The invention relates to a plaster for treatment of pains in necks, shoulders, waists and legs. The plaster is prepared from the following bulk drugs: sesame oil, minium, long-nosed pit viper, scorpion, centipede, gecko, ground beetle, Mylabris, pangolin, dog's jaw bone, Gynura segetum(Lour.)Merr., ferula assafoetida, frankincense, dragon's blood, myrrh, toad, leech, monkshood, achyranthis bidentatae, Aconitum kusnezoffii, radix paeoniae rubrathe, Arisaema heterophyllum Blume, chinese prickly ash, piper longum, safflower, peach kernel, notopterygium root, seed of sinapis alba, Suberect Spatholobus Stem, Clematis Root, fructus liquidambaris, pinellia ternate, Common Clubmoss Herb, radix angelicae pubescentis, rhubarb, cassia, Chinese Angelica, pawpaw, syzygium aromaticum, eucommia, Cattail Pollen, asarum herb, rheum officinale, Pseudo-ginseng, Herba Artemisiae Anomalae, Phryma leptostachya L., Chinese honeylocust spine, rhizoma atractylodis, Common Cnidium Fruit, Nardostachyos Root and Rhizome, Dahurian Angelica Root, Chinese gall, rhizoma drynariae, Carbonized Human Hair, crataegus pinnatifida, borneol, and camphor. The plaster provided by the invention has the characteristics of carefully selected raw materials, reasonable compatibility and complementary efficacy, and can generate a good synergistic effect. The plaster can treat both symptoms and root causes of pains in necks, shoulders, waists and legs, no recurrence occurs after cure, the therapeutic effects are consolidated, and the total effective rate can reach over 94%.