118results about How to "Inhibition of value added" patented technology

The invention relates to a paclitaxel-loaded sustained release nano-fibre material which comprises the components of bio-degradable polymer material and pure paclitaxel, the mol ratio of which is 1.33 to 10. The diameter of the nano-fibre is 90nm to 1.44micrometer, and the drug-loading rate can be regulated within the range of 0 percent to 100 percent. The preparation of the nano-fibre comprises the steps as follows: (1) the bio-degradable polymer material is solved in organic solvent and stirred to be solved completely to obtain lamella spinning solution A; (2) the white pure paclitaxel powder is solved in trifluoroethanol and stirred to be solved completely to obtain core spinning solution B; (3) clear transparent solutions A and B are respectively added into two injectors; the speed of a microinjection pump, the voltage of a static generator and the receiving distance between a grounded aluminum foil and a spinning needle are adjusted, and unordered drug-loaded nano-fibre is obtained by a coaxial electrostatic spinning technology. A nanometer control release system composed by the drug-loaded nano-fibre effectively controls the sustained release of the drug and is applied to the preparation of the drug for remedying malignant tumor.

The invention provides tricyclic compounds shown as a formula (I), and also discloses a preparation method and application for the compounds and a medicinal composition containing the compounds. The compounds are protein kinase inhibitors and can be used for treating diseases caused by abnormality of protein kinase activity, such as tumors and the like.

The invention provides a spirotricyclic compound as shown in formula (I), and simultaneously discloses a preparation method of the compound and application thereof, as well as a pharmaceutical composition containing the spirotricyclic compound. Being an inhibitor of protein kinase, the compound in the invention can be used to treat diseases caused by abnormal protein kinase activity, such as tumors and the like.

The invention discloses an agricultural ecological technique capable of preventing and controlling liberobacter asiaticum as well as harvesting oranges. The agricultural ecological technique is characterized by comprising production and culture: a biological organic fertilizer is used, a metabolic photosynthetic accelerant and ion liquid for improving resistance are sprayed, and a biological source agricultural chemical and artificial and mechanical weeding are used for preventing and treating diseases and pests and weeds. The agricultural ecological technique disclosed by the invention has the advantages that the productivity, the immunity, the disease resistance and the disease tolerance of the oranges can be improved; the spreading speed of the liberobacter asiaticum is reduced, so that healthy trees can obtain high yield; the trees suffering from light and moderate diseases restore the productivity which achieves or approaches the level of that of trees free from diseases; the trees suffering from serious diseases restore growing trend, definite productivity is maintained, and the fruiting period is prolonged; the fruit quality can be improved, and besides, good-quality organic orange products are harvested; the agricultural ecological technique has important significance on guaranteeing the production benefit of orange fruit growers, and promoting the steadily forward development of orange industry in rural economy.

The invention discloses a method for feeding crayfishes by nano feeds. The method comprises the following steps: putting juvenile prawns into a paddy field with the characteristics of sufficient water source, convenience in irrigation and drainage, good water retention capability, non drought in dry weather, no flooding, good ecological environment, no pollution source, fertile soil and natural substrate, and then putting grass carp summer flowers, bighead carp summer flowers, snails and the like into the paddy field. By adding a compound microorganism fertilizer, the crayfishes can be promoted to grow quickly, the EPA (eicosapentaenoic acid) content can be increased, the diseases of the crayfishes are reduced, the fatality rate is reduced, beneficial microorganisms in a water body are added, and the final quality is improved.

The invention discloses a weaned piglet non-antibiotics feed, which comprises a specific antibacterial peptide and a plant essential oil component and has the effects of improving body immunity of piglets, inhibiting reproduction of harmful bacteria, preventing diarrhea and increasing feed intake of the piglets. The feed can improve immunity and has the anti-bacterial, pest-killing and anti-oxidizing effects, can improve appetite of the piglet and improve digestion and absorption, effectively inhibits parasites, has antibacterial and mildew-proofing effects and can inhibit ulcer. The feed, by completely combining physiological properties of the weaned piglets, can effectively solve the problems of incomplete immune functions, poor disease resistance and high diarrhea incidence of the weaned piglet, etc., thereby increasing daily weight gain of the piglets. The feed can completely replace antibiotics, thereby ensuring intestinal health of the piglet. The feed is an ideal piglet feed.

