The invention discloses a nano-emulsion with good stability. A formula of the nano-emulsion is prepared from the following components in percentage by weight: 30.0-82.13 percent of purified water, 0.01-0.1 percent of EDTA disodium, 0.5-5.0 percent of hydrogenated lecithin, 0.3-5.0 percent of a nonionic surfactant, 0.5-5.0 percent of caprylic acid/caprinic acid triglyceride, 5.0-30 percent of squalane, 1.0-5.0 percent of isononyl isononanoate, 0.01-0.5 percent of tocopheryl acetate, 0.5-3.0 percent of 1,2-hexanediol, 10.0-40.0 percent of glycerin and 0.05-8.0 percent of an oil-soluble skin conditioner. Through reasonable selection and ratio blending of components of the nano-emulsion, the strength and the elasticity of an interfacial film are improved, the interface energy is lowered, the mobility of the interfacial film is reduced, and the nano-emulsion with the stability to temperature change is prepared. The nano-emulsion wraps various efficient skin-care components and promotes transdermal absorption of functional components; and in addition, the hydrogenated lecithin as an emulsifier has better physiological activity, promotes substance metabolism of epidermic cells and enablesskin to be more pliable, tougher and more elastic; and modified soyasterol has the effect of relieving skin inflammation.