Preparation method of medical polyurethane sponge for wound surface sealing negative pressure drainage

A technology of polyurethane sponge and negative pressure drainage is applied in the field of preparation of medical polyurethane sponge, which can solve the problems of high use cost of patients, secondary wound injury, and excessive bleeding of the sponge, achieve secondary injury of light scar wound, inhibit bacterial growth, Anti-adhesion effect

Pending Publication Date: 2021-03-12
NANJING SHUANGWEI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the negative pressure medical polyurethane sponge dressing products in the market are mainly hydrophobic sponges, and the pore size of the sponges is mostly ≥300 μm. The main problems in clinical use are: compared with hydrophilic drainage dressings, the single use time is shorter, and the patient’s use cost is higher; pressure The new granulation tissue can easily grow into the sponge, making it impossible to replace the sponge or bleeding too much when replacing it, causing secondary damage to the wound

Method used

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  • Preparation method of medical polyurethane sponge for wound surface sealing negative pressure drainage

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Experimental program
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Effect test

Embodiment 1

[0020] A kind of preparation method of the medical polyurethane sponge that is used for wound sealing negative pressure drainage, specifically comprises the following steps:

[0021] (1) Pretreatment of the polyurethane sponge: cut the medical polyurethane sponge 1 into 15cm×10cm×3cm; then put it into purified water at a temperature of 30°C for 2 hours, and dry at 50°C for 2 hours.

[0022] (2) Polyurethane sponge soaking solution configuration: the soaking solution consists of 0.05% polyglutamic acid, 0.1% polylysine, 0.1% Phellodendron cortex extract, 0.1% carbomer 980, and the balance is deionized water, of which polyglutamine The molecular weight of acid is 1000kDa, and the molecular weight of polylysine is 9kDa. The process is first to uniformly disperse Phellodendron Phellodendri extract in deionized water, then evenly sprinkle other materials in the formula on the surface of deionized water, leave it overnight, and finally stir evenly.

[0023] (3) Soak the polyurethan...

Embodiment 2

[0026] A kind of preparation method of the medical polyurethane sponge that is used for wound sealing negative pressure drainage, specifically comprises the following steps:

[0027] (1) Medical polyurethane sponge pretreatment: cut the medical polyurethane sponge into 10cm×10cm×3cm; then put it into water for injection at a temperature of 30°C for 2 hours, and dry at 60°C for 2 hours.

[0028] (2) Configure the soaking solution: the soaking solution is composed of 0.1% polyglutamic acid, 0.05% polylysine, 0.2% Phellodendron cortex extract, 0.1% growth factor, 0.5% gelatin, and the balance is deionized water, wherein polyglutamine The molecular weight of acid is 800kDa, and the molecular weight of polylysine is 10kDa. The process is first to uniformly disperse Phellodendron Phellodendri extract in deionized water, then evenly sprinkle the solid materials in the formula on the surface of deionized water, leave it overnight, and finally add growth factors and stir evenly.

[00...

Embodiment 3

[0032] A kind of preparation method of the medical polyurethane sponge that is used for wound sealing negative pressure drainage, comprises the following steps:

[0033] (1) Medical polyurethane sponge pretreatment: cut the medical polyurethane sponge into 10cm×10cm×3cm; then put it into water for injection at a temperature of 30°C for 2 hours, and dry at 60°C for 2 hours.

[0034] (2) Configure the soaking solution: the soaking solution is composed of 0.1% polyglutamic acid, 0.05% polylysine, 0.25% Phellodendron cortex extract, 0.1% growth factor, 0.15% carbomer 940, 0.1% mupirocin, and The amount is deionized water, wherein the molecular weight of polyglutamic acid is 50kDa, and the molecular weight of polylysine is 10kDa. The process is first to uniformly disperse Phellodendron Phellodendri extract in deionized water, then evenly sprinkle the solid materials in the formula on the surface of deionized water, leave it overnight, and finally add growth factors and stir evenly....

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Abstract

The invention discloses a preparation method of a medical polyurethane sponge for wound surface sealing negative pressure drainage. The preparation method specifically comprises the following steps: (1) pretreatment of the polyurethane sponge: sequentially carrying out cutting, cleaning and drying process treatment; (2) preparing a polyurethane sponge impregnation liquid, wherein the impregnationliquid comprises polyglutamic acid, polylysine, a cortex phellodendri extract and a thickening agent; and (3) putting the polyurethane sponge into the impregnation liquid for impregnation treatment, putting the polyurethane sponge into a drying oven or a drying room at the temperature of 40-70 DEG C after impregnation is finished, and forming a gel layer on the surface of the polyurethane sponge in contact with the impregnation liquid after drying. According to the medical polyurethane sponge for wound surface sealing negative pressure drainage, the gel layer is arranged on the side, making contact with the wound surface, of the medical polyurethane sponge, and the gel layer has the effects of resisting bacteria, promoting cell repair and proliferation, accelerating wound healing, reducingadhesion between newly-generated granulation and the polyurethane sponge and avoiding secondary damage to the wound.

Description

technical field [0001] The invention relates to a preparation method of a medical polyurethane sponge used for wound sealing and negative pressure drainage. Background technique [0002] Vacuum-assisted closure (VAC) is a new technology for wound treatment developed in recent years. This technique requires the use of wound drainage dressings and a negative pressure source, and works in two ways: intermittent negative pressure suction or continuous negative pressure suction. Evidence-based medical research has considered that VAC is significantly superior to traditional dressings in the treatment of various acute and chronic wounds, full-thickness wounds, deep cavities or sinus wounds. It is especially suitable for all kinds of chronic refractory wounds that are ineffective by traditional surgical methods and wounds where deterministic surgical wound closure methods such as skin flap transplantation cannot be tried immediately. Compared with conventional dressing changes, V...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/42C08L75/04A61F13/00A61F13/02A61M1/00
CPCC08J9/42A61F13/00063A61F13/00987C08J2375/04A61F13/01017A61F13/05
Inventor 何琴玲潘维超乔梦娜谢伟娟李郑周军肖国锋
Owner NANJING SHUANGWEI BIOTECH
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