61 results about "Vascular lesion" patented technology

The application provides a blood vessel lesion determination method and device, electronic equipment and storage medium. The determination method comprises: inputting acquired no-label images and labeled images as input images into a blood vessel lesion analysis model in a single-alternating input manner; if the input image is a no-label image, training the blood vessel lesion analysis model according to a reconstruction loss function; if the input image is a labeled image, determining whether the reconstruction loss function, a lesion type loss function and a lesion degree loss function simultaneously satisfy a target condition, and if the target condition is satisfied, obtaining a trained blood vessel lesion analysis model; and determining a lesion type result and a lesion degree result of a blood vessel image according to the trained blood vessel lesion analysis model. The technical solution provided by the application can reduce manual labeling operations, reduce the workload of doctors, and ensure the accuracy of blood vessel lesion determination.

Provided are small-fragment RNA derived from a circular RNA and the use thereof in the treatment of diabetic vascular diseases. The nucleotide sequence of the small-fragment RNA is CUAGCCGAAUGUUAAAAAAU. The provided small-fragment RNA has the effects of well protecting and maintaining the biological functions of vascular endothelial cells, has good structural stability, has a long half-life in vivo, and has the advantages of low effective concentration, high biological safety, etc. The provided small-fragment RNA has good application potentials in the field of clinical nucleic acid drug development, and provides a new idea for the treatment of chronic progressive vascular lesions caused by diabetes.

The application discloses a micro blood flow imaging method based on adaptive density filtering and a related device, and relates to the technical field of ultrasonic imaging. The method comprises the following steps: extracting a static frame in original ultrasonic data, screening a high-quality static frame through correlation analysis to eliminate motion interference; performing SVD clutter filtering, and cutting off high spatiotemporal coherence singular values to separate tissue clutter and microbubble signals; performing adaptive density filtering and subtracting a preliminary filtering result to realize noise suppression and overlapping microbubble decoupling; and enhancing microbubble motion signals through time-lag autocorrelation processing, and finally completing power Doppler imaging and ultrasonic localization microscope reconstruction. The scheme effectively solves the problem that the prior art cannot simultaneously consider PDI noise suppression and ULM microbubble decoupling, significantly improves image signal-to-noise ratio and super-resolution, avoids problems such as signal distortion, artifacts and loss of low-speed blood flow, and provides more reliable imaging support for clinical diagnosis such as blood vessel lesion detection and tumor blood flow evaluation.

The invention belongs to the technical field of diabetic foot clinical path management, and discloses a diabetic foot patient path management method and system based on lower limb vasculopathy grading. Mapping the ulcer position to the corresponding perfusion area and the artery segment to generate ulcer space characteristics; calculating a blood supply risk score of the perfusion area and generating a space risk map by combining the blood vessel image detection data and the microcirculation detection data; then collecting time sequence data including an ulcer index, an infection index, a blood supply index and a space risk map, and predicting the progress speed and the risk level of the future ulcer course; and finally, according to the blood supply risk score and the disease course prediction result, generating an individualized path management scheme through a joint triggering rule. According to the invention, precise and dynamic management of the diabetic foot ulcer is realized, the healing rate is improved, and the recurrence rate and the medical cost are reduced.

The application discloses a kind of multi-element fusion carotid vascular monitoring method, system, electronic equipment and storage medium, it is related to medical monitoring field.The method comprises: obtaining the time-domain acoustic signal of carotid artery of the individual to be measured, and the time-domain acoustic signal is carried out frequency domain transformation, and frequency-domain acoustic signal is obtained;Nonlinear flow state feature and topological form feature are extracted based on the frequency-domain acoustic signal;The nonlinear flow state feature and the topological form feature are compared with the corresponding baseline feature in the historical acoustic baseline of the individual to be measured, and feature deviation result is obtained;Risk assessment is carried out based on the feature deviation result, when the feature deviation result exceeds preset range, risk early warning is triggered.The application suppresses the interference such as power frequency, baseline drift, respiratory body movement and environmental noise mixed in time-domain waveform, thereby reducing the false positive rate of carotid vascular acoustic monitoring, and realizing early risk early warning of vascular lesion.

