63 results about "Neural tissues" patented technology

A device and system for real-time visualization of the electrophysiologic activity of a brain, particularly at the cortical surface. The neural device can acquire, process, and display high-spatiotemporal-resolution electrophysiologic data in real-time across entire electrode arrays spanning many thousands of electrodes over identified anatomic regions. The system is compatible with thin-film cortical surface electrodes that record from neural tissues without damaging those tissues. The system can be used to guide diagnostic and therapeutic actions with high precision, and also provides the basis for a brain-computer interface.

The invention discloses a neural tissue stimulator, characterized in that the neural tissue stimulator comprises a multiple of microneedles and a chip comprising at least one comparator with adaptive level, sequence control circuit, at least one capacitor stack built by n capacitors and 2n switches, at least one buffer capacitor outside the at least one capacitor stack, at least two additional switches outside the at least one capacitor stack, a CMOS-Logic, wherein further, the neural tissue stimulator comprises an interposer layer comprising holes for the multiple of microneedles and a lid. The neural tissue stimulator is characterized in, that the chip is located on one surface of the interposer layer and that the lid and the interposer layer form a capsule for the chip. Further, the neural tissue stimulator is adapted to be electrically self-sufficient.

The invention discloses a dynamic image motion correction method based on a graph neural network, and the method comprises the following steps: a), constructing a target region trajectory tracking model based on the graph neural network, and achieving the high-precision motion trajectory modeling; b) analyzing an image displacement mode in real time through a dynamic discrimination algorithm; and c) realizing adaptive image motion correction based on the target area track features. According to the method, the problem of complex motion trail modeling limitation caused by dependence on fixed template matching in a traditional method is innovatively solved, and the problem of spatial-temporal characteristic aliasing caused by unsteady state deformation of nervous tissues is effectively solved. According to the technical scheme, the dependence on a hardware synchronization signal acquisition module is eliminated, the resource configuration requirement of the edge computing equipment is remarkably reduced, and meanwhile, the multi-scale time sequence integration efficiency is improved. According to the method, dynamic imaging reconstruction of subcellular neural activities can be realized, and dynamic change details in a target neuron issuing process can be accurately restored.

The invention relates to the technical field of neurosurgical operation simulation, and provides a method for transmitting grid deformation in real time in neurosurgical operation simulation, which comprises the following steps: S1, carrying out input detection, including active interactive input for simulating left and right hand virtual surgical instrument operation and passive continuous input for simulating nervous tissue self deformation, so as to obtain collision point data; s2, positioning and extracting target vertex data based on the collision point data; s3, determining a nearest vertex based on the extracted target vertex data; s4, triggering conditions are judged, and different grid deformation modes are selected based on different triggering conditions; s5, calculating actual action point offset according to the selected grid deformation mode, and dynamically generating a deformation action point; and S6, driving neural tissue grid deformation real-time updating and physical synchronization based on the dynamically generated deformation action points. High-precision deformation simulation and low-delay tactile feedback are achieved, and the authenticity and practical operation value of neurosurgery operation training are remarkably improved.

Systems, apparatuses, and methods described herein facilitate the placement of spinal cord stimulator (SCS) electrode in relationship to neural tissue of the spinal cord based on electromyography (EMG) data. The systems, apparatuses, and methods are designed to assist physicians and surgeons target specific neurophysiological locations through stimulation and subsequent visualization of EMG activity in response to stimulation to more precisely identify the location of the SCS electrodes that will maximize the intended therapeutics effects of SCS.

According to an aspect of the present inventive concept there is provided a system for determining an estimate of an anatomy of neural tissue of a subject. The system comprises an electrode arrangement comprising a plurality of electrodes, wherein different electrodes in the plurality of electrodes are configured to be arranged in different electrode locations adjacent the neural tissue, wherein the plurality of electrodes is configured to receive a plurality of stimulation signals, a sensor arrangement configured to generate indications of changes in at least one of a neural activity or a physiological activity in response to the stimulation signals and a processing unit, configured to receive data representing relations between the plurality of stimulation signals and the indications of changes in the neural activity or physiological activity, wherein the processing unit is configured to generate the estimate of the anatomy of the neural tissue of the subject.

The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3):(1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGFβ family signal transduction pathway inhibiting substance and / or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state,(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.

Provided is an intravascular device for sensing or stimulating activity of neural tissue and having excellent delivery to blood vessels and high sensitivity of sensing or stimulation. An intravascular device (1) configured inside a blood vessel of a living organism, the first end portion (1a) of which has an electrode for sensing or stimulating activity of neural tissue located outside the blood vessel, the intravascular device (1) having: a wire member (10) having electrical conductivity; at least one electrode member (20) provided at the first end portion (1a) and electrically connected to the wire member (10); and a step difference reducing portion (30, 40) that reduces a step difference resulting from an outer diameter difference between the outer diameter of the electrode member (20) and the outer diameter of the wire member (10), the electrical resistance value between the electrode member (20) and the second end portion (1b) of the wire member (10) on the opposite side from the first end portion (1a) being 100 Ω or less.

