61results about How to "Trauma" patented technology

The invention discloses a construction method of a cerebral artery ischemia reperfusion model, and belongs to the technical field of animal models. Three-dimensional positioning coordinates of the middle cerebral artery are obtained through magnetic resonance scanning, the far end of the middle cerebral artery can be accurately positioned, the middle cerebral artery is induced to be blocked after irradiation by setting the blood vessel irradiation position, the rose red dosage and the laser irradiation intensity and time, blood vessel recanalization is caused along with blood impact within 4-5 hours, and finally an ischemia reperfusion model is formed. Compared with a traditional craniotomy electrocoagulation middle cerebral artery (permanent occlusion) and a traditional balloon embolism middle cerebral artery (ischemia reperfusion), the construction method has the advantages that wounds on animals are smaller, the animals are easy to survive, and compared with traditional photochemical induction which can only form infarction lesions on the surface layer of the brain, the method can induce deep brain tissue to form infarction, so that the method has the advantages of being simple and convenient to operate and the like. The method can also be expanded to other brain areas to induce deep vascular occlusion. Meanwhile, the method is also suitable for carrying out model construction on old animals, and the modeling success rate is increased.

The invention relates to the technical field of prostate treatment equipment, in particular to a prostate enucleation and tissue smashing integrated device based on a laser technology, the prostate enucleation and tissue smashing integrated device comprises an export pin, a tissue smashing system and a laser excision system which are sequentially arranged from front to back, and a driving motor is arranged below the tissue smashing system. According to the prostatic enucleation and tissue smashing integrated device based on the laser technology, a tube wall convex groove is formed in the outer side wall of a telescopic tube, when the telescopic tube rotates, a lower convex rod extending into the tube wall convex groove is matched, the telescopic tube can rotate and move back and forth in a reciprocating mode at the same time, a tissue suction groove can cover a wider area, and therefore the tissue suction effect is improved. And prostate tissues at different positions can be captured and sucked more easily, so that the tissues with irregular shapes can be effectively treated.

The utility model provides an auxiliary positioning lighting device for a jaw osteomyelitis operation, belongs to the technical field of jaw osteomyelitis operation equipment, and solves the technical problems that a doctor needs to spend a long time in judging the position and boundary of a jaw osteomyelitis focus in the operation process, the operation view is not clear, lighting is difficult and the like. The device comprises a positioning guide plate, the positioning guide plate comprises a tooth socket and a wound covering plate, a connecting plate is integrally formed between the tooth socket and the wound covering plate, a sliding groove is formed in the rear end of the connecting plate, a sliding block is connected in the sliding groove in a sliding mode, a bolt is fixed to the upper position of the rear end of the sliding block, and a long groove used for sliding of the bolt is formed in the connecting plate. A connecting mechanism is arranged at the lower position of the rear end of the sliding block, and a supporting mechanism is arranged on the connecting mechanism. The device has the advantages that the nidus of jaw osteomyelitis is positioned in real time, illumination of the operation field is kept, illumination does not need to be continuously adjusted after the position of the head of a patient is adjusted in the operation process, operation wounds are reduced, operation efficiency is improved, and the like.

The invention discloses a bone tissue biopsy minimally invasive device which comprises a sampling assembly, a cutting assembly and a sleeve assembly, the sampling assembly comprises a sampling piece and a sampling handle installed on the sampling piece, the sleeve assembly comprises a sleeve arranged in the vertical direction and a handle arranged in the horizontal direction, the handle is installed at the top of the sleeve, and the cutting assembly is connected with the sleeve. The sampling piece extends into the sleeve, and the cutting assembly is installed at the bottom of the sleeve and connected with the sampling piece. The bone taking time can be remarkably shortened, trauma of the bone taking part is reduced, and meanwhile the efficiency and the curative effect of the autogenous bone grafting operation are improved.

