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Ocular surface biomembrane and preparation method thereof

A production method and biofilm technology, which can be used in eye implants, medical science, prostheses, etc., can solve the problems of limited source of human placental amniotic membrane, insufficient virus killing, and inability to popularize and apply, so as to be beneficial to wound healing. , good protective therapeutic effect, good air permeability and bacterial filtration effect

Active Publication Date: 2008-05-07
SUMMIT GD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fixation method used for placental amniotic membrane is treated with traditional glutaraldehyde. Glutaraldehyde fixation will have residual toxicity, which will directly affect the healing effect
And only 10-15KGy of gamma-ray irradiation is used to inactivate, and there is no specially designed anti-antigen treatment, and the killing of possible viruses is not strict enough, which makes people worry about the spread of viruses
In addition, the source of human placental amniotic membrane is very limited and cannot be widely used.

Method used

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  • Ocular surface biomembrane and preparation method thereof

Examples

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Embodiment 1

[0046] Take fresh pig pericardium or pig small intestine membrane, put it into a special preservative to sterilize and keep it fresh, carefully remove the impurities on the membrane, drain the water, put it in organic solvents such as absolute ethanol, ethyl acetate, acetone, chloroform, etc. Extract for more than 6 hours to remove the fat impurities. Then use protease enzymatic hydrolysis to remove the cells. The protease can be trypsin, pepsin or a mixture of the two. The enzymolysis temperature is 18-25°C, and the enzymolysis time is more than 2 hours. Then cross-link and fix with epoxide, the epoxide used is . Here R=C n h 2n+1 -or , n=0, 1, 2,...n, wash, drain, and then block the active antigen group with butyric anhydride or butyryl chloride, where the active antigen group mainly contains -OH, -NH 2 ,-SH specific active group to remove its antigenicity. Wash it, then press it into a curved surface with a spherical film tool and stretch it to shape. Packaging, g...

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Abstract

The invention provides a preparation method of an ocular surface biofilm, which uses animal pericardium, intestinal membrane and adipose omentum as raw materials through degreasing, decellularization, multi-directional antigen removal, epoxy fixation, curved surface molding, surface Modification, cobalt-60γ-ray irradiation sterilization and other process steps. The ocular surface biofilm obtained by the method of the present invention has a curved surface similar to that of the eyeball, can be close to the eyeball, has no antigenicity, good histocompatibility, can participate in the healing process of ocular surface wounds, and is beneficial to wound healing; Good air permeability and bacterial filtration can play a good role in the protection and treatment of the ocular surface; it has good strength, can be pasted and sewed, and is easy to use. In addition, through the surface modification of drug sustained release, it can also be made into a therapeutic ocular surface biofilm that can release anti-infective drugs slowly.

Description

technical field [0001] The invention relates to an ocular surface dressing for ophthalmic care and treatment, which belongs to the third category of medical equipment, in particular to an ocular surface biofilm and a production method thereof. Background technique [0002] Eye surface dressings are required for the treatment and care of corneal and conjunctival injuries, inflammation, and care after corneal transplantation. The traditional ocular surface dressing is a general sterile gauze, which cannot be in close contact with the eye surface and can only play a simple covering role. In recent years, scientists have developed a tissue membrane made of human placental amniotic membrane as an ocular surface dressing, which can be directly attached to the surface of the eye, and has a good effect on promoting the healing of injuries and inflammation. The fixation method used for placental amniotic membrane is treated with traditional glutaraldehyde. Glutaraldehyde fixation wi...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61F2/14
Inventor 徐国风陈建苏徐斌
Owner SUMMIT GD BIOTECH
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