108 results about "Neural tissues" patented technology

The invention provides a nervous tissue identification method based on artificial intelligence, and relates to the technical field of medical intelligent detection. According to the nervous tissue identification method, nervous tissue region annotation is carried out on 452 HE-dyed section images of bladder cancer, pancreatic cancer and porta-bile duct cancer by using QuPath software. 70% is used as a training set, 10% is used as a verification set of a training process, and 20% is used as an independent test set to train the nnUnet model. The whole training process is combined with an active learning strategy to enhance the specificity of the model. By using the algorithm and the deep learning technology, the nerve peripheral infiltration in the pathology is accurately and quickly evaluated, the workload of manual identification is greatly reduced, and the diagnosis accuracy is improved. The machine identification of tumor peripheral nerve invasion has obvious practicability, importance, clinical diversity and actual clinical value, and shows that the deep learning technology improves the potential of tumor detection and diagnosis.

The invention relates to a graphene hydrogel neural microelectrode and a preparation method thereof.The neural microelectrode comprises a long-strip-shaped electrode body, the electrode body comprises an insulating substrate layer, a conductive layer and an insulating covering layer, and the conductive layer is wrapped and sealed by the insulating substrate layer and the insulating covering layer; a contact window is arranged at one end, close to the electrode body, of the insulating covering layer, a conductive expansion layer made of graphene hydrogel is arranged below the contact window and the insulating covering layer on the periphery of the contact window, the conductive expansion layer is electrically connected with the conductive layer, and the conductive expansion layer can expand after being heated or absorbing water to form an electrode contact protruding outwards from the contact window. Amino multi-walled carbon nanotubes, amino graphene quantum dots and gold nanoparticles are loaded in the graphene hydrogel. The electrode contact has the advantages that after the electrode contact is heated or absorbs water, the conductive expansion layer expands to form the electrode contact protruding out of the contact window, and the electrode contact is good in tissue affinity, capable of making better contact with nervous tissue and more excellent in performance.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.

A device and system for real-time visualization of the electrophysiologic activity of a brain, particularly at the cortical surface. The neural device can acquire, process, and display high-spatiotemporal-resolution electrophysiologic data in real-time across entire electrode arrays spanning many thousands of electrodes over identified anatomic regions. The system is compatible with thin-film cortical surface electrodes that record from neural tissues without damaging those tissues. The system can be used to guide diagnostic and therapeutic actions with high precision, and also provides the basis for a brain-computer interface.

The invention discloses a neural tissue stimulator, characterized in that the neural tissue stimulator comprises a multiple of microneedles and a chip comprising at least one comparator with adaptive level, sequence control circuit, at least one capacitor stack built by n capacitors and 2n switches, at least one buffer capacitor outside the at least one capacitor stack, at least two additional switches outside the at least one capacitor stack, a CMOS-Logic, wherein further, the neural tissue stimulator comprises an interposer layer comprising holes for the multiple of microneedles and a lid. The neural tissue stimulator is characterized in, that the chip is located on one surface of the interposer layer and that the lid and the interposer layer form a capsule for the chip. Further, the neural tissue stimulator is adapted to be electrically self-sufficient.

The invention discloses a dynamic image motion correction method based on a graph neural network, and the method comprises the following steps: a), constructing a target region trajectory tracking model based on the graph neural network, and achieving the high-precision motion trajectory modeling; b) analyzing an image displacement mode in real time through a dynamic discrimination algorithm; and c) realizing adaptive image motion correction based on the target area track features. According to the method, the problem of complex motion trail modeling limitation caused by dependence on fixed template matching in a traditional method is innovatively solved, and the problem of spatial-temporal characteristic aliasing caused by unsteady state deformation of nervous tissues is effectively solved. According to the technical scheme, the dependence on a hardware synchronization signal acquisition module is eliminated, the resource configuration requirement of the edge computing equipment is remarkably reduced, and meanwhile, the multi-scale time sequence integration efficiency is improved. According to the method, dynamic imaging reconstruction of subcellular neural activities can be realized, and dynamic change details in a target neuron issuing process can be accurately restored.

