380 results about "Functional connectivity" patented technology

The invention discloses a multi-modal dynamic structure-function multilayer brain network calculation method and terminal, and the method comprises the steps: obtaining a multi-modal brain image, and carrying out the preprocessing of the multi-modal brain image, and obtaining a target multi-modal brain image; constructing a dynamic functional brain network, a structural brain network and a grey matter morphological similar brain network according to the target multi-modal brain image; and calculating according to the dynamic functional brain network, the structural brain network and the grey matter morphological similar brain network through a network topology similarity principle to obtain structural-functional coupling. According to the method, after MRI data is preprocessed, a morphological brain network is obtained through sMRI, a functional connection brain network is obtained through fMRI, a structural connection brain network is obtained through DTI, a multi-layer brain network coupling index is calculated, while structural and functional connection is considered, morphological information is also considered, then exploration of the model on the brain structure and function is improved, and the method has the advantages of being high in practicability and the like. And more comprehensive and accurate brain structure and function information can be provided.

The invention discloses a functional connection and dynamic model-based anatomical connection prediction method, which comprises the following steps of: firstly, constructing a neurodynamic model, taking a random matrix as initial input, combining functional connection data and the neurodynamic model, and generating a coupling matrix which is more in line with neurodynamic characteristics by iteratively optimizing the random matrix; and the coupling matrix is used for predicting anatomical connection and replacing anatomical connection data to construct a high-precision brain model. According to the method, the initial random matrix is iteratively optimized, so that the generated coupling matrix gradually approaches real anatomical connection, non-intrusive anatomical connection prediction is realized, dependence on intrusive structure connection data is remarkably reduced, and compared with an existing neurodynamics modeling method depending on dMRI data, the method has the advantages that the modeling efficiency is improved, and the modeling cost is reduced. The used DMF model achieves higher fitting degree in structure and function, has higher flexibility and adaptability, is beneficial to revealing deep connection between functional connection and anatomical connection, and provides more efficient technical support for brain network research.

The invention provides a multichannel transcranial direct current stimulation cognitive function assessment method and system, and belongs to the field of neuroscience and brain cognitive function assessment. The method comprises the steps that electroencephalogram signal data of a subject under multi-channel transcranial direct current stimulation are collected and preprocessed; respectively performing micro-state analysis, brain function connectivity analysis and oscillation power analysis on the preprocessed data; constructing a linear mixed effect model, and inputting the results of the micro-state analysis, the brain function connectivity analysis and the oscillation power analysis into the model for quantitative evaluation of the cognitive function state; and a time sequence database is constructed, and the time sequence database is used for storing cross-time-point analysis results and analyzing the long-term change trend of the cognitive function based on a statistical model. Dynamic, accurate and high-temporal-spatial-resolution evaluation of the cognitive state of the subject is achieved, the long-term change trend of the cognitive state is dynamically monitored, and technical support is provided for early warning and rehabilitation effect tracking of neurodegenerative diseases.

The invention provides a mental disease identification method based on pulse structure-functional brain network coupling, belongs to the technical field of intelligent auxiliary medical diagnosis, and effectively solves the technical problem of neglected neurobiological mechanism between structural connection and functional connection in the traditional mental disease diagnosis process. According to the technical scheme, firstly, functional and structural brain networks are extracted from functional magnetic resonance imaging and diffusion tensor imaging; then, information feature maps of the two brain networks are extracted through a BrainNetCNN; then constructing a pulse coupling neural network to learn a brain structure-function coupling mechanism so as to obtain pulse structure-function coupling; and finally, inputting the obtained coupling information into a classification layer to obtain a disease recognition result, and training and optimizing the result by using a cross entropy loss function. The beneficial effects of the invention are that the method is helpful for deep understanding of neurological mechanisms of mental diseases, and has wide application prospects in clinical application.

