5 results about "Intestinal submucosa" patented technology

The invention discloses lactobacillus paracasei CFCFC018, a microbial agent and application of the lactobacillus paracasei CFCFC018, and belongs to the technical field of microorganisms. The lactobacillus paracasei CFCFC018 is separated from intestinal contents of rural cats in half-farming and half-pastoral areas in Inner Mongolia, does not need genetic engineering modification, can highly express amino acids and neurotransmitters, can remarkably relieve mammary gland alveolar structure damage in mammary gland tissues of rats suffering from mastitis induced by staphylococcus aureus, and has the advantages of being high in safety and good in stability. The thickening of a mammary gland interacellular matrix layer is avoided, the infiltration number of neutrophils is reduced, the damage degree of mammary gland tissues is reduced, and a certain protection effect on the mammary gland tissues is achieved. The research also shows that the strain can reduce the abundance of harmful bacteria in excrement, improve intestinal inflammation and relieve edema of intestinal submucosa, which provides a new thought for preventing and treating mastitis by regulating intestinal microbiota.

This invention discloses a composite scaffold for bone repair and its preparation method. The composite scaffold for bone repair consists of a porous polylactic acid (PLA) scaffold in the middle and an outer layer of small intestinal submucosal matrix sponge. The ratio of the diameter of the composite scaffold to the diameter of the PLA porous scaffold is 2-4. The preparation method includes the following steps: S1: preparing small intestinal submucosal matrix; S2: preparing a small intestinal submucosal matrix solution; S3: preparing a PLA porous scaffold; S4: preparing a composite scaffold of small intestinal submucosal matrix sponge and PLA porous scaffold; S5: cross-linking treatment, placing the composite scaffold of small intestinal submucosal matrix sponge and PLA porous scaffold in a cross-linking treatment solution, and finally freeze-drying to obtain the composite scaffold for bone repair. The composite scaffold for bone repair prepared by this invention has good mechanical properties and will be gradually degraded and replaced and absorbed by newly formed bone tissue.

This invention discloses a method for preparing a composite nanofiber bone scaffold, belonging to the field of medical engineering technology. First, a bacterial cellulose (BC) membrane is prepared. BC membrane powder is then prepared by pre-cooling with liquid nitrogen and mechanical grinding, and subsequently dispersed in a polydopamine solution to obtain a BC polydopamine solution. The prepared decellularized submucosal layer (SIS) of the biological matrix membrane is incubated overnight in the BC polydopamine solution, and finally freeze-dried to obtain the composite nanofiber bone scaffold. This invention provides a method for preparing a composite bone scaffold using polydopamine, which has excellent film-forming properties and biocompatibility, does not hinder cell growth and differentiation, and combines BC and SIS in a green synthesis process with simple operation.

The application discloses absorbable anti-inflammatory catgut and a manufacturing method thereof, and belongs to the technical field of biomedical materials. The catgut is prepared from a sheep intestinal submucosa, and is prepared through the steps of cleaning and swelling, degreasing, submucosa stripping, decellularization, winding and dehydration shaping. An enzyme treatment step is introduced in the decellularization step, which significantly reduces the immunogenicity of the material and endows the catgut with active anti-inflammatory properties. The catgut prepared by the method has less cell residues, complete collagen structure, appropriate mechanical strength, slight inflammatory reaction after being implanted into a body, fast wound healing speed and excellent biocompatibility, and is suitable for suture of various surgical operations.

The invention discloses a preparation method of a biodegradable and absorbable hemostatic composition, and belongs to the technical field of medical materials. The technical problems to be solved are that in the preparation process of an existing hemostatic material containing polysaccharide components, a cross-linking agent is used, so that the safety is poor, and the water absorption expansibility is reduced due to poor uniformity of raw materials in the preparation process. According to the technical scheme, the method is characterized by comprising the following steps: firstly, dissolving water-soluble polysaccharide in water to form a water-soluble polysaccharide solution; fully mixing the decellularized small intestinal submucosa particles with sodium carboxymethyl starch, spraying a water-soluble polysaccharide solution, and carrying out wet granulation to obtain wet particles; and carrying out size stabilization, drying and sterilization on the wet particles to obtain the hemostatic composition. Wherein in wet granulation, the pressure of a spray gun is set to be 0.2-0.3 MPa.