149 results about "Vascular lesion" patented technology

A graftless prosthetic stent for treatment of vascular lesions such as aneurysms and arterio-venous fistulas, especially in neurovascular vessels, comprises a continuous helical ribbon formed of a shape-retaining metal having a transition temperature at which the stent expands from its contracted condition to a radially expanded condition, the stent remaining substantially cylindrical in its contracted and expanded conditions. The helical windings have variable width, thickness, number or size of openings, or combinations of these features, which affect the stiffness, rate of expansion at the transition temperature, and the area of vessel wall covered by the stent. A catheter device which includes the stent, and a method of treatment using the stent are also provided.

A graftless prosthetic stent for treatment of vascular lesions such as aneurysms and arterio-venous fistulas, especially in neurovascular vessels, comprises a continuous helical ribbon formed of a shape-retaining metal having a transition temperature at which the stent expands from its contracted condition to a radially expanded condition, the stent remaining substantially cylindrical in its contracted and expanded conditions. The helical windings have variable width, thickness, number or size of openings, or combinations of these features, which affect the stiffness, rate of expansion at the transition temperature, and the area of vessel wall covered by the stent. A catheter device which includes the stent, and a method of treatment using the stent are also provided.

A catheter is disclosed for providing pressure measurements at a vascular lesion. The catheter includes an outer component having a side opening the providing transverse access to a lumen thereof and an inner component slidably disposed within the lumen. The inner component has a guidewire lumen with a proximal side port. When the inner component is longitudinally translated relative to the outer component, the side port of the inner component is accessible through the side opening of the outer component for providing transverse access to a guidewire. A first pressure sensor is disposed proximate of a distal end of the outer component and a second pressure sensor is disposed proximate of a distal end of the inner component, such that relative longitudinal translation between the inner and outer components permits a distance between the first and second pressure sensors to be varied.

A solidifying implant composition of a polymer mixed with a bioabsorbable solvent. A method of treating a patient, by implanting the solidifying implant composition into bone, and solidifying the implant composition. A method of improving bone structure in patients by applying the solidifying implant composition to bone, shoring up bone structure, and improving load bearing capacity and aiding healing of microfractures. A method of fixing an implant, by applying the solidifying implant composition to an implant, and shoring up the implant. A method of devascularizing and treating a tumor or vascular lesion. A method of treating a vascular disease. A method of treating aneurysms/pseudoaneurysms.

The invention relates to a vascular recanalization system for cardiovascular stenosis lesions. The vascular recanalization system comprises a balloon, an energy generation controller and a catheter. The catheter comprises a main body tube, one end of the catheter is connected with the energy generation controller, and the main body tube at the other end of the catheter is connected with one end ofthe balloon; wherein the balloon mainly comprises a balloon main body, an inner tube and an electrode pair, and the inner tube is arranged in the balloon main body; and the energy generation controller can send out and regulate a vibration signal with a specific frequency to enable the electrode pair to generate a vibration wave. The system further has a drug delivery function, can inhibit increase of endovascular membranes after recanalization and avoid restenosis after recanalization, thereby achieving the function of long-term treatment of stenotic lesions. For many vascular diseases needing to be implanted with stents, the purpose of achieving long-term patency rate without stent implantation is achieved, and therefore real intervention implantation-free is achieved.

This invention provides drugs which are already known to be able to act effectively on informational molecules of the NET and their acceptors or influence informational molecules and their acceptors' signal transduction pathways, and their applications in preparing medicine for angiopathy treatment. The said drugs include single Chinese herbs, compound Chinese herbs and their preparations, chemical effective constituents, medicinal compounds and their preparations, biologic effective constituents, medicinal compounds and materials for their preparations. It also provides a new kind of drugs which can effectively act on the said mutual informational molecules of the NET and their acceptors, or influence their signal transduction pathways so as to treat angiopathy; and furthermore provides these drugs' preparation methods.

Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver.

The invention relates to a minimally invasive intervention medical instrument, in particular to a delivery system capable of precisely releasing a scaffold with single hand. An outer tube is connected to a sliding block; a push rod is connected to an inner tube and a Luer joint; the outer tube is sleeved outside the inner tube; a hollow structure is formed by two sliding rods; the far ends and the near ends of the sliding rods are respectively fixed by a front fastener and a rear fastener; the outer surfaces of the sliding rods are provided with threaded structures; turning wheel mechanisms are formed by rapid-release buttons and turning wheels; the turning wheel mechanisms are sleeved on the sliding rods; and when the turning wheel mechanisms rotate, the sliding block, inside the sliding rods, can drive the outer tube and the inner tube to do relative motion, so that the scaffold loaded therein is pushed out and released. The delivery system disclosed by the invention has the beneficial effects that during an operation, a handle is held in one hand and the scaffold is released, and radiography observation is conducted by the other hand at the same time; meanwhile, by virtue of a sheath canal which is good in mechanical delivery performance, the scaffold is released on a lower-extremity vascular lesion part, so that the release position can be precisely controlled and the probability of vascular restenosis due to inaccurate scaffold release can be reduced; and in addition, the delivery system also has the advantages of simple structure, convenient operation and the like.