In one embodiment of the present invention, a backlight device is disclosed wherein a contrast ratio is improved with a decrease in light source service life being suppressed, and a liquid crystal display device using such backlight device. The backlight device is provided with an, optical layer whose main surface is a light outgoing surface; a main light source that is arranged at a position facing a main surface of the optical layer and emits light toward the optical layer; a light guide plate that is arranged on a main surface side, so as to be parallel to the main surface, and has a main surface on an optical layer side as a light outgoing surface; a sub-light source that is arranged at a position facing a side surface of the light guide plate and emits light toward the side surface; and a driving portion for driving the main light source and the sub-light source. The main light source is provided with a plurality of fluorescent tubes arranged parallel to the optical layer. The driving portion outputs drive pulses to the plurality of the fluorescent tubes, respectively, and adjusts the light amounts of the plurality of the fluorescent tubes by modulating the pulse widths of the drive pulses (PWM dimming method).

The invention discloses a cultivation method capable of reducing stichopus japonicus disease and pest injuries with corrosion inhibition nanometer materials. The method includes the following steps that a stichopus japonicus cultivation pool and an adhesion base are constructed; according to the requirement for habits of the stichopus japonicus biology, the pool suitable for growth of stichopus japonicus is built up by combining with real conditions and stichopus japonicus offspring seeds are put; normally, large seeds with the density of more than 600 per kilogram are put according to the density of 10 per m<2> to 20 per m<2>, the larger the specifications are, the less the put amount per unit area is; a formula of the cast feed comprises, by weight, 20-25 parts of animal proteolysis article dry powder, 15-20 parts of meat and bone meal, 20-22 parts of soybean meal, 4-6 parts of honeysuckle, 2-3 parts of medicated leaven, 3-5 parts of angelica sinensis, 2-3 parts of soya bean lecithin, 1-2 parts of alginate-derived oligosaccharide, 1-2 parts of vitamin C, 1-2 parts of spiral seaweed, 2-3 parts of hunmulus lupulus, 3-5 parts of tea saponin, 2-3 parts of common cnidium fruit, 3-4 parts of fructus ulmi and 1-2 parts of cortex pseudolaricis. The stichopus japonicus offspring seeds are managed. In winter, the depth of water in the pool is increased, changes of dissolved oxygen and a base material must be paid attention to and sea grass is prevented and controlled; in spring, when the temperature of the water in the pool goes up, firstly, the water goes rich, the transparency of the water is reduced and cultivation of the sea grass is controlled.

The invention discloses a probiotic mixing preparation with anti-influenza capability and application thereof, and belongs to the technical fields of microorganisms and medicine. The probiotic mixingpreparation has an anti-influenza effect which is concretely shown in the aspects of (1) obviously relieving the weight loss degree of an influenza mouse; (2) obviously improving the blood index of the influenza mouse; (3) obviously relieving the respiratory tract infection inflammatory conditions of the influenza mouse; (4) obviously reducing the lung viral load quantity of the influenza mouse (obviously inhibiting the duplication and the value increase in the influenza mouse); (5) obviously enhancing the expression quantity of lung antivirus protein MxA of the influenza mouse. Therefore theprobiotic mixing preparation has huge application prospects in preparation of products for preventing and / or treating atopic dermatitis and preventing and / or treating the influenza.

Relating to the technical field of aquaculture, the invention provides a water quality improver for aquaculture. The water quality improver comprises the following raw materials by weight: 8-15 partsof straw, 4-8 parts of lignin, 3-6 parts of sodium humate, 10-15 parts of polyacrylamide, 6-13 parts of chitosan powder, 4-9 parts of gram-positive actinomycetes, 4-9 parts of photosynthetic bacteria,2-6 parts of bacillus, 5-10 parts of lactic acid bacteria, 5-10 parts of bacillus natto, 7-14 parts of saccharomycetes and 6-18 parts of a Chinese herbal medicine additive. The water quality improvercan effectively improve the water quality of water in aquaculture, promote propagation of aquatic organisms and increase the survival rate, and meanwhile, the preparation method of the water qualityimprover is simple and easy to master, thus facilitating promotion.