The invention belongs to the field of electroencephalogram signal processing, and provides a time-frequency space electroencephalogram emotion recognition method based on three-dimensional space position embedding, which comprises the following steps of: firstly, constructing a three-dimensional electrode space position matrix based on an international 10-20 system standard, determining a space adjacency relation between electrodes, and calculating a phase locking value to obtain a functional connection matrix; then, deep feature fusion of an electrode spatial position matrix and a functional connection matrix is realized by adopting a hierarchical cross Transform architecture, the spatial position matrix represents spatial distribution features of a cerebral cortex region, and the functional connection matrix quantifies phase synchronization features of cross-brain region neural oscillation and simulates a brain spatial topological structure; and finally, extracting time, frequency and spatial features of the electroencephalogram signals through combination of a graph attention network and bidirectional long-short-term memory with an attention mechanism for emotion recognition. The method can effectively extract space structure information highly related to the emotional state, and significantly improves the accuracy of emotion recognition.

The invention discloses a Parkinson's dyskinesia individualized SCAN network positioning method based on a multi-modal image and deep learning. The method comprises the steps of obtaining multi-modal medical image data, preprocessing the multi-modal medical image data, obtaining a multi-modal structure image and functional connection data, and calculating a spontaneous neural activity index of a whole-brain voxel level; taking a priori brain region related to the spontaneous neural activity index and dyskinesia as a seed point, constructing a seed point voxel function connection graph representing individual brain function connection, and performing nonlinear feature fusion and extraction through the deep learning network model; the bilinear attention network is adopted to capture the interaction information of the feature data and the individual dyskinesia symptom which is significantly related, an individualized SCAN network positioning result is obtained, the structure-function coupling characteristics of the individual brain are comprehensively described, the cross-modal pathological features related to the dyskinesia can be more sensitively recognized, and the accuracy and accuracy of the diagnosis and treatment of the dyskinesia can be improved. And the accuracy and robustness of abnormal brain region detection are obviously improved.

The invention relates to the technical field of medical care informatics, and discloses an intelligent post-stroke cognitive impairment assessment method based on brain network dynamic reconstruction, which comprises the following steps: acquiring multi-modal brain image data of a patient, dynamically compensating the difference between haemodynamic delay and white matter conduction velocity through a nerve-blood vessel coupling model, and calculating the post-stroke cognitive impairment; precise space-time alignment of function and structure signals is realized; a pulse neural network dynamic entropy change model is constructed based on the alignment data, functional connection strength change is coded into a pulse distribution sequence, and Gamma wave band synchronization enhancement and other compensatory features are extracted; constraining rationality of brain network reconstruction by adopting an energy optimal transmission model, and generating a compensatory thermodynamic diagram; and real-time calculation of the edge end is realized through pulse time sequence compression coding. The limitation of traditional static analysis is avoided, the algorithm achieves microsecond response on embedded equipment through the pulse coding technology, and a reliable stroke rehabilitation evaluation tool is provided for primary hospitals.

The invention discloses a multi-modal feature combined depression auxiliary diagnosis system. The system comprises a sampling unit which is used for constructing a multi-modal depression data set by acquiring a depression screening scale, an electroencephalogram, a magnetoencephalogram and functional magnetic resonance imaging based on acquisition equipment; the feature extraction unit is used for extracting multi-modal brain features based on the depression data set, and the multi-modal brain features comprise power spectral density obtained by electroencephalogram signals, event-related potential, micro-state, prefrontal lobe gamma frequency band power spectral density obtained by magnetoencephalogram and event-related magnetic field; gray matter volume and resting state functional connection density are obtained through functional magnetic resonance imaging; a data preprocessing unit; the diagnosis model unit is used for constructing a multi-modal depression diagnosis model and training the model on the basis of the multi-modal brain features in combination with a fusion strategy; and an analysis and prediction unit. The extracted features are comprehensive and reasonable, the defect of each mode is overcome by the feature fusion method, and the fused features are advanced.

