18 results about "Mupirocin" patented technology

The invention relates to the field of high-molecular compounds, in particular to a mupirocin nano prodrug, a preparation method and application of the mupirocin nano prodrug to improvement of antibacterial activity in plasma, the general formula of the mupirocin nano prodrug is shown in the specification, X is O or NH, and n is equal to 1 or 6, the mupirocin nano prodrug can form regular and uniform spherical nanoparticles in a water phase in a nano precipitation mode, and the nano prodrug can be applied to preparation of antibacterial activity in plasma. According to the present invention, the mupirocin nano-prodrug has a certain antibacterial activity in vitro, the stability of mupirocin can be effectively improved by the self-assembly prodrug in the subsequent plasma antibacterial experiment, and the mupirocin nano-prodrug has the activity superior to the activity of the mupirocin active drug in the plasma antibacterial experiment.

The application relates to a kind of dosing device for mupirocin ointment, relate to medical instrument technical field, it includes storage part, connecting part and extrusion part, storage part includes chute sleeve and storage box slidably arranged in chute sleeve, storage box is used to store mupirocin ointment in;Connecting part includes connecting ring, the two ends of connecting ring are respectively with the detachable link of storage part and extrusion part, the bottom of gauze can be contacted with mupirocin ointment in storage box when storage box vertically moves upward;Extrusion part includes fixed shell and extrusion assembly arranged in the inside of fixed shell, extrusion assembly is used to apply pressure to gauze, and gauze is adhered at wound site;Temperature adjusting assembly for heating or cooling extrusion assembly is arranged in extrusion part, and hot compress or cold compress of wound is realized.The application has the effect of evenly applying mupirocin ointment on wound site while alleviating patient's discomfort, improving the recovery efficiency of wound.

The invention relates to the technical field of medicines, and particularly discloses mupirocin ointment containing andrographolide and hydroxysafflor yellow A and a preparation method of the mupirocin ointment. The ointment comprises active ingredients of mupirocin, andrographolide and hydroxysafflor yellow A, and auxiliary materials of polyethylene glycol 3350 and polyethylene glycol 400. The mupirocin, the andrographolide and the hydroxysafflor yellow A are scientifically compounded, and different antibacterial mechanisms of the mupirocin, the andrographolide and the hydroxysafflor yellow A are utilized, so that a remarkable synergistic antibacterial effect is generated, drug-resistant bacteria can be effectively resisted, and generation of bacterial drug resistance is delayed. Meanwhile, by adding andrographolide and hydroxysafflor yellow A, the chemical stability of mupirocin in a polyethylene glycol matrix is accidentally improved, the validity period of the product is prolonged, and local microcirculation is improved. The invention further provides a preparation method of the ointment, the process is simple, and industrial production is easy.

The invention discloses mupirocin ointment easy to smear and good in stability and a preparation method of the mupirocin ointment, and belongs to the technical field of medicine preparation. The preparation method comprises the following steps: firstly, forming an alcohol-soluble supramolecular system by adopting citric acid and glycerol, and then adding mupirocin into the supramolecular system to form a mixed solution; uniformly mixing polyethylene glycol 3350, polyethylene glycol 400 and propylene glycol to obtain a matrix solution; finally, mixing, stirring and condensing the mixed solution and the matrix solution to obtain the mupirocin ointment. The mupirocin ointment prepared by the invention is easy to smear and good in stability, and has a wider application prospect.

The invention discloses a mupirocin ointment preparation device capable of accurately controlling temperature and slowly cooling, and relates to the technical field of ointment preparation. According to the scheme, the reaction kettle comprises a tank body with a jacket and further comprises a stirrer and a shaft body rotationally connected with the tank body, one end of the shaft body extends into the tank body, and a cooling flow channel is formed in the shaft body; the plurality of stirring blade units are distributed along the axial direction of the stirring shaft and are communicated with the cooling flow channel, and a cavity for a cooling medium to circulate is formed in each stirring blade unit; and the partition flow adjusting mechanism is arranged in the shaft body and is used for independently controlling on-off or flow of the cooling medium flowing to each stirring blade unit. Independent cooling loops are integrated in the stirring shaft and the blades, so that an internal cooling mode of directly exchanging heat from the inside of a material is realized, and an internal and external synergistic three-dimensional cooling network is formed by combining the internal cooling mode with external cooling of the jacket.

A Pharmaceutical composition for treating bacterial skin infections, burns and wounds is disclosed. It comprises an active ingredient, preferably Mupirocin, a biopolymer, preferably Chitosan, with molecular weight ranging from 250,000 Da to 600,000 Da, and a degree of deacetylation of not less than 80%, hydrolyzed Collagen, preferably of type I, with molecular weight ranging from 3 kDa to 6 kDa, and an ointment base comprising emulsifying agents, glycols and solubilizers. The invention has improved stability than the existing ointments, it heals skin and re-epithelializes faster than existing treatments thereby reducing hospitalisation period.

This invention provides a heating melting tank for producing mupirocin ointment, relating to the field of mupirocin ointment production technology. The heating melting tank for producing mupirocin ointment includes a tank body, a stirring shaft, stirring blades, a scraper, and a limiting assembly. The scraper is parallel to the stirring shaft and movably disposed on one side of the stirring shaft. The scraper has a first position and a second position. In the first position, the scraper abuts against the inner wall of the tank; in the second position, the scraper has a gap with the inner wall of the tank. The limiting assembly is disposed on the stirring shaft and connected to the scraper, used to limit and fix the scraper in the first and second positions. This invention has the effect of scraping off the mupirocin ointment adhering to the inner wall of the tank after discharge, thereby reducing waste.