An inner cavity of a sheath tube and an inner cavity of a large head portion are communicated, an air bag is arranged on the outer side face of the front end portion of the sheath tube, a medical felt tube sleeve is sleeved on the sheath tube, a section of light tube is reserved between the medical felt tube sleeve and the air bag, a section of external threads is arranged on the rear end portion of the sheath tube close to the medical felt tube sleeve, and the external threads are communicated with the air bag. A medical felt gasket and a nut are sequentially arranged on the external thread, a plurality of narrow kerfs which are through front and back are formed in the peripheral side of the nut, a plurality of winding hooks are arranged on the rear side face of the nut, the winding hooks are circularly arranged to form a wire spool, the inner diameter of a base circle where the winding hooks are located is larger than the outer diameter of a base circle of the large head part, and a containing cavity is formed in the large head part. A blood blocking valve is arranged on a base of the containing cavity, an internal thread port is formed in the outer end of the large head portion, and the blood blocking valve blocks the internal thread port. When an artificial heart device is implanted, the heart of a patient does not need to be stopped and cardiac muscle does not need to be cut off, surgical operation is simplified, the surgical process is shortened, and the influence on the heart function of the patient is relieved.

A combined endoscopic surgery device comprises a plurality of combined bases which are used for being placed in a human body cavity to be combined or placed in the human body cavity after being combined, each combined base comprises a plurality of connecting modules used for being matched with one another, and a connecting plug is arranged on one side of each connecting module. The other side of each connecting module is provided with a plug-in groove used for being matched with the corresponding plug-in head, and the plug-in grooves are used for achieving combined connection between the connecting modules. A plurality of supporting bodies are further rotationally installed on each connecting module, fixing interfaces used for installing surgical instruments are formed in the supporting bodies, and circuit interfaces are formed in the connecting plugs, the inserting grooves and the fixing interfaces and used for achieving electric power and / or communication signal transmission. The device can be put into a human body cavity to be combined, so that endoscopic surgery operation is facilitated, limitation of the endoscopic surgery operation is avoided, meanwhile, utilization of surgery channels is optimized, the number of unnecessary surgery channels is reduced, and wounds of a patient and postoperative recovery burden are relieved.

The invention provides an implantable medical device and a positioning method of a wireless energy transmission coil thereof, and the method comprises the steps: re-exciting a magnetic field through a transmitting coil in a process that the spatial position of the transmitting coil is adjusted; acquiring an induced electrical signal at the receiving coil corresponding to the process of re-exciting the magnetic field; and extracting slope characteristics from the acquired induction electric signals, and judging whether the receiving coil is aligned with the transmitting coil or not according to the slope characteristics. Sensors (such as a magnetoresistive sensor and an electronic compass) hardware do not need to be additionally arranged, the size of the implantation end is small, trauma to a patient in the implantation process is reduced, the coil alignment state is judged by extracting slope characteristics instead of judging the coil alignment state based on signal intensity (such as an absolute value of induced voltage), and the accuracy of the coil alignment state is improved. The judgment method based on the slope characteristics is higher in accuracy and better in anti-interference performance.

The utility model discloses a three -sided formula bone knife structure, include: connecting seat, joint, the joint fixed setting in the upper end of connecting seat, handle, the lower extreme of handle with the upper end of joint is detachably connected, three -sided formula cutter body, three -sided formula cutter body setting in the lower end of connecting seat. Through the application of the utility model, provide a three -sided formula bone knife structure for taking bone, especially applicable to the acquisition operation of double cortex ilium, it can be realized in one insertion process smoothly intercepts double cortex bone piece, shortens the operation time and reduces the trauma to the patient, can carry out multidirectional cutting in the narrow bone surface area through three -sided formula design, reduces the demand of repeatedly changing sword or using other turning cutter, further improves the operation efficiency.