A device for introduction into a body vessel includes a shaft (105), a balloon (115) positioned at the distal end of the shaft (105), and at least one longitudinal scoring wire (135) to score a vascular lesion attached to the distal end of the shaft (105), disposed over the balloon (115). The shaft (105) includes a support (119), such as a wire or tube having one or more spirally cut portions (119A, 119B), which improves pushability and trackability, thereby allowing for use with an external guidewire in a “short rapid exchange” (SRX) format. The balloon (115) expands when fluid is delivered to the balloon (115) through the inflation lumen. This expansion pushes the scoring wire and guidewire against the vascular lesion.

The invention discloses a medical image key structure extraction method for vascular surgery preoperative evaluation, which comprises the following steps: an image acquisition and multi-modal data acquisition stage: acquiring a multi-source medical image and clinical hemodynamic parameters, and generating a blood vessel initial segmentation map after processing; a structural feature reconstruction stage: extracting morphological features of a vascular wall and geometric features of a lumen, and generating a vascular tree three-dimensional structure map; in the pathological feature fusion stage, the vascular tree three-dimensional structure atlas and clinical hemodynamic parameters are fused, and vasculopathy risk confidence is generated; in the operation planning decision-making stage, the vasculopathy risk confidence coefficient, the vascular tree three-dimensional structure atlas and the clinical hemodynamic parameters are converted into an executable operation planning suggestion set, and the executable operation planning suggestion set is issued to an operation navigation system. According to the method, multi-modal images and hemodynamic parameters can be seamlessly integrated, accurate vascular structure extraction and lesion risk assessment are realized, and a more comprehensive and objective decision basis is provided for vascular surgical operation planning.

The invention provides a cardiovascular image processing system and method based on deep learning. The method comprises the following steps: acquiring a standardized cardiovascular image of a target patient; extracting a blood vessel edge texture feature and a lesion area texture feature of the target patient; determining a feature association relationship between each continuous image sub-block in the standardized cardiovascular image and a blood vessel edge texture feature, and determining a detail fusion feature map of the cardiovascular lesion area of the target patient according to all the feature association relationships and the lesion area texture features; determining a lesion trend characteristic spectrum of the target patient according to a historical cardiovascular image set similar to the cardiovascular image of the target patient and the cardiovascular image of the target patient; and determining a lesion labeling result of the cardiovascular image of the target patient according to the detail fusion feature map and the lesion trend feature map. According to the scheme, cross-time-sequence dynamic risk assessment can be carried out on the high-heterogeneity lesion features of the cardiovascular system of the patient based on the single-time static cardiovascular image.

A catheter system for treating a treatment site within or adjacent to a vessel wall includes a light source, a balloon, a light guide, and an optical analyzer assembly. The light source generates light energy. The balloon is positionable substantially adjacent to the vascular lesion. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The light guide receives light energy from the light source at a guide proximal end and guides the light energy toward a guide distal end and into the balloon interior. The optical analyzer assembly is configured to optically analyze light energy emitted from the guide proximal end of the light guide.

The invention belongs to the technical field of medicinal chemistry, and relates to a benzazepine compound or pharmaceutically acceptable salt thereof as well as a preparation method and application of the benzazepine compound, in particular to a compound with a structural general formula as shown in a formula (I). The benzoazepine compound disclosed by the invention has a remarkable curative effect on treating brain organic lesion diseases, including vascular lesion and degenerative lesion, especially vascular dementia, Alzheimer's disease and cholinergic deficiency related diseases. Formula (I).

