The application discloses absorbable anti-inflammatory catgut and a manufacturing method thereof, and belongs to the technical field of biomedical materials. The catgut is prepared from a sheep
intestinal submucosa, and is prepared through the steps of cleaning and swelling,
degreasing,
submucosa stripping,
decellularization, winding and
dehydration shaping. An
enzyme treatment step is introduced in the
decellularization step, which significantly reduces the
immunogenicity of the material and endows the catgut with active anti-inflammatory properties. The catgut prepared by the method has less
cell residues, complete collagen structure, appropriate
mechanical strength, slight inflammatory reaction after being implanted into a body, fast
wound healing speed and excellent
biocompatibility, and is suitable for suture of various surgical operations.