The invention relates to a neural function detection and regulation method and system for a magnetic stimulation coil, and the method comprises the steps: driving a capacitor through a control circuit to discharge to a dual-path stimulation coil, and generating a millisecond pulse magnetic field; utilizing the pulsed magnetic field to act on nervous tissue to generate a nerve regulation effect comprising suprathreshold stimulation and subthreshold stimulation; acquiring evoked potential signals generated by stimulation and induction of the pulsed magnetic field in real time; the evoked potential signal is analyzed, and the nerve conduction time and excitation inhibition ratio is calculated; according to the nerve conduction time and the excitement inhibition ratio, a double-path stimulation time sequence and / or a capacitor discharge parameter are / is adjusted, detection and cooperative regulation and control of the nerve function are carried out, and the purposes of real-time detection, quantitative evaluation and self-adaptive precise regulation and control of the nerve function are achieved.

The invention relates to the technical field of neurosurgical operation simulation, and provides a method for transmitting grid deformation in real time in neurosurgical operation simulation, which comprises the following steps: S1, carrying out input detection, including active interactive input for simulating left and right hand virtual surgical instrument operation and passive continuous input for simulating nervous tissue self deformation, so as to obtain collision point data; s2, positioning and extracting target vertex data based on the collision point data; s3, determining a nearest vertex based on the extracted target vertex data; s4, triggering conditions are judged, and different grid deformation modes are selected based on different triggering conditions; s5, calculating actual action point offset according to the selected grid deformation mode, and dynamically generating a deformation action point; and S6, driving neural tissue grid deformation real-time updating and physical synchronization based on the dynamically generated deformation action points. High-precision deformation simulation and low-delay tactile feedback are achieved, and the authenticity and practical operation value of neurosurgery operation training are remarkably improved.

Chronic pain management can be achieved by electrically anesthetizing a peripheral nerve with on-demand electrical nerve block (OD-ENB). OD-ENB can be provided by an implantable capsule. Externally, at least a portion of the capsule can be constructed of a conductive membrane and the rest of the capsule comprises a biocompatible material. A blocking electrode contact, a return electrode contact, and a powering / communication component can be within the capsule. The blocking electrode contact can deliver a direct current (DC) through a portion of the conductive membrane to block conduction in the neural tissue to provide the OD-ENB. The return electrode contact can receive a return current from the neural tissue through another portion of the conductive membrane. The powering / communication component can communicate with one or more external components located external to the patient's body to receive a power signal. Notably the capsule has no internal battery.

Systems, apparatuses, and methods described herein facilitate the placement of spinal cord stimulator (SCS) electrode in relationship to neural tissue of the spinal cord based on electromyography (EMG) data. The systems, apparatuses, and methods are designed to assist physicians and surgeons target specific neurophysiological locations through stimulation and subsequent visualization of EMG activity in response to stimulation to more precisely identify the location of the SCS electrodes that will maximize the intended therapeutics effects of SCS.

According to an aspect of the present inventive concept there is provided a system for determining an estimate of an anatomy of neural tissue of a subject. The system comprises an electrode arrangement comprising a plurality of electrodes, wherein different electrodes in the plurality of electrodes are configured to be arranged in different electrode locations adjacent the neural tissue, wherein the plurality of electrodes is configured to receive a plurality of stimulation signals, a sensor arrangement configured to generate indications of changes in at least one of a neural activity or a physiological activity in response to the stimulation signals and a processing unit, configured to receive data representing relations between the plurality of stimulation signals and the indications of changes in the neural activity or physiological activity, wherein the processing unit is configured to generate the estimate of the anatomy of the neural tissue of the subject.

The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.

An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.

To facilitate multiple steps of tissue processing.SOLUTION: A tissue processing container is specifically designed to achieve automated tissue processing, exposure of tissues to processing media, and efficiency of multi-step tissue processing protocols. The described tissue processing containers include a cup-like cavity with a central hole covered by a mesh screen, a trough for separate processing steps, and are stackable in a substantially air-tight and substantially water-tight manner. Tissues for processing using the described tissue processing containers include neural tissue. A transport housing for transporting stacks of the tissue processing containers is also described herein, which may directly incubate the containers, or the transport housing may be placed inside a separate incubator for incubating the containers.SELECTED DRAWING: Figure 1A

The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3):(1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGFβ family signal transduction pathway inhibiting substance and / or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state,(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.

