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93 results about "Foam cell" patented technology

Foam cells are a type of cells that contain cholesterol. These can form a plaque that can lead to atherosclerosis and trigger heart attacks and stroke. Foam cells are fat-laden M2 macrophages containing low density lipoproteins (LDL). They can only be truly detected by examining a fatty plaque under a microscope after it is removed from the body. They are named because the lipoproteins give the cell a foamy appearance.

Ultrasound imaging

ActiveCN101023376AImprove the contrast-to-noise ratioSuppression of linear scatter signalsUltrasonic/sonic/infrasonic diagnosticsInfrasonic diagnosticsSonificationCalcification
New methods of ultrasound imaging are presented that provide images with reduced reverberation noise and images of nonlinear scattering and propagation parameters of the object, and estimation of corrections for wave front aberrations produced by spatial variations in the ultrasound propagation velocity. The methods are based on processing of the received signal from transmitted dual frequency band ultrasound pulse complexes with overlapping high and low frequency pulses. The high frequency pulse is used for the image reconstruction and the low frequency pulse is used to manipulate the nonlinear scattering and / or propagation properties of the high frequency pulse. A 1st method uses the scattered signal from a single dual band pulse complex for filtering in the fast time (depth time) to provide a signal with suppression of reverberation noise and with 1st harmonic sensitivity and increased spatial resolution. In other methods two or more dual band pulse complexes are transmitted where the frequency and / or the phase and / or the amplitude of the low frequency pulse vary for each transmitted pulse complex. Through filtering in the pulse number coordinate and corrections of nonlinear propagation delays and optionally also amplitudes, a linear back scattering signal with suppressed pulse reverberation noise, a nonlinear back scattering signal, and quantitative nonlinear scattering and forward propagation parameters are extracted. The reverberation suppressed signals are further useful for estimation of corrections of wave front aberrations, and especially useful with broad transmit beams for multiple parallel receive beams. Approximate estimates of aberration corrections are given. The nonlinear signal is useful for imaging of differences in tissue properties, such as micro-calcifications, in-growth of fibrous tissue or foam cells, or micro gas bubbles as found with decompression or injected as ultrasound contrast agent.
Owner:比约恩・A・J・安杰尔森 +2

Chromene-3-carboxylate derivatives

The present invention provides a compound of the formula (I):wherein R1, R2, R3 and R4 are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy or the like, R5 is optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocyclic or the like, R6 is hydrogen, optionally substituted alkyl or the like, R7 is hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclic or the like, A is S or O and a broken line represents presence or absence of a bond,pharmaceutically acceptable salt or hydrate thereof and a pharmaceutical composition or a pharmaceutical composition for use as an endothelin receptor antagonist, a peripheral circulation insufficiency-improving agent or a macrophage foam cell formation inhibitor comprising the compound.
Owner:SHIONOGI & CO LTD

Production of Polyhydroxyalkanoate Foam

InactiveUS20110306693A1Molecular weight can be difficult to maintainLong cycle timePolymer scienceNucleation
Cell nucleation compositions and pellets, methods for making same, methods and compositions for making polymer foam, and polymer foams made by the methods are disclosed.
Owner:METABOLIX

Foam in wound treatment

The present invention relates to a hydrophilic foam material, which is of particular use in wound treatment, and to a method for producing said hydrophilic foam material. The hydrophilic foam material has nucleating particles, wherein at least 85% of all foam cells in said foam material have an average cell size of 0.01 mm2 or less.
Owner:MOLNLYCKE HEALTH CARE AB

Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of blood cholestrol and triglycerides and oxidative stress

InactiveCN1809284ALowered blood levelsReduce oxidation levelsAnhydride/acid/halide active ingredientsEdible oils/fatsCoronary heart diseaseAtheroma
The present invention relates to the use of a composition comprising a combination of diacylglycerol(s) (DAG), mainly 1,3-diacylglycerol(s), and phytosterol and / or phytostanol ester(s) (PSE) dissolved or dispersed in edible oil and / or edible fat, in the manufacture of nutritional supplements and orally administrable pharmaceutical preparations which are capable of reducing blood levels of both cholesterol and triglycerides and / or for lowering serum, serum LDL and macrophage oxidation levels, inhibiting the formation of foam cells and / or preventing the deleterious effects generated by lipid-induced oxidative stress. In addition, the composition of the invention, as well as the pharmaceutical preparations thereof, is suitable for the treatment and prevention of conditions related to atherosclerosis, such as cardiovascular disease (CVD), coronary heart disease (CHD) and diabetes mellitus.
Owner:ENZYMOTEC

Wound treatment-dressing and method of manufacture

A wound treatment-dressing is shown which includes a dressing body formed from a medically inert, moisture permeable, urethane open-cell foam which is hydrophilic in nature. The foam body has a foam matrix of interconnected foam cells with cell walls which have incorporated therein a combination of inorganic antimicrobials as active agents, the active agents being incorporated into the foam matrix both topically on a foam cell surface and integrally within the foam cell wall. The antimicrobials are manufactured in a selected particle size range which improves predictability and performance of the wound dressing.
Owner:KENERIC HEALTHCARE LLC

Pleurotus eryngii polysaccharide capable of reducing accumulation of foam cell lipid and preparation method thereof

The invention discloses a pleurotus eryngii polysaccharide capable of reducing the accumulation of foam cell lipid and a preparation method of the pleurotus eryngii polysaccharide. The pleurotus eryngii polysaccharide is the pleurotus eryngii polysaccharide PEPE-1 of which the average molecular weight is 37.50kDa or the pleurotus eryngii polysaccharide PEPE-2 of which the average molecular weight is 30.00kDa; and the monosaccharide mainly consists of glucose, and a small quantity of mannose and galactose. The preparation method of the pleurotus eryngii polysaccharide comprises the following steps of: digesting and dialyzing pleurotus eryngii sporocarp dry powder by hot water, and further passing through an anion-exchange column DEAE-52 and separating and purifying by the salt concentration gradient elution to obtain PEPE-A; and further separating and purifying the PEPE-A by SephadexG-100, so that the components PEPE-1 and PEPE-2 can be obtained. The PEPE-1 and the PEPE-2 have a single peak, so that the pleurotus eryngii polysaccharide can preferably prevent the foam cell lipid accumulation function and the anti-oxygenation function; and the pleurotus eryngii polysaccharide can be used as a food additive.
Owner:NANJING NORMAL UNIVERSITY

In-vitro foam cell formation model and application thereof in asymptomatic carotid atherosclerosis study

The invention discloses an in-vitro foam cell formation model and application thereof in asymptomatic carotid atherosclerosis study. A construction method of the foam cell formation model provided bythe invention comprises the following steps: sequentially culturing, from bottom to top, smooth muscle cells, endothelial cells and mononuclear cells in a cell culture device capable of performing mechanical stretching so as to obtain a multi-cell co-culture system; treating the multi-cell co-culture system by utilizing a low density lipoprotein, applying a tension effect to induce formation of foam cells by virtue of the cell culture device capable of performing mechanical stretching, thus obtaining the foam cell formation model during early occurrence of asymptomatic carotid atherosclerosis.According to the method disclosed by the invention, consumption of an animal model can be reduced, expenditure is saved, an economic and high-efficiency in-vitro screening model is provided for carotid atherosclerosis resistant new drug screening, and the in-vitro foam cell formation model has the advantages of being simple in preparation method, convenient in experimental operation, low in timeconsumption and stable in performance.
Owner:UNIVERSITY OF CHINESE ACADEMY OF SCIENCES
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