The invention relates to the technical field of biomedicine, in particular to application of CCN2 serving as a target spot to preparation of a medicine for diagnosing, preventing and / or treating anti-phospholipid syndrome. The invention provides application of CCN2 serving as a biomarker to diagnosis of APS and other related vasculopathy, application of CCN2 serving as a treatment target to preparation of drugs for preventing and / or treating anti-phospholipid syndromes and an establishment method of an APS related vasculopathy model. According to the invention, it is found for the first time that CCN2 targets in APS blood vessels play a crucial role in promoting proliferation and migration of vascular endothelial cells and vascular smooth muscle cells, a new perspective is provided for knowing cell and molecular mechanisms of vasculopathy, and it is determined that CCN2 can be used as a potential biomarker for diagnosing APS vasculopathy and evaluating disease progression of APS vasculopathy. And potential targets for clinical anti-proliferation treatment.

The invention relates to the technical field of diabetic hypoglycemia, and discloses a diabetic hypoglycemia response induced vascular injury biomarker which is a combination of high-sensitivity C reactive protein, 8-isoprostaglandin F2alpha, von willebrand factor, free fatty acid and D-dimer. The invention further discloses application of the diabetic hypoglycemic response induced vascular injury biomarker in preparation of a reagent for early auxiliary diagnosis of diabetic hypoglycemic response induced vascular injury. According to the invention, a combination of high-sensitivity C-reactive protein, 8-isoprostaglandin F2alpha, von willebrand factor, free fatty acid and D-dimer is used as a vascular injury biomarker induced by diabetes mellitus hypoglycemia response; acute vascular dysfunction, cardiovascular system injury, microvascular complications and atherosclerosis can be effectively diagnosed, diabetic vasculopathy can be found at an early stage, disease progression can be predicted, and clinical treatment can be guided; the sensitivity and the specificity are high.

This application relates to the field of medical device technology, specifically to a distal protection device, including a filter and a support stent. The proximal end of the support stent has an opening, and the support stent includes a column segment. The distal end of the column segment is connected to the proximal opening of the filter. The radial dimension of the support stent is adjustable and has an expanded state and a contracted state. In the expanded state, the radial dimension of the column segment is not less than the radial dimension of the proximal opening of the filter. In this distal protection device, the support stent is connected to the proximal opening of the filter. In the expanded state, the radial dimension of the column segment is not less than the radial dimension of the proximal opening of the filter. The column segment adheres to the inner wall of the blood vessel. Compared to related technologies that rely solely on a support ring to provide radial force, the column segment can provide greater radial support force, significantly improving the adhesion performance between the filter and the inner wall of the blood vessel, reducing the risk of thrombus escape from between the proximal opening of the filter and the inner wall of the blood vessel. This makes the distal protection device suitable for the treatment of vascular lesions with severe plaque and calcification.

The application discloses a shock wave balloon catheter and belongs to the technical field of medical devices, which comprises a tube body, a balloon arranged on the outer wall of the tube body, at least one shock wave generator arranged in the balloon, and a convex device arranged on the outer surface of the balloon, wherein the convex device and the outer surface of the balloon are provided with a drug coating, at least one liquid injection cavity and a guide wire cavity are arranged in the tube body, and the liquid injection cavity is communicated with the balloon; the application integrates multi-form mechanical convex devices on the surface of the balloon, and coats anti-proliferation drugs on the surface of the convex device and the balloon, so that the trinity treatment of mechanical cutting / piercing, shock wave and drug elution is realized, the three functions of mechanical fragmentation of calcification / fibrosis lesions, shock wave deep lysis of calcified substances and local drug delivery are simultaneously achieved by the same instrument, one-time comprehensive treatment of complex vascular lesions is realized, and instrument replacement is avoided.

The present disclosure relates, in part, to a method of treating acne, excessive sweating, unwanted hair, and / or unwanted blood vessels. The method can include providing a needle array comprising a plurality of needles; inserting the plurality of needles into a dermis of a treatment area; detecting a location of an enlarged sebaceous gland; and exciting one or more of the plurality of needles to treat the sebaceous gland, one or more sweat glands, a vascular lesion, an unwanted hair follicle, and / or an unwanted blood vessel.

