153results about How to "Effective inactivation" patented technology

The invention provides a production method of human fibrinogen, which is against the method that domestic conventional manufacturers extract and separate human fibrinogen from component I, and the method for extracting fibrinogen from cryoprecipitate is adopted; an S/D method and a water-bath heat treating method are adopted to carry out double-virus inactivation, thereby effectively inactivating fat enveloped virus and non-fat enveloped virus, and ensuring the security of products; the purity of extracted products reaches as high as more than 90%, the protein content of impurities is low, and the clinical side reaction of the product is small. In the production process of the human fibrinogen of the invention, glycine is utilized as a stabilizer, the freeze-drying time is prolonged about 6-8 days to ensure the temperature variation of the product to be stable in freeze-dying process, but the freeze-drying time of general manufacturers is about 3 days; after being freeze-dried for 6-8 days, the product has uniform structure, then water bath heat treatment is carried out on the product, thus the product can be evenly heated in the shortest time, thereby achieving the purposes of effectively inactivating DNA and RNA non-fat enveloped virus and simultaneously ensuring the stability of human fibrinogen.

The presenten invention also relates to a liquid immunoglobulin G (IgG) product which has a purity of more than 95%, a content of IgG monomers and dimers of at least 95% and, a content of IgA of less than 6 mg of IgA/I. The liquid product is stable and ready for instant intravenous administration.

The invention relates to a method for producing a human prothrombin complex. The method is characterized in that the following steps of direct separation and extraction from blood plasma, virus inactivation, refining and secondary virus inactivation are adopted to obtain finished human prothrombin complex. As the method adopts the step of direct separation and extraction from the blood plasma, the separation condition is mild, the batch-to-batch difference of the products is small, the blood coagulation factor activity is stable, the yield rate is high, and the activation phenomenon basicallydoes not exist. The virus inactivation process adopts a method of combining an S/D (organic solvent/detergent) method and a dry and thermal activation method and fully ensures that the virus safety of the human prothrombin complex.

The invention discloses a high-temperature kitchen waste degradation microbial agent and a preparing and using method thereof. A microbial strain comprises, by weight, 15-30 parts of nuby land anoxybacillus, 10-25 parts of liquefaction thermophilic bacillus, 20-40 parts of hot nitrogen bacillus and 25-50 parts of geobacillus stearothermophilus. Compared with the prior art, the high-temperature kitchen waste degradation microbial agent has the beneficial effects that as for kitchen waste with different integrants, reasonable matching on single bacterium powder can be carried out, and single bacterial strains are cooperated for degrading the kitchen waste in a collaborative mode; the number of effective viable bacteria in the single bacterium powder in the composite microbial agent is large, and when the microbial agent is used for degrading the kitchen waste, only a small number of microbial agents is needed for sufficiently and rapidly degrading the kitchen waste; components in the microbial agent are high-temperature cultures, the optimum fermentation temperature ranges from 55 DEG C to 65 DEG C, pathogenic bacteria such as escherichia coli and staphylococcus aureus in the kitchen waste can be effectively inactivated in the fermentation process, and the biosecurity is high.

The invention relates to a protoporphyrin fluorescent carbon dot, and a preparation method and application thereof. The preparation method comprises the following concrete steps: reacting protoporphyrin with polyethyleneimine (PEI) at 170 to 220 DEG C for 7 to 10 h; and then successively carrying out cooling, dialysis and filtering so as to obtain the protoporphyrin fluorescent carbon dot. The protoporphyrin fluorescent carbon dot prepared in the invention has good water solubility and maintains the intact properties of protoporphyrin; photodynamic effect produced by a porphyrin photosensitizer can effectively inactivate yeast cells, so bactericidal effect is exerted; and the preparation method has the advantages of simple reaction steps, mild reaction conditions, small danger, low toxicity, etc.

The invention discloses a ship exhaust and ballast water integrated treatment system and belongs to the field of an environmental technology. The integrated treatment system comprises an electrochemical seawater modification reactor, a ballast water treatment reactor and an exhaust gas purifying scrubbing tower and is characterized in that the exhaust gas purifying scrubbing tower comprises a micro-nano-bubble generating device, an oxidizing scrubber and an alkaline absorbing scrubber. The basic principle of the system is that the electrochemical seawater modification reactor carries out electrolysis on seawater so that two liquid flows such as a strong oxidizing liquid flow and an alkaline liquid flow having different performances are formed. The strong oxidizing liquid flow can be used to deactivate microbes in ballast water and to oxidize ship exhaust. The alkaline liquid flow can be used to neutralize and absorb oxidized ship exhaust. H2 produced by the electrochemical seawater modification reactor is used for a hydrogen fuel cell so that H2 recovery and recycle are realized and explosion damage is prevented. The system provides a novel energy supply method for a ship with limited energy. The system realizes efficient treatment on ship exhaust and ballast water, has a small size and is conducive to use in the ship.

