154 results about "Vascular lesion" patented technology

A method and apparatus are disclosed for enhancing the absorption of light in targeted skin structures and for the inhibition of pain transmission during light based treatments of the skin. After applying a vacuum to a vacuum chamber placed on a skin target and modulating the applied vacuum, the concentration of blood and / or blood vessels is increased within a predetermined depth below the skin surface of the skin target. Optical energy associated with light directed in a direction substantially normal to a skin surface adjoining the skin target is absorbed within the predetermined depth. The apparatus is suitable for treating vascular lesions with a reduced treatment energy density level than that of the prior art and for evacuating condensed vapors produced during the cooling of skin. The vacuum chamber may also have a skin flattening transmitting element which inhibits pain transmission upon applying a sufficiently high vacuum.

An improved optical system for treatment of disorders of the skin, especially vascular lesions, such as Port Wine Stains. The system irradiates the skin with radiation at a predetermined wavelength and cools the skin during a predetermined time interval in coordination with delivery of the radiation. The absorption of the radiation by the skin and the change in temperature of the skin is monitored by the system and the operation of the radiation delivery system is controlled to optimize treatment of the vascular lesion. The source of irradiation is an arc lamp and the cooling system delivers a cooling gas to a lens in contact with the skin. The cooling gas can be carbon dioxide, freon, or any other appropriate gas. The lens used has a high heat conductivity and may be formed of sapphire.

Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer and a biocompatible solvent.The biocompatible solvent is miscible or soluble in blood and also solubilizes the polymer during delivery. The biocompatible polymer is selected to be soluble in the biocompatible solvent but insoluble in blood. Upon contact with the blood, the biocompatible solvent dissipates from the embolic composition whereupon the biocompatible polymer precipitates. Precipitation of the polymer in the presence of the non-particular agent permits the agent to act as a structural lattice for the growing polymer precipitate.In another embodiment, the biocompatible polymer composition can be replaced with a biocompatible prepolymer composition containing a biocompatible prepolymer.

A graftless prosthetic stent for treatment of vascular lesions such as aneurysms and arterio-venous fistulas, especially in neurovascular vessels, comprises a continuous helical ribbon formed of a shape-retaining metal having a transition temperature at which the stent expands from its contracted condition to a radially expanded condition, the stent remaining substantially cylindrical in its contracted and expanded conditions. The helical windings have variable width, thickness, number or size of openings, or combinations of these features, which affect the stiffness, rate of expansion at the transition temperature, and the area of vessel wall covered by the stent. A catheter device which includes the stent, and a method of treatment using the stent are also provided.

A bifurcated or straight intravascular folded tubular member is deliverable percutaneously or by small cutdown to the site of a vascular lesion. Its inserted state has a smaller nondeployed diameter and a shorter nondeployed length. The intravascular tubular member has a folded tubular section that is unfolded following insertion into the blood vessel. The length of the intravascular folded tubular member is sized in situ to the length of the vessel lesion without error associated with diagnostic estimation of lesion length. The folded tubular member is self-expandable or balloon-expandable to a larger deployed diameter following delivery to the lesion site. An attachment anchor can be positioned at the inlet or outlet ends of the intravascular folded tubular member to prevent leakage between the tubular member and the native vessel lumen and to prevent migration of the tubular member. The attachment anchor has a short axial length to provide a more focal line of attachment to the vessel wall. Such attachment is valuable in attaching to a short aortic neck in the treatment of abdominal aortic aneurysm. The attachment anchor can have barbs which are held in a protected conformation during insertion of the tubular member and are released upon deployment of the attachment anchor. The intravascular tubular member can be formed of woven multifilament polymeric strands with metallic strands interwoven along with them. Double weaving is incorporated to prevent leakage at crossover points.

A catheter system comprising a guidewire, an endovascular catheter, and an aspiration catheter. The guidewire has an expandable occluder mounted on a distal end. The guidewire and the endovascular catheter are insertable into a lumen of the aspiration catheter. The aspiration catheter also includes infusion and aspiration lumen(s) and port(s). Methods of using the catheter system for treating a vascular lesion and removing embolic material during the procedure are also disclosed.

