15 results about "Amniotic Sheet" patented technology

An amniotic membrane insert configured for self-retaining, sutureless, clear-cornea application to an ocular surface. The insert has an outer edge and an inner edge inside the outer edge. The inner edge defines an opening sized to extend around a circumference of a cornea. The outer edge of the insert has a shape that is non-circular in which a height of the insert is greater than a width of the insert. Related devices, systems, and methods are provided.

The application relates to the field of medical devices, in particular to a support frame for cervical cerclage surgery, which comprises a transport pipe, one end of the transport pipe being provided with a pipe cover used for buckling to close one end of the transport pipe; and a filling bag, which is made of flexible material and the inside of which is communicated with the other end of the transport pipe. The support frame for cervical cerclage surgery can solve the problem that during the cervical cerclage surgery, the amnion bag slides to the vagina through the cervix, thereby pushing against the cervical orifice to make the cervical orifice keep excessively open, which makes it difficult for a doctor to perform a suture operation on the cervical orifice and to pull up the cervical orifice, the support frame is convenient for the doctor to perform the suture operation on the cervical orifice and to pull up the cervical orifice, and the support frame is easy to be collected.

To provide production methods in which the growth rate during culture of adherent stem cells obtained from an amnion is increased by devising a method of preserving the amnion before culturing, to reduce the manufacturing costs.SOLUTION: By preserving an amnion in a solution in which platelet lysate (PL) is added to the solution for preserving the amnion, the proliferation during culture of adherent stem cells collected from the amnion is enhanced.SELECTED DRAWING: None

This invention provides a dressing for difficult-to-heal wounds and its preparation method, to solve the problems encountered when using amniotic membrane to promote the healing of difficult-to-heal wounds, such as easy breakage, difficulty in fixing wrinkles, and low mechanical strength; a dressing for difficult-to-heal wounds and its preparation method, wherein the dressing includes at least one amniotic membrane layer, wherein the amniotic membrane layer is formed by splicing several individual amniotic membranes of the same size through an amniotic membrane assembly, wherein the amniotic membrane assembly consists of a substrate and several microneedles perpendicular to the substrate.

This invention relates to the field of biomedical technology, and more particularly to a miniature amniotic trephine device for macular hole surgery. It includes a support shell, on one side of which is slidably connected a ring-shaped array of blades. When fully extended, the ring-shaped array of blades will not extend beyond the adjacent side of the support shell. A power assembly for moving the ring-shaped array of blades is disposed within the support shell. A support assembly for temporarily supporting the surgical site is also disposed within the support shell. Two annular inclined plates and two annular guide plates are fixedly connected to the side of the support shell near the ring-shaped array of blades. This invention utilizes a ring-shaped array structure composed of multiple blades to form a standardized cutting profile, ensuring that the size and shape of the amniotic membrane slices obtained each time are within a predetermined range, thereby avoiding quality instability problems caused by variations in existing operations.

This invention provides a dual-segment, dual-color pH comparison catheter for clinical identification of premature rupture of membranes, belonging to the field of medical catheter technology. It includes a main catheter tube with a urine segment pH membrane and an amniotic fluid segment pH membrane sequentially arranged along the axial direction on the anterior outer wall of the main tube. The urine segment pH membrane has a color development range of pH 5.5-6.5, and its color change is a continuous gradient from yellow to green. This invention achieves zero-sampling detection under sterile conditions, highly integrating pH identification function into routine catheterization procedures. The pH value of urine and any potentially mixed amniotic fluid is simultaneously detected upon catheter insertion into the bladder, without the need for vaginal speculum, sampling swabs, or any form of secondary sterile opening. This design completely blocks the path of exogenous bacteria into the maternal reproductive tract at a physical level, thereby fundamentally and effectively reducing the incidence of clinically common chorioamnionitis and urinary tract infections, and improving perinatal medical safety and quality.

The utility model relates to a kind of filtering devices for amniotic membrane tissue digestion cell liquid, belong to the technical field of cell liquid processing equipment.It is formed by the cooperation of first filter assembly, second filter assembly and filter cup assembly, and forms sealed flow channel in vertical direction, accelerates high viscous liquid flow in the whole filtration process, reduces blockage;At the same time, the flow guide pipe is connected to the lowest point of filter cup, and cooperates with liquid stop clamp to realize rapid collection, reduce sample loss;Single operation completes filtration operation, eliminates external pollution and eliminates the risk of liquid leakage.