The invention relates to field of polycrystalline silicon ingot casting, in particular to an opening-free heat insulation cage ingot casting device and method. The device comprises a heat insulation cage, wherein a lateral heater is arranged on the inner side face of the heat insulation cage, a top heater is arranged at the top in the heat insulation cage, and the lateral heater and the top heater are separately controlled by double power supplies. In a melting step, the temperature of an air cooling DS block is controlled not to be higher than 1400 DEG C. In astep of change from melting to crystal growth, the temperature of an air cooling DS block is 1300-1360 DEG C, the temperature of the top heater is 1530-1545 DEG C. In a crystal growth step, the temperature of the top heater is reduced from 1430 DEG C to 1400 DEG C, and the temperature of the air cooling DS block is reduced from 1300 DEG C to 1000 DEG C. By the adoption of the opening-free heat insulation cage ingot casting device, the heat insulation cage cannot be needed to be opened, the subfissurescrap ratio of cut silicon wafers is reduced by about 15%, the dislocation number of silicon ingots in growth is effectively controlled, the photoelectric conversion efficiency of silicon wafer products is high, and the stability is good.

The invention discloses a furocoumarin compound with a hypertension activity reducing function and preparation method thereof; the furocoumarin compound has similar nature to imperatorin, shows the activity of dilating blood vessels in isolated vascular ring tension research, and can be applied to the preparation of antihypertensive drugs. The preparation method of the furocoumarin compound has the advantages of easily available raw material sources, mild reaction conditions, simple reaction process operation, and inexpensive and easily available reagent.

The invention discloses essence for dispelling acne traces, and relates to the technical field of cosmetics. The essence comprises the following components of water, butanediol, a PEG / PPG-17 / 6 copolymer, nicotinamide, a centella asiatica extract, PEG / PPG / polytetramethylene glycol polytetramethylene glycol-8 / 5 / 3 glycerine, a radix sophorae yellowish sophora extract, a glycyrrhiza inflata root extract, a scutellariae extract, glycerine, a harba dendrolii nobilis stem extract, an aloe vera leaf extract, a lycium barbarum l. fruit extract, a purple echinacea Echinacea purpurea extract, 1,2-hexanediol,hydroxyacetophenone, phenoxyethanol, carbomer, triethanolamine, sodium hyaluronate, PEG-40 hydrogenated castor oil and cananga odorata flower oil. The nicotinamide in the raw materials has the efficacy of resisting inflammation and dispelling melanin, and can lighten acne traces, besides, components of the centella asiatica extract and the like are added, so that wound healing can be promoted,and the regeneration capacity of skin can be strengthened. Through effective combination of restraining melanin and repairing regenerated skin and muscle, the purpose of dispelling acne traces can beachieved, and the effect of dispelling acne traces is good.

The invention discloses a composite fermentation type traditional Chinese medicine for improving stress resistance of livestock and poultry. The composite fermentation type traditional Chinese medicine is prepared from the following active pharmaceutical ingredients in parts by weight: 10-40 parts of lancelesf lily bulbs, 20-60 parts of kudzuvine root, 10-50 parts of silktree albizzia bark, 40-80 parts of cortex acanthopanacis radicis, 40-80 parts of eucommia bark, 5-25 parts of liquorice root, 10-40 parts of common anemarrhena rhizome and 5-20 parts of gypsum. The composite fermentation type traditional Chinese medicine is prepared by combining a traditional Chinese medicine recipe with a modern microbial technology, adding wheat bran, soybean meal, ammonium sulfate, magnesium sulfate, calcium carbonate and an appropriate amount of water after ultrasonic crushing to constitute a fermentation culture medium, adding a certain proportion of a strain culture solution of composite bacteria, fermentating, adding a stabilizer into a mature solid fermented matter, and performing low-temperature drying for preparation. The traditional Chinese medicine biological preparation prepared after microbial fermentation metabolism can significantly improve absorption and utilization of the medicine, improve the stress resistance of organisms of livestock and poultry, strengthen the immunity of the organisms, improve the production performance of livestock and poultry, effectively prevent and treat immunity suppression diseases and stress diseases and the like.

