Application of compound as JAK-STAT3 signal passage inhibitor
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of JAK-STAT3 and signaling pathways, which is applied in the direction of drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems that have not yet been clinically treated for cancer, and achieve the effect of improving prognosis and improving curative effect
Inactive Publication Date: 2009-09-23
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
View PDF0 Cites 10 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0015] At present, there is no literature report about the drug or its derivatives or its analogs and its salts being used in the clinical treatment of cancer
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0154] Mix 1 mmol of 5-chloro-2-methoxybenzoic acid and 2 ml of thionyl chloride and heat to reflux for one hour. Thionyl chloride was distilled off, then diluted with 2 ml of anhydrous tetrahydrofuran, and then used.
[0155] 2 mmol of 4-fluoroaniline compounds were dissolved in 2 ml of anhydrous tetrahydrofuran, and then added dropwise to the previously prepared 5-chloro-2-methoxybenzoyl chloride solution at room temperature, and stirred overnight at room temperature. After the reaction was detected by thin layer chromatography, at room temperature, an appropriate amount of water and dichloromethane were added, the mixture was transferred to a separatory funnel, and the organic layer was taken. The organic layer solution was washed successively with appropriate amount of dilute sodium hydroxide solution (once), saturate...
[0171] MS(ES+APCI), m / z: 333.0(M+H) + , 331.2(M-H) -
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses an application of a compound as a JAK-STAT3 signal passage inhibitor, and particularly relates to an application of a compound with a formula I or pharmaceutically acceptable salt of the compound in the process of preparing an anti-tumor medicament. The application provides a novel treating candidate medicament for a tumor patient, thereby probably further improving the treatment effect on the patient and improving the prognosis of the patient. The compound with the formula I or the pharmaceutically acceptable salt of the compound has the effect on various tumor cells, which indicates that the compound can be used for treating various cancers including cerebral tumor, genitourinary system tumor, lymphatic system tumor, stomach cancer, laryngeal cancer, nasopharyngeal cancer, skin cancer, bone cancer, blood cancer, leukemia, breast cancer and histiocytic lymphoma, non-small cell lung cancer, small-cell lung cancer, lung adenocarcinoma, lung squamous cell cancer, pancreatic cancer, prostatic cancer, liver cancer, epithelial cell cancer and the like. The definition of genes in the formula refers to description for details.
Description
technical field [0001] The present invention relates to the application of a class of compounds as JAK-STAT3 signaling pathway inhibitors. technical background [0002] Tumor is currently the number one killer of human health and life, and its incidence rate is second only to cardiovascular diseases. And with the impact of environmental pollution and other factors, the incidence of malignant tumors is rising rapidly. According to the data released by the World Health Organization in 2003, there were 10 million malignant tumor patients in the world in 2000, and 6.2 million deaths due to malignant tumors, accounting for 12% to 25% of the total deaths. It is expected that by 2020, there will be 15 million new cases worldwide each year. In recent years, although some novel tyrosine protein inhibitors and other targeted new drugs have been developed and marketed, they are still far from meeting the growing needs of clinical cancer patients. The research and development of anti...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more