A catheter system (100) for treating vascular lesions (106A) within or adjacent to the vessel wall (108A) of a patient (109) (107) includes a catheter fluid (132), an energy source (124) for generating energy, an energy guide (122A), and an energy manifold (129). The energy guide (122A) includes a distal end (122D) selectively positioned near the vascular lesion (106A). The energy guide (122A) is configured to receive energy from the energy source (124) and generate plasma bubbles (134) within the catheter fluid (132). The energy manifold (129) is coupled to the energy guide (122A) near the distal end (122D). The energy manifold (129) includes: (i) a manifold body (260) defining a body chamber (266) configured to retain at least some of the catheter fluid (132); and (ii) a manifold orifice (262) extending through the manifold body (260). The energy manifold (129) directs energy from the plasma bubble (134) out of the body chamber (266) and toward the vascular lesion (106A) through the manifold orifice (262).

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a salvia miltiorrhiza salvianolic acid and notoginsenoside composition, and the mass ratio of notoginsenoside to salvianolic acid in the composition is 1: 5 or 5: 3 or 3: 5. The invention further discloses application of the composition in preparation of drugs for preventing and treating vasculopathy related to metabolic syndromes of metabolic organs. The composition disclosed by the invention can be used for remarkably relieving liver lipid deposition induced by high-fat diet and reducing abnormal accumulation of white and beige fat; wherein the optimal compatibility ratio is 1: 5, and the mechanism of playing the role is related to down-regulation of the expression of liver lipid transport key protein CD36; the invention provides a new intervention strategy and compatibility basis for preventing and treating vasculopathy related to metabolic syndrome, and provides a precise intervention thought of'combining diseases and syndromes' for the research of early prevention of atherosclerosis.

The present application relates to a device for introduction into a body vessel, comprising a shaft (105), a balloon (115) at a distal end of the shaft (105), and at least one longitudinal scoring line (135) for scoring a vessel lesion, the scoring line being attached to the distal end of the shaft (105) and arranged above the balloon (115). The shaft (105) comprises a support (119), e.g. a wire or tube, having one or more helical cut portions (119A, 119B) that improve pushability and trackability, enabling use with an external guidewire in the form of a "short rapid exchange" (SRX). The balloon (115) is inflated when fluid is delivered to the balloon (115) through an inflation lumen. The inflation will push the scoring line and the guidewire against the vessel lesion.

The invention discloses a cerebral arterial thrombosis fundus image classification method based on multi-scale blood vessel features, and the method comprises the following steps: gradually extracting multi-scale blood vessel features of a fundus image through a feature extraction module; gradually fusing blood vessel features of different scales through a feature fusion module; and through a classification and identification module, according to the fused multi-scale blood vessel features, classification of normal and ischemic cerebral apoplexy fundus images is realized. According to the method, the capacity of extracting tiny morphological features of fundus image blood vessels is enhanced through asymmetric convolution blocks, a vascular lesion area is positioned on channel and spatial dimensions by using a coordinate attention mechanism, deep semantic features and shallow detail features are effectively combined in combination with a multi-level feature fusion strategy, and the method is more accurate in feature fusion. Therefore, more accurate cerebral arterial thrombosis fundus image classification is realized.

This invention relates to a self-assembling polypeptide for regulating the permeability of retinal pigment epithelium (RPE), its preparation method, and its applications. The self-assembling polypeptide comprises an integrin receptor-targeting peptide, a self-assembling polypeptide, and a hydrophobic molecule sequentially linked. The self-assembling polypeptide designed in this invention can self-assemble into nanoparticles and specifically target RPE cells. After interacting with receptors on the cell membrane, the nanoparticles transform into nanofibers, achieving rapid targeted enrichment of RPE tissue. Furthermore, by regulating the permeability of RPE tissue, it can enhance the transcellular drug transport capacity, providing a new clinical application strategy for the treatment of macular neovascularization, especially polypoid choroidal vascular lesions.