A method and apparatus are disclosed for enhancing the absorption of light in targeted skin structures and for the inhibition of pain transmission during light based treatments of the skin. After applying a vacuum to a vacuum chamber placed on a skin target and modulating the applied vacuum, the concentration of blood and / or blood vessels is increased within a predetermined depth below the skin surface of the skin target. Optical energy associated with light directed in a direction substantially normal to a skin surface adjoining the skin target is absorbed within the predetermined depth. The apparatus is suitable for treating vascular lesions with a reduced treatment energy density level than that of the prior art and for evacuating condensed vapors produced during the cooling of skin. The vacuum chamber may also have a skin flattening transmitting element which inhibits pain transmission upon applying a sufficiently high vacuum.

A graftless prosthetic stent for treatment of vascular lesions such as aneurysms and arterio-venous fistulas, especially in neurovascular vessels, comprises a continuous helical ribbon formed of a shape-retaining metal having a transition temperature at which the stent expands from its contracted condition to a radially expanded condition, the stent remaining substantially cylindrical in its contracted and expanded conditions. The helical windings have variable width, thickness, number or size of openings, or combinations of these features, which affect the stiffness, rate of expansion at the transition temperature, and the area of vessel wall covered by the stent. A catheter device which includes the stent, and a method of treatment using the stent are also provided.

A catheter is disclosed for providing pressure measurements at a vascular lesion. The catheter includes an outer component having a side opening the providing transverse access to a lumen thereof and an inner component slidably disposed within the lumen. The inner component has a guidewire lumen with a proximal side port. When the inner component is longitudinally translated relative to the outer component, the side port of the inner component is accessible through the side opening of the outer component for providing transverse access to a guidewire. A first pressure sensor is disposed proximate of a distal end of the outer component and a second pressure sensor is disposed proximate of a distal end of the inner component, such that relative longitudinal translation between the inner and outer components permits a distance between the first and second pressure sensors to be varied.

A solidifying implant composition of a polymer mixed with a bioabsorbable solvent. A method of treating a patient, by implanting the solidifying implant composition into bone, and solidifying the implant composition. A method of improving bone structure in patients by applying the solidifying implant composition to bone, shoring up bone structure, and improving load bearing capacity and aiding healing of microfractures. A method of fixing an implant, by applying the solidifying implant composition to an implant, and shoring up the implant. A method of devascularizing and treating a tumor or vascular lesion. A method of treating a vascular disease. A method of treating aneurysms / pseudoaneurysms.

The invention relates to a vascular recanalization system for cardiovascular stenosis lesions. The vascular recanalization system comprises a balloon, an energy generation controller and a catheter. The catheter comprises a main body tube, one end of the catheter is connected with the energy generation controller, and the main body tube at the other end of the catheter is connected with one end ofthe balloon; wherein the balloon mainly comprises a balloon main body, an inner tube and an electrode pair, and the inner tube is arranged in the balloon main body; and the energy generation controller can send out and regulate a vibration signal with a specific frequency to enable the electrode pair to generate a vibration wave. The system further has a drug delivery function, can inhibit increase of endovascular membranes after recanalization and avoid restenosis after recanalization, thereby achieving the function of long-term treatment of stenotic lesions. For many vascular diseases needing to be implanted with stents, the purpose of achieving long-term patency rate without stent implantation is achieved, and therefore real intervention implantation-free is achieved.

Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.

This invention provides drugs which are already known to be able to act effectively on informational molecules of the NET and their acceptors or influence informational molecules and their acceptors' signal transduction pathways, and their applications in preparing medicine for angiopathy treatment. The said drugs include single Chinese herbs, compound Chinese herbs and their preparations, chemical effective constituents, medicinal compounds and their preparations, biologic effective constituents, medicinal compounds and materials for their preparations. It also provides a new kind of drugs which can effectively act on the said mutual informational molecules of the NET and their acceptors, or influence their signal transduction pathways so as to treat angiopathy; and furthermore provides these drugs' preparation methods.

Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver.

A graftless prosthetic stent for treatment of vascular lesions such as aneurysms and arterio-venous fistulas, especially in neurovascular vessels, comprises a continuous helical ribbon formed of a shape-retaining metal having a transition temperature at which the stent expands from its contracted condition to a radially expanded condition, the stent remaining substantially cylindrical in its contracted and expanded conditions. The helical windings have variable width, thickness, number or size of openings, or combinations of these features, which affect the stiffness, rate of expansion at the transition temperature, and the area of vessel wall covered by the stent. A catheter device which includes the stent, and a method of treatment using the stent are also provided.