The invention relates to a neural tissue unit for use in implantation into the nervous system of a human or non-human mammal, wherein said neural tissue unit contains differentiated post-mitotic neuronal cells in an extracellular matrix, said unit being obtained from a cellular microcompartment comprising a hydrogel capsule surrounding the neural tissue unit, and said hydrogel capsule being at least partially removed before use of the neural tissue unit. The invention also relates to a process for preparing such a neural tissue unit.

In some embodiments, a method of providing a neurostimulation therapy to a patient, comprises: generating electrical pulses, by an implantable pulse generator (IPG), comprising respective bursts of a plurality of anodic pulses with each anodic pulse being separated by a time gap, wherein (1) the plurality of anodic pulses comprise successively increasing charge; (2) the plurality of anodic pulses are charge limited to be sub-threshold; (3) each burst of anodic pulses is followed by a discharge phase of intermittent time periods to discharge charge build up from the anodic pulses; and (4) each successive intermittent time period increases in time through the discharge phase to avoid action potential (AP) generation; and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient.

Techniques for measuring single synaptic signals under varying experimental conditions include controlling a video recording microscope to capture, at multiple different times, a first imaged area in a sample holder as a video frame when the sample holder is disposed on a stage and holds a sample of neuronal tissue combined with at least one fluorophore that emits a corresponding electromagnetic wavelength in a synapse during synaptic activity. At least one synaptic region of interest is determined based on a group of pixels in the first imaged area that record electromagnetic emissions from the fluorophore at the different times. An ordered time series of emission intensity is recorded in each of the synaptic region of interest. Peak emission intensity values in the time series are corrected for transmitter label transients. The ordered time series with corrected peak emission intensity values are stored in a data structure with a standard format.

This invention relates to the field of microfluidic chip technology, specifically to a dynamic microfluidic chip device, its preparation method, and its applications for studying CAR-T therapy for gliomas. The preparation method includes: fabrication of the microfluidic chip; reconstruction of neural tissue; reconstruction of the blood-brain barrier; and simulation of the glioma microenvironment. The dynamic microfluidic chip device includes a microfluidic chip; the microfluidic chip includes, from left to right, a vascular channel, a brain parenchyma channel, a tumor channel, and a subarachnoid channel; each of the vascular channel, brain parenchyma channel, tumor channel, and subarachnoid channel includes a cell culture chamber with an inlet on one side; the cell culture chambers of the vascular channel and the subarachnoid channel have corresponding outlets on the other side. The applications include: CAR-T cell infusion; observation of transmembrane migration; and detection of biomarkers. This invention, through the dynamic microfluidic chip device, its preparation method, and its applications, aims to achieve more accurate in vitro evaluation of CAR-T cell therapy.

A laryngeal pacemaker is configured for external placement on skin of a patient to produce respiration stimulation signals. An implantable stimulation electrode delivers the respiration stimulation signals to adjacent target neural tissue for vocal fold abduction during respiration of the recipient patient. A triaxial accelerometer produces a body motion signal reflecting energy expenditure of the recipient patient. A respiration sensor includes a flexible skin-transferrable printed tattoo electrode having a tetrapolar configuration for impedance pneumography measurement to produce a sensed respiration signal for the laryngeal pacemaker. The respiration sensor is configured for transfer and release by guided placement from a sensor applicator to the skin at the angulus sterni of the recipient patient. And the laryngeal pacemaker is configured to interpret the body motion signal and the sensed respiration signal to make a real time determination of respiratory phase and frequency for adaptively adjusting the respiration stimulation signals accordingly.

A microelectrode probe for implantation in soft tissue, comprising a sheath of flexible polymeric material divided by a wall into a distal and a proximal compartment, said distal and proximal compartments being filled with a matrix of biocompatible material dissolvable or degradable in aqueous body fluids, and comprising a centrally disposed electrically conductive core passing through the wall and attached to it. The core is insulated at its proximal portion, from which it extends to a holder for attachment to tissue other than said soft tissue. The sheath and the core extending distally from said holder are embedded in a kindred additional matrix. The invention also discloses a method for its manufacture, an array comprising two or more microelectrode probes and a microelectrode probe for incorporation into the array and a method for the manufacture of the array.

