3 results about "Regadenoson" patented technology

This invention provides a method for detecting related substances in Reganosine starting materials. The method is a high-performance liquid chromatography (HPLC) method. The related substances include residual impurities in the starting materials, process by-product impurities, and diastereomers of the Reganosine starting materials. The chromatographic conditions are: mobile phase A: aqueous acetic acid; mobile phase B: methanol; gradient elution. The method provided by this invention can effectively separate 2-chloroadenosine and its impurities. Furthermore, studies on the specificity, accuracy, precision, limit of detection, limit of quantitation, linear range, and robustness of the method demonstrate that this detection method has high specificity and high sensitivity.

The application discloses a pharmaceutical equipment and method for regadenoson injection and the medicine thereof, and particularly relates to the technical field of the pharmaceutical equipment for regadenoson injection, and comprises the manufacturing pharmaceutical equipment and the injection. The knocking device is arranged, and the impurities adhered to the inner wall of the feeding hopper are not easy to be accumulated to cause the blockage of the discharge port of the feeding hopper and affect the later filtering through the continuous knocking of the knocking rod. In addition, the injection is a colorless and transparent liquid, the pH value is 3.9-5.0, and the content of regadenoson is 93.0%-103.0% of the marked amount.

The utility model discloses an extraction mechanism for Regadenoson injection preparation, which comprises a mixing box, the mixing box is provided with a stirring mechanism and a circulating mechanism, the stirring mechanism comprises a stirring assembly, the stirring assembly comprises a support, the support is fixedly installed on the side face of the mixing box, the top end of the support is fixedly provided with a vertical plate, and the vertical plate is fixedly installed on the side face of the mixing box. A first motor is fixedly installed on the side face of the vertical plate, the rotating shaft end of the first motor penetrates through the vertical plate and is fixedly provided with a rotating disc, a sliding rod is fixedly installed on the rotating disc, a limiting plate is fixedly installed on the side face of the vertical plate, and a lifting rod penetrates through the limiting plate in a sliding mode. By arranging the stirring mechanism, molecular diffusion between a to-be-separated solution and an extraction solution can be accelerated, so that the to-be-separated solution and the extraction solution reach a more uniform mixing state in a short time, the speed and the efficiency of the extraction process are improved, and meanwhile, the extraction solution is favorably ensured to be uniformly distributed in the whole to-be-separated solution through stirring; and the condition that the local concentration is too high or too low is avoided.