Process for producing immunolobulins for intravenous administration and other immunolobulin products

A technology of immunoglobulin and products, which is applied in the field of immunoglobulin products and medical applications, can solve problems such as transfer and hepatitis C virus infection, and achieve the effect of improving product purity
CN1311797AInactive Publication Date: 2001-09-05CSL BEHRING AG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CSL BEHRING AG
Publication Date
2001-09-05
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The presenten invention also relates to a liquid immunoglobulin G (IgG) product which has a purity of more than 95%, a content of IgG monomers and dimers of at least 95% and, a content of IgA of less than 6 mg of IgA / I. The liquid product is stable and ready for instant intravenous administration.
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Description

Field of the invention

[0001] The present invention relates to a method for purifying immunoglobulin, ie immunoglobulin G (IgG), from crude plasma or crude plasma protein components. The invention also relates to an immunoglobulin product and the medical use of such an immunoglobulin product. Background of the invention

[0002] Human normal immunoglobulin (HNI) was introduced in the late 1940s for the prevention and treatment of some infectious diseases. By Cohn & Oncley's refrigerated ethanol fractionation (Cohn E et al., (1946), J. ACS., 68, 459-475), (Oncley et al., (1949), J. ACS., 71, 541-550), and later Kistler And Nitschmann also carried out the improved method and prepared HNI, which proved to be safe and effective when administered subcutaneously or intramuscularly, avoiding the spread of viral infection.

[0003] Congenital or acquired complete or partial absence of immunoglobulins (primary and secondary immunodeficiency syndromes, respectively) manifests in fre...

Claims

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