45 results about "Complete occlusion" patented technology

The present invention includes materials and methods for providing vehicles useful for providing drug formulations that address the potential drawbacks of known nonaqueous formulations. In particular, the present invention includes nonaqueous vehicles that are formed using a combination of polymer and solvent that results in a vehicle that is miscible in water. The nonaqueous vehicles facilitate the formulation of drug formulations that are stable over time, even when stored at, or exposed to, elevated temperatures. Moreover, the miscible vehicles of the present invention allow the preparation of drug formulations that work to reduce the occurrence of partial or complete occlusions of the delivery conduits included in delivery devices used to administer the drug formulations.

A steerable distal support system for accessing stenosis, partial occlusions, or complete occlusions within a body lumen. The steerable distal support system generally includes an elongate member that comprises a proximal portion, a more flexible intermediate portion and a deflectable distal tip. The deflectable distal tip is at a distal end of the elongate body to facilitate directionality and positioning of the steerable distal support system to the target site. Optionally, an expandable centering assembly may be disposed on the steerable support assembly to center and anchor the steerable support assembly within the body lumen.

A system for recanalizing chronic total occlusions comprises a catheter having multiple channels that are substantially coextensive distally and distensible. In addition, the catheter may have a bullet-shaped distal tip and / or torquing grooves in the proximal and distal shaft.

Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing an intravascular device having a distal portion with a side port, inserting the device into the vascular lumen, positioning the distal portion in the vascular wall, directing the distal portion within the vascular wall such that the distal portion moves at least partially laterally, and directing the side port towards the vascular lumen.

Apparatus and methods for treating a hollow anatomical structure comprises an implant sized for insertion into a hollow anatomical structure. The implant comprises a plurality of loose, bulked fibers. The fibers are formed from one or more bioabsorbable materials. Upon implantation, the apparatus causes a partial occlusion of the hollow anatomical structure, followed by a complete or substantially complete occlusion.

Systems and methods for crossing stenosis, partial occlusions, or complete occlusions within a body lumen. The systems generally include an elongate member such as a hollow guidewire that houses a rotatable and translatable drive shaft. The drive shaft typically has a distal portion that is advanced to create a path in the occlusive material that is large enough to allow the hollow guidewire to cross the occlusive material.

An apparatus and method for detecting, tracking and registering a device (218) within a tubular organ (210) of a subject. The devices include guide wire (216) tip or therapeutic devices, and the detection and tracking uses fluoroscopic images taken prior to or during a catheterization operation. The devices are fused with images or projections of models depicting tile tubular organs. Tile method and apparatus are used for treating chronic total occlusion or near total occlusion situations, by navigating a driller along the tubular organ (210) proximally to the occlusion point, in areas which are-not viewable in an angiogram, and optionally enabling the penetration of the occlusion in a preferred area.

Systems and methods for crossing stenosis, partial occlusions, or complete occlusions within a body lumen. The systems generally include an elongate member such as a hollow guidewire that houses a rotatable and translatable drive shaft. The drive shaft typically has a distal portion that is advanced to create a path in the occlusive material that is large enough to allow the hollow guidewire to cross the occlusive material.

A balloon catheter is disclosed including a “no-fold” balloon at a distal end thereof that surrounds a distal portion of a guidewire shaft having a compliant shaft or tubular section for selectively gripping a guidewire there within. Upon introduction of inflation fluid at low pressure values, the compliant shaft section of the guidewire shaft is radially compressed to “lock” onto the guidewire while an outer diameter of the no-fold balloon remains unchanged. The simultaneous compression of the compliant shaft section against a guidewire located within the guidewire lumen and the filling of the balloon with inflation fluid without expanding the balloon provides a clinician with a conjoined balloon catheter and guidewire ensemble that together may be pushed through a tight stenosis such as a chronic total occlusion (CTO).

A method and systems for treating chronic total occlusions (CTOs), particularly those that are difficult to treat. CTO recanalization is achieved using radiofrequency ablation directed at the occlusion between antegrade and retrograde guidewires placed on either side of the occlusion.