This disclosure relates to medical implant systems and apparatuses capable of treating a seizure condition through the use of recording and stimulating electrodes. The apparatus includes an internal pulse generator in communication with a wireless communication module; one or more recording electrodes in communication with the internal pulse generator, wherein the one or more recording electrodes are configured to monitor to detect one or more field potentials produced by neural tissue in proximity to the one or more recording electrodes; one or more stimulating electrodes in communication with the internal pulse generator, wherein the one or more stimulating electrodes are configured to stimulate the vagus nerve.

In some embodiments, a method of providing a neurostimulation therapy to a patient comprises: generating, by an implantable pulse generator (IPG), electrical pulses comprising a plurality of pulses having a uniform pulse width over time and a pulse amplitude that changes over time, and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient. The pulse amplitude may change sinusoidally, linearly, or exponentially over time.

The systems and methods described herein generally relate to adjusting a neurostimulation (NS) therapy based on drug pharmacokinetics of a patient. The systems and methods deliver an NS therapy to a portion of electrodes of a lead positioned proximate to neural tissue of interest, which is associated with a target region. The NS therapy is defined by stimulation parameters. The systems and methods determine a trigger event indicative of a drug being administered to a patient. The drug is configured to affect at least one of the neural tissue of interest or the target region. The systems and methods adjust one or more of the stimulation parameters based on the PS profile.

Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.

A method of providing therapy to a patient according to one embodiment includes generating an electrical noise signal by at least one noise generator controlled by a controller of a tunable noise system, partitioning the electrical noise signal into a plurality of discrete frequency bands, each of the discrete frequency bands having a corresponding bandwidth, delivering the electrical noise signal through one or more electrodes to the patient to target at least one of neural tissue or non-neural tissue of the patient, adjusting an amplitude of one or more of a voltage or current of the electrical noise signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted electrical signal based on feedback received from the patient, and delivering the adjusted electrical signal through the one or more electrodes to provide therapy to the patient.

A system for controlling selective stimulation of neural tissue of a subject is provided. Said system comprises a first electrode arrangement, comprising a plurality of electrodes, configured to be arranged in in relation to a first longitudinal position of the neural tissue, a second electrode arrangement, comprising at least one electrode and configured to be arranged at a second longitudinal position of the neural tissue, and a stimulation signal generating unit. The stimulation signal generating unit is configured to generate a first intermittent current waveform comprising a first pulse and a second intermittent current waveform comprising a second pulse, for causing interferential stimulation of a plurality of nerve fibers of the neural tissue. The stimulation signal generating unit is further configured to generate and output a blocking pulse to the second electrode arrangement, for temporally selectively blocking propagation of signals through the neural tissue at the second longitudinal position.

The invention relates to a neural tissue unit for use in implantation into the nervous system of a human or non-human mammal, wherein said neural tissue unit contains differentiated post-mitotic neuronal cells in an extracellular matrix, said unit being obtained from a cellular microcompartment comprising a hydrogel capsule surrounding the neural tissue unit, and said hydrogel capsule being at least partially removed before use of the neural tissue unit. The invention also relates to a process for preparing such a neural tissue unit.

The present application proposes a system for differential recording in real-time navigation, connectable to an electrical lead having at least two electrodes, comprising: at least one electrical lead having a longitudinal axis and a distal end and at least two electrodes for recording electrical signals; a memory configured for storing a differential signal between the at least two electrodes and a reference indication of electrical signals associated with a neural tissue; a processing circuit, wherein the processing circuit: during advancement of the at least one electrical lead, computes in real-time a differential signal between electrical signals recorded from the at least two electrodes, processes the differential signal and the reference indication of electrical signals associated with the neural tissue; and computes an anatomical position of the electrical lead based on the processing, wherein the computing an anatomical position comprises estimating a proximity between at least one of the electrodes or the distal end of the electrical lead and a boundary between anatomical regions.

The present disclosure pertains to universal and adoptable cell culture substrates designed for applications in biology, medicine, pharmaceutics, and other relevant fields. The disclosure particularly focuses on processes and methodologies for manufacturing such substrates, which prove advantageous for both non-neural (cells exhibiting robust adhesion and weak cell-cell junctions, as well as cells with regular adhesion and cell-cell junctions) and neural cell sheet engineering. These substrates aim to enhance cell adhesion, stimulate cell growth, and enable rapid and uniform harvesting of cell sheets. Additionally, the present invention introduces a scaffold-free method for tissue engineering, facilitating the creation of a 2D / 3D neural tissue construct featuring unidirectional neuron bundles.

The present invention provides a method for maintaining a continuous epithelial structure of a retinal tissue including culturing the retinal tissue in a medium comprising a methyl group donor or a substrate of the methyl group donor at a concentration at which cell differentiation of a neural retinal progenitor cell is suppressed, and a neurite extension inhibitor at a concentration at which neurite extension is suppressed.

