Protoporphyrin fluorescent carbon dot, and preparation method and application thereof

A fluorescent carbon dot, protoporphyrin technology, applied in the directions of botanical equipment and methods, applications, chemical instruments and methods, etc., to achieve the effects of good water solubility, low risk and mild reaction conditions

Active Publication Date: 2017-08-04
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of this, the object of the present invention is to overcome the shortcoming that protoporphyrin is insoluble in water, obtain a kind of w

Method used

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  • Protoporphyrin fluorescent carbon dot, and preparation method and application thereof
  • Protoporphyrin fluorescent carbon dot, and preparation method and application thereof
  • Protoporphyrin fluorescent carbon dot, and preparation method and application thereof

Examples

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Example Embodiment

[0025] Example 1

[0026] The preparation method of protoporphyrin fluorescent carbon dots 1 comprises the following steps:

[0027] 1) Prepare 10 mL of PEI (Mn=550~650) solution of 2 mg / mL, weigh 10 mg of protoporphyrin, add them to the hydrothermal reactor together, and react at 220° C. for 10 h;

[0028] 2) After the reaction is completed, cool to room temperature, conduct dialysis with a 1000D dialysis bag for 3 days, and then filter the dialyzed product with a 0.22 μm pinhole filter, and the obtained filtrate is the protoporphyrin fluorescent carbon dots.

Example Embodiment

[0029] Example 2

[0030] The preparation method of protoporphyrin fluorescent carbon dots 2 comprises the following steps:

[0031] 1) Prepare 10 mL of PEI (Mn=550~650) solution of 2 mg / mL, weigh 10 mg of protoporphyrin, add them to the hydrothermal reactor together, and react at 220° C. for 8 h;

[0032] 2) After the reaction is completed, cool to room temperature, conduct dialysis with a 1000D dialysis bag for 3 days, and then filter the dialyzed product with a 0.22 μm pinhole filter, and the obtained filtrate is the protoporphyrin fluorescent carbon dots.

Example Embodiment

[0033] Example 3

[0034] The preparation method of protoporphyrin fluorescent carbon dots 3 comprises the following steps:

[0035] 1) Prepare 10 mL of PEI (Mn=550~650) solution of 2 mg / mL, weigh 10 mg of protoporphyrin, add them to the hydrothermal reactor together, and react at 180° C. for 8 h;

[0036] 2) After the reaction is completed, cool to room temperature, conduct dialysis with a 1000D dialysis bag for 3 days, and then filter the dialyzed product with a 0.22 μm pinhole filter, and the obtained filtrate is the protoporphyrin fluorescent carbon dots.

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Abstract

The invention relates to a protoporphyrin fluorescent carbon dot, and a preparation method and application thereof. The preparation method comprises the following concrete steps: reacting protoporphyrin with polyethyleneimine (PEI) at 170 to 220 DEG C for 7 to 10 h; and then successively carrying out cooling, dialysis and filtering so as to obtain the protoporphyrin fluorescent carbon dot. The protoporphyrin fluorescent carbon dot prepared in the invention has good water solubility and maintains the intact properties of protoporphyrin; photodynamic effect produced by a porphyrin photosensitizer can effectively inactivate yeast cells, so bactericidal effect is exerted; and the preparation method has the advantages of simple reaction steps, mild reaction conditions, small danger, low toxicity, etc.

Description

technical field [0001] The invention belongs to the technical field of polymer material synthesis and preparation, and relates to a protoporphyrin fluorescent carbon dot and a preparation method thereof. Background technique [0002] In recent years, the overuse of antibiotics has led to the emergence and spread of "superbugs". The so-called "super bacteria" means that these bacteria are multi-resistant to current antibiotics, which adds great difficulty to the treatment of clinical trauma infection. Therefore, it is urgent to develop new anti-infection strategies. Photodynamic antibacterial therapy, one of the most promising new treatments, has shown good efficacy for infections caused by bacteria, fungi and viruses, especially for infections caused by drug-resistant bacteria. [0003] Protoporphyrins are well-known aromatic macrocyclic compounds widely found in nature. Protoporphyrin is a purple-brown crystalline powder, easily soluble in methanol, insoluble in dilute a...

Claims

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Application Information

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IPC IPC(8): C08G73/02C09K11/06A01N43/90A01P1/00A01P3/00
CPCA01N43/90C08G73/0213C09K11/06C09K2211/1466
Inventor 徐立群宁玲贵蔡晓燕
Owner SOUTHWEST UNIVERSITY
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