46 results about "Microangiopathy" patented technology

The invention relates to a waveform characteristic point based method for analyzing a volume pulse wave pattern and a detection device, belonging to the field of electronic medical instruments. In the waveform characteristic point based method for analyzing a volume pulse wave pattern, the collection environment comprises a pulse wave pattern collection device and a computer, wherein the pulse wave pattern collection device is used for obtaining a digitalized volume pulse wave pattern and transmitting the wave pattern data to the computer and the analysis of the wave pattern is completed in the computer; the waveform characteristic point based method for analyzing a volume pulse wave pattern comprises the steps of: dividing the whole wave pattern into two parts of an ascending branch and a descending branch from the maximum point of the wave pattern; respectively acquiring the area characteristic quantity parameters of the two parts; and observing the relationship between the area of the parts and the area of the whole wave pattern to finally obtain the parameter. Shown in the research, the ascending branch and the descending branch of the volume pulse wave pattern respectively represent different physiology processes and the characteristic parameter obtained by the method represents the physiology states in detail. The pulse pattern analysis method and the device thereof have the prompting function for microangiopathy.

The invention relates to a novel-structure dopamine tripolymer aspongopus amide A extracted from insect Chinese medicine aspongopus capable of warming the middle-jiao and invigorating yang, a pharmaceutical composition containing the aspongopus amide A, and application thereof in preparing medicines and health food for treating diabetic nephropathy or chronic nephropathy. The clinical application of insect collateral-dredging theory proves that collaterals are related to pathological changes of blood capillaries. The aspongopus amide A has the functions of obviously inhibiting high-saccharide induced kidney mesenteric cell secretory cell epimatrix and inflammatory factor, and is a Smad3 phosphorylation inhibitor capable of obviously inhibiting TGF-beta1-induced Smad3 phosphorylation and Smad3 expression. The signal route of the TGF-beta / Smad3 is the main pathology of mediated organ fibrosis, which indicates that the compound has application value in chronic nephropathy, including diabetic nephropathy, renal fibrosis and the like.

Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.

The invention relates to alkyl pyrazine dobesilate monohydrate compounds or their hydrates having formula (I), wherein R is C1-C5 alkyl, a is an integer of 1-5, b is an integer of 1-4, m and n are identical or different, the preparing process is also disclosed. The medicament can be used for the preventing and treating blood capillary pathology of diabetic retina, kidney, peripheral nerve and skin pruritus, and for preventing and treating angina pectoris, myocardial infarction, cerebral embolism, lacuna brain infarction, brain thrombogenesis and brain blood supply insufficiency.

The invention provides a vaccinium bracteatum thunb extract and an application thereof. Diabetic retinopathy is one of the serious complications of diabetes, which is an ocular fundus lesion with specific change as well as the most important expression of microangiopathy caused by diabetes. The vaccinium bracteatum thunb extract provided by the invention is prepared by the following steps: heating and extracting vaccinium bracteatum thunb with ethanol of certain concentration; concentrating the extract and adsorbing with a macroporous adsorption resin column; washing with water for removing impurities; eluting with a high-concentration ethanol solution; and concentrating the eluent and drying to obtain the vaccinium bracteatum thunb extract. The pharmacodynamics study indicates that the vaccinium bracteatum thunb extract provided by the invention can be used for preparing a medicine or food for preventing and treating diabetic retinopathy and realizes a remarkable prevention or treatment effect. The invention provides a new way of searching for a new medicine for treating diabetic complications.

The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation endproducts). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.

The various embodiments herein provide a topical drug composition for the treatment of diabetes-related complications. According to one embodiment herein, the composition comprises of a compound belonging to a group of chemicals containing borates. Boric acid is used as the base material of the drug. Boric acid is dissolved in saline 0.9% or half saline serum or water, distilled water or boiled water to obtain a boric acid solution with given concentration. The best concentration is 3-5% solution. Alcohol at preset concentration is added to the boric acid solution. According to another embodiment, a method is provided for preparing a topical drug composition for the treatment of diabetes-related disorders.

A method for the treatment of endothelial dysfunction in a diabetic patient, including both diabetes induced macrovascular disorders and diabetes induced microvascular disorders, comprises administration, preferably parenteral administration, to the patient of an effective amount of high density lipoprotein (HDL).

A Chinese medicine for preventing and treating the chronic complications of diabetics, such as the diabetic nephrosis, eye diseases and microangium disease, is prepared from rhubarb, scutellaria root and medical additive through extracting the free anthraquinone from rhubard, extracting scutelloside from scutellaria root, and post-processing. Said extracting process is also disclosed.

A method and a detection device for analyzing volumetric pulse wave images based on waveform feature points belong to the field of electronic medical instruments. A method for analyzing volume pulse waves based on waveform feature points, comprising an acquisition environment composed of a pulse wave image acquisition device and a computer, the wave image acquisition device is used to obtain a digital volume pulse wave image, and transmits the wave image data to the computer , complete the analysis of the wave map in the computer, and analyze the method of the volume pulse wave map based on the waveform feature points, that is, divide the whole wave map into the ascending branch from the maximum point of the wave map and reduce it to two parts, and obtain the two parts respectively The parameter of the area characteristic parameter, and then investigate the relationship between the area of ​​each part and the area of ​​the whole wave map, and finally get the parameter. Studies have shown that the ascending branch and descending branch of the volume pulse wave map represent different physiological processes, and the characteristic parameters obtained by the above method can represent each physiological state in more detail. The pulse diagram analysis method and device thereof of the present invention have the function of prompting microangiopathies.

A vibratory treatment device has a motor driving an output shaft on which is mounted an eccentric weight to create vibration of the motor as the shaft rotates. A frame is connected to the motor to which frame said vibrations are transmitted through the connection of the frame to the motor. A pad surrounds the frame and into which said vibrations of the frame are transmitted. The pad is applied to the affected limb or limbs of the patient and activated to cause vibrations of the motor to be transmitted through the frame and pad into the tissue of the patent's limb or limbs. The treatment is continued for a therapeutically effective period of time and repeated periodically.

Provides a dopamine trimer with a novel structure, that is, a dopamine trimer extracted from Jiuxiangworm, an insect traditional Chinese medicine that can warm the middle and help yang, and a pharmaceutical composition containing it, as well as its preparation for treating diabetic nephropathy or chronic kidney disease. application in medicine or health food. The clinical application of the theory of worm dredging collaterals shows that collaterals are related to microvascular lesions. Ninecyclopamide A can significantly inhibit high glucose-induced mesangial cell secretion of extracellular matrix and inflammatory factors, and is an inhibitor of Smad3 phosphorylation, which can significantly inhibit TGF-β1-induced Smad3 phosphorylation and Smad3 expression, in view of TGF-β / Smads signaling pathway is the main pathology mediating organ fibrosis, suggesting the application value of this compound in chronic kidney disease including diabetic nephropathy and renal fibrosis.