The invention discloses a liver protecting beverage and a preparation method thereof. The liver protecting beverage comprises the following components according to parts by weight: 5 to 20 parts of stringy stonecrop, 2 to 10 parts of liquorice, 5 to 15 parts of Chinese wolfberry, 5 to 10 parts of hawthorn fruit, 10 to 15 parts of red dates and 100 to 300 parts of water. Compared with the prior art, the liver protecting beverage has the advantages that since the stringy stonecrop, the liquorice, the Chinese wolfberry, the hawthorn fruit and the red dates are used altogether, the beverage not only has the liver protecting effect, but also can inhibit the proliferation of hepatoma cells, enhance the resistance and immunity of human bodies and help people with insomnia to sleep.

The invention discloses a mandarin fish interferon gene and interferon protein mIFN and a preparation method and application of the mandarin fish interferon protein mIFN. The mandarin fish interferon gene has a nucleotide sequence as shown in SEQ ID No.1, and the mandarin fish interferon protein mIFN is obtained through prokaryotic expression. The prepared mandarin fish interferon protein mIFN of the invention can effectively reduce the rana grylio virus load in a mandarin fish body, and achieves the effect of inhibiting rana grylio virus proliferation, so that the morbidity and mortality of mandarin fishes are greatly reduced, economic losses are reduced for raising households, and the interferon protein mIFN has good application prospects.

The invention provides a preparation method of a fungus chaff type poultry manure deodorizing bactericide and relates to a preparation method of a deodorizing bactericide. The preparation method of the fungus chaff type poultry manure deodorizing bactericide is characterized by comprising the following steps: firstly, sufficiently stirring and mixing 14.5 percent of rice bran, 14 percent of oil meal, 13 percent of soybean meal, 8 percent of sugar and 0.5 percent of yeast powder according to a ratio formula, and then stacking; after fermenting, blending and stirring; secondly, mixing lactic acid bacteria, bacillus, actinomyces and saccharomycetes according to the formula ratio of 1 to 1 to 1 to 1, so as to prepare a deodorizing bactericide; finally, spraying the mixed deodorizing bactericide on a support made of a fungus chaff carrier at the ratio of 1 to 1. According to the poultry manure deodorizing bactericide taking fungus chaff as a carrier, the deodorizing bactericide which is fixed by the carrier through adopting a fungus chaff covering technology has an inhibition effect on harmful gas generated in a stacking process of biological fertilizer including poultry manure and the like.

The invention discloses a wormwood pig feed which comprises the following raw materials in parts by weight: 6-8 parts of wormwood, 1-5 parts of honeysuckle leaves, 0.1-0.3 part of RADIX ASTRAGALI, 5-9parts of fine powder of mineral substances, 0.5-1.5 parts of composite vitamins, 10-18 parts of wheat bran, 15-20 parts of rice chaff, 1-2 parts of a plant extract, 4-10 parts of starch, 0.1-0.2 partof a composite enzyme preparation, 7-9 parts of rapeseed bran, 2-4 parts of fish flour, 5-7 parts of carrots, 5-10 parts of corn, 1-3 parts of a composite acidification agent and 0.1-0.2 part of an antioxidant. By adopting the pig feed disclosed by the invention, not only are nutrition requirements of pigs to growth met, but also pig feed digestion intestinal tracts can be improved, digestion andabsorption of nutrition substances can be improved, the disease infection rate can be reduced, and particularly African swine fever can be reduced; and meanwhile, the preparation method disclosed bythe invention is low in material cost, easy in raw material obtaining, clear and simple in process, high in practical value and good in application prospect.