The invention presents methods and systems for accessing a pericardial space and preventing strokes arising from a left atrial appendage (“LAA”) by achieving a complete occlusion of the LAA using an epicardial approach without creating a puckering of the LAA ostium. A complete occlusion of the LAA is desired because bleeding arising from the LAA often leads to embolic strokes. Due to the peculiar anatomy of the LAA ostium, traditional LAA ligation techniques using sutures can lead to puckering, thus compromising the occlusion of the LAA. The invention achieves a complete occlusion and a more effective hemostatic seal with the use of inflatable balloons having electromagnetic coils internally, as well as hydrogels, sponges, and caliber tubes attached to the respective balloon's exterior, anchoring balloons, a closure device having a suture looped through two semi-rigid hollow tube that can be coated with hydrogel or silicone, and locking mechanisms.

A multi-element occlusion device (10, 20, 30, 40) provides an improvement over existing systems by increasing the occupation of a vascular lumen. The device (10, 20, 30) comprises an anchoring element (12, 22, 32), a lead element (14, 24, 34) and at least one fiber (16, 26, 36) attaching said elements. The elements and fibers produce a cumulative occlusive effect greater than the sum of the individual elements. When placed in the blood stream, the anchoring element (12, 22, 32) lodges against the vessel wall and the lead element (14, 24, 34) is carried to a position distal thereto. In another embodiment, an “umbrella” of support members extend from the lead element. A fabric web extends between these support members. The umbrella intravascular device expands upon its exit from the catheter. The fabric web produces complete occlusion of the vessel without the need for thrombosis to form between the elements. With the use of multi-element deployment, the device decreases the risk of continued canalization and recanalization.

A dual lumen guidewire support catheter for accurately crossing a chronic total occlusion in a vessel is disclosed. The dual lumen guidewire support catheter includes a first lumen portion and a second lumen portion sharing a common side and a common distal end. The first lumen portion can be a rapid exchange or over-the-wire portion, while the second lumen portion is an over the wire portion. One or both of the portions can include a discontinuity to enable removal of a guidewire following placement through or at an occlusion or lesion.

The invention presents methods and systems for accessing a pericardial space and preventing strokes arising from a left atrial appendage (“LAA”) by achieving a complete occlusion of the LAA using an epicardial approach without creating a puckering of the LAA ostium. A complete occlusion of the LAA is desired because bleeding arising from the LAA often leads to embolic strokes. Due to the peculiar anatomy of the LAA ostium, traditional LAA ligation techniques using sutures can lead to puckering, thus compromising the occlusion of the LAA. The invention achieves a complete occlusion and a more effective hemostatic seal with the use of inflatable balloons having electromagnetic coils internally, as well as hydrogels, sponges, and caliber tubes attached to the respective balloon's exterior, anchoring balloons, a closure device having a suture looped through two semi-rigid hollow tube that can be coated with hydrogel or silicone, and locking mechanisms.

Disclosed is a guide catheter that includes one or more RF antennas to enhance the visibility of the guide catheter in MR imagery. One embodiment of the guide catheter includes a loop coil at the distal end of the guide catheter and a loopless antenna between the distal end and the proximal end. By combining a loop coil and a loopless antenna on the catheter, the shaft of the catheter may be visible in MR imagery while the distal end may appear in the MR imagery more brightly than the shaft.

A perfusion catheter is used to avoid ischemia in case of failure of a conventional balloon angioplasty procedure on a stenotic blood vessel and a resulting partial or complete occlusion of the vessel. The balloon catheter is first removed from the vessel while the guide wire and the guide catheter are left in place. The perfusion catheter is immediately inserted into the guide catheter and run past the stenosis using the guide wire already in place. Blood is drawn from a side port in the sheath introduced at the point of entry into the vascular system of the patient under normal arterial pressure or after passing through an exterior pump for pressurization and re-injection in the perfusion catheter. Thus, blood flow to the part of the vessel past the occlusion can be reestablished within minutes of angioplasty failure and the patient can be stabilized in preparation for heart surgery.