The present application discloses a surgical apparatus for aneurysms comprising: a stent, a delivery guide wire, an introducer sheath and a microcatheter, wherein: the stent is a self-expanding stent; the delivery guide wire outside of which the stent is restrained to is provided in a lumen of the introducer sheath; the introducer sheather is connected with the microcatheter, with lumnes communicating, to form a passageway through which the delivery guide wire and the stent are delivered into a human body. The surgical apparatus for aneurysms provided in the examples of the present application is able to deliver and release the stent which has high density and is super soft to a vascular lesion. A lattice structure of the stent is of high coverage at the vascular lesion such that the stent released into the vessel prodeces the same effects as healing of parent vessel, and thus improves the treatment of vascular aneurysms.

The invention discloses a device for conveying a bracket in an operation, which comprises a coating film, a suture and a pulling line, wherein the suture is sewed on the coating film through the pulling line, the suture and the pulling line are used to sew two sides of the coating film, so that the bracket in the operation is closed and coated in the coating film, connection which can be disconnected when the pulling line is pulled out is formed between the suture and the coating film. An aorta is cut open on the end part of a vascular lesion position; the bracket in the operation, which is mounted on the conveying device, is conveniently and fast implanted into the corresponding lesion position including lesion positions of branch vessels; and thereby the corresponding suture can be released only by pulling out the pulling line; and then the bracket with branches in the operation is released and located in a blood vessel with branches, such as the aortic arch; and a cut is sutured after the conveying device is withdrawn. By using the invention, number of anastomotie stomas in the operation is reduced, the operation process is simplified, the operation time is shortened, the complications of the operation are reduced, the survival rate of the patient is improved, the treatment effect is increased, and wounds to patients with aortic arch parts and other diseases are more effectively reduced.

A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and / or aiding healing of microfractures.

A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and / or aiding healing of microfractures.

The invention relates to a minimally invasive intervention medical instrument, in particular to a delivery system capable of precisely releasing a scaffold with single hand. An outer tube is connected to a sliding block; a push rod is connected to an inner tube and a Luer joint; the outer tube is sleeved outside the inner tube; a hollow structure is formed by two sliding rods; the far ends and the near ends of the sliding rods are respectively fixed by a front fastener and a rear fastener; the outer surfaces of the sliding rods are provided with threaded structures; turning wheel mechanisms are formed by rapid-release buttons and turning wheels; the turning wheel mechanisms are sleeved on the sliding rods; and when the turning wheel mechanisms rotate, the sliding block, inside the sliding rods, can drive the outer tube and the inner tube to do relative motion, so that the scaffold loaded therein is pushed out and released. The delivery system disclosed by the invention has the beneficial effects that during an operation, a handle is held in one hand and the scaffold is released, and radiography observation is conducted by the other hand at the same time; meanwhile, by virtue of a sheath canal which is good in mechanical delivery performance, the scaffold is released on a lower-extremity vascular lesion part, so that the release position can be precisely controlled and the probability of vascular restenosis due to inaccurate scaffold release can be reduced; and in addition, the delivery system also has the advantages of simple structure, convenient operation and the like.

Abstract: The present invention relates to a catheter system and methods of using such catheter system for the treatment of vascular and non-vascular pathologies. More specifically, the present invention is directed towards a catheter system for the actuation of a temporarily implantable member elastically deformable by hydraulic means.

The invention discloses a composite medicine coating balloon. The composite medicine coating balloon comprises a balloon body and a composite medicine coating covering the surface of the balloon body,wherein the composite medicine coating comprises a bottom-layer coating, a middle-layer coating and an outer-layer coating; the bottom-layer coating is used for coating the surface of the balloon body, and consists of medicines A and a hydrophilic excipient; the middle-layer coating consists of a medicine B packed with a packing agent and hydrophilic excipients / lipophilic excipients / amphipathic excipients; and the outer-layer coating consists of a medicine C and lipophilic excipients / amphipathic excipients. The invention further discloses a preparation method of the composite medicine coatingballoon and a composite medicine coating balloon dilatation catheter. According to the composite medicine coating balloon, the loss of traditional Chinese medicines in the balloon transporting process can be reduced, besides, the vasculopathy position can have effective medicine concentration within a short term, vascular restenosis is restrained, long-time medicine release can be provided, durable medicine action time can be maintained, and the restenosis rate can be reduced.

