45 results about "Magnetoencephalography" patented technology

Central nervous system, autonomic nervous system, and effector data is measured and analyzed to determine the effectiveness of marketing and entertainment stimuli. A data collection mechanism including multiple modalities such as Magnetoencephalography (MEG), Electrooculography (EOG), Galvanic Skin Response (GSR), etc., collects response data from subjects exposed to marketing and entertainment stimuli. A data cleanser mechanism filters the response data. The response data is enhanced using intra-modality response synthesis and/or a cross-modality response synthesis.

A set of brain data representing a time series of neurophysiologic activity acquired by spatially distributed sensors arranged to detect neural signaling of a brain (such as by the use of magnetoencephalography) is obtained. The set of brain data is processed to obtain a dynamic brain model based on a set of statistically-independent temporal measures, such as partial cross correlations, among groupings of different time series within the set of brain data. The dynamic brain model represents interactions between neural populations of the brain occurring close in time, such as with zero lag, for example. The dynamic brain model can be analyzed to obtain the neurophysiologic assessment of the brain. Data processing techniques may be used to assess structural or neurochemical brain pathologies.

One embodiment is a magnetic field measurement system that includes at least one magnetometer having a vapor cell, a light source to direct light through the vapor cell, and a detector to receive light directed through the vapor cell; at least one magnetic field generator disposed adjacent the vapor cell; and a feedback circuit coupled to the at least one magnetic field generator and the detector of the at least one magnetometer. The feedback circuit includes at least one feedback loop that includes a first low pass filter with a first cutoff frequency. The feedback circuit is configured to compensate for magnetic field variations having a frequency lower than the first cutoff frequency. The first low pass filter rejects magnetic field variations having a frequency higher than the first cutoff frequency and provides the rejected magnetic field variations for measurement as an output of the feedback circuit.

A magnetic field measurement system, non-transitory computer-readable medium or method can include instructions for, or performance of, actions including receiving output of multiple first magnetic field sensors and multiple second magnetic field sensors; and demixing, using the output of the first and second magnetic field sensors, at least one signal from at least one target source from signals from other magnetic field sources. The demixing may be performed using a model in which the output of the first magnetic field sensors includes the at least one signal from the at least one target source and that the output of the second magnetic field sensors does not include the at least one signal from the at least one target source.

According to certain embodiments of the present invention, there is provided a magnetoencephalography and method employing a portable cart having a SQUID dewar mounted in an inverted manner thereon, and having a headrest assembly mounted on the cart for supporting the head of a patient and forming a portion of the dewar. The headrest assembly includes an array of magnetic sensors of the SQUID dewar for responding to electrical activity of the brain of the head.

Techniques, devices and systems are disclosed for magnetoencephalography (MEG) source imaging. In one aspect, a method includes selecting signal data associated with one or more frequency bands from a spectrum of the signal data in the frequency domain, in which the signal data represents magnetic signals emitted by a brain of a subject and detected by a plurality of sensors outside the brain, defining locations of sources within the brain that generate the magnetic signals, in which the number of locations of the sources is selected to be greater than the number of sensors, and generating a source value of signal power based on the selected signal data corresponding to a respective location of the locations at the one or more frequencies.

According to certain embodiments of the present invention, there is provided a mounting arrangement for a magnetoencephalography (MEG) system headrest assembly forming a portion of a SQUID dewar and having a fixed headrest and an array of sensors, wherein a sensor array plate positions the sensors relative to the headset. A plurality of first rods interconnecting the array plate and the movable mounting member. A plurality of second rods are fixed at one of their ends relative to the dewar and are connected at their opposite ends to the movable mounting member. Each one of the first and second rods is composed of material expandable and contractible with changes in temperature, whereby the movable mounting member tends to be moved in one direction toward or away from the sensor array plate, and tends to be moved in an opposite direction away from or toward the array plate, resulting in temperature changes affecting the first and second rods, so that the sensor array plate and its sensors maintain a substantially constant spacing between the sensors and the headrest with changes in temperature. A plurality of second rods are fixed at one of their ends relative to the dewar and are connected at their opposite Each one o the rods is composed of material expandible and contractable with changes in temperature, whereby the movable mounting member tends to be moved in one direction toward or away from the sensor array plate, and tends to be moved in an opposite direction away from or toward the array plate resulting in temperature changes affecting the first and second rods, so that the sensor array plate and its sensors maintain a substantially constant spacing between the sensors and and headrest with changes in temperature.