A method for using nanometer slow release feed to breed mandarin fish includes: building a pond which has a sandy bottom with 15cm of sludge, is more than 1.5m in water depth, convenient in drainage and irrigation and good in water quality, and has no waste water inflow; allowing the water temperature to be 25-29 DEG C which is most appropriate growth water temperature in artificial breeding; in winter and spring, fishing up robust parent fish without surface damage from the breeding pond to breed in a pond of a greenhouse and using the same for artificial breeding, and placing the breeding parent fish of the parent fish into the pond of the greenhouse; feeding four times each day during breeding, calculating feeding amount according to 20-50% of fish weight, feeding sufficiently to avoid feed competition, and flexibly control the feeding amount according weather conditions. By adding the composite microorganism feed of the method, fast growth of mandarin fish can be promoted, EPA content is increased, disease is reduced, mandarin fish death caused by diseases is reduced, beneficial microorganisms in water are increased, and final quality of mandarin fish is improved.

The invention discloses a method for breeding bluefin tuna by nano slow-release carrier feeds. The method comprises the following steps: putting adult bluefin tuna into a pond with fresh water, the depth of 2.0-2.5m and the pH value of 7.0-8.5 in the morning from the middle of March to the middle of April under the condition that the water temperature is 15-20 DEG C, and breeding 2250-3000 silver carp fries being 10-12cm per hm<2> and 375 spotted silver carp fries per hm<2> in the pond at the same time, wherein a net box is made of polyethylene net pieces. By adding a compound microorganism fertilizer, the bluefin tuna can be promoted to grow quickly, the EPA (eicosapentaenoic acid) content can be increased, the diseases of the bluefin tuna are reduced, the fatality rate is reduced, beneficial microorganisms in a water body are added, and the final quality is improved.

The invention discloses a coumarin NEDD8 activating enzyme inhibitor in the general formula I as well as pharmaceutically acceptable salts, solvate, polymorphic substances, tautomers, metabolites and prodrugs of the coumarin NEDD8 activating enzyme inhibitor. The invention further discloses an application of the coumarin NEDD8 activating enzyme inhibitor to preparation of anti-tumor drugs and a preparation method of the coumarin NEDD8 activating enzyme inhibitor. Pharmacological results show that the compound has a good effect of resisting tumor cell proliferation and is clinically applicable to preparation of drugs for treating tumors.

A provided reinforced tuberculosis subunit vaccine comprises mycobacterium tuberculosis antigen Ag85b protein, recombination mycobacterium tuberculosis ESAT6-CFP10, a BCG-CpG adjuvant, an aluminium adjuvant and a PolyIC adjuvant. The vaccine is capable of mitigating the pathological change degree of guinea-pig visceral organs infected by Mtb, and effectively inhibiting or killing mycobacterium tuberculosis latently infecting a guinea pig in the body.

The invention discloses a preparation method of a medical polyurethane sponge for wound surface sealing negative pressure drainage. The preparation method specifically comprises the following steps: (1) pretreatment of the polyurethane sponge: sequentially carrying out cutting, cleaning and drying process treatment; (2) preparing a polyurethane sponge impregnation liquid, wherein the impregnationliquid comprises polyglutamic acid, polylysine, a cortex phellodendri extract and a thickening agent; and (3) putting the polyurethane sponge into the impregnation liquid for impregnation treatment, putting the polyurethane sponge into a drying oven or a drying room at the temperature of 40-70 DEG C after impregnation is finished, and forming a gel layer on the surface of the polyurethane sponge in contact with the impregnation liquid after drying. According to the medical polyurethane sponge for wound surface sealing negative pressure drainage, the gel layer is arranged on the side, making contact with the wound surface, of the medical polyurethane sponge, and the gel layer has the effects of resisting bacteria, promoting cell repair and proliferation, accelerating wound healing, reducingadhesion between newly-generated granulation and the polyurethane sponge and avoiding secondary damage to the wound.

The invention discloses two kinds of coumarins NEDD8 activating enzyme inhibitors different in general formula as well as salts, solvates, polymorphic substances, tautomers, metabolites and prodrugs of the coumarins NEDD8 activating enzyme inhibitors. The invention further discloses application of the coumarins NEDD8 activating enzyme inhibitors to preparation of antitumor drugs. Pharmacological results show that the compounds, namely the coumarins NEDD8 activating enzyme inhibitors, have remarkable effects on NEDD8 inhibitory activity, anti-tumor cell proliferation and tumor cell apoptosis promotion and therefore can be used for preparing the drugs for treating the tumors clinically.