The utility model relates to a diameter-variable blood vessel sheath structure, which solves a series of problems of large operative wound, incapability of intraoperative radiography and the like in the process of treating lower limb artery embolism by opening a Fogarty catheter to take thrombus. The device comprises an outer sheath, an inner sheath and a sheath core which are sequentially nested from outside to inside, the outer sheath comprises an outer sheath main body and an outer sheath base arranged at the near end of the outer sheath main body; the inner sheath comprises an inner sheath body, an inner sheath base is arranged at the near end of the inner sheath body and connected with a hemostasis valve, the far end of the inner sheath body is connected with a self-expansion covered stent sample structure with two open ends, and the length of the inner sheath is larger than that of the outer sheath. The sheath core comprises a sheath core body, a sheath core base is arranged at the near end of the sheath core body, a conical end with the outer diameter gradually reduced is arranged at the far end of the sheath core body, a middle hole for a guide wire to penetrate through is formed in the sheath core body, and the length of the sheath core is larger than that of the inner sheath. The utility model has the advantages of high effectiveness, high safety, strong adaptability, good adaptability, simple structure and convenient operation.

The present invention belongs to the field of pancreatic cancer diagnosis, and specifically relates to a platelet marker and a detection kit for detecting pancreatic cancer. The present invention collects platelets from non-cancer individuals and pancreatic cancer patients for transcriptome sequencing, and identifies for the first time through differential expression analysis the genes that are specifically highly expressed in the platelets of pancreatic cancer patients, including DERA, TPP1, and CREG1. In the receiver operating characteristic curve analysis of the training set, the area under the curve is as high as 0.989, and in the validation set, the AUC value is as high as 1. This shows that the mRNA expression levels of the platelet DERA, TPP1, and CREG1 genes identified by the present invention can be used to diagnose pancreatic cancer. This discovery not only has important clinical significance, but also indicates a broad potential for promotion, providing a new approach and method for detecting pancreatic cancer.

The present invention discloses a single-port laparoscopic fixation device for pneumoperitoneum-free, the single-port laparoscopic fixation device comprising an incision retractor and an in-vivo telescopic support system. The in-vivo telescopic support system uses the anterior superior iliac spine as a support point, and controls an air cushion support frame to lift the incision retractor through a pneumatic adjustment mechanism, so that the angle between the incision retractor and the human abdomen is between 20°-45°. The in-vivo telescopic support system and the pelvis form an isosceles triangle support system. The present invention adopts internal support to make the incision retractor form an angle of 20-45 degrees with the abdominal wall, converting the original surgical blind area into direct vision surgery, which is more conducive to operation, greatly reducing the difficulty of surgery and the risk of surgical side effects, while reducing the establishment of external brackets, reducing trauma, reducing pollution links, and streamlining the surgical process.

The present invention discloses a minimally invasive implantable heart assist device, comprising: a blood pump positioning bracket, the blood pump positioning bracket comprising a deformable cylinder, a nut, and a central cylinder; a bracket conveyor, the bracket conveyor comprising an outer cylinder, an inner cylinder assembly, and a locking structure, the other end of the outer cylinder and the inner cylinder assembly is provided with a cylindrical receiving groove structure for accommodating the deformable cylinder and the central cylinder; the outer diameter of the deformable cylinder increases when the outer cylinder and the inner cylinder assembly are in an unlocked state and the outer cylinder is separated from the inner cylinder assembly; a blood pump, the blood pump is provided with a blood inlet placed in the central cylinder and a blood vessel for connecting to the aorta; a positioning device, the positioning device is used to connect and position the blood pump and the blood pump positioning bracket. It can quickly realize the implantation of the blood pump through minimally invasive surgery, solving the problems of high surgical skills and great trauma to patients.

The utility model relates to the technical field of medical instruments, and discloses a channel screw positioning instrument which comprises a positioner main body, a guide sleeve, a locking mechanism, an adapter and an adjusting device, the positioner main body is of an arc-shaped structure, and the top end of the positioner main body is connected with the adjusting device. The positioner main body and the adjusting device are made of medical grade stainless steel or polymer materials; the guide sleeve is in sliding fit with the adjusting device and slides in the length direction of the adjusting device, and an observation opening is formed in the guide sleeve and used for facilitating observation of a doctor and guiding insertion of a screw; sliding blocks are connected to the front side and the rear side of the middle of the guide sleeve correspondingly and slide in the second sliding grooves. The channel screw positioning instrument is easy and convenient to operate, the fracture part is stabilized by placing the screws in the white channel of the pelvis and the hip, and fracture healing and functional recovery are promoted; compared with a traditional operation method, the technology has the advantages of being small in trauma, fast in recovery, short in operation time and the like.