Provided is an intravascular device for sensing or stimulating activity of neural tissue and having excellent delivery to blood vessels and high sensitivity of sensing or stimulation. An intravascular device (1) configured inside a blood vessel of a living organism, the first end portion (1a) of which has an electrode for sensing or stimulating activity of neural tissue located outside the blood vessel, the intravascular device (1) having: a wire member (10) having electrical conductivity; at least one electrode member (20) provided at the first end portion (1a) and electrically connected to the wire member (10); and a step difference reducing portion (30, 40) that reduces a step difference resulting from an outer diameter difference between the outer diameter of the electrode member (20) and the outer diameter of the wire member (10), the electrical resistance value between the electrode member (20) and the second end portion (1b) of the wire member (10) on the opposite side from the first end portion (1a) being 100 Ω or less.

The invention relates to a neural tissue unit for use in implantation into the nervous system of a human or non-human mammal, wherein said neural tissue unit contains differentiated post-mitotic neuronal cells in an extracellular matrix, said unit being obtained from a cellular microcompartment comprising a hydrogel capsule surrounding the neural tissue unit, and said hydrogel capsule being at least partially removed before use of the neural tissue unit. The invention also relates to a process for preparing such a neural tissue unit.

In some embodiments, a method of providing a neurostimulation therapy to a patient, comprises: generating electrical pulses, by an implantable pulse generator (IPG), comprising respective bursts of a plurality of anodic pulses with each anodic pulse being separated by a time gap, wherein (1) the plurality of anodic pulses comprise successively increasing charge; (2) the plurality of anodic pulses are charge limited to be sub-threshold; (3) each burst of anodic pulses is followed by a discharge phase of intermittent time periods to discharge charge build up from the anodic pulses; and (4) each successive intermittent time period increases in time through the discharge phase to avoid action potential (AP) generation; and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient.

Techniques for measuring single synaptic signals under varying experimental conditions include controlling a video recording microscope to capture, at multiple different times, a first imaged area in a sample holder as a video frame when the sample holder is disposed on a stage and holds a sample of neuronal tissue combined with at least one fluorophore that emits a corresponding electromagnetic wavelength in a synapse during synaptic activity. At least one synaptic region of interest is determined based on a group of pixels in the first imaged area that record electromagnetic emissions from the fluorophore at the different times. An ordered time series of emission intensity is recorded in each of the synaptic region of interest. Peak emission intensity values in the time series are corrected for transmitter label transients. The ordered time series with corrected peak emission intensity values are stored in a data structure with a standard format.

This invention relates to the field of microfluidic chip technology, specifically to a dynamic microfluidic chip device, its preparation method, and its applications for studying CAR-T therapy for gliomas. The preparation method includes: fabrication of the microfluidic chip; reconstruction of neural tissue; reconstruction of the blood-brain barrier; and simulation of the glioma microenvironment. The dynamic microfluidic chip device includes a microfluidic chip; the microfluidic chip includes, from left to right, a vascular channel, a brain parenchyma channel, a tumor channel, and a subarachnoid channel; each of the vascular channel, brain parenchyma channel, tumor channel, and subarachnoid channel includes a cell culture chamber with an inlet on one side; the cell culture chambers of the vascular channel and the subarachnoid channel have corresponding outlets on the other side. The applications include: CAR-T cell infusion; observation of transmembrane migration; and detection of biomarkers. This invention, through the dynamic microfluidic chip device, its preparation method, and its applications, aims to achieve more accurate in vitro evaluation of CAR-T cell therapy.

The invention relates to a neural tissue unit for use in implantation into the nervous system of a human or non-human mammal, wherein said neural tissue unit contains differentiated post-mitotic neuronal cells in an extracellular matrix, said unit being obtained from a cellular microcompartment comprising a hydrogel capsule surrounding the neural tissue unit, and said hydrogel capsule being at least partially removed before use of the neural tissue unit. The invention also relates to a process for preparing such a neural tissue unit.

