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Carotid atherosclerosis rabbit model making and detecting method

A technology of atherosclerosis and detection method, applied in the field of traditional Chinese medicine research, can solve the problem that the success rate of high-fat feeding model is not high enough

Pending Publication Date: 2021-12-07
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

Because the success rate of conventional high-fat feeding is not high enough

Method used

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  • Carotid atherosclerosis rabbit model making and detecting method
  • Carotid atherosclerosis rabbit model making and detecting method
  • Carotid atherosclerosis rabbit model making and detecting method

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Embodiment

[0054] Such as Figure 1-6 As shown, a carotid atherosclerosis rabbit model modeling and detection method, including the selection of experimental materials, grouping, modeling, sampling, serum preparation, paraffin section, detection seven steps, the modeling steps include feeding and administration two processes.

[0055] In the process of selecting experimental materials, New Zealand male rabbits, 4 months old, normal grade, weighing 2.0-2.5kg, were used.

[0056] After adaptive feeding, the rabbits were weighed. During the grouping process, the New Zealand rabbits were randomly divided into normal control group and model group. To further illustrate, in the normal control group, each rabbit eats 150g of ordinary pellet feed every day, drinks water freely, and after feeding for 1 week, it is fed with double distilled water 5ml / kg / d for 11 consecutive weeks; in the model group, each rabbit Eat 150g of high-fat feed (2% cholesterol, 2% lard, 96% common granule feed for rabb...

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Abstract

The invention discloses a carotid atherosclerosis rabbit model making and detecting method, which comprises seven steps of experimental material selection, grouping, model making, material taking, serum preparation, paraffin section and detection, wherein the model making step comprises two processes of feeding and operation applying. In the actual operation process, the complete carotid atherosclerosis model is established through early-stage experimental material selection, grouping and model making, detection materials are arranged through material taking, serum preparation, paraffin slicing, and the completeness of the model is verified.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine research, in particular to a method for making and detecting a rabbit model of carotid atherosclerosis. Background technique [0002] Modern medical research has confirmed that hyperlipidemia and diabetes play a very important role in atherosclerosis. Patients with certain metabolic factors, such as elevated homocysteine, have a significantly higher incidence of coronary heart disease, and it will be even more severe if combined with diabetes Its severity, and diabetes can also be combined with abnormal lipid metabolism. [0003] In the process of treating atherosclerosis, the establishment of animal models of atherosclerosis can better study the pathogenesis of atherosclerosis, and is also a key issue in the pathological research of atherosclerosis and drug development. In recent years, many scholars have conducted a large number of experimental studies on atherosclerosis us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027A23K20/158A23K20/168A23K50/50G01N1/28G01N1/30G01N1/36G01N1/44
CPCA01K67/027A23K20/158A23K20/168A23K50/50G01N1/2813G01N1/36G01N1/30G01N1/44A01K2267/0375
Inventor 顾耘潘露茜徐辉赵彦超张涵瑜杜文婷龚路王臻楠韩素静邱理许若玢陈明荃吴建文陈家和黄启尧
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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