The invention relates to the technical field of small nucleic acid drug targeted delivery, and particularly provides an oligonucleotide delivery ligand compound, a conjugate and application thereof. The ligand compound provided by the invention has the effect of improving the delivery capacity of oligonucleotide in extrahepatic tissues such as eye tissues, adipose tissues, nervous tissues and skeletal muscle tissues, and can effectively deliver siRNA drugs to target tissues; it is helpful to alleviate, prevent and / or treat pathological conditions or diseases caused by abnormal expression of specific genes in tissue cells.

The present invention relates to preparation and use of biocompatible and electrically conductive 3D hydrogels comprising nanocellulose fibrils, such as disintegrated bacterial nanocellulose, plant derived nanocellulose, tunicate derived nanocellulose, or algae derived nanocellulose, together with carbon nanotubes or graphene oxide, as a biocompatible and conductive 3D hydrogel for diagnostics and intervention to mimic or restore tissue and organ function. Biocompatible conductive 3D hydrogels described in this invention can be extruded, casted or injected. The 3D hydrogels described in this invention are cohesive 3D structures and provide electrical conductivity in wet form. 3D hydrogels described in this invention can be further crosslinked using divalent ions such as Calcium ions which improve mechanical stability. Such crosslinking can take place in an animal or human body in a physiological environment after injection into the tissue. 3D hydrogels are biocompatible and show preferable mechanical properties and electrical conductivity through printed lines (4.10−1 S cm−1). The 3D hydrogels prepared by this invention are suited as bioassays to screen drugs against neurodegenerative diseases such as Alzheimer's and Parkinson's, study brain function, and / or be used to link the human brain with electronic and / or communication devices. They can also be injected to replace neural tissue or stimulate guiding of neural cells. They can also be used to inject into the heart and stimulate the heart by using electrical signaling or to repair myocardial infarction.

Disclosed is an implantable device for measuring an evoked neural response. The implantable device comprises a stimulus source configured to deliver neural stimuli via one or more stimulus electrodes to neural tissue, the neural stimuli being configured to evoke a neural response from the neural tissue. The implantable device further comprises a measurement amplifier configured to amplify a signal sensed between a first input of the measurement amplifier by a first measurement electrode and a second input of the measurement amplifier by a second measurement electrode subsequent to a provided neural stimulus, the sensed signal comprising the evoked neural response. The implantable device further comprises a control unit configured to: control the stimulus source to deliver a neural stimulus; and measure the evoked neural response of the amplified sensed signal. The implantable device further comprises one or more impedance elements configured to provide a negative impedance to at least one of the first and second inputs of the measurement amplifier.

To provide a nervous tissue imaging system that does not require fluorescent dyes, fluorescent tissue probes or other fluorescent markers to increase visual contrast between the nerve / dura mater and non-nervous tissue surrounding the nerve / dura mater.SOLUTION: The system includes a housing containing an excitation light source, optically coupled with a source optical train, where the excitation light source emits excitation light in a first wavelength range, which can be in a near ultraviolet light range, to illuminate a tissue region of interest including healthy nervous tissue and healthy non-nervous tissue. The excitation light is in the first wavelength range that causes the healthy nervous tissue, in response to being illuminated with the excitation light, to endogenously autofluoresce and emit first autofluorescence light at a first luminance in a second wavelength range. The healthy non-nervous tissue, in response to being illuminated with the excitation light, either avoids emitting any autofluorescence light in the second wavelength range, or endogenously autofluoresces and emits second autofluorescence light in the second wavelength range at a second luminance that is lower than 50%of the first luminance.SELECTED DRAWING: Figure 1

This document relates to a catheter system that delivers electrical stimulation to targeted neural tissue proximate the spinal column of a patient. The catheter system can include an inner shaft comprising an inner shaft electrode attached to a distal end of the inner shaft and an outer sheath comprising an outer sheath electrode attached to a distal end of the outer sheath, the outer sheath defining a lumen sized to receive the inner shaft. The inner shaft is movable within the lumen relative to the outer sheath to position the inner shaft electrode and the outer sheath electrode for delivering the electrical stimulation to the targeted neural tissue.

Methods and systems for improving or enabling delivery of antibodies, immunoglobulin receptors, or immunotherapy agents across the Blood-Brain Barrier (BBB) are disclosed. Exosomes are derived from stem cells, immune cell progenitors, or immune cells, and are loaded with an antibody, immunoglobulin receptor, or antibody fragment. Focused energy, preferably low-intensity focused ultrasound, is applied to a region of the BBB of a patient, and loaded exosomes are administered to the patient. Exosomes target the region for delivery of the loaded antibody, receptor, or fragment, either by traversing the BBB at the region or releasing the loaded antibody to neural tissue at the region.