Systems and methods for treatment of vascular lesions. The system includes a drug-eluting distal portion of a drug-eluting catheter and a balloon of a balloon catheter configured for positioning with a vascular lesion. The method entails securing the drug-eluting distal portion to the inner wall of a blood vessel with the balloon, and delivery of therapeutic agents into the blood vessel wall while the drug-eluting distal portion is held against the wall of the blood vessel by the balloon. The distal infusion portion of the drug infusion catheter is first located within the lesion. After the drug infusion portion is in position, the balloon of the balloon catheter is translated into the lesion and inflated to press the drug-eluting portion into contact with the blood vessel wall and a therapeutic agent is delivered through the drug-eluting portion.

Disclosed herein are devices, systems, and methods useful in facilitating the removal of thrombus, embolus, or debris from a blood vessel and other intravascular interventional actions, including proximal embolic protection when treating a vascular lesion or condition.

The application discloses an oil-phase drug solution for intravascular long-term retention, which comprises an oil-phase solvent and a therapeutic drug; the oil-phase solvent is selected from one or more than two of fatty acids and phospholipids. The application also provides application of the oil-phase drug solution for intravascular long-term retention in a liquid infusion balloon, and the liquid infusion balloon is used for treating vascular diseases. The liquid infusion balloon is delivered to a vascular lesion site, the liquid infusion balloon is inflated, and the oil-phase drug solution is squeezed out, so that the oil-phase drug solution can be retained in the blood vessel for a long time and dissolve cholesterol crystals in the blood vessel, thereby removing atherosclerotic plaques. The application can solve the problems of low drug coating delivery efficiency, great damage to blood vessels, difficult long-term treatment and the like of the current balloon, and the problems of short drug retention and short activity maintenance time of the existing liquid infusion balloon.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition for treating diabetic microangiopathy and a preparation method thereof, the pharmaceutical composition comprising the following raw materials in parts by weight: active drug 5-10 parts, shell copolymer 20 parts, PLGA 35-50 parts, emulsifier 1.5 parts and freeze-drying protective agent 4 parts. The shell copolymer prepared and synthesized from PCL, PEG and a targeting peptide has functions such as drug loading, self-assembly, responsiveness and targeting, the responsiveness of which depends on a disulfide bond connecting the PCL and the PEG, the disulfide bond is broken in an abnormal blood flow environment of a vascular lesion, various drugs in the nanoparticle core are released, and the drug delivery efficiency and the treatment effect are greatly improved.

The application discloses a kind of image velocimetry system for blood vessel, the method for blood vessel pathological change risk assessment, blood vessel detection device-nanoparticle composition and its application, it is related to image processing field, the system includes: targeted visualization nanoparticle administration unit, double-ring scanning optical probe, CMOS imaging device, image acquisition and double-domain correlation processing module, coupling mechanics parameter calculation module.The application utilizes double-ring scanning optical probe to combine external CMOS imaging device, realizes the efficient transceiving and transmission of nanoparticle fluorescence signal;By performing digital image correlation and microscopic particle image velocimetry on image sequence, finally obtain the time synchronization data of blood vessel wall deformation, near-wall blood flow velocity and shear stress and other mechanical parameters, and based on this, the assessment and early warning of blood vessel pathological change risk are carried out.

The utility model relates to an intervention catheter and an intervention system for calcification lesion microneedle puncture. The interventional catheter solves the technical problem that an existing interventional catheter is unreasonable in design. The interventional catheter for calcification lesion microneedle puncture comprises a catheter main body, wherein an infusion cavity, a positioning cavity and a cable cavity are formed in the catheter main body at intervals; the infusion balloon is connected to the outer side of the catheter body in a sleeving mode and connected with the infusion cavity, and the infusion balloon comprises arc-shaped convex-face balloon bodies arranged at intervals in the circumferential direction, infusion elastic balloon bodies connected with the adjacent arc-shaped convex-face balloon bodies and capable of protruding out of the outer walls of the arc-shaped convex-face balloon bodies, and micro-needle puncture faces arranged on the outer walls of the infusion elastic balloon bodies; the two positioning balloons are arranged on the two sides of the infusion balloon in a spaced mode and communicated with the positioning cavity. According to the utility model, the infusion balloon is controlled to be relatively closed through the two positioning balloons, meanwhile, the aim that the infusion balloon is attached to a vascular lesion position is achieved, the administration rate is controlled, and quantitative and accurate drug delivery is realized.

