Dynamic brain function detection method and system synchronous with transcranial magnetic stimulation

Abstract

The present invention relates to a dynamic brain function detection method and system synchronous with transcranial magnetic stimulation. The system comprises a transcranial magnetic stimulation device for magnetically stimulating a targeted brain region of a subject to achieve a purpose of activating or inhibiting functions of a corresponding brain region; a functional near-infrared spectrometerfor collecting brain blood oxygen signals of the targeted brain region of the subject and other function connection related brain blood oxygen signals; an analysis module for analyzing blood oxygen signals of multiple-frequency bands of the brain blood oxygen signals; and a synchronous marking module for synchronously marking a stimulation moment in near infrared time domain signals when the transcranial magnetic stimulation (TMS) device starts to perform magnetic stimulation so as to instantly collect changes of the blood oxygen signals when the magnetic stimulation starts. The method provides a feasible scheme for researching brain disorder and cortical changes caused by the TMS and can also objectively measure an effect of the transcranial magnetic stimulation on different regions of abrain on a premise that the effect of the transcranial magnetic stimulation on the different regions of the brain cannot be quantified.

Description

technical field [0001] The invention relates to a dynamic brain function detection method and system based on fusion of near-infrared spectrum and transcranial magnetic stimulation. Background technique [0002] Transcranial magnetic stimulation (TMS) is a technique used to study normal brain function and various neuropsychiatric disorders. It can be divided into three stimulation modes: single-pulse sTMS, double-pulse dTMS and repetitive rTMS. Among them, repetitive transcranial magnetic stimulation (rTMS) can deliver continuous pulses in a single stimulation cycle for the treatment of neurological and psychiatric diseases. Transcranial magnetic stimulation uses fast alternating current to induce a time-varying magnetic field. These magnetic fields are transmitted from the coil to the brain unimpeded to generate an induced electric field, which depolarizes neurons. When the induced current reaches the threshold of nerve tissue, the stimulated The nervous system will be ex...

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Problems solved by technology

[0006] The stimulation depth of TMS is related to the current intensity of the excitation. Chinese patent 201721229885.8 arranges the stimulation coil on the near-infrared probe. If the distance between the stimulation coil and the scalp is too long (15mm), the required stimulation intensity will increase, which limits the impact on the target. The focus of the stimulation of the brain area will also cause greater stimulation and even unnecessary harm to the subjects

Chinese patent 201810564890.7 proposes a built-in reflector at the near-infrared emitting probe to change the optical path by 90°, thereby reducing the height of the probe to 5mm, but it still does not perfectly solve the stimulation depth of TMS under the premise of ensuring that the near-infrared probe receives signals. Able to reach the stimulation site of the target brain area

[0009] 1. Although the transmission of light is not affected by TMS pulses, the instruments used to measure near-infrared light may be susceptible to electromagnetic interference, especially the host part of near-infrared equipment

[0010] 2. The TMS coil will cause mechanical deformation in the process of passing through the transient current, which will cause the micro motion and vibration of the coil

[0012] 4. During the stimulation process of TMS, it will also cause somatosensory stimulation of the scalp and muscle tissue under the magnetic stimulation coil

If this surface tissue artifact is present, it is not easy to separate from cortical activation, which presents the greatest challenge to the combination of TMS and NIR

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