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50 results about "Tissue Grafting" patented technology
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Method and apparatus for tissue grafting
ActiveUS20120041430A1Heal fastPromote healingIncision instrumentsSurgical needlesTissue GraftingAnatomy
Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and / or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs.
Owner:THE GENERAL HOSPITAL CORP
Controlled absorption biograft material for autologous tissue support
An implantable tissue grafting medical system and material using a combination of bio-absorbable and non bio-absorbable fibers and materials such as Poly Glycolic Acid (PGA) and polyester (PET), provides a permeable mesh or weave of fibers with an initial interstice size and permeability factor suitable to initial implant requirements, and a pre-engineered bio-absorption pattern and rate that controls the gradual expansion of interstice size within the mesh or weave in one or two dimensions up to a pre-engineered maximum interstice size, consistent with the anticipated rate of tissue regeneration on the implant, while retaining a primary grid or circumferential pattern of non-absorbable fibers at the maximum interstice size for supporting the new tissue for an extended period. Various means for combining materials to obtain initial interstice size, pattern and permeability, with the desired absorption pattern and rate, and the desired end point interstice size and spacing, are also disclosed.
Owner:WARWICK MILLS INC
Method and apparatus for tissue grafting and copying
ActiveUS9060803B2Heal fastPromote healingSurgical needlesVaccination/ovulation diagnosticsTissue GraftingCopying
Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and / or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and / or viability of the harvested tissue.
Owner:THE GENERAL HOSPITAL CORP
Tissue graft
The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.
Owner:CRYOLIFE
Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom
Owner:CARNEGIE MELLON UNIV +2
Lyophilized platelet rich plasma for the use in wound healing (chronic or acute) and bone or tissue grafts or repair
InactiveUS20050191286A1Simple compositionPrevent flow awayBiocidePeptide/protein ingredientsWhite blood cellAntibiotic Y
This invention relates to an improved Lyophilized platelet rich plasma used to make a platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises therapeutically effective amounts of activated growth factors, platelet ghost, plasma (know as the plasma back bone), white blood cells with optional none, one or more additional anti-oxidant such as vitamin A and / or C and / or E, and / or none one or more antibiotics and / or GHK-Cu (produced by ProCyte Inc.)
Owner:WALKER MACKIE J JR
Methods of increasing proliferation of adult mammalian cardiomyocytes through p38 map kinase inhibition
InactiveUS20060281791A1Increased proliferationSlow and reduce and prevent onsetBiocidePeptide/protein ingredientsTargeted disruptionTissue Grafting
Compositions and methods for increasing proliferation and / or de-differentiation of postmitotic mammalian cardiomyocytes are disclosed to slow, reduce, or prevent the onset of cardiac damage. In addition, the methods and compositions of the invention can used to produce de-differentiated cardiomyocytes, which can then be used in tissue grafting, implantation or transplantation. The invention is based, in part, on the discovery that postmitotic mammalian cardiomyocytes can proliferate as a result of targeted disruption of p38 MAP kinase. p38 inhibition with optional growth factor stimulation can induce cytokinesis in adult cardiomyocytes.
Owner:CHILDRENS MEDICAL CENT CORP
Milk protein biofilm and uses thereof
A biofilm for preparing laminated tissue constructs comprising at least one milk protein forming a sheet like structure can be used to support at least one layer of cells adhered to that. The biofilm allows for a easy handling of cultured cell sheets that can be used as tissue graft. The biofilm, comprising milk proteins and at least one plasticizer, when adhered by a cell layer can form a laminated tissue construct for body tissue replacement.
Owner:UNIV LAVAL
Tissue graft
The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.
Owner:CRYOLIFE
Tissue graft
Owner:CRYOLIFE
Soft tissue repair grafts and processes for preparing and using same
Soft tissue repair grafts are provided for supporting, covering, and / or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and / or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.
Owner:MUSCULOSKELETAL TRANSPLANT FOUND INC +1
Combination grafts for tissue repair or regeneration applications
The described invention provides soft tissue grafts, hard tissue grafts, and composite soft / hard tissue grafts and methods of producing such grafts. The grafts comprise a three-dimensional carrier matrix, a growth factor composition comprising an autologous platelet-rich fibrin and a cell culture composition comprising a culture medium, a population of cells suspended in the culture medium, and cells impregnated on or in a surface of osteoconductive particles.
Owner:REJUVABLAST LLC
Ceramic implant placement systems and superelastic suture retention loops for use therewith
ActiveUS20170000476A1Twisting of the sutures or graft is preventedAvoid distortionSuture equipmentsDiagnosticsTissue GraftingBone tissue
Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply a precise amount of tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone, preferably while maintaining the requisite pre-determined suture tension and without introducing spin to the suture. Particularly preferred embodiments allow for the placement of small diameter knotless anchors. For example, the implant placement system may include a cannulated tensioning device having disposed therein an elongate member of a suitably elastic metallic or polymeric material, such as nitinol, that includes at its distal end a loop of material suitable for suture retention. The implant placement system may further include high tensile strength knotless anchors provided with internal drive features that coordinate with torque-transmitting features unique to the driver devices of the present invention.