A laryngeal pacemaker is configured for external placement on skin of a patient to produce respiration stimulation signals. An implantable stimulation electrode delivers the respiration stimulation signals to adjacent target neural tissue for vocal fold abduction during respiration of the recipient patient. A triaxial accelerometer produces a body motion signal reflecting energy expenditure of the recipient patient. A respiration sensor includes a flexible skin-transferrable printed tattoo electrode having a tetrapolar configuration for impedance pneumography measurement to produce a sensed respiration signal for the laryngeal pacemaker. The respiration sensor is configured for transfer and release by guided placement from a sensor applicator to the skin at the angulus sterni of the recipient patient. And the laryngeal pacemaker is configured to interpret the body motion signal and the sensed respiration signal to make a real time determination of respiratory phase and frequency for adaptively adjusting the respiration stimulation signals accordingly.

A microelectrode probe for implantation in soft tissue, comprising a sheath of flexible polymeric material divided by a wall into a distal and a proximal compartment, said distal and proximal compartments being filled with a matrix of biocompatible material dissolvable or degradable in aqueous body fluids, and comprising a centrally disposed electrically conductive core passing through the wall and attached to it. The core is insulated at its proximal portion, from which it extends to a holder for attachment to tissue other than said soft tissue. The sheath and the core extending distally from said holder are embedded in a kindred additional matrix. The invention also discloses a method for its manufacture, an array comprising two or more microelectrode probes and a microelectrode probe for incorporation into the array and a method for the manufacture of the array.

Presented herein are techniques for generating a neural survival map of nervous tissue adjacent to a body cavity of a recipient of an implantable medical device that includes an implantable stimulation assembly. For example, during insertion of the implantable stimulation assembly into a recipient, the implantable medical device captures a plurality of evoked responses of nervous tissue adjacent to a body cavity, and a plurality of intra-operative measurements associated with the implantable stimulation assembly. The computing device is configured to determine a plurality of position estimates of the implantable stimulation assembly relative to the body cavity using the plurality of intra-operative measurements. The computing device generates a neural survival map of nervous tissue adjacent to the body cavity using the plurality of evoked responses and the plurality of position estimates.

Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and / or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.

The invention generally relates to systems and methods for targeting of specific tissue(s) of interest in a sino-nasal region of a patient for the treatment of a rhinosinusitis condition. A device of the present invention includes an end effector comprised of one or more segments, each segment comprising one or more struts which can be in the form of loop-shaped struts or independent struts and each comprising a flexible printed circuit board (PCB) member for delivering energy to one or more target sites within the sino-nasal cavity of the patient while minimizing or avoiding collateral damage to surrounding or adjacent non-targeted tissue, such as blood vessels, bone, and non-targeted neural tissue.

The invention provides systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition. The method includes providing a treatment device comprising a treatment comprising a plurality of electrodes and advancing the treatment element into the nasal cavity of a subject such that two or more of the plurality of electrodes of the treatment element are positioned relative to targeted neural tissue within the nasal cavity. The method further includes controlling, via a console unit operably coupled to the treatment device, delivery of one or more treatment applications applied via the treatment element for altering transmission of signals through the targeted tissue.

This disclosure relates to medical implant systems and apparatuses capable of treating a seizure condition through the use of recording and stimulating electrodes. The apparatus includes an internal pulse generator in communication with a wireless communication module; one or more recording electrodes in communication with the internal pulse generator, wherein the one or more recording electrodes are configured to monitor to detect one or more field potentials produced by neural tissue in proximity to the one or more recording electrodes; one or more stimulating electrodes in communication with the internal pulse generator, wherein the one or more stimulating electrodes are configured to stimulate the vagus nerve.

A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

In some embodiments, a method of providing a neurostimulation therapy to a patient comprises: generating, by an implantable pulse generator (IPG), electrical pulses comprising a plurality of pulses having a uniform pulse width over time and a pulse amplitude that changes over time, and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient. The pulse amplitude may change sinusoidally, linearly, or exponentially over time.