11 results about "Pericardium tissue" patented technology

The invention belongs to the technical field of bioprosthetic valves, and relates to a pericardial tissue decellularization method for bioprosthetic valve preparation, which comprises the following steps: decompressing to a target vacuum state by using a staged decompression method, carrying out vacuum-assisted decellularization treatment on pericardial tissue, washing the decellularized pericardial tissue, and drying to obtain the pericardial tissue decellularization method for bioprosthetic valve preparation. And finally, pressurizing the washed pericardial tissue to complete cell removal of the pericardial tissue. The washing treatment is carried out by adopting a periodic pressure difference auxiliary washing mode. According to the present invention, the integrity of the extracellular matrix is effectively maintained while the cell components are efficiently removed, and the residues during the decellularization process are reduced.

A safe, reliable, reproducible system and method for entry into the pericardial sac. The method and system described generally includes penetration of the subcutaneous tissue with a guide sheath or a relatively blunt stylet contained within a sheath. The stylet is removed from the sheath and a vacuum mechanism is installed. Once in contact with the pericardium, the sheath is engaged with the pericardial tissue, allowing the vacuum mechanism to draw the pericardium away from the heart to create a greater space between the heart and pericardium allowing needle insertion onto the pericardial cavity in a much safer and controlled manner.

The present application belongs to the technical field of biological valve, and relates to a pericardial tissue decellularization method for biological valve preparation, which comprises the following steps: first, using a phased decompression method to decompress to a target vacuum state; then, performing vacuum-assisted decellularization treatment on the pericardial tissue; then, performing washing treatment on the pericardial tissue after the decellularization treatment; finally, performing pressure treatment on the pericardial tissue after the washing treatment, so as to complete the cell removal of the pericardial tissue; and the washing treatment is performed in a periodic pressure difference auxiliary washing mode. The present application can effectively remove cell components, effectively maintain the integrity of the extracellular matrix, and reduce residues in the decellularization process.

This application discloses a pericardial puncture sheath needle, comprising an outer sheath needle, a puncture needle, a needle slide, and a negative pressure injector. The outer sheath needle is fitted onto the puncture needle, and the puncture needle slides inside the outer sheath needle via the needle slide. The negative pressure injector is connected to the outer sheath needle via a Luer interface. The outer sheath needle includes an upturned tip and a straight sheath needle, the straight sheath needle being connected to the upturned tip. A negative pressure hole is provided at the end of the straight sheath needle near the upturned tip. The puncture needle has a drainage hole. When the puncture needle slides to its outermost position, the tip of the puncture needle is located on the side of the negative pressure hole away from the upturned tip. When the puncture needle slides to its innermost position, the drainage hole corresponds to the negative pressure hole. By setting the upturned tip, the sheath needle can conform to the human body structure when entering the body. By setting the negative pressure hole, the puncture site can be drawn into the sheath needle by negative pressure, and then the puncture needle can be used to puncture the pericardial tissue.

A method of treating a native mitral valve without open-heart surgery is disclosed. An expandable prosthesis includes an anchoring portion and an occluding member coupled to the anchoring portion. The prosthesis is loaded into a distal end portion of a delivery catheter and is advanced through a femoral vein and through a pre-made puncture in an atrial septum. The anchoring portion self-expands within the left atrium for anchoring the occluding member in a fixed position. The anchoring portion is preferably a laser cut structure that conforms to the left atrium and uniformly distributes anchoring forces within the left atrium. After deployment, the occluding member prevents blood from flowing from the left ventricle to the left atrium during systole. The occluding member is preferably made from a flexible material, such as pericardial tissue.

The pericardium puncture sheath needle comprises an outer sheath needle, a puncture needle, a needle threading sliding plug and a negative pressure injector. The puncture needle is sleeved with the outer sheath needle, the puncture needle slides in the outer sheath needle through the needle threading sliding plug, and the negative pressure injector is connected with the outer sheath needle through a Luer interface; the outer sheath needle comprises an upwarp head and a straight sheath needle, the straight sheath needle is connected with the upwarp head, and a negative pressure hole is formed in the end, close to the upwarp head, of the straight sheath needle; the puncture needle is provided with a drainage hole; when the puncture needle slides to the outermost side, the needle point of the puncture needle is located on the side, away from the upwarp head, of the negative pressure hole. When the puncture needle slides to the innermost side, the drainage hole corresponds to the negative pressure hole. By arranging the upwarp head, the sheath needle can conform to the human body structure when entering the human body, by arranging the negative pressure hole, the part to be punctured can be adsorbed into the sheath needle through negative pressure, and then pericardial tissue is punctured through the puncture needle.

The present application provides a pericardial traction exposure device for minimally invasive cardiac surgery, and relates to the technical field of medical devices, which comprises a dilatation ring and a traction assembly arranged on the dilatation ring. The dilatation ring is a deformable elastic ring structure, which can gently and uniformly expand the pericardial tissue after being inserted into the pericardial cavity. The number of traction assemblies is multiple, and they are uniformly arranged on the outer periphery of the dilatation ring along the circumference. The traction assemblies work together to provide more uniform and stable traction force for the pericardial tissue, effectively exposing the heart and providing a clearer surgical field for the surgeon, simplifying the surgical steps, reducing the operation complexity, and improving the overall efficiency and safety of the surgery. Moreover, the dilatation ring and the traction assembly of the present application do not need to be pulled out from the chest wall after traction of the pericardial tissue, avoiding additional surgical incisions and being beneficial to the postoperative recovery of the patient.

The embodiment of the invention provides a cardiac pace-making mode, a cardiac pace-making electrode wire for realizing the mode and a pace-making control method, and belongs to the technical field of cardiac pace-making. The cardiac pacing mode is mainly characterized in that the lead is fixed on the pericardial tissue instead of being embedded or sewn on the myocardium. The cardiac pacing electrode wire is composed of a heart fixing assembly, a signal transmission assembly and an electrode assembly. According to the pace-making control method, pace-making parameter combinations including pace-making voltage, pace-making current, pace-making pulse width and pace-making electrode polarity combinations are automatically adjusted. According to the embodiment of the invention, on the premise of meeting pace-making requirements, damage to myocardium and surrounding tissues thereof can be reduced.

A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

Embodiments herein relate to prosthetic heart valves constructed with animal tissue wherein the leaflets are unitary with the inner skirt. In an embodiment, an implantable heart valve assembly is included having a plurality of valve leaflets, an inner skirt, and a metal frame, wherein the plurality of valve leaflets and the inner skirt are formed of a continuous piece of animal tissue. In another embodiment, a method of making an implantable heart valve assembly is included, the method including placing a piece of pericardial tissue over a mold, cross-linking the pericardial tissue in place over the mold, removing the pericardial tissue from the mold, and attaching the pericardial tissue to a frame, wherein the pericardial tissue forms a seamless junction between a plurality of valve leaflets and an inner skirt. Other embodiments are also included herein.

Valve repair device for repairing a patient's native valve, the valve repair device comprising: a basic arrangement comprising several pivotable links and a shaft, wherein the pivotable links are moved by the shaft; a pair of paddles attached to the base assembly, wherein the movement of the pivoting links moves the paddles between an open position and a closed position; a pair of gripping elements attached to the base assembly, the paddles and gripping elements being configured to be attached to the patient's valve leaflets; at least one spacer element that surrounds the shaft and is arranged between the pair of gripping elements; wherein the spacer element is made of at least one material selected from the group of materials consisting of woven mesh, fabric, biocompatible material, foam and pericardial fabric; the spacer element fills a space between the gripping elements when the paddles are in the closed position.