Owner:TENJIN
Method and composition for treating inflammatory bowel disease
ActiveUS20190076574A1Avoid seizuresReciprocity can be facilitated and improvedDigestive systemUnknown materialsMucosal resectionDamages tissue
Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
Owner:REGENTYS CORP +1
Tissue interface augmentation device for ligament/tendon reconstruction
ActiveUS20160157992A1Promote reconstructionPromote osseointegrationLigamentsMusclesFiberOSTEOINDUCTIVE FACTOR
The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material. The present invention is also directed to a method for the manufacturing of such augmentation devices, a method for fixation of the thus fabricated tissue interface augmentation devices onto ligament or tendon grafts, a method for applying such devices for ligament and / or tendon reconstruction to tendon grafts, as well as their application in ligament and tendon reconstruction.
Owner:NAT UNIV OF SINGAPORE +1
Method and apparatus for creating a reconstructive graft
ActiveUS11246697B2Relieve pressureSelective expandabilityMammary implantsCosmetic implantsTissue GraftingSynthetic materials
Owner:MARKMAN BIOLOGICS CORP
Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration
InactiveUS20100166827A1Slow and reduce and prevent onsetIncreased proliferationBiocidePeptide/protein ingredientsTissue GraftingCardiac muscle
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and / or proliferation of postmitotic mammalian differentiated cardiomyocytes. The invention can be used to slow, reduce, or prevent the onset of cardiac damage caused by, for example, myocardial ischemia, hypoxia, stroke, or myocardial infarction in vivo. In addition, the methods and compositions of the invention can be used to enhance proliferation of differentiated cardiomyocytes in vitro and / or ex vivo, which can then be used in tissue grafting.
Owner:CHILDRENS MEDICAL CENT CORP
Soft tissue repair grafts and processes for preparing and using same
Soft tissue repair grafts are provided for supporting, covering, and / or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and / or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.
Owner:MUSCULOSKELETAL TRANSPLANT FOUND INC +1
Method and apparatus for tissue grafting
ActiveUS9827006B2Heal fastPromote healingIncision instrumentsSurgical needlesTissue GraftingBiomedical engineering
Owner:THE GENERAL HOSPITAL CORP
Culture method for multicolor magnolia flower
InactiveCN106134801AStrong plant growthProlong flowering periodGraftingTissue GraftingPlant cultivation
The invention discloses a culture method for multicolor magnolia flowers. The method mainly comprises steps: parent plant cultivation, tissue grafting, culturing management after grafting, and vegetative propagation character stabilization. The multicolor magnolia flowers cultured by the method can have multiple colors and multiple flower types, and on a same magnolia flower tree, flowers can be white, purple, lavender, yellow, and rosy. Growth of plants is robust, the number of flowers is multiple, and florescence is long. The method shortens cultivation time, reduces variety breeding cost, and improves ornamental value and economical value of the magnolia flowers.
Owner:YIBIN YUNCHEN ARBOR GARDEN
Compositions and methods featuring il-6 and il-21 antagonists
InactiveUS20130224109A1Extended half-lifeHybrid immunoglobulinsIn-vivo radioactive preparationsDiseaseTissue Grafting
The present invention features compositions for inhibiting both the IL-6 and the IL-21 pathways and methods of making and using such compositions. Our work to date indicates the importance of the redundancy of IL-6 and IL-21 to perform certain crucial functions. The pathways can be inhibited by inhibiting the ligands (i.e., IL-6 and IL-21) and / or their respective receptors (i.e., the IL-6 receptor and IL-21 receptor). Alternatively, or in addition, upstream and downstream effectors in the IL-6 and IL-21 pathways can be blocked. The agents used can be antibody or antibody-based proteins or peptides including circulating receptors, optionally coupled to an immunoglobulin or a portion thereof (e.g., the Fc region). Also provided are methods for using the compositions, for example, in organ transplantation, tissue grafting, or autoimmune disorders.
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC
Perfusion bioreactor
ActiveUS20160194593A1Bioreactor/fermenter combinationsBiological substance pretreatmentsPerfusion bioreactorTissue Grafting
In some embodiments the present invention provides perfusion bioreactors and cell culture scaffolds suitable for the preparation of tissue grafts, such as bone tissue grafts. In some embodiments, the perfusion bioreactors comprise a graft chamber and / or a graft chamber insert configured to hold a tissue graft having a certain shape and / or certain dimensions, and / or to allow culture of such tissue grafts under press-fit direct perfusion conditions. In some embodiments, the perfusion bioreactors comprise an equilibration chamber.