The invention discloses a preparation method of a wear-resisting ceramic tile capable of releasing a negative ion. A finished product of the ceramic tile is obtained by ball-milling a powder material,pulping, spraying a powder, forming, biscuiting, glazing, glaze-firing and edging; a used glaze comprises a negative ion powder; the powder material comprises potassium feldspar, albite, nepheline, kaolin, washing mud, barium carbonate, calcined talcum, nano-zinc oxide, methylcellulose, sodium tripolyphosphate, a preservative. The preparation method adopts the low-temperature biscuiting and high-temperature glaze-firing process; the ceramic tile produces a large quantity of negative ions, the glaze is flat and smooth, the resistance to thermal shock and the stain resistance are good, and thepreparation method has excellent performances of wear resistance and acid corrosion resistance, and has excellent economic and social benefits.

The invention discloses a preparing method for pig thrombin freeze-dried powder. The preparing method comprises the following steps that anticoagulant pig plasma and gel are mixed and stirred for adsorption and pass through a column for elution, and a prothrombin solution is obtained; normal saline is added to rabbit brain powder, then the prothrombin solution and CaCl2 are added for zymogen activation, a crude thrombin enzyme solution is obtained, subjected to ultrafiltration for desalination and concentrated, viral inactivation is carried out, an obtained crude enzyme solution passes through DEAE-Sepharose Fast Flow chromatographic column, elution is carried out, target peaks are collected, and pig thrombin is obtained; the pig thrombin is added with mannitol or dextran 40, filtering, sterilizing, subpackaging, freeze drying and vacuum tamponing are carried out, an aluminum plastic combined cover is rolled, and a pig thrombin freeze-dried product is obtained; the freeze-dried product is subjected to dry heat treatment at 100 DEG C for secondary virus inactivation, and the pig thrombin freeze-dried powder is obtained after packaging. The specific activity of pig thrombin in the product is not lower than 130 U/mg, the whole process is simple in step and easy to implement, the product safety is improved, and the preparing method is suitable for industrial production.

The invention relates to a microfiber collagen hemostatic material and a preparation method thereof. The preparation method of the material includes the first step of sodium sulfide unhairing, the second step of shredding and fibrosis, the third step of swelling control, the fourth step of drying, the fifth step of depolymerisation and fluffing, and the sixth step of Co60 radiation sterilization, wherein in the fifth step, the obtained fasciculus is treated using a hammer mill to obtain a microfiber collagen product. According to the method, the use concentration of sodium sulphide is reduced, the efficiency of unhairing is improved, and degreasing and impure protein removal are effectively conducted; collagen materials are not oxidized and degenerated, the activity of microfiber collagen is easy to maintain, and the hemostatic effect is improved. Acid is introduced in the treating process, the degreasing and protein removal are more effective, and the adhesion property of the hemostatic material is guaranteed.

The invention provides a virus inactivation method for solution of globulin. An optimum proportion with a practical value of various parameters during virus inactivation with sodium caprylate is provided by a large number of researches on various conditions such as a temperature, a pH value, concentration of caprylate, concentration of protein and hatch time during the virus inactivation. Experiments prove that the virus inactivation method for the solution of the globulin has the advantages of simpleness, safety, rapidness, effectiveness, high protein recovery and no effect on the bioactivity of a target protein.

The invention discloses a photodynamic sterilization fresh-keeping film for packaging ready-to-eat jellyfish. The photodynamic sterilization fresh-keeping film is prepared in the mode that food-gradecurcumin and food-grade EDTA disodium are compounded to serve as a photosensitizer compound, chitosan and glycerinum are combined to serve as a matrix material, and a solution-casting method is conducted. After the photodynamic sterilization fresh-keeping film is adopted to package the ready-to-eat jellyfish, the photodynamic sterilization fresh-keeping film is matched with non-toxic LED visible light sources for use, and thus the aerobic bacterial count on the ready-to-eat jellyfish is effectively decreased. The tests show that the disinfection rate of the photodynamic sterilization fresh-keeping film on the ready-to-eat jellyfish is up to 99.9%, the sterilization effect is significant, the flavor and taste of the ready-to-eat jellyfish are not significantly affected, the shelf life of the ready-to-eat jellyfish can be prolonged from one month to five months, and the food safety problem of the ready-to-eat jellyfish is ensured.

The invention relates to a lost label detection method for an RFID (Radio Frequency Recognition Device) system, which comprises the following steps that: a reader inactivates unknown labels in the RFID system through a grid table constructed by the reader according to IDs (Identities) and hash functions of all known labels, f1 represents the length of each frame, and l represents the number of random seeds; and the reader detects lost tags in the RFID system according to the IDs of all known tags and multiple hash operations based on ID right shift, performs multiple mapping on each tag duringhash operations, and performs hash operations before the ith mapping and after the IDs of the remaining tags shift rightwards by i-1 bits. According to the method, most of unknown tags can be effectively inactivated, the influence of the unknown tags on detection of the lost tags is greatly reduced, the response time can be shortened, and the detection efficiency of the lost tags is improved.