A juvenile depression cognitive impairment subtype classification and prognosis prediction method relates to the technical field of medical treatment, and mainly comprises the following steps: performing clinical evaluation and therapeutic response evaluation on a subject, performing MRI and magnetoencephalogram data acquisition, constructing a whole brain MSN of the subject, identifying MSN abnormal characteristics, obtaining functional connection change of a frequency band when magnetoencephalogram is abnormal, and determining the cognitive impairment subtype classification and prognosis prediction of the cognitive impairment subtype of the subject. A subtype classification model is established by fusing the MSN and cognitive function evaluation data, and a prognosis prediction model is established by analyzing MSN abnormal features, functional connection changes of frequency bands during abnormality, multi-dimensional treatment reactions and high-risk behaviors. According to the method, different levels of fusion measurement are carried out on the juvenile depression with cognitive function impairment brain mechanism through multi-modal brain images, a subtype classification model with diagnosis and treatment values is established, and a prognosis prediction model with clinical transformation potential is constructed; therefore, a theoretical basis and a technical means are provided for individualized precise diagnosis and treatment of the cognitive impairment of the juvenile depression.

The invention discloses a GNN-based multi-mode brain imaging infantile autism spectrum disorder detection method, which is characterized in that a function connection network which is different from traditional characteristics and takes an edge as a center is introduced, higher-order information interaction in a brain interval is mined, and a brain function abnormity mode of an infantile autism patient is accurately captured. Meanwhile, integrating brain imaging data and clinical text information into a unified multi-modal graph by utilizing the graph structure learning ability of GNN, capturing a complex nonlinear relationship, and realizing deep combination of multi-modal features; according to the method, the accuracy and robustness of autism detection are effectively improved, technical support is provided for personalized diagnosis and treatment, key technical problems in multi-modal data fusion and brain network analysis are solved, and the accuracy and reliability of ASD early diagnosis are improved.

The invention discloses a brain age prediction method based on structure and functional MRI image multi-modal fusion, and belongs to the technical field of medical image processing. The method comprises the following steps: firstly, extracting spatial structure characteristics of a structural magnetic resonance image by using DenseNet121; meanwhile, a function connection matrix is constructed according to the time sequence of the functions, a graph structure is constructed on the basis of the matrix, the characteristic of each node is the connection strength between the node and other nodes, and the edge is converted into sparse graph representation from the absolute value of the connection strength; then extracting functional features by using a graph attention network, and fusing the structure and the functional features by using a cross attention mechanism; and applying a gating mechanism fusion result to a brain age prediction regression task. According to the brain age prediction method, complementary information of multi-modal data is fully utilized, and biological markers of brain aging can be accurately captured.

The invention discloses a functional connection network analysis method based on a group sparse attention converter. The method mainly comprises the following steps: preprocessing brain functional magnetic resonance imaging data output by a functional magnetic resonance instrument; dividing the preprocessed brain function image into a plurality of brain regions according to a standard; based on Pearson correlation and group sparse characteristics, calculating a dependency relationship between brain regions, and respectively constructing an initialized brain network and a guidance network; taking the initialized brain network as the input of a group sparse attention converter, and carrying out learning under the assistance of a guidance network so as to learn a brain network with a group similar topological structure; and subsequent classification is carried out. The method integrates priori knowledge of a population level, allows more comprehensive modeling across multiple brain networks, is designed for end-to-end adaptive learning, dynamically updates the brain networks through back propagation, and significantly improves the construction and analysis performance of the brain networks.

The invention discloses a data classification method and system based on a deep multi-path attention adaptive graph convolutional network, and relates to the technical field of medical image processing. Rs-fMRI data is acquired and preprocessed to obtain a BOLD sequence, a function connection feature vector is constructed and input into a DMAGCN model, and finally an optimal model is acquired through five-fold cross validation for classification. The data quality is guaranteed through data preprocessing, and a foundation is laid for accurate analysis. Functional connection feature vectors effectively represent data, after a model is input, a Transform backbone network and an MLP branch network can extract multi-source domain features, non-imaging data are utilized in combination with a graph network, the model can learn rich features, and generalization and adaptability are enhanced. According to the method, the classification accuracy is improved, the performance is excellent when uncertain data classification such as autism spectrum disorder is processed, related disease research is promoted, and an efficient and reliable method is provided for medical data classification.