Methods for purifying, culturing and selecting mesenchymal stem cell (MSC) subpopulations with neonatal quality and adult tissue specificity that are for use in production of advanced therapeutic medicinal products.

The application discloses a kind of based on dynamic softening polycarbonate composite ring's free suture biological amniotic membrane and preparation method thereof.The based on dynamic softening polycarbonate composite ring's free suture biological amniotic membrane includes the amniotic membrane tissue piece of decellularization processing and the modified polycarbonate composite ring for fixing the amniotic membrane tissue piece;The modified polycarbonate composite ring includes polycarbonate continuous phase and the dispersed phase of intelligent polymer in it, and the intelligent polymer is PLGA-PEG-PLGA tri-block copolymer.The application is by specially-made PLGA-PEG-PLGA intelligent polymer and gives modified PC composite ring dynamic modulus adjustable characteristics.After the composite ring is implanted in eye, under the action of body temperature and tear, its contact surface modulus can be reduced by 40%-68% within 24 hours, realize from "surgical rigidity" to "in situ soft" adaptive change.This fundamentally greatly reduces the mechanical friction with cornea / conjunctiva, relieves the strong foreign body sensation, pain and irritation symptom of patient after operation.

The present application relates to the field of cell detection and screening, and particularly relates to a method and system for detection and screening of amniotic epithelial stem cells. The method comprises: generating a structured sample task sheet based on multi-source information; performing tissue digestion processing based on the task sheet to obtain a candidate cell group; then performing phenotype detection, molecular detection and quality detection to generate corresponding data packets and label data packets; based on the quality label data packets, performing gating, batch normalization, abnormality rejection, fusion scoring and consistency determination processing through a screening engine to generate a screening result packet; and finally generating a disposal work order and a traceability report based on the screening result packet. The present application realizes standardized and auditable automatic processing of the whole process of amniotic epithelial stem cells from receiving, detection to sorting and disposal, greatly improving the detection efficiency, result consistency and traceability.

The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.

The present disclosure relates to an amniotic membrane dressing including an amniotic membrane that is treated with ethylene oxide gas and a method of manufacturing the same. The amniotic membrane dressing of the present disclosure has an effect of improving transparency and structural stability of the amniotic membrane dressing by reacting the amniotic membrane with the ethylene oxide gas.

A method for preoperative preparation to facilitate the therapeutic application of an amniotic membrane to an eye, leveraging its regenerative and anti-inflammatory properties to enhance corneal health prior to surgery. Comprising identifying patients requiring cataract surgery, diagnosing ocular surface conditions, applying the amniotic membrane to the eye to improve corneal health prior to biometric measurements, thereby ensuring enhanced accuracy in intraocular lens selection, allowing the therapeutic properties of the amniotic membrane to be absorbed by the eye, and evaluating the patient's ocular surface health after applying the amniotic membrane.

The deformable amniotic membrane endoscope device of the present invention includes an amniotic membrane and a deformable amniotic membrane support device. The deformable amniotic membrane support device includes a C-shaped open ring and a solid annular cylinder nested together. The C-shaped open ring is a ring with a C-shaped cross-section, and the opening of the C-shaped structure faces inward. The solid annular cylinder is also an annular structure. The amniotic membrane, after being stripped of its chorionic villi and flattened, is inserted into the C-shaped open ring. The annular cylinder supports the amniotic membrane, pressing it into the groove of the C-shaped open ring. The periphery of the amniotic membrane is trimmed, leaving a certain width of free amniotic membrane tissue around the opening of the C-shaped open ring, thus forming the amniotic membrane endoscope. The beneficial effect of this invention is that the nickel-titanium shape memory alloy has a 37% [unclear meaning - possibly referring to a specific feature or characteristic] in the human body. 0 The amniotic membrane does not deform, allowing it to completely cover the entire conjunctival and corneal surface according to the anatomy of the conjunctival sac. This achieves full coverage of the entire ocular surface without any blind spots, preventing or reducing further adhesion between the eyelid and the eyeball.