This invention relates to a method that comprises the introduction of a catheter via left subclavian vein, advancing into the right atrium and then positioning it in the inferior vena cava, just at the cava-diaphragm junction, where it is anchored at its extreme; and thereafter an external inflation of a balloon positioned in said catheter takes place through a physiological solution to reach a diameter corresponding to half the diameter of the inferior vena cava, resulting in hemi-occlusion in the expiration phase (breath-out) and total occlusion for a short period during the inspiration phase (breath-in), regulating (normalizing) the venous return and decreasing the cardiac volume overload, as a treatment for heart failure. The invention also comprises hydromechanics devices to normalize the venous return in the circulatory system. Said venous return is increased in 90% of patients with heart failure. In particular, it refers to a combined catheter with an inflatable balloon, producing said balloon a cyclical occlusion of the inferior vena cava (IVC). The said balloon is adaptable to the area of its location in the inferior vena cava, proximal to the right atrium (RA), which comprises of means for its fixation within said vein, as well as the capacity of modifying the volume in response to the requirements of the patient. This device is implanted for an extended period of more than three months. The final objective is to treat and stop the progression of heart failure.

A balloon catheter is disclosed including a “no-fold” balloon at a distal end thereof that surrounds a distal portion of a guidewire shaft having a compliant shaft or tubular section for selectively gripping a guidewire there within. Upon introduction of inflation fluid at low pressure values, the compliant shaft section of the guidewire shaft is radially compressed to “lock” onto the guidewire while an outer diameter of the no-fold balloon remains unchanged. The simultaneous compression of the compliant shaft section against a guidewire located within the guidewire lumen and the filling of the balloon with inflation fluid without expanding the balloon provides a clinician with a conjoined balloon catheter and guidewire ensemble that together may be pushed through a tight stenosis such as a chronic total occlusion (CTO).

A perfusion catheter is used to avoid ischemia in case of failure of a conventional balloon angioplasty procedure on a stenotic blood vessel and a resulting partial or complete occlusion of the vessel. The balloon catheter is first removed from the vessel while the guide wire and the guide catheter are left in place. The perfusion catheter is immediately inserted into the guide catheter and run past the stenosis using the guide wire already in place. Blood is drawn from a side port in the sheath introduced at the point of entry into the vascular system of the patient under normal arterial pressure or after passing through an exterior pump for pressurization and re-injection in the perfusion catheter. Thus, blood flow to the part of the vessel past the occlusion can be reestablished within minutes of angioplasty failure and the patient can be stabilized in preparation for heart surgery.

A device and method for opening blood vessel blockages, such as chronic total occlusions, is disclosed. The device has drilling unit and a stationary unit having a plurality of curved alignment structures along its outer edge for bracing against the inner surface of a blood vessel wall. A torque-transmitting member (drive shaft) is disposed within the stationary unit and extends into the rotating drilling unit. The curved alignment structures along the outer surface of the device help to centrally align the device within the blood vessel, thereby preventing the device from deflecting and puncturing blood vessel walls. The drilling unit that has a plurality of loops on its distal tip, located at the distal region of the drilling unit. These loops break apart occlusions as the device advances and rotates through the blood vessel.

An apparatus capable of generating flow in cerebrospinal fluid (CSF) shunt systems by vibrating the shunt, tubing or shunt valve dome, or applying cyclical pressure to the various parts of the shunt system. A method of generating flow and method of using the apparatus in shunt patency assessment, for example, hydraulic resistance assessment, is also disclosed. The apparatus allows, in conjunction with a thermal dilution method or radionuclide method, a quick CSF shunt patency assessment based upon CSF shunt resistance and not upon CSF flow or intracranial pressure (ICP) separately. This provides a more objective measure of shunt obstruction compared to other methods. Furthermore, the apparatus can be used to enhance flow in shunts, identify partial occlusion before symptoms occur, differentiate between patent, partially-occluded and occluded shunts. The apparatus can be used to generate flow in shunts if there is a need to lower ICP or move drugs administered via an injection chamber or a shunt dome.