The invention relates to the technical field of cognitive defect evaluation, in particular to a brain connection mode detection method, device and equipment based on cognitive function defects. Firstly, a prediction model is constructed, the model obtains a brain weight network of a cognitive process through a machine learning algorithm by using a whole brain structure and functional connection group data of an individual, and then abnormal brain connection group modes among different diagnosis groups are compared by adopting a large-scale multivariate edge-by-edge analysis method. By comparing abnormal connection group features of each diagnosis group obtained by a large-scale multivariate edge-by-edge analysis method with connection group features related to cognition, whether the anomalies relate to a core brain region related to cognition or not can be identified, so that whether the anomalies are related to cognition defects or not is determined. By comparing the sharing degree and difference of abnormal connection group modes among different diagnosis groups, whether the cross-diagnosis cognitive defect is from shared macroscopic brain network abnormality or from respective diagnosis specific neuropathology basis can be judged.

The invention relates to the technical field of multi-modal nerve images and machine learning, in particular to an execution function prediction method, device and equipment based on a Riemannian manifold and a multi-modal connection group. According to the method, the structure connection group and the function connection group are mapped to the agent space of the Riemannian manifold, the multi-modal brain connection group is constructed, prediction modeling is carried out in combination with the random forest algorithm, and therefore the model capable of effectively predicting the performance of the individual execution function is constructed; projecting the extracted individual connection group to a tangent space by synthesizing data of the structure connection group and the function connection group, and constructing a Tangent connection matrix reflecting individual differences; and connecting the matrix by using a random forest algorithm and combining with a Tangent. The method not only overcomes the limitation of dependence on a single data source, but also optimizes the information extraction process, improves the capability of identifying the related mode from the complex neural network data, and improves the accuracy and robustness of the prediction result.

The invention discloses a white matter fiber bundle structure-function connection coupling method based on a distance function. The method comprises the steps that brain imaging data are collected and preprocessed; extracting white matter fiber bundle structure attributes and function signals of the preprocessed brain imaging data; constructing a structure connection matrix and an individualized function connection matrix according to the white matter fiber bundle structure attributes and the function signals; measuring the connection weight similarity between corresponding columns of the structure connection matrix and the function connection matrix through a distance function, and carrying out white matter fiber bundle structure-function connection coupling according to the connection weight similarity; through the method, the relationship of the white matter fiber bundle structure and function of the brain can be quantified, and the method is suitable for brain structure and function analysis based on the white matter fiber bundle and research on brain development and mental diseases.

The invention discloses a time interference electrical stimulation system for suppressing, controlling and adjusting, which comprises an image acquisition module for acquiring functional magnetic resonance images to acquire functional connection data; the stimulation module is used for respectively generating time interference electrical stimulation waveforms in the plurality of stimulation areas so as to stimulate the corresponding stimulation areas and adjusting stimulation parameters; the evaluation module is electrically connected with the image acquisition module and the stimulation module, acquires cognitive emotion evaluation data, and obtains an emotion and cognitive neural circuit regulation result by combining the emotion evaluation data and the function connection data as an inhibition control capability evaluation index; and the control module is electrically connected with the stimulation module and the evaluation module, and controls the stimulation module to adjust the stimulation parameters based on the emotion and cognitive neural circuit adjustment result. According to the system, effective time interference electrical stimulation is carried out on a plurality of inhibition control intervention brain regions, stimulation parameters are improved by implementing stimulation effect evaluation, and a favorable adjustment means is provided for inhibition control of multi-region and complex network modulation.