This invention discloses methods and apparatuses for 3D imaging in Magnetoencephalography (MEG), Magnetocardiography (MCG), and electrical activity in any biological tissue such as neural/muscle tissue. This invention is based on Field Paradigm founded on the principle that the field intensity distribution in a 3D volume space uniquely determines the 3D density distribution of the field emission source and vice versa. Electrical neural/muscle activity in any biological tissue results in an electrical current pattern that produces a magnetic field. This magnetic field is measured in a 3D volume space that extends in all directions including substantially along the radial direction from the center of the object being imaged. Further, magnetic field intensity is measured at each point along three mutually perpendicular directions. This measured data captures all the available information and facilitates a computationally efficient closed-form solution to the 3D image reconstruction problem without the use of heuristic assumptions. This is unlike prior art where measurements are made only on a surface at a nearly constant radial distance from the center of the target object, and along a single direction. Therefore necessary, useful, and available data is ignored and not measured in prior art. Consequently, prior art does not provide a closed-form solution to the 3D image reconstruction problem and it uses heuristic assumptions. The methods and apparatuses of the present invention reconstruct a 3D image of the neural/muscle electrical current pattern in MEG, MCG, and related areas, by processing image data in either the original spatial domain or the Fourier domain.

A method is provided for identifying multidimensional parameters of a plurality of P>1 sources of interest present in a predetermined multidimensional conductive environment by a plurality of observations (60) in a finite number of N≧1. The method includes using i) a factorisation of a problem matrix formulation, ii) the creation of a virtual network of the order 2q (q>1) sensors by using cumulants of order 2q from observations and iii) the concept of an extended deflation of order 2q taking into consideration the presence of potentially (but not entirely) correlated sources. The method and device can be used for electroencephalograpy, magnetoencephalography, geophysics and seismology.

The invention discloses a location method for a dynamic neuromagnetic source. The location method comprises following steps: collecting a brain MR structure image and a magnetoencephalography MEG signal B and setting measurement space; setting space where a source signal is formed in the cerebral cortex as source space; determining the space-shifting relation between measurement space and source space and further determining the relation between an MEG signal B and a source signal matrix X, constructing subspace for the time domain, projecting the MEG signal B and the source signal matrix X to the subspace for the time domain, solving in order to obtain a source signal X, and extracting position information of the source signal X and intensity information thereof so that a location process for the dynamic neuromagnetic source is finished. The location method for the dynamic neuromagnetic source has following beneficial effects: the technical problem that the dynamic neuromagnetic source is not easily positioned is solved; and especially the technical problem that a transmitting process for a mutant neuromagnetic source signal is not easily studied is also solved.

The invention relates to an encephalic region causal connection detection method combining functional magnetic resonance imaging (FMRI) and magnetoencephalography (MEG), which comprises the following steps that: firstly, a coordinate of an active region is extracted from a FMRI image after the data preprocessing; secondly, an encephalic region time sequence of a corresponding position region is extracted from an MEG data after being preprocessed on the basis of the extracted FMRI active region coordinate; and thirdly, the causal connection strength and direction between every two adjacent encephalic regions are calculated according to the extracted MEG encephalic region time sequence, and an oriented network image is used for displaying a remarkable connection. The method is a valid encephalic region causal connection detection method combining two imaging modes such as FMRI and MEG, so the encephalic region causal connection can be more complete and more accurate to detect compared to the detection method by only utilizing the FMRI image.

The invention discloses a wearable type portable quantum magnetoencephalography system and method. The wearable type portable quantum magnetoencephalography system comprises a magnetoencephalographiccap, fixed slots, limiting clamping sleeves and quantum detectors, wherein the magnetoencephalographic cap is a rubber cap which is made of a flexible material and has flexibility; the magnetoencephalographic cap is provided with a plurality of fixed slots which are uniformly arrayed; one limiting clamping sleeve is arranged at the periphery of each fixed slot; each quantum detector is fixedly mounted on the corresponding limiting clamping sleeve; a detection end of each quantum detector extends into the corresponding fixed slot. The quantum detectors are used for replacing traditional ultrasonic equipment and a detection array is formed into a wearable form, so that portable acquisition of magnetoencephalographic signals is realized and the system has a wide application prospect in clinical and scientific researches. The magnetoencephalographic cap with certain flexibility is matched with the fixed slots with the matched size to from the detection array which can extend and retract toa certain extent; the wearable type portable quantum magnetoencephalography system is applicable to almost people by just designing the magnetoencephalographic caps with different sizes.