This invention discloses a pre-placed adjustable hernia repair patch and its preparation method, relating to the field of medical device technology. The patch body is a polypropylene woven mesh with a weight of less than 50 g / m². The polypropylene woven mesh has a double-layer gradient structure with different densities on both sides. This pre-placed adjustable hernia repair patch uses a double-layer gradient structure of the same woven mesh. The outer layer has large pores (80-300 μm) to facilitate fibroblast ingrowth and tissue fixation, while the inner layer has small pores (15-80 μm) to form a physical barrier, effectively inhibiting visceral adhesions. It addresses both fixation and anti-adhesion needs. Temporary fixation is achieved through sliding PLGA fixation pins, pre-drilled holes, and elastic rings. The fixation pins are available in various lengths, and the elastic rings enable temporary fixation and position adjustment. Blue marking lines facilitate directional identification, and barium sulfate contrast markers aid in intraoperative positioning and postoperative follow-up.

The invention belongs to the technical field of medicines, and relates to application of polydocanol in preparation of a medicine for treating lymphatic leakage through a drainage tube or direct puncture application, and the polydocanol is a polydocanol foaming agent. The poly-docanol foaming agent is prepared by rapidly sucking and mixing a liquid preparation containing 5-30 mg of poly-docanol per milliliter and sterile air for 30 times through a three-way cock according to the volume ratio of 1: (1-5), wherein the volume ratio of the liquid preparation to the sterile air is 1: (1-5); the lymphatic leakage is armpit lymphatic leakage caused after breast cancer operation. The invention also provides a treatment method for applying the polydocanol in the lymphatic leakage patient and a medicine for treating the lymphatic leakage, and the medicine comprises the polydocanol and pharmaceutically acceptable auxiliary materials. The method has the advantages of small trauma, simplicity and convenience in operation, high safety, short treatment period, quick response and the like.

This invention relates to the field of interbody fusion device technology, specifically a 3D-printed porous interbody fusion device, comprising a fusion device body, a first filling hole penetrating through the middle of the fusion device body, and a plurality of internal reinforcing ribs evenly distributed circumferentially on the inner wall of the first filling hole. Based on the biomimetic mechanical design concept of the biomedical engineering industry, this interbody fusion device can break through the limitations of traditional fixed-width fusion devices, and can accurately match the anatomical width of the intervertebral space of different patients without the need for manual cutting and modification during surgery. It can fully adapt to the individualized needs of various heights, weights and disease segments, and fundamentally avoid the risks of endplate damage, infection and anchoring structure damage caused by cutting. After implantation, the self-locking component can achieve immediate rigid locking, completely blocking the reverse rebound path of the adjustment block. Combined with the multi-occlusal tooth structure, it forms a stable mechanical anchor, eliminating postoperative micromovement, displacement and slippage problems, and greatly improving the overall stability of the fusion device in the early stage of implantation.

This invention relates to an anastomosis device for gingival surgical incisions, comprising a main body structure, a gripping structure, several staple structures, a staple delivery structure, two power structures, and a staple separation structure. Its advantages lie in that, by rotating the gripping structure to the main body structure, the gripping structure drives the two power structures to move along the length of the main body structure, pressing the staple separation structure towards the staple structure, thus separating the staples; simultaneously, the power structures push the separated staple structures, causing them to move along the staple delivery structure. The staple delivery structure clamps both sides of the surgical incision and deforms the staple structures, separating them from the staple delivery structure, thereby compressing both sides of the surgical incision and achieving anastomosis. This eliminates the need for staples to puncture the gums, reducing trauma, and is simple and convenient to operate. It allows for rapid suturing of surgical incisions, and the protruding staple delivery structure allows for anastomosis of gums deep within the oral cavity.