The invention discloses a transcranial magnetic stimulation positioning system based on a deep effect brain region, and the system comprises the steps: obtaining the data of a tested magnetic resonance image, which comprises a resting state functional image and a high-resolution T1 structure image; performing data preprocessing on the function image and the structure image, and establishing an individual space; the deep effect brain region template is converted to an individual space through nonlinear registration, and a target region of interest is defined; calculating functional connections between voxels of the deep effect brain region and the cortical region by adopting a Granger causality analysis method based on wavelet transformation; and screening Top block masses according to the functional connection strength, calculating the gravity centers of the Top block masses, and determining individualized stimulation targets in combination with the skull surface distance. According to the method, spontaneous brain activity function variation of the brain of an individual and the brain signal propagation direction are fully considered, accurate positioning of different individual levels is achieved, relatively stable cortex stimulation targets are obtained, and therefore the clinical curative effect of TMS is optimized.

The invention discloses a disturbance of consciousness stimulation regulation and control system and method fused with electroencephalogram connection recognition. The system comprises a simulated electroencephalogram signal data acquisition stage, a connection recognition analysis stage, a stimulation parameter optimization stage and an executable stimulation instruction conversion stage. The method has the following advantages and effects that a whole-electroencephalogram activity distribution diagram is generated by simulating an electroencephalogram signal data acquisition stage, a key connection area is identified, and a brain function connection map is generated by utilizing a function connection analysis network and a phase synchronization algorithm in a connection identification analysis stage; in the stimulation parameter optimization stage, space-time correlation between a whole electroencephalogram activity distribution map and a brain function connection map is established, a multi-objective optimization algorithm is adopted to generate an optimized stimulation parameter set through a fusion network, and finally, in the executable stimulation instruction conversion stage, the optimized stimulation parameter set is converted into an executable stimulation instruction based on a self-adaptive control model. Therefore, the accuracy and the self-adaptive capability of electroencephalogram signal stimulation regulation and control are remarkably improved.

The invention belongs to the field of brain-computer interfaces, and particularly relates to a decision-making brain-computer method and device based on virtual reality induction, which combines two psychological decision-making tasks of auditory stimulation and visual stimulation and utilizes virtual reality equipment to create a decision-making brain-computer interface normal form of panoramic interaction, so that a subject can fit a scene facing a decision in reality to the greatest extent, and the accuracy of decision making is improved. The sensory motor cortex is effectively activated, and cooperative activation of the cognitive-motor neural network is induced; a decision interaction feedback link is added to enhance a decision stimulation effect and a cranial nerve feedback mechanism by analyzing related characteristics P300, power spectral density and brain network function connection quantity of the acquired electroencephalogram signals during normal form execution decision reaction. Compared with the prior art, the method has the advantages that immersive audio-visual stimulation and task interaction feedback are brought into a decision-making brain-computer interface for the first time, and a new scheme with neural rehabilitation and human-computer interaction functions is provided for neural feedback training of cognitive functions.

The invention discloses a brain region correlation analysis system and method for autistic children. The system comprises a brain region division module used for dividing the cerebral cortex into a plurality of brain regions; the training data set construction module is used for constructing a training data set, and each training sample comprises a sensor space function connection matrix and a source space function connection matrix corresponding to the sensor space function connection matrix; the signal preprocessing module is used for acquiring a real electroencephalogram signal and calculating a real value of a corresponding sensor space function connection matrix; the deep learning mapping module is used for learning a mapping relation from the sensor space function connection matrix to the source space function connection matrix and outputting a predicted value of the source space function connection matrix; and the brain region correlation analysis module is used for calculating the correlation between the brain regions. The method can be used for accurately analyzing the correlation between the brain areas of the autism children.