Abstract: The present invention relates to a catheter system and methods of using such catheter system for the treatment of vascular and non-vascular pathologies. More specifically, the present invention is directed towards a catheter system for the actuation of a temporarily implantable member elastically deformable by hydraulic means.

The invention discloses an estimating system and method for fluid velocity. The estimating system comprises a positioning device, a transducer and a processor. The positioning device is used for determining position of to-be-detected fluid through ultrasonic imagining and selecting a plurality of signal sampling sites on a determined section of to-be-detected velocity. The transducer is used for, under the control of the processor, sending ultrasonic to the fluid and receiving pulse echo signals. The processor is used for processing the pulse echo signals, calculating the fluid velocities of the signal sampling sites and performing curve fitting to fluid velocity values of the signal sampling sites to acquire a section curve of the fluid velocity. With the processor, such as FPGA (field-programmable gate array), blood flow velocities with different depth in blood vessels are simultaneously sampled and measured so as to achieve the blood flow velocities. In this way, abnormal blood flow is timely reflected, and signal processing timeliness and calculation accuracy are higher, so that diagnostic basis is provided for diagnosis of vascular diseases.

A catheter is disclosed for providing a pressure measurement at a vascular lesion. The catheter includes a tubular component having dual lumens along at least a segment thereof in which a first lumen acts as a pressure inlet and a second lumen allows the catheter to be tracked over a guidewire. A plurality of openings are located along a distal segment of the tubular component that permit blood flow into the first lumen when disposed in vivo. A pressure sensor is located within a handle component of the catheter or within the tubular component to be in fluid communication with a proximal end of the first lumen. When the catheter is positioned at the vascular lesion, the first lumen fills with blood via the plurality of openings such that the pressure sensor is able to sense a pressure of the blood at a distal end of the catheter.

A cosmetic condition (e.g., a pigmented lesion or a vascular lesion) can be treated using a delivery system that displaces blood from a target region of skin. The delivery system can include an optical element having a convex surface. The optical element can be a non-converging optical element that transmits the beam of radiation to the target region of skin.

To provide a method for differentiating primate embryonic stem cells into vascular endothelial cells, and a technique using the method. A method for differentiating primate embryonic stem cells into early developmental vascular endothelial cells comprising differentiating primate embryonic stem cells into vascular endothelial cell parker-positive cell population; the early developmental vascular endothelial cells; a method for producing the vascular endothelial cells; a method for amplifying the vascular endothelial cells; a vascular lesion-therapeutic agent containing the early developmental vascular endothelial cells as an active ingredient; a method for revascularization comprising supplying the early developmental vascular endothelial cells; a method for transplantation comprising transplanting the early developmental vascular endothelial cells; and a method for treatment comprising administering the early developmental vascular endothelial cells in a therapeutically effective dose.

Fluid delivery systems capable of introducing first and second fluids into first and second lumens of a multi-lumen catheter are provided. The first and second fluids are generally a dissolution fluid and a dissolution fluid attenuating fluid. Also provided are fluid delivery devices and kits that include the subject systems. The subject fluid delivery systems find use in a variety of different applications, and are particularly suited for use in the chemical ablation of internal vascular lesions.

The invention relates to a nanometer medicinal elution apparatus in microcellular structure for storing and releasing multiple medicines and a preparation method thereof. The multiple medicines in the invention are selected from medicine therapeutic agents, carrier therapeutic genes and bioactive substances, wherein one or two of the medicine therapeutic agents is/are taxol and/or probucol. The preparation method of the medicinal elution apparatus in the invention mainly comprises the followings: 1) nanometer holes are prepared on the surface of the apparatus body; 2) multiple medicines are coated in the nanometer holes and on the surface of the apparatus body. The apparatus body in the invention does not contain polymers, thereby reducing the risk of long-term thrombus possibly caused by polymers; the nanometer holes on the surface of the apparatus body do not have any influence for mechanical property of the body, thereby being capable of efficiently controlling the releasing rate of medicines and obviously reducing the restenosis rate after surgical operations. The invention can be applied to various medicinal elution implanting apparatuses, particularly having good effects for curing vascular lesion and preventing blood vessel restenosis in vascular stents.

The present invention describes stem cells and progenitor cells derived from hemangiomas, including testing of angiogenic inhibitors using these cells. The invention as described is useful in providing a process to culture and propagate hemangioma stem cells and generate xenograft models to develop treatments for infantile hemangiomas and other types of vascular lesions.