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Nano-emulsion with good stability

A nanoemulsion technology with good stability, applied in skin care preparations, cosmetics, cosmetic preparations, etc., can solve problems such as loss of commercial value and particle size changes, achieve superior skin care effects, reduce interface energy, and ensure stability Effect

Active Publication Date: 2019-03-12
NOX BELLCOW COSMETICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the nanoemulsions on the market will change in particle size under the temperature test of 45°C and -15°C, which will cause great limitations to the use of nanoemulsions in different dosage forms, and may even lose commercial value

Method used

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  • Nano-emulsion with good stability
  • Nano-emulsion with good stability
  • Nano-emulsion with good stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: a kind of nanoemulsion with good stability, its weight formula proportioning is:

[0037] Phase A

[0038] Purified water 74.8%, disodium EDTA 0.05%;

[0039] Phase B

[0040]

[0041] The preparation method follows the following steps: (1) Set the temperature of the water phase tank to 80°C, start stirring at 40r / min, slowly add each component in group A under stirring, and stir until it is colorless and transparent;

[0042] (2) Set the temperature of the emulsification tank to 75°C, start stirring at 40r / min, and mix hydrogenated lecithin, nonionic surfactant, squalane, caprylic acid / capric triglyceride, isononyl isononanoate in phase B . Add the oil-soluble skin conditioner to the emulsification tank and mix evenly. After heating to 75°C, turn on the homogenizer for 3 minutes, and the rotation speed is 2500r / min;

[0043] (3) After the above process is completed, add 1,2-hexanediol in phase B to the emulsification tank, stir at 40r / min for 3 minu...

Embodiment 2

[0057] A kind of nanoemulsion with good stability, the weight percentage of its formula is:

[0058] Phase A

[0059] Deionized water 56.77%, disodium EDTA 0.03%,

[0060] Phase B

[0061]

[0062] Its preparation method is as follows:

[0063] (1) Set the temperature of the water phase tank to 80°C, start stirring at 40r / min, and slowly add each component in group A under stirring, and stir until it is colorless and transparent;

[0064] (2) Set the temperature of the emulsification tank to 75°C, start stirring at 40r / min, and mix hydrogenated lecithin, nonionic surfactant, squalane, caprylic acid / capric triglyceride, isononyl isononanoate in phase B . Add the oil-soluble skin conditioner to the emulsification tank and mix evenly. After heating to 75°C, turn on the homogenizer for 3 minutes, and the rotation speed is 2500r / min;

[0065] (3) After the above process is completed, add 1,2-hexanediol in phase B to the emulsification tank, stir at 40r / min for 3 minutes, the...

Embodiment 3

[0071] A kind of nanoemulsion with good stability, the weight percentage of its formula is:

[0072] Phase A

[0073] Deionized water 57.55%, disodium EDTA 0.10%, phase B

[0074]

[0075] Its preparation method is as follows:

[0076] (1) Set the temperature of the water phase tank to 80°C, start stirring at 40r / min, and slowly add each component in group A under stirring, and stir until it is colorless and transparent;

[0077] (2) Set the temperature of the emulsification tank to 75°C, start stirring at 40r / min, and mix hydrogenated lecithin, nonionic surfactant, squalane, caprylic acid / capric triglyceride, isononyl isononanoate in phase B . Add the oil-soluble skin conditioner to the emulsification tank and mix evenly. After heating to 75°C, turn on the homogenizer for 3 minutes, and the rotation speed is 2500r / min;

[0078] (3) After the above process is completed, add 1,2-hexanediol in phase B to the emulsification tank, stir at 40r / min for 3 minutes, then add glyc...

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Abstract

The invention discloses a nano-emulsion with good stability. A formula of the nano-emulsion is prepared from the following components in percentage by weight: 30.0-82.13 percent of purified water, 0.01-0.1 percent of EDTA disodium, 0.5-5.0 percent of hydrogenated lecithin, 0.3-5.0 percent of a nonionic surfactant, 0.5-5.0 percent of caprylic acid / caprinic acid triglyceride, 5.0-30 percent of squalane, 1.0-5.0 percent of isononyl isononanoate, 0.01-0.5 percent of tocopheryl acetate, 0.5-3.0 percent of 1,2-hexanediol, 10.0-40.0 percent of glycerin and 0.05-8.0 percent of an oil-soluble skin conditioner. Through reasonable selection and ratio blending of components of the nano-emulsion, the strength and the elasticity of an interfacial film are improved, the interface energy is lowered, the mobility of the interfacial film is reduced, and the nano-emulsion with the stability to temperature change is prepared. The nano-emulsion wraps various efficient skin-care components and promotes transdermal absorption of functional components; and in addition, the hydrogenated lecithin as an emulsifier has better physiological activity, promotes substance metabolism of epidermic cells and enablesskin to be more pliable, tougher and more elastic; and modified soyasterol has the effect of relieving skin inflammation.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a nanoemulsion with good stability and a preparation method thereof. Background technique [0002] (1) In the use of skin care products, in order to achieve better results, it is usually necessary to consider whether the functional active ingredients (such as whitening and anti-aging ingredients) in the product can penetrate the stratum corneum and epidermis of the skin, reach the base layer or related It works according to the site, that is, it needs to consider whether the active ingredients in the formula can achieve high bioavailability. The particle size of the dispersed phase of ordinary emulsions is usually several microns to tens of microns, while the particle size of the dispersed phase of nanoemulsions is about 100 times smaller than that of ordinary emulsions, ranging from several nanometers to hundreds of nanometers. A more common definition is: the par...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/34A61K8/55A61K8/63A61Q19/00
CPCA61K8/068A61K8/345A61K8/553A61K8/63A61Q19/00
Inventor 李美停邱晓锋郑冯峰
Owner NOX BELLCOW COSMETICS CO LTD
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