The invention belongs to the technical field of deep learning and brain science, and particularly relates to an ADHD graph convolution model construction method based on fMRI spatial-temporal characteristics, and the method comprises the following steps: processing resting state functional magnetic resonance data; fMRI sequence processing: randomly cutting fMRI sequences from different sites to obtain fMRI sequences with consistent sequence lengths, and obtaining a functional connection matrix according to Pearson's correlation; model input data: the model input data is composed of an fMRI sequence, ADHD phenotype information and a functional connection matrix, and the input data is divided to obtain a training set, a verification set and a test set; constructing a model; and model training: model evaluation. According to the method, the gated feature fusion module is proposed to fuse the captured fMRI features to obtain the spatial-temporal features, the phenotypic information of the subject is considered, the ADHD graph convolution model based on the fMRI spatial-temporal features is constructed, and the classification accuracy of ADHD diseases is improved.

The invention is applicable to the technical field of brain discipline, and provides a brain function connection modeling and coding method, device and equipment and a storage medium, the method comprises the following steps: constructing a first brain function connection graph according to rs-fMRI data, performing graph enhancement processing on the first brain function connection graph by adopting a preset adaptive graph enhancement strategy to obtain a second brain function connection graph, performing feature coding on the second brain function connection graph by adopting a preset topological attention coding strategy to obtain corresponding graph features, and performing feature projection on the graph features by adopting a preset feature projection strategy to obtain brain function discrimination features for brain function connection classification, therefore, the generated brain function discrimination features can accurately identify subtle differences of different types of brain function connections, and high-accuracy discrimination can be realized whether normal and abnormal brain function states or brain connection modes corresponding to different diseases, so that powerful support is provided for clinical aid decision making, and the accuracy of brain function discrimination is improved. And the accuracy and scientificity of brain disease diagnosis and treatment can be improved.

The invention provides an individualized TMS target positioning method and system for spastic cerebral palsy children, and aims to realize TMS precise nerve regulation and control for different types of SCP children. According to the method, the structural features of the healthy child are obtained, and after image processing, accurate division of the SCP child brain region is achieved, the defects of a current brain injury child brain region spectrogram are overcome, and a basis is provided for seed point selection of different SCP symptoms; multi-modal image parameter features are further scanned, whole-brain voxel correlation analysis is performed based on seed points to construct functional connection diagrams, the crossed and overlapped functional connection diagrams are searched to serve as a liability focus network of different symptoms, a voxel set close to the scalp surface serves as a TMS target, and SCP child treatment targets of different clinical symptoms are accurately positioned. Based on a focus network mapping technology, functional connection characteristics related to different symptoms or symptom complexes are better positioned, a specific brain network is identified, and an accurate intervention target is provided for TMS treatment.

The invention discloses a multi-mode autism diagnosis method and system based on resting state fMRI and phenotypic text information, a medium and a product. FMRI and phenotypic text information are processed through a pre-trained heterogeneous graph neural network model to output a diagnosis result; the resting state fMRI is utilized to construct a brain function connection graph, and the phenotypic text information is coded into a two-dimensional vector; respectively extracting brain connection feature embedding of the fMRI mode and phenotype information feature embedding of the text mode; fusing the feature embedding in the two modes through a gating fusion network; and constructing a heterogeneous group diagram based on the fusion features and phenotypic information similarity, and obtaining group diagram features on the heterogeneous group diagram by using dual-channel information aggregation and adaptive feature fusion to output a diagnosis result. The invention aims to improve the accuracy of autism diagnosis by using multi-modal information, and can be applied to the fields of neuroimaging analysis, intelligent medical treatment and the like.

The invention provides a network graph generation method based on brain image data, and relates to the technical field of brain connection.The method comprises the steps that brain image data (including fMRI data and sMRI data) of a target object are obtained, the brain image data are preprocessed and registered, and registered brain graph data are obtained; dividing the brain map data into a plurality of brain regions based on a set brain map, and determining time sequence data of each brain region; based on the time sequence data of each brain region, a function connection matrix is determined, and non-diagonal elements in the function connection matrix reveal the connection strength between the brain regions; and based on the brain region and the functional connection matrix of the brain map data, generating a brain network map (which can be visualized) of the target object. According to the scheme, the sMRI data (the precision is millimeter level) is introduced as a registration basis, so that the registration precision can be improved, and a brain network diagram with higher precision can be generated subsequently.