The invention discloses a low-rate cooling control preparation device for mupirocin ointment, and relates to the technical field of ointment preparation. According to the scheme, the stirring device comprises a support and a tank body which is horizontally arranged on the support and provided with a jacket, the tank body comprises a movable section and fixed sections for rotationally sealing the two ends of the movable section, and the movable section can rotate around the axis of the movable section; comprising a fixed shaft, a stirring sleeve rotationally arranged outside the fixed shaft in a sleeving manner, and a plurality of blades mounted on the stirring sleeve; the driving mechanism is mounted on the bracket and is used for driving the movable section to rotate; and the synchronizing assembly is used for transmitting the rotary motion of the movable section to the stirring sleeve, so that the stirring sleeve and the movable section rotate in opposite directions. A strong two-way shear flow field is formed through autorotation of the tank body and reverse rotation of the stirrer in the tank body, so that the mixing efficiency is improved.

The invention relates to a dosing device for mupirocin ointment, and relates to the technical field of medical instruments, the dosing device comprises a storage part, a connecting part and an extrusion part, the storage part comprises a sliding groove sleeve and a storage box arranged in the sliding groove sleeve in a sliding mode, and the storage box is used for storing mupirocin ointment; the connecting part comprises a connecting ring, the two ends of the connecting ring are detachably connected with the storage part and the extrusion part respectively, gauze is contained in the connecting ring, and when the storage box vertically moves upwards, the bottom of the gauze can make contact with mupirocin ointment in the storage box; the extrusion part comprises a fixed shell and an extrusion assembly arranged in the fixed shell, and the extrusion assembly is used for applying pressure to the gauze and attaching the gauze to the wound; a temperature adjusting assembly used for heating or cooling the extrusion assembly is arranged in the extrusion part, and hot compress or cold compress on the wound is achieved. The application has the effects that the mupirocin ointment can be uniformly smeared on a wound while the discomfort of a patient is relieved, and the recovery efficiency of the wound is improved.

Mupirocin hydrogel system comprising chitosan and carboxymethyl chitosan nanoparticles for sustained drug release and improved wound healing.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application is used in the preparation of products for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The invention discloses a mupirocin purification method, and belongs to the field of medical chemistry, according to the dissolution characteristic of mupirocin, by controlling the pH value, mupirocin fermentation liquor is firstly pretreated, then the fermentation liquor is filtered by using a ceramic membrane and transferred to a water phase, active ingredients of mupirocin in the fermentation liquor are enriched in a composite solvent, and the mupirocin purification method is obtained. The method comprises the following steps: washing a fermentation broth with saline water, adjusting the pH value of the solution, carrying out reverse extraction on mupirocin to a water phase, effectively removing impurities in the solution, improving the purity of mupirocin, removing part of organic matters with small polarity by using a composite solvent after reverse extraction, further improving the content of the effective component mupirocin, removing part of impurities with small polarity by using the composite solvent after reverse extraction, and further improving the purity of mupirocin. Through one-time crystallization, the product can meet the EP quality requirement.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application has the use in preparing the product for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application is used in the preparation of products for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The invention provides a mupirocin ointment composition, a preparation method, application and related products, and belongs to the technical field of external ointment. The mupirocin ointment composition provided by the invention is prepared from the following components in parts by weight: 0.5 to 5.0 parts of mupirocin, 58 to 68 parts of liquid polyethylene glycol, 20 to 36 parts of solid polyethylene glycol, 1.07 to 5.07 parts of borneol, 0.30 to 0.82 part of quercetin, 0.41 to 0.93 part of S-acetyl-L-glutathione and 0.7 to 3.2 parts of urea. The mupirocin ointment composition can be used for preparing the mupirocin ointment, and compared with the prior art, the mupirocin ointment has higher transdermal speed, intradermal retention volume and drug utilization rate, and is high in storage stability and good in biocompatibility.

The present application relates to a kind of mupirocin ointment and its preparation method, the ointment preparation specifically includes mupirocin, polyethylene glycol 400, polyethylene glycol 3350, cyclodextrin, the prepared preparation can solve mupirocin ointment stability problem, effectively control the period of validity within impurity increase, guarantee preparation quality and clinical curative effect, and the ointment preparation process is simple, easy to operate, suitable for industrialization scale production.

A method for extracting mupirocin. The main steps thereof comprise: resin adsorption, desorption and concentration, multi-step extraction, and dehydration and decoloration, wherein the multi-step extraction comprises at least one ester solvent extraction and at least one alkaline water extraction. The method is suitable for industrialization, the extraction recovery rate of mupirocin is 80% or more, and the purity of the mupirocin is 80% or more.

The invention discloses an antibacterial and antioxidant intelligent hydrogel dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the hydrogel dressing, polyvinyl alcohol serves as a matrix, tannic acid serves as a natural functional cross-linking agent, a three-dimensional network is constructed through a physical cross-linking method, and cannabidiol and mupirocin are cooperatively loaded. According to the invention, a safe freezing and thawing cycle process is adopted for molding, so that the biotoxicity risk of a chemical cross-linking agent is thoroughly avoided. The hydrogel not only has excellent biocompatibility, but also has the remarkable characteristics that the hydrogel has pH-responsive drug release capacity, and drug release can be intelligently accelerated in a wound alkaline microenvironment; meanwhile, the antioxidant activity and the broad-spectrum antibacterial property are high, and particularly, the bacteriostasis rate on staphylococcus aureus is close to 100%. In-vitro and animal experiments prove that the dressing can remarkably promote wound healing, the healing rate reaches up to 97% or above within 14 days, and the dressing has wide clinical application prospects in the field of intelligent wound dressings.