder is selected from neuroinflammation, a neurological disorder, a neuropsychiatric disorder, and a behavioral disorder. In some embodiments, the prebiotic, Lactobacillus reuteri, and Lactobacillus plantarum are provided as a powder inside an ingestible capsule.

Disclosed herein methods and compositions for diagnosing, stratifying risk, and treating hypoxia-related brain disorders using NHIP genetic variants, DNA methylation signatures, and circulating NHIP peptide levels, as well as NHIP based peptide therapeutics for improving neurological and developmental outcomes.

1. Name of the product in this design: Brain-computer interface rehabilitation training device. 2. Purpose of this design: A device for rehabilitation training of patients with brain disorders. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

An extended reality (XR)-based platform integrated with real-time eye-tracking technology that assesses brain functions by leveraging artificial intelligence (AI) models is provided. In a first aspect, a method includes: receiving sensor data from an extended reality (XR) apparatus, and generating, using an artificial intelligence (AI) model, a functional map of a brain of a subject based on the sensor data. The sensor data includes eye-tracking data and is collected by the XR apparatus while the subject performed one or more tasks presented to the subject in a virtual environment by the XR apparatus. The one or more tasks stimulate a plurality of neurotransmitters of the subject. The functional map indicates neurological function of a plurality of regions of the brain. Other aspects and features are also claimed and described.