The invention belongs to the technical field of artificial intelligence and physiological signal processing, and discloses an electroencephalogram emotion recognition method and system based on a multi-task self-supervision and dynamic graph fusion network, and the method comprises the steps: obtaining and preprocessing electroencephalogram and other physiological signals, and extracting multi-band energy features; constructing a dynamic graph structure, taking electrodes as nodes, taking frequency band energy as characteristics, and fusing spatial distance and functional connectivity to generate a dynamic adjacency matrix; designing multi-task self-supervised pre-training, including spatial jigsaw, frequency jigsaw and cross-modal contrast learning tasks, to learn general characterization; a dynamic graph fusion network is adopted to carry out end-to-end training, and a shared feature extraction module of the dynamic graph fusion network realizes adaptive fusion of multi-modal features by utilizing Chebyshev graph convolution and embedding a cross-modal attention mechanism; the classification module sets an independent classification head for each task, and optimization is carried out through a joint loss function. According to the method, the accuracy and generalization ability of electroencephalogram emotion recognition are remarkably improved.

The invention discloses a brain function magnetic resonance imaging data analysis method based on a contrast graph neural network, and the method comprises the steps: firstly carrying out the data enhancement of a brain function connection graph, and simulating the heterogeneity of brain function magnetic resonance data, so as to improve the diversity of a data set; secondly, the hidden space embedding features of the brain function connection diagram are efficiently learned by fusing a double-Hough-Laplacian diagram convolutional network and a contraction incentive mechanism; the embedded features are mapped to a group of prototype vectors, and prototype allocation codes corresponding to the embedded features are calculated by adopting a Sinkhorn-Knopp algorithm; performing exchange optimization on prototype codes between different enhanced brain connection diagrams of the same subject through a contrast learning strategy, and compelling codes of homologous subjects to be aligned at the minimum cost in combination with a cross entropy loss function; and finally, applying the pre-training model to a functional magnetic resonance imaging data set of the Alzheimer's disease, and carrying out interpretability analysis on learning features to improve the classification efficiency and pathological analysis of the Alzheimer's disease under a limited tag condition.

The present invention belongs to the field of rehabilitation therapy technology and discloses a longitudinal analysis method and system for magnetic resonance imaging data of mild brain injury. The method extracts BOLD signals from the magnetic resonance imaging data of subjects; constructs a symmetric positive definite sparse brain functional connectivity network set of subjects based on sparse inverse covariance matrix estimation; determines the brain functional connectivity network dictionary and sparse coefficient matrix in kernel space based on Riemannian manifold sparse coding; performs spatial distribution analysis of brain functional connectivity atomic networks; and performs longitudinal analysis of magnetic resonance imaging data of mild brain injury. By analyzing the differences in the spatial distribution of these highly present brain functional connectivity atomic networks in the brain, the present invention digs out brain functional connectivity imaging markers for distinguishing the three mild brain injury rehabilitation treatment stages: acute phase, subacute phase, and complete recovery, thereby realizing longitudinal analysis of the mild brain injury rehabilitation process.

The present disclosure relates to techniques for automated neuroimaging signal processing. In particular, the techniques can be used for cognitive impairment prediction using machine learning models and processed neuroimaging data. Aspects of the present disclosure are directed to accessing structural neuroimaging signals and functional neuroimaging signals for a brain of a subject, inputting the structural neuroimaging signals and the functional neuroimaging signals into a structure-function model, determining an atrophy score and a functional connectivity score for each of a predetermined number of principal structure-function components of the structure-function model, inputting the scores into a cognitive impairment model, and generating a measure of cognitive impairment for the subject using the cognitive impairment model based on an estimation of relationships between the scores and cognitive performance.