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Bioprosthetic valve and processing method thereof

A treatment method and technology of biological valve, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor treatment effect and difficult treatment of biological valve, achieve sufficient removal, enhance anti-calcification and anti-coagulation performance, and achieve uniform treatment Effect

Pending Publication Date: 2020-09-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In view of the above-mentioned prior art, the present invention provides a biological valve and its treatment method to solve the problems of difficult treatment and poor treatment effect of the biological valve

Method used

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  • Bioprosthetic valve and processing method thereof
  • Bioprosthetic valve and processing method thereof
  • Bioprosthetic valve and processing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A biological valve, which is obtained after being processed through the following steps:

[0034] S1: Flatten the edge of the fresh porcine pericardium tissue and fix it physically, then insert the pericardium tissue 4 vertically into the figure 1 In the middle part of the shown container 1, the pericardial tissue thus separates the container 1 into two spaces, cavity one 2 and cavity two 3;

[0035] S2: Add polyethylene glycol octyl phenyl ether (Triton-100) solutions with a concentration of 0.1wt% in the two spaces respectively, and then alternately apply pressures of 200KPa and 100KPa on both sides of the liquid, and the pressure alternating period is 10min. Complete the decellularization treatment after 24h;

[0036] S3: Release the Triton-100 solution, then add physiological saline to the two spaces respectively, and then alternately apply pressures of 200KPa and 100KPa on both sides of the liquid, the pressure alternating cycle is 10min, and the cleaning process ...

Embodiment 2

[0042] A biological valve, which is obtained after being processed through the following steps:

[0043] S1: Flatten the edge of fresh bovine pericardium tissue and fix it physically, then insert the pericardium tissue vertically figure 1 The middle part of the container shown, the pericardial tissue thus divides the container into two spaces;

[0044] S2: Add a polyethylene glycol octyl phenyl ether (Triton-100) solution with a concentration of 1wt% in the two spaces respectively, and then alternately apply pressures of 200KPa and 100KPa on both sides of the liquid, and the pressure alternating cycle is 1min, 20h Afterwards, the decellularization treatment was completed;

[0045] S3: Release the Triton-100 solution, then add ethanol into the two spaces respectively, then apply pressures of 200KPa and 100KPa alternately on both sides of the liquid, the pressure alternating cycle is 10min, and the cleaning process is completed after 24h;

[0046] S4: Release ethanol, then add...

Embodiment 3

[0051] A biological valve, which is obtained after being processed through the following steps:

[0052] S1: Flatten the edge of the fresh porcine pericardium tissue and fix it physically, then insert the pericardium tissue 4 vertically into the figure 1 In the middle part of the shown container 1, the pericardial tissue thus divides the container 1 into two spaces, cavity one 2 and cavity two 3, and an air-permeable solid plate is installed in the cavity two 3 to make the pericardial tissue 4 tight Paste air-permeable solid panels;

[0053] S2: Add polyethylene glycol octyl phenyl ether solution with a concentration of 5wt% in cavity one 2, then vacuumize cavity two 3 to form a pressure difference of 0.5 MPa on both sides of pericardial tissue 4, and complete the process after 10 hours decellularization;

[0054] S3: Release polyethylene glycol octylphenyl ether solution, add glycerin aqueous solution into cavity 1 2, then vacuumize cavity 2 3 to form a pressure difference ...

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Abstract

The invention discloses a bioprosthetic valve and a processing method thereof. The processing method comprises the following steps: flattening a flat pericardial tissue material and fixing the edge; sequentially contacting a pericardial tissue material with the fixed edge with an acellular solution, a cleaning solution, a fixing solution, a capping reagent, a deloading solution and a cleaning solution, forming a pressure difference between the two sides of the pericardial tissue material in the solution contact process, and enabling various solutions to pass through the interior of the pericardial tissue material under the action of the pressure difference so as to finish the treatment of the pericardial tissue material. According to the treatment method disclosed by the invention, phospholipid, cell components, immunogenicity, calcification sites, toxic reagent residues and the like in tissues can be effectively removed, the anti-calcification and anti-coagulation properties of the treated tissue are remarkably enhanced, and the pericardial material can be extruded under the action of pressure, so that the treated pericardial material has excellent mechanical properties.

Description

technical field [0001] The invention belongs to the technical field of biological tissue processing, and in particular relates to a biological valve and a processing method thereof. Background technique [0002] When severe stenosis and regurgitation occur in the human native biological valve, it can be treated by artificial valve replacement. Damaged valves can be replaced with biological or mechanical valves, but long-term anticoagulant therapy is usually required after mechanical valve implantation, so biological valves have become a preferred choice for patients. In addition, biological valves can also be delivered to the heart through catheters, which improves the safety of valve implantation, shortens the recovery period of patients, and has good effectiveness. [0003] Current bioprostheses are often sewn onto a frame using processed xenogeneic pericardial tissue and then implanted in the body. As a long-term implant, the pericardial tissue needs to have good stabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3604A61L27/3641A61L27/3687A61L27/3691A61L27/50A61L2430/20A61L2430/40
Inventor 王云兵郭高阳
Owner SICHUAN UNIV
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