The invention discloses a weak supervision
cell nucleus segmentation method based on
wavelet differential
convolution and region expansion, and relates to the technical field of
image processing, and the method comprises the following steps: obtaining an image sample containing a
cell nucleus, and marking the position of the
cell nucleus through central point
annotation; a
wavelet differential
convolution module is designed, multi-scale features are extracted through
discrete wavelet transform, and
cell nucleus boundary and detail information are enhanced in combination with the differential
convolution module; a region expansion module is constructed, pseudo labels are generated based on point
annotation iteration, a complete
cell nucleus region is expanded step by step, and the problems of
noise and nucleus missing detection are reduced; building a segmentation network, adding a
wavelet difference convolution module to extract detail features, and optimizing
network performance by using a pseudo tag as a weak supervision
signal; carrying out segmentation prediction, and outputting the accurate position and shape of the
cell nucleus; therefore, high-precision segmentation is realized under a small amount of
annotation information, the annotation dependence is reduced, and particularly, the effects of reducing adjacent cell nucleus boundary adhesion and
small cell nucleus
leak detection are remarkable.