The invention discloses an estimating system and method for fluid velocity. The estimating system comprises a positioning device, a transducer and a processor. The positioning device is used for determining position of to-be-detected fluid through ultrasonic imagining and selecting a plurality of signal sampling sites on a determined section of to-be-detected velocity. The transducer is used for, under the control of the processor, sending ultrasonic to the fluid and receiving pulse echo signals. The processor is used for processing the pulse echo signals, calculating the fluid velocities of the signal sampling sites and performing curve fitting to fluid velocity values of the signal sampling sites to acquire a section curve of the fluid velocity. With the processor, such as FPGA (field-programmable gate array), blood flow velocities with different depth in blood vessels are simultaneously sampled and measured so as to achieve the blood flow velocities. In this way, abnormal blood flow is timely reflected, and signal processing timeliness and calculation accuracy are higher, so that diagnostic basis is provided for diagnosis of vascular diseases.

A catheter is disclosed for providing a pressure measurement at a vascular lesion. The catheter includes a tubular component having dual lumens along at least a segment thereof in which a first lumen acts as a pressure inlet and a second lumen allows the catheter to be tracked over a guidewire. A plurality of openings are located along a distal segment of the tubular component that permit blood flow into the first lumen when disposed in vivo. A pressure sensor is located within a handle component of the catheter or within the tubular component to be in fluid communication with a proximal end of the first lumen. When the catheter is positioned at the vascular lesion, the first lumen fills with blood via the plurality of openings such that the pressure sensor is able to sense a pressure of the blood at a distal end of the catheter.

A cosmetic condition (e.g., a pigmented lesion or a vascular lesion) can be treated using a delivery system that displaces blood from a target region of skin. The delivery system can include an optical element having a convex surface. The optical element can be a non-converging optical element that transmits the beam of radiation to the target region of skin.

To provide a method for differentiating primate embryonic stem cells into vascular endothelial cells, and a technique using the method. A method for differentiating primate embryonic stem cells into early developmental vascular endothelial cells comprising differentiating primate embryonic stem cells into vascular endothelial cell parker-positive cell population; the early developmental vascular endothelial cells; a method for producing the vascular endothelial cells; a method for amplifying the vascular endothelial cells; a vascular lesion-therapeutic agent containing the early developmental vascular endothelial cells as an active ingredient; a method for revascularization comprising supplying the early developmental vascular endothelial cells; a method for transplantation comprising transplanting the early developmental vascular endothelial cells; and a method for treatment comprising administering the early developmental vascular endothelial cells in a therapeutically effective dose.

Fluid delivery systems capable of introducing first and second fluids into first and second lumens of a multi-lumen catheter are provided. The first and second fluids are generally a dissolution fluid and a dissolution fluid attenuating fluid. Also provided are fluid delivery devices and kits that include the subject systems. The subject fluid delivery systems find use in a variety of different applications, and are particularly suited for use in the chemical ablation of internal vascular lesions.

A catheter is disclosed for providing pressure measurements at a vascular lesion. The catheter includes an outer component having a side opening the providing transverse access to a lumen thereof and an inner component slidably disposed within the lumen. The inner component has a guidewire lumen with a proximal side port. When the inner component is longitudinally translated relative to the outer component, the side port of the inner component is accessible through the side opening of the outer component for providing transverse access to a guidewire. A first pressure sensor is disposed proximate of a distal end of the outer component and a second pressure sensor is disposed proximate of a distal end of the inner component, such that relative longitudinal translation between the inner and outer components permits a distance between the first and second pressure sensors to be varied.

The invention relates to a nanometer medicinal elution apparatus in microcellular structure for storing and releasing multiple medicines and a preparation method thereof. The multiple medicines in the invention are selected from medicine therapeutic agents, carrier therapeutic genes and bioactive substances, wherein one or two of the medicine therapeutic agents is / are taxol and / or probucol. The preparation method of the medicinal elution apparatus in the invention mainly comprises the followings: 1) nanometer holes are prepared on the surface of the apparatus body; 2) multiple medicines are coated in the nanometer holes and on the surface of the apparatus body. The apparatus body in the invention does not contain polymers, thereby reducing the risk of long-term thrombus possibly caused by polymers; the nanometer holes on the surface of the apparatus body do not have any influence for mechanical property of the body, thereby being capable of efficiently controlling the releasing rate of medicines and obviously reducing the restenosis rate after surgical operations. The invention can be applied to various medicinal elution implanting apparatuses, particularly having good effects for curing vascular lesion and preventing blood vessel restenosis in vascular stents.

The present invention relates to a catheter system and methods of using such catheter system for the treatment of vascular and non-vascular pathologies. More specifically, the present invention is directed towards a catheter system for the actuation of a temporarily implantable member elastically deformable by hydraulic means.