The invention relates to a magnetoencephalography epileptic spike wave recognition method and system. The method comprises the following steps of dividing MEG data into spike wave data and non-spike wave data, and pretreating the MEG data to respectively obtain the spike wave data and the non-spike wave data, of which the N segment phases are the same in length; performing analytical treatment onthe obtained segments of data, performing extraction to obtain characteristic vectors of various segments of data to form a sample dataset, and dividing the sample dataset into a training set and a test set; training a radial primary kernel function support vector machine classifier through the training set to obtain a trained classifier model; and inputting the test set to the classifier model torecognize whether epileptic spike waves exist or not. Automatic recognition of epilepsy brain magnetic signals can timely judge the condition of the patients, wherein the judgment accuracy rate can achieve 93.8%, the labor intensity of doctors is reduced, the detection accuracy rate is increased, and the omission factor and the false positive rate are reduced. The magnetoencephalography epilepticspike wave recognition method and system have important significance clinically.

Compositions and methods for diagnosing neurological disorders such as autism spectrum disorders are disclosed.

The invention discloses a quantum magnetoencephalography system and method based on a magnetic shielding cylinder. The system comprises a quantum detector and array system, an environmental magnetic field shielding system, a quantum detector control system, a data acquisition and analysis system, and a stimulation and feedback system, wherein the quantum detector and array system are bidirectionally connected with the quantum detector control system through signals; the quantum detector control system and the stimulation and feedback system are connected with the data acquisition and analysissystem through signals; and the quantum detector and array system is externally provided with the environmental magnetic field shielding system. The quantum magnetoencephalography system and method disclosed by the invention have the technical effects that the operating cost is low; a detection array can be flexibly changed for matching the contour of an individual head, so that the detection efficiency is increased; meanwhile, the system and device can be extended to high-efficiency signal detection of people at different ages; the extra loss of brain magnetic signals is avoided in the spatial distance, and the absolute signal strength is improved; and the magnetic shielding cylinder is used for replacing a shielded room necessary for traditional magnetoencephalography, so that the performance of magnetic shielding is significantly improved while the cost is saved.

In order to draw up data which can be used to assess the cognitive or sensomotor capabilities or capacities of people subjected to a test, measuring samples collected by measuring methods known per se (e.g. magnetoencephalography or electro-encephalography) and representing the cerebral activities of the test person, are recorded in a synchronized manner with a sequence of different test situations which the test person faces. Relevant changes in activity are traced and localized from the recorded measuring samples. Groups are then formed based upon the locality of the relevant activity changes, each of the groups containing activity changes of a pre-determined cerebral region. The groups are interrelated and data describing the relation between the groups of relevant activity changes is prepared for the assessment, for example visualized or acoustically presented with experimentally determined limiting values or comparison data.

The present invention provides an optically pumped magnetometer, a magnetoencephalography meter, and an MRI device. The optically pumped magnetometer is used for measuring a magnetic field of a subject of interest by utilizing optical pumping, and comprises: a non-magnetic cell in which at least an alkali metal is encapsulated and which has light transmissivity and heat resistance; a laser beam emission unit which emits a laser beam toward the cell to achieve the optical pumping of at least the alkali metal; a detection unit which receives the transmitted laser beam that has been transmitted through the cell and which detects a detection signal associated with the magnetic field; and a high-frequency voltage application unit which applies a high-frequency voltage to a pair of application sections arranged in the cell and which heats the cell by dielectric heating.

The invention belongs to the technical field of magnetoencephalography detection, and provides a wearable magnetoencephalography instrument environmental noise suppression system and method. The system comprises a magnetic shielding room, a magnetoencephalography measuring cap, an atomic magnetometer detection sensor array and an atomic magnetometer reference sensor array, wherein a testee wears the magnetoencephalography measuring cap on the head and is placed in the magnetic shielding room, the atomic magnetometer detection sensor array is arranged in the magnetoencephalography measuring cap, and the atomic magnetometer reference sensor array is arranged above the head of the testee. The system is simpler in structure, light and flexible. In addition, according to the wearable magnetoencephalography instrument environmental noise suppression method, gradient arrangement configuration does not need to be carried out on each atomic magnetometer detection sensor, on the basis that the configuration of the detection sensors on the original flexible measuring cap is kept unchanged, the intensity of magnetoencephalography signals can be kept not attenuated, the environmental noise of the shielding room can be effectively suppressed, and the signal-to-noise ratio of the magnetoencephalography signals is improved.

A system assists users in time and frequency analysis of magnetoencephalography (MEG) signals. In one aspect, a system includes an analysis module, a configuration module and a user interface. The analysis module performs a time and frequency analysis of the MEG signal, for example a short time Fourier transform (STFT) or a continuous wavelet transform (CWT) analysis. The analysis is parameterized by a parameter set that affects the time and frequency resolution of the analysis, for example window size and overlap size for STFT or center frequency and decay parameter for CWT. The configuration module automatically determines or assists the user to determine correct values for the parameter set.