The invention discloses a system for detecting whether coronary angiography has a complete occlusion lesion or not based on deep learning. A deep learning recurrent neural network is used for analyzing an overall video, a GPU (graphics processing unit) is used for accelerating calculation to obtain a detection result, the calculation delay is small, and the real-time problem of detection is solved. The system comprises a video input module, a convolutional neural network module, a coding and decoding attention module and a classification module. Particularly, the encoding and decoding attention module and the supervision algorithm thereof provided by the invention are used for generating a proper attention weight to improve the detection accuracy. The end-to-end system design achieves automation of the coronary artery complete occlusion detection process, and complex intermediate steps are not needed. Compared with other systems for detecting whether the complete occlusion lesion exists or not, the whole video instead of a single image is analyzed, the situation of misjudgment caused by the single image is reduced, and the accuracy of existence judgment of the complete occlusion lesion is remarkably improved.

The invention discloses a multiple object tracking method. The multiple object tracking method comprises step 1, outputting the positional information of detected objects in every frame; step 2, executing step 5 when complete occlusion of a moving object occurs and calculating similarity values between interacted objects and executing step 3 or step 4 otherwise; step 3, associating corresponding objects in two consecutive frames directly when the similarity values meet the strong conditions simultaneously and finishing the process; step 4, solving the matching relation between the objects through an objective function and constraint conditions when the similarity values do not meet the strong conditions simultaneously and partial occlusion of the moving object occurs, associating the corresponding objects in the two consecutive frames according to the matching relation and finishing the process; step 5, monitoring a few continuous following frames of the current frame until the complete occlusion does not occur, recording a corresponding objective frame at present, calculating the similarity values between the objects, enabling the middle position between the current frame and the objective frame to serve as the position of a complete occlusion frame and finishing the process.

Systems and methods for crossing stenosis, partial occlusions, or complete occlusions within a body lumen. The systems generally include an elongate member such as a hollow guidewire that houses a rotatable and translatable drive shaft. The drive shaft typically has a distal portion that is advanced to create a path in the occlusive material that is large enough to allow the hollow guidewire to cross the occlusive material.

Disclosed are systems and method for effecting the total and partial occlusion of a blood vessel, e.g., the aorta. The systems include a balloon catheter, a reservoir for an inflation fluid, a switch, and a pressure regulator / accumulator. The systems are configured to operate in a first mode and a second mode as established by the switch. During the first mode the balloon is fully inflated by the inflation fluid to completely occlude the blood vessel. During the second mode the balloon is partially inflated so that blood can flow past the balloon in the blood vessel. The pressure regulator / accumulator includes a chamber for receipt of the inflation fluid during the second mode to automatically regulate the pressure within the balloon to a desired operating pressure. The system is configured to operate in a third mode to prime the pressure regulator / accumulator to establish a desired operating pressure in the second mode.

An apparatus capable of generating flow in cerebrospinal fluid (CSF) shunt systems by vibrating the shunt, tubing or shunt valve dome, or applying cyclical pressure to the various parts of the shunt system. A method of generating flow and method of using the apparatus in shunt patency assessment, for example, hydraulic resistance assessment, is also disclosed. The apparatus allows, in conjunction with a thermal dilution method or radionuclide method, a quick CSF shunt patency assessment based upon CSF shunt resistance and not upon CSF flow or intracranial pressure (ICP) separately. This provides a more objective measure of shunt obstruction compared to other methods. Furthermore, the apparatus can be used to enhance flow in shunts, identify partial occlusion before symptoms occur, differentiate between patent, partially-occluded and occluded shunts. The apparatus can be used to generate flow in shunts if there is a need to lower ICP or move drugs administered via an injection chamber or a shunt dome.

The invention discloses an occlusion detection method based on block correlation. A target area is selected, and the target area is sequentially divided into a first number of first target blocks in afirst direction, and the target area is sequentially divided into a second number of second target blocks in a second direction. The method comprises: calculating a first target block of a predetermined position and a normalized cross correlation value of the second target block and the block of a position corresponding to the predetermined template; judging the occlusion degree and the occlusiondirection of the target region according to the normalized cross correlation value, wherein two adjacent first target blocks have a first overlap portion and two adjacent second target blocks have asecond overlap portion. The embodiment of the invention can quickly and effectively judge the process of the target from entering the occlusion to the complete occlusion and then to the outgoing occlusion by dividing the target area into blocks in different directions, and then judging the occlusion degree and the occlusion direction, and carries out corresponding processing.