This invention discloses a photocurable fixation auxiliary device for ingrown toenail correction, comprising an ingrown toenail body and a flexible rectangular frame. The correction mechanism includes an Ω-shaped correction wire, with hooks fixed to both ends of the Ω-shaped correction wire to hook onto the side edge of the ingrown toenail body. Each hook has an anti-slip strip fixed to its inner front surface. A curing pen is provided on the top of the flexible rectangular frame. This invention, through the cooperation of the Ω-shaped correction wire, auxiliary wire, and hooks, can form a central bridging fulcrum and bilateral symmetrical ring arms on the surface of the ingrown toenail body, thereby achieving three-dimensional correction force on the ingrown toenail body in an upward, outward, and forward direction. This addresses the growth trajectory of the ingrown toenail body from the root cause, with minimal trauma and a low recurrence rate. Simultaneously, through the cooperation of the curing pen, conical shell, and flexible rectangular frame, the photocurable resin inside the flexible rectangular frame can be photocured, ensuring that the entire ingrown toenail correction device remains securely fixed after installation.

This invention discloses an electrode implantation tool. The distal end of the electrode is provided with a fixing component. The implantation tool includes an outer sheath and an inner sheath. The inner sheath includes an inner sheath tube and a first handle. The outer sheath includes an outer sheath tube and a second handle. The inner sheath tube can be inserted into the outer sheath tube. The first handle can be locked within the second handle. The second handle has at least a first locking position and a second locking position in the axial direction, allowing the first handle to move from the first locking position to the second locking position. The inner diameter of the inner sheath tube is smaller than the outer diameter of the fixing component, and the inner diameter of the outer sheath tube is larger than the outer diameter of the fixing component. Other parts of the electrode, excluding the fixing component, can be inserted into the inner sheath tube. This invention allows for a single puncture of the electrode and implantation tool near the target nerve tissue. After successful testing, the electrode is directly released and fixed, ensuring consistency between the test point and the implantation point.

The invention discloses an RPA-CRISPR / Cas12a detection system for genetic detection before blastocyst cavity fluid free DNA single-tube double-gene non-invasive embryo implantation, and belongs to the technical field of genetic detection. The biradical consists of a TBC1D3 gene and a TSPY1 gene; the RPA-CRISPR / Cas12a detection system comprises an RPA (recombinase polymerase amplification) reaction system and a CRISPR / Cas12a reaction system. According to the invention, TSPY1 and TBC1D3 genes are selected as target genes for research, a dual RPA-CRISPR / cas12a detection system is established, embryo preliminary screening of sexual linkage genetic disease patients before implantation can be rapidly completed, a new detection platform is provided for sexual linkage genetic family embryo selection, a foundation is laid for further genetic prenatal breeding, time, manpower and material resource costs are reduced, and the method has a good application prospect. And wounds are reduced.

The invention discloses a hydrogel repair method using alveolar crest to preserve bone and soft tissue defects and application thereof, and relates to the technical field of alveolar crest bone and soft tissue defects, high-molecular polymers are used as raw materials, the purity of the raw materials needs to reach 99% or above, raw material powder is dissolved in a PBS (phosphate buffer solution) according to the mass ratio of 10%, and the raw material powder is mixed with a water solution to prepare a hydrogel solution for repairing the alveolar crest bone and soft tissue defects. In the dissolving process, a magnetic stirrer needs to be used for stirring at room temperature (25 DEG C) for at least 4 hours until the solution is completely transparent and has no visible particles or blocks; the stirring speed is controlled to be 300-500 rpm, so that excessive foam is prevented from being generated. The dental implant has the advantage of efficient biocompatibility, in the actual using process, along with rapid development of biological material science, novel materials such as injectable hydrogel bring revolutionary changes for repairing of alveolar ridge bone and soft tissue defects, and the materials have good biocompatibility, degradability and certain mechanical strength, and can be used for repairing of the alveolar ridge bone and soft tissue defects. The microenvironment of natural bone tissues can be simulated.

