Construction method of carotid atherosclerosis plaque animal model

A technology of atherosclerosis and construction methods, which is applied in veterinary surgery, medical science, veterinary instruments, etc., can solve the problems of large trauma, difficult operation, low animal survival rate, etc., so that other factors have little influence and can be modeled The effect of high success rate and high animal survival rate

Pending Publication Date: 2020-08-18
THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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Problems solved by technology

Among them, the method of implanting silicone rubber rings has a large surgical trauma and low animal survival rate; the electrical stimulation method has many procedures, complicated operations, time-consuming, and feasibility is questionable; the air modeling method does not have a definite gas flow rate, and the degree of damage to the intima The difference is large, and the complete occlusion of the carotid artery will inevit

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  • Construction method of carotid atherosclerosis plaque animal model
  • Construction method of carotid atherosclerosis plaque animal model
  • Construction method of carotid atherosclerosis plaque animal model

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Experimental program
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Embodiment 1

[0047] Embodiment 1, the construction of carotid atherosclerotic plaque animal model of the present invention

[0048] 1. Experimental animals

[0049] Healthy male New Zealand white rabbits, each weight (2.1±0.63kg), rabbit age (5.0±0.12) months, fed in a single cage, indoor temperature and humidity constant, free to drink water, day and night each 12h, from West China School of Clinical Medicine, Sichuan University. Provided by Experimental Middle School.

[0050] 2. Construct animal model of rabbit common carotid artery atherosclerotic plaque

[0051] 2.1 Injury of rabbit common carotid artery intima by balloon catheter

[0052] (1) Preoperative preparation

[0053] The experimental animals were fed with high-fat feed for 4 weeks in advance, and fasted but not allowed to drink for 12 hours before the operation.

[0054] (2) Surgical steps

[0055]Use teletamine hydrochloride, zolazepam hydrochloride, and intramuscularly inject a dose of 30-40 mg / kg for anesthesia. Afte...

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Abstract

The invention provides a construction method of a carotid atherosclerosis plaque animal model, and belongs to the field of animal model construction. According to the construction method, the common carotid artery intima of the central auricular artery injury is combined with high-fat feed for feeding and modeling. According to the invention, the carotid atherosclerosis plaque animal model is successfully constructed. The construction method comprises the step of modeling through a rabbit ear central artery approach; the animal model is simple in structure, small in wound, simple and convenient to operate, high in animal survival rate, high in modeling success rate and small in influence of other factors, solves the problems existing in construction of the carotid atherosclerosis plaque animal model in the prior art, can be used for screening drugs for treating atherosclerosis plaque and the like, and has important significance in research of carotid atherosclerosis.

Description

technical field [0001] The invention belongs to the field of animal model construction, and in particular relates to a method for constructing a carotid atherosclerotic plaque animal model. Background technique [0002] Atherosclerosis is a lesion in which a layer of wax-like lipid is deposited on the arterial wall, which reduces the arterial elasticity and narrows the lumen. When these waxy deposits form in one piece, it is called an atherosclerotic plaque. These plaques are flat on the intima of the blood vessel in the early stage, usually distributed longitudinally along the blood vessel, and then if they continue to progress, the plaque will slowly protrude inward on the vessel wall, causing varying degrees of stenosis of the inner diameter of the artery; if there are predisposing factors, When part of the plaque in an artery ruptures, a blood clot forms to block the blood vessel. Carotid atherosclerosis is associated with many cardiovascular and cerebrovascular diseas...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 郭应坤叶鹏飞刘灵军文凌仪许华燕谢林均傅航陈林许可
Owner THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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