Owner:NEW YORK STEM CELL FOUND
Tissue grafts with pre-made attachment points
The present disclosure pertains to membranous tissue grafts comprising one or more pre-made attachment points. The one or more pre-made attachment points may include pre-made markings and / or pre-made suture holes. The membranous tissue grafts can be in the form of a tube. The membranous tissue grafts can also be rectangular in shape and can be used in a nerve repair by wrapping the severed or damaged nerve. In some embodiments, the membranous tissue grafts are suitable for repairing severed nerves that have a short gap or no gap with a gap of less than 5 mm between the severed stumps. Accordingly, methods are provided for repairing a damaged or severed nerve by implanting the membranous tissue grafts on to the damaged or severed nerve.
Owner:AXOGEN CORP
Methods for complex tissue engineering
A simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and / or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.
Owner:VERSITECH LTD
Methods and materials for immunomodulation of tissue grafts
PendingUS20200139012A1Organic active ingredientsPharmaceutical non-active ingredientsLocal immunitySpinal cord
Embodiments described herein relate to restorative solutions for segmental peripheral nerve (PN) defects using allografted PNs for stimulating PN repair. More specifically, embodiments described herein provide for localized immunosuppression (LIS) surrounding PN allografts as an alternative to systemically suppressing a patient's entire immune system. Methods described herein provide for injection of ISV agents into a nerve graft prior to implantation of the nerve graft into a recipient. Methods described herein also provide for injection of ISV agents with a polymerizable carrier into a nerve graft, polymerization of the carrier within the graft, and implantation of the nerve graft into a recipient. Certain embodiments provide for reinnervation of central nervous system (CNS) axons in a spinal cord utilizing a peripheral nerve graft.
Owner:UNIVERSITY OF WYOMING
Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration
InactiveUS8936806B2Slow and reduce and prevent onsetIncreased proliferationBiocidePeptide/protein ingredientsRisk strokeCells heart
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and / or proliferation of postmitotic mammalian differentiated cardiomyocytes. The invention can be used to slow, reduce, or prevent the onset of cardiac damage caused by, for example, myocardial ischemia, hypoxia, stroke, or myocardial infarction in vivo. In addition, the methods and compositions of the invention can be used to enhance proliferation of differentiated cardiomyocytes in vitro and / or ex vivo, which can then be used in tissue grafting.
Owner:CHILDRENS MEDICAL CENT CORP
Methods and devices for tissue graft fixation
Methods and devices for tissue graft fixation include fixation devices attached to an adjustable fixation loop of suture without compromising the graft or requiring additional material to complete the repair. Other fixation devices are attachable to an independent adjustable suture system. Adjustable fixation loops minimize slip / creep of the suture within the loop.
Owner:SMITH & NEPHEW INC +2
A tissue graft direct suspending and fixing device
PendingCN107157617AFully contactedHeal as soon as possibleLigamentsMusclesTissue GraftingFemoral bone
The invention provides a tissue graft direct suspending and fixing device comprising a fixing member, a suspension rod and sewing threads. The fixing member is provided with thread penetration holes; the sewing threads are arranged in the thread penetration holes in a penetrating manner and connected with the fixing member; the suspension rod is arranged on the lower side of the fixing member. The device enables a graft to be placed in a femoral tunnel completely, promotes full contact between the graft and the femoral tunnel and promotes rapid healing.
Owner:上海利格泰生物科技股份有限公司
Tissue grafting method
ActiveUS20140037595A1Readily apparentBiocidePackage sterilisationTissue GraftingEthylene Oxide Sterilization
The tissue grafting method relates to a tissue graft material, a method of preparing the material, and a method of using the material. The tissue graft material is made from the tunica serosa of the small intestine of a warm-blooded vertebrate, which has been delaminated from the tunica muscularis, tunica submucosa, and the tunica mucosa of the intestinal tissue. The tissue graft material may be perforated by discrete punctures. The tissue graft material is dehydrated by air drying or vacuum drying, sterilized with ethylene oxide, and stored in a hermetically sealed enclosure at room temperature until needed, having an indefinite storage life. When needed, the tissue graft material is rehydrated, cut to match the size of the wound, and applied to the wound. The graft may be overlaid with nylon mesh, or bandaged with an elastic tubular dressing.
Owner:ALVARADO CARLOS A
Laminated tissue graft product
ActiveUS10548705B2Risk minimizationLayered productsTransportation and packagingTissue GraftingRepair tissue
A tissue graft comprising two or more layers of material wherein each layer comprises extracellular matrix (ECM) or polymeric material and wherein the layers are laminated together by interlocking portions of one layer with portions of another layer. In one embodiment, a tissue graft comprises a first layer of material having multiple lugs and a second layer of material having multiple holes, each lug of the first layer being located through a hole in the second layer, the holes and the lugs having dimensions so that the lugs engage with a surface of the second layer and interlock the first layer with the second layer. In further embodiments, a method of preparing a tissue graft by laminating and interlocking two or more layers, the use of a tissue graft for replacing or repairing tissue in a human or animal, and an apparatus comprising a mould, a lug cutting means, a piercing means and a means for pushing lugs through piercings in layers of a tissue graft.
Owner:AROA BIOSURGERY LTD
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