To provide devices and methods that can help enable real-time, full-color, diagnostic-quality resolution, direct intravascular visualization of cerebrovascular lesions.SOLUTION: The sheath catheter 102 may be advanced toward a cerebrovascular lesion. The balloon at the tip can be inflated. An angioscope 104 may be inserted through the working lumen for viewing. The Sheath Catheter can have a stepped down lateral profile and can extend the working channel a distance beyond the balloon. The dual concentric lumen structure can include an inner body and an outer body defining an inflation lumen therebetween, with one or more portions of one or more layers being stretched or cut or both, such as to provide bending flexibility. Reflow techniques may be used to help bond the layers together.SELECTED DRAWING: Figure 1

The invention relates to the field of medical risk prediction, in particular to a scleroderma early diagnosis method based on vasculopathy and a related device. Acquiring vasculopathy parameters of the subject, wherein the vasculopathy parameters comprise a nail fold microcirculation total score, a metacarpophalangeal artery systolic period peak flow rate, an ischemia reperfusion blood flow value and a two-hand grip value; s2, substituting the vasculopathy parameters in S1 into a scleroderma risk calculation formula to obtain a risk probability value; the risk probability value is compared with a preset threshold value, and when the risk probability value exceeds the preset threshold value, it is judged that the subject is a high-risk patient suffering from scleroderma; according to the method, the vascular lesion total score obtained after multiple dimensions are integrated can quantify the onset risk of the patient, disease diagnosis is facilitated, and more accurate quantitative indexes are provided for disease assessment and diagnosis and treatment methods.

The invention provides an intervention consumable advancing control method and system, and the method comprises the steps: planning a first path of an intervention consumable in a vascular intervention operation in a preoperative image, the first path comprising a starting point and an ending point of an advancing path, a central line of a passing blood vessel, the diameter of the blood vessel, a bifurcation point of the blood vessel, and a vascular lesion position; registering a first path in the preoperative image in the intraoperative image to obtain a planned second path displayed in the intraoperative image displayed in real time; in the advancing process, advancing information of the intervention consumable is obtained; automatically controlling the interventional consumable to advance along a second path based on the advancing information of the interventional consumable; the advancing information of the interventional consumables comprises at least one of the following items: the deviation angle of the interventional consumables, the advancing speed of the interventional consumables, the advancing direction of the interventional consumables and the arriving position of the interventional ends of the interventional consumables. Based on the technical scheme provided by the invention, the safety of automatically controlling the intervention consumables to advance in the operation can be improved.

The application provides a multifunctional nano-coated stent for preventing and treating in-stent restenosis and a preparation method and application thereof. Based on the multifunctional nano interface of EGCG-Cys, the liposome targeting VCAM-1 is used to deliver MnO2 nanoscale enzyme and FGF21 growth factor, so that the triple treatment effects of active oxygen scavenging, immune regulation and endothelial regeneration can be realized at the vascular lesion site. The EC-MFVL-WE43 stent creates a new paradigm for the design of interventional instruments, realizes the spatiotemporal precise release of drugs through the oxidative stress triggered degradation mechanism, and verifies the excellent anti-restenosis and anti-thrombosis performance in mouse, rabbit and pig models. Mechanism research shows that the nano-coated stent can reprogram macrophages to M2 repair type polarization, and effectively inhibit the abnormal proliferation of smooth muscle cells, providing a biological activity solution to break the vicious cycle of "inflammation-oxidation-restenosis".