8 results about "Spinal Nerve Disorders" patented technology

Disclosed are methods for quantification of a perivascular space in a subject's central nervous system. The methods include administering contrast agent into cerebrospinal fluid of the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in the perivascular space within the region of interest.

This invention discloses an essential oil-based intervention system for the simultaneous treatment of heart and brain function based on dual feedback of eye movement and heart rate variability, belonging to the field of rehabilitation medicine technology. The system includes: a data synchronization acquisition module, which acquires heart rate variability data and eye movement characteristic data and generates a synchronized physiological data stream; a dual feedback joint assessment module, which assesses the patient's real-time physical and mental state level based on the synchronized physiological data stream; a synchronized intervention decision module, which generates essential oil atomization control instructions and eye movement training control instructions in parallel according to the physical and mental state level; and a synchronized intervention execution module, which drives the essential oil atomization unit and the eye movement training unit to execute corresponding intervention actions synchronously at the hardware level on the time axis. This invention achieves integrated and precise intervention of heart and brain function through dual-modal physiological feedback closed loop and synchronized control, effectively solving the problems of brain separation, delayed intervention, and poor coordination in traditional rehabilitation centers, and improving the synchronous rehabilitation effect of cognitive function and autonomic nervous function in stroke patients.

The present disclosure provides an AI-based clinical decision support system comprising an input module configured to receive clinical information comprising brain scan data, an analysis module configured to parse the clinical information using statistical measures from functional connectivity analysis with counterfactual explanations to identify brain connectivity patterns associated with brain disorders, and an output module configured to present a recommended diagnosis and explanation comprising attribution information identifying connectivity features contributing to the diagnosis. The brain scan data comprises functional magnetic resonance imaging, electroencephalography, and magnetoencephalography data. The statistical measures comprise functional connectivity analysis and graph theory metrics including degree metrics, betweenness centrality measures, and clustering coefficients. The analysis module comprises a functional connectivity engine configured to process brain scan data and generate connectivity features, a feature bank configured to store connectivity features, and modeling backbones configured to analyze connectivity features using machine learning techniques.

Provided herein are tetracyclic heterocyclic compounds which can be useful for methods of treating a disease or for increasing neural plasticity. The compounds can also be useful for increasing dendritic spine density.

Provided herein are tetracyclic heterocyclic compounds useful in methods of treating a disease or for increasing neural plasticity. These compounds can also be used to increase dendritic spine density.

The present invention provides compositions, systems, and methods for treating or preventing brain disorder with compositions comprising a prebiotic (e.g., green banana flour) and one or both of Lactobacillus reuteri, and Lactobacillus plantarum. In certain embodiments, the brain disorder is selected from neuroinflammation, a neurological disorder, a neuropsychiatric disorder, and a behavioral disorder. In some embodiments, the prebiotic, Lactobacillus reuteri, and Lactobacillus plantarum are provided as a powder inside an ingestible capsule.

Disclosed herein methods and compositions for diagnosing, stratifying risk, and treating hypoxia-related brain disorders using NHIP genetic variants, DNA methylation signatures, and circulating NHIP peptide levels, as well as NHIP based peptide therapeutics for improving neurological and developmental outcomes.