The invention discloses a self-locking arc-shaped nail, and relates to the field of fracture fixing nails, the self-locking arc-shaped nail comprises a middle connecting end comprising a plurality of connecting joints, the axial head and tail ends of the connecting joints are respectively provided with a hinge shaft and a hinge hole, and the connecting joints are axially provided with wire passing holes in a penetrating manner; the arc screw thread end is connected with one end of the middle connecting end, and threads are arranged on the peripheral surface of the arc screw thread end; the front-end outer sleeve is connected with the other end of the middle connecting end, a pull wire is arranged in the front-end outer sleeve, one end of the pull wire is connected with an inner shrinkage pipe arranged in the front-end outer sleeve, the other end of the pull wire penetrates through a wire passing hole of the connecting joint to be connected with the threaded end of the arc screw, and the inner shrinkage pipe is matched with the front-end outer sleeve; according to the self-locking arc-shaped nail, the whole arc-shaped nail is driven by the thread end of the arc-shaped nail to rotate and advance along the arc-shaped nail channel, after the arc-shaped nail reaches a preset position, the thread and the front-end outer sleeve lock and fix a pull wire, and finally the arc-shaped nail is bent, locked and fixed along the arc-shaped channel.

The invention provides application of N-glycan as an acute ischemic stroke biomarker, and the application is as follows: serum characteristic N-glycan is taken as the human acute ischemic stroke biomarker, and the serum characteristic N-glycan is one or more of H4N4F1, H5N4F1, H5N4F1S1, H5N4F1S2, H5N4S2 and H6N5S3; or the brain tissue characteristic N-glycan is used as a biomarker of the acute ischemic stroke of the mouse, and the brain tissue characteristic N-glycan is one or more of H5N2, H4N3F1, H4N4F1S1, H4N6F1, H5N4F3, H5N5F2, H4N6F1S1, H5N5F2S1 and H6N5F3S1. The marker provided by the invention has the advantages of strong specificity, small trauma and low cost when being used for predicting the early ischemic stroke.

The utility model relates to an endoscopic minimally invasive transmural interventional operation incision device with a step-by-step expansion function, which comprises a handle part, a step-by-step expansion part, a cutter head and a guide wire, one end of the step-by-step expansion part is connected with the handle part, the other end of the step-by-step expansion part is connected with the cutter head, and the cutter head is conical; the guide wire penetrates in from the handle part and penetrates out from the scalpel head through the step-by-step expansion part. The utility model has the advantages that due to the design of the short and small conical cutter head, a transmural incision is small, the electric cautery range is small, the trauma of an endoscopic minimally invasive intervention transmural operation is obviously reduced, the accuracy of approach incision is improved, the risks of bleeding, infection and other serious diseases are greatly reduced, and the success rate of the operation is improved; the step-by-step, segmented and step-by-step expansion design is adopted, it is ensured that step-by-step expansion is implemented while incision is conducted, instruments do not need to be replaced, the operation process and steps are greatly simplified, the operation risk is reduced, and the operation cost is saved; due to the sectional fusiform expansion design, expansion propelling is smooth, expansion resistance is reduced, and operation difficulty is lowered.

The application discloses a set of bile acid marker combinations, kits and applications for female sarcopenia patients with liver fibrosis risk stratification. The bile acid marker combinations are GCA, GDCA, GCDCA, TDCA, TDCA-3S, TCDCA, GLCA-3S and GDCA-3S in serum or plasma. Through quality control, difference screening and multi-model verification, a joint scoring model is constructed to distinguish the basic bile acid metabolism type and the liver fibrosis susceptible type subgroup. The experimental results show that the AUC of the model verification queue reaches 0.982; the median of the susceptible type subgroup LSM is 6.0 kPa, and the high-risk proportion is 20.7%, which is significantly higher than that of the basic type. The application can realize early and accurate stratification of the liver fibrosis risk of female sarcopenia patients, and is especially suitable for clinical screening and risk assessment.

The utility model relates to shearing force technical field discloses a kind of adjustable synovial fold shearing force, including handle one, the one end of handle one is fixedly connected with turning plate, the inside rotation of turning plate is connected with handle two, reset component is provided between handle one and handle two, the reset component is used to drive handle two reset, the one end of turning plate is rotatably connected with extension rod, the one end of extension rod is rotatably connected with hook knife and segmentation knife.The utility model in which, first through small diameter, pipe-like shearing force with scale design, allow to enter inside through very small incision, realize minimally invasive treatment, greatly reduce the trauma of operation, while not only reduce the complexity of doctor operation, can also be flexibly operated in narrow operation space, facilitate hooking synovial fold and cutting in operation, in addition, the shearing force simple structure is lower in cost, effectively reduce medical cost.