The invention discloses a method for breeding artificial aeguidens rivulatus fries by nano feeds. The method comprises the following steps: selecting a breeding facility, namely a square pond with the characteristics of flat bottom, less sludge, convenience in irrigation and drainage and average water depth of 0.8m; disinfecting the pond by 10mg / L of trichloroisocyanuric acid in 10 days before aeguidens rivulatus is put into the pond; keeping clear water and the pH value to be 7.8, wherein aeguidens rivulatus fries are hatched out by fertilized ova after 2-3 days and can freely move for finding foods in another 5-6 days; feeding the aeguidens rivulatus fries with fairy shrimps or small water fleas for four times each day in the beginning; after half a month, feeding the aeguidens rivulatus fries with blood worms (cladocerans); after a month, feeding the aeguidens rivulatus fries with artificial compound feeds, optimally selecting and using feeds with high protein content such as fresh fish meat, shrimp meat and snail meat, also selecting and using compound feeds, and generally feeding the aeguidens rivulatus fries with animal feeds for improving the nutrition and promoting the gonad development of parent fishes in a breeding season.

The invention provides a medicine, particularly relating to a Chinese medicine composition for treating arteriosclerosis. The Chinese medicine composition for treating arteriosclerosis is characterized in that the mass portions of the components are: 1 to 2 grams of mint, 1 to 2 grams of chrysanthemum, 1 to 2 grams of cimicifuga foetida, 1 to 2 grams of bark of tree peony root, 1 to 2 grams of rhubarb, 1 to 2 grams of euphorbia kansui, 1 to 2 grams of common andrographis herb, 1 to 2 grams of asiatic plantain seed, 1 to 2 grams of akebia stem, 2 to 4 grams of orange peel, 2 to 4 grams of cyrtomium rhizome, 2 to 4 grams of baical skullcap root, 2 to 4 grams of abalone shell, 2 to 4 grams of safflower, 2 to 4 grams of salvia, 2 to 4 grams of earthworm, 2 to 4 grams of frankincense and 2 to 4 grams of jasper powder. The medicine of the invention is safe, effective and good in tolerance, so that the medicine can be routinely prescribed to treat a patient with carotid atherosclerosis and prevent cardiocerebrovascular events and has the advantages of safety and reliability, obvious curative effect, small side effect and high cure rate.

The invention relates to a 2-(indol-3-yl)-pyridinoimidazole. The chemical structure of the 2-(indol-3-yl)-pyridinoimidazole is represented by formula (I), and R<1> in the formula (I) is a 4-quinolyl group, a 4-isoquinolyl group, a 4-2-methylpyridyl group, a 4-2-methoxypyridyl group or a 4-fluorophenyl group. The 2-(indol-3-yl)-pyridinoimidazole can inhibit tumor cell proliferation, and provides anew inhibitor for inhibiting the tumor cell proliferation.

The invention discloses a submicron powder composition for preventing and treating poultry infectious diseases. The composition is prepared by the following steps: (1) weighting the following raw materials: astragalus mongholicus, ginseng, saffron, artemisia annua, pseudo-ginseng, Chinese lobelia and Chinese trumpet creeper; (2) chopping the astragalus mongholicus, the ginseng, the pseudo-ginseng, the Chinese lobelia and the Chinese trumpet creeper, and preparing submicron powder by applying an ultra-fine crushing technology to ensure that the crushing granularity is lower than 10mu m and the plant cell wall-broken rate is over 90 percent; (3) extracting the saffron and the artemisia annua at normal temperature for 1 to 3 days with petroleum ether, concentrating and drying, and preparing the submicron powder by applying the ultra-fine crushing technology to ensure the crushing granularity of lower than 10mu m; and (4), mixing, roasting and boiling, and screening the submicron powder prepared in the step (2) and the step (3) to obtain the submicron powder composition for preventing and treating poultry infectious diseases. The composition is added into poultry premix to feed egg-laying poultry for a long time, so that the egg-laying poultry is protected from invasion of pathogenic microorganisms, and the egg laying rate of the infected poultry is recovered to be normal gradually.