The invention provides an ultraviolet/titanium dioxide (UV/TiO2) reactor for disinfecting drinking water treated by the activated carbon, aiming at solving the problem on the biosafety of bacteria, particularly the carbon-adsorbed bacteria in drinking water treated by activated carbon. The UV/TiO2 reactor is an integrated UV/TiO2 reactor system which has the advantage of disinfecting by UV and the characteristic of catalyzing by TiO2 and is optimized and integrated with the process. The UV/TiO2 reactor can effectively inactivate the free bacteria and the carbon-adsorbed bacteria in the drinking water treated by the activated carbon, can ensure the disinfected drinking water to reach the sanitary standard for drinking water (GB5749-2006) and can bear the water supplying load change on some degree, thereby having wide application prospect.

The invention provides a preparation method of antibacterial and antiviral nano water-based slurry. The preparation method comprises the following steps: dropwise adding an inorganic zinc salt solution into a sodium hydroxide solution, controlling the temperature and pH value to prepare columnar nano ZnO powder; then, mixing columnar nano ZnO powder, a Cu2SO4 water solution, and a certain amount of NaOH, CTAB, a GO water solution and hydrazine hydrate, carrying out an ultrasonic reaction to prepare Cu2O-ZnO-GO nano composite powder, finally adding the Cu2O-ZnO-GO nano composite powder into a mixed dispersion liquid, and stirring to obtain the antibacterial and antiviral nano water-based slurry. The slurry is characterized in that columnar nano ZnO and Cu2O simulate a dragonfly wing nano bulge structure; and ZnO and Cu2O are uniformly loaded by virtue of the large surface area of GO. The formed nano composite powder can effectively inactivate bacteria such as escherichia coli, staphylococcus aureus and streptococcus pneumoniae and non-enveloped viruses such as influenza viruses and SARS, and has a wide application prospect in the fields of coatings, paints, implants, household appliances and the like.

The invention discloses a BODIPY-containing bactericidal material and a preparation method and application thereof. The preparation method comprises that BODIPY-Br and sodium azide undergo a reactionto produce BODIPY-N3, BODIPY-N3 and acetylated maltoheptaose undergo a reaction under the catalytic action of a CuCl/PMDETA complex to produce BODIPY-Mal, and the BODIPY-Mal, iodic acid and iodine undergo an iodination reaction to produce the BODIPY-Mal-I bactericidal material. The BODIPY-Mal-I bactericidal material has good water solubility and completely retains the properties of BODIPY. The photodynamic power generated by BODIPY-Mal-I can effectively inactivate yeast cells and especially kill gram-positive bacteria. The preparation method has the advantages of simple processes, mild reaction conditions, low risk and low toxicity.

The invention discloses an antibacterial household paper, which comprises pulp, additives and antibacterial agents. The pulp comprises 45-65 parts of unbleached hardwood pulp, 10-20 parts of bamboo pulp, 15-25 parts of grass pulp, additives Including 2-4 parts of retention and drainage aid, 2-6 parts of defoamer, 1-5 parts of resin barrier remover, 2-7 parts of APAM, 3-7 parts of cationic disperse rosin, 6-10 parts of cationic starch, 2-7 parts of PPE 6 parts, 3-9 parts of surface enhancer, 2-10 parts of modified alkyd resin, 1-5 parts of amine type or quaternary ammonium cationic surfactant, antibacterial agent including 2-6 parts of quaternary ammonium salt, 3 parts of guanidine salt ~10 parts, chitosan 7~12 parts, haloamine polymer 3~8 parts; this product has the advantages of cheap price and good bactericidal effect.

The method of deactivating pathogen in mud of city waste water treating yard belongs to the field of mud resource utilizing technology. Material refluxing method is adopted to realize the circulation of dominant fermentation colony, marketable VT bacteria is used as inducing bacteria in initial fermentation, and the ratio between the thrown amendment and refluxed material is regulated based on the property of mud. In the dynamic aerobic fermentation reactor, dynamic aerobic fermentation is performed for about 10 days to deactivate pathogen under certain ventilation and stirring conditions. The method can raise the temperature of the material to over 55 deg.c and maintain the temperature for over one week without needing outer heat source in deactivating pathogen. The method makes mud become harmless in low cost and high efficiency.

The invention relates to the chemical industry, in particular, to a substance which exhibits antiseptic properties and to a method for the production and use thereof. The inventive substance can be used as a filtering material or an additive for the mixture of filtering materials, or as a component of filtering composites used for disinfecting and cleaning liquids, mainly drinking water, or gases. The inventive antiseptic material consists of a solid non-water soluble cross-linked polymer material, which contains chlorine atoms reversibly bound with nitrogen atoms and is characterised by the following general formula: M(F)l.0-5.5(Ph)0,6-1.0Cl-4.2, where M - melamine, F - bridge and terminal groups-formaldehyde producers, Ph - phosphorus in oxidation state of +5, Cl - chlorine atoms bound with nitrogen atoms, wherein the above-mentioned material is cross-linked by binding phosphorus-containing ions with melamine links of polymer chains. The inventive antiseptic material producing method involves chlorinating the solid non-water soluble cross-linked polymer material which is produced by the condensation of melamine phosphate and paraform in an aqueous solution, wherein the above-mentioned material is cross-linked by binding the phosphorus-containing ions with the melamine links ofpolymer chains directly during the production process of said product.