The application discloses a windowed guide plate and relates to the medical field, which comprises a top plate and a side plate, the top plate and the side plate are integrally formed into a guide plate, a punching head is integrally formed at the top of the top plate, a positioning head is integrally formed on the outer side of the side plate, and a window is formed on the outer side of the side plate. The application significantly improves the accuracy of the implanting process by using the digital technology assisted guide plate implanting, and reduces surgical trauma. The application adopts a minimally invasive incision, does not need to cut the gum in a large area, has a short operation time and small trauma, and has faster postoperative recovery. The application is suitable for complex diseases such as alveolar bone defect, abnormal position of nerves and blood vessels and multiple implanting requirements, can improve the success rate, guides the drill bit by means of the punching of the guide hole, fixes the guide plate in the mouth of a patient in advance by means of the punching of the positioning hole and the use of a screw, avoids the change of the position of the guide plate in the punching process, can accurately control the position, angle and depth of the implant, and reduces human error.

The utility model provides an assembled brachial intramedullary nail plate, and belongs to the technical field of medical instruments. The assembly type humeral intramedullary nail plate comprises a bone fracture plate, an intramedullary nail, an intramedullary fixing nail and a plate locking nail, the inner side wall of the bone fracture plate conforms to the side wall curve of a greater tuberosity of a humeral head, the intramedullary nail is in a bent shape conforming to the shape of a humeral marrow cavity, a middle locking hole is formed in the middle of the bone fracture plate, and the plate locking nail is arranged in the middle of the bone fracture plate. The upper end of the intramedullary nail is located on the inner side of the middle locking hole, the threaded part of the intramedullary fixing nail penetrates through the middle locking hole and is matched with a threaded nail hole in the upper end of the intramedullary nail, multiple sets of edge locking holes are formed in the circumferential direction of the bone fracture plate, and the plate locking nail penetrates through the edge locking holes to fix the bone fracture plate to the greater tuberosity of the humerus head. According to the assembly type humeral intramedullary nail plate, after an intramedullary nail is implanted, the bone fracture plate is installed at the upper end of the intramedullary nail, trauma is small, operation is easy, and fixation is stable.

An implant (52) for insertion into a patient is provided. The implant includes a layer of a three-dimensionally printed structure. Each layer includes a filling pattern of a three-dimensionally printed structure, the filling pattern of each layer including a set of filling lines. The implant comprises a plurality of hollow channels (21). The layers are arranged atop each other such that a plurality of hollow channels are formed within the implant, with the walls of each channel being formed by segments of fill lines of a plurality of of the layers of the printed structure. At least one hollow channel (21) extends between a first outer surface of the implant and a second outer surface of the implant. The at least one hollow channel is oriented in a direction inclined with respect to a reference axis (37) perpendicular to the first outer surface of the implant.

The invention discloses a closed-loop insulin controlled release system based on a microneedle array patch. The method for achieving closed-loop insulin controlled release comprises the steps that the glucose microneedle sensor in the system is used for monitoring the blood glucose concentration, and when the blood glucose concentration is too high, the subcutaneous release state of insulin is regulated and controlled by applying voltage to the insulin controlled release microneedle; wherein each insulin controlled-release microneedle is provided with an independent current path, so that each microneedle is independently addressed, and the release of a single piece or a plurality of pieces of insulin can be regulated and controlled; the insulin gel part of the insulin controlled release microneedle comprises insulin, sodium alginate and metal ions. The invention relates to a closed-loop insulin controlled release system based on a microneedle array patch, and discloses an insulin closed-loop system suitable for diabetics, which can continuously monitor blood sugar and realize active control of insulin release through electric triggering when the blood sugar concentration is relatively high, and has the advantages of convenience, minimally invasive property and controllability.