88 results about "Acute ischemia" patented technology

A system and a method for scheduling an emergency procedure in response to detecting that a patient has a high probability of acute myocardial infarction. The system is able to identify patients that are suspected of having acute myocardial infarction (or acute ischemia). The system uses one or more expert software tools or algorithms to analyze received ECG records. Each software tool has logic (e.g., thresholds and/or settings) for automatic routing which is configurable by the customer via a graphical user interface. If any sufficient condition for automatic routing is satisfied, the system routes the data (including the underlying ECG record) and an alert to an electronic device which is accessible by the cardiologist “on call” via a bidirectional pager. If the cardiologist decides that the requested emergency treatment or procedure should be performed, the system accesses the schedules of all associated catheterization labs across multiple hospitals to identify a lab having optimum time-to-treatment. Then the system automatically contacts the selected catheterization lab via a network to schedule the PTCA procedure.

A heart monitor is disclosed. The monitor computes ST segment deviations and stores the results in heart rate based histograms. Periodically, the monitor analyzes the histogram data to determine a normal range of ST deviation for a particular heart rate range. The monitor computes heart rate dependent ischemia detection thresholds based on the upper and lower boundaries of the normal range.

A device for detecting a cardiac event is disclosed. Detection of an event is based on a test applied to a parameter whose value varies according to heart rate. Both the parameter value and heart rate (RR interval) are filtered with an exponential average filter. From these filtered values, the average change in the parameter and the RR interval are also computed with an exponential average filter. Before computing the average change in the parameter, large changes in the parameter over short times, which may be caused by body position shifts, are attenuated are removed, so that the average change represents an average of small/smooth changes in the parameter's value that are characteristic of acute ischemia, one of the cardiac events that may be detected. The test to detect the cardiac event depends on the heart rate, the difference between the parameter's value and its upper and lower normal values, and its average change over time, adjusted for heart rate changes. The upper and lower normal parameter values as a function of heart rate are determined from long term stored data of the filtered RR values and parameter values. Hysteeresis related data and transitory deviations from normal (e.g. vasospasm related data) are excluded from the computation of normal upper and lower parameter bounds.

The present invention provides compositions and methods for protecting tissues and organs from damage during transplantation or from acute ischemia due to, e.g., injury or surgery. The compositions protect the tissue or organ from acidosis, oxidative damage, ischemia and repurfusion injury while the organ is isolated from the normal circulation or receives inadequate arterial flow.

The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke from other forms of stroke and TIAs and “stroke mimic” events. Moreover, methods and compositions are provided to facilitate the treatment of acute ischemic stroke patients.

The invention discloses two bromophenol compounds and a pharmaceutical application of their pharmaceutically-acceptable salts, specifically an application in the preparation of a myocardial ischemia-reperfusion injury protection drug. The two compounds and their pharmaceutically-acceptable salts can protect cardiomyocytes during rat heart acute ischemia so as to make rat heart functions complete.After routine intravenous administration, SOD activity after myocardial ischemia-reperfusion is raised, myocardial compliance is improved, serum LDH, serum CK, serum cTnT and MDA level after myocardial ischemia-reperfusion is remarkably reduced, myocardial injury is minimized, and FasmRNA after myocardial ischemia-reperfusion can be remarkably inhibited and reduced so as to inhibit cardiomyocyte apoptosis after myocardial ischemia-reperfusion. Therefore, the two bromophenol compounds and their pharmaceutically-acceptable salts have a clear myocardial ischemia-reperfusion injury protection function, thus providing a new method and means for the clinical treatment of myocardial ischemia-reperfusion injury and opening up a new direction for clinical medication.

The invention discloses miR-106b-5p, a detection primer thereof and application of the antisense nucleotide sequence thereof in the fields of ischemic cerebral stroke diagnosis and treatment, and belongs to the field of application of micro ribonucleic acid. The sequence of a reverse transcription primer in the detection primer of the miR-106b-5p is 5'-CTCAACTGGTGTCGTGGAGTCGGCAATTCAGTTGAGATCTGCAC-3'. The antisense nucleotide sequence of the miR-106b-5p is 5'-AUCUGCACUGUCAGCACUUUA-3'. The miR-106b-5p, the detection primer thereof and the antisense nucleotide sequence thereof are associated with acute ischemic cerebral strokes, the miR-106b-5p can become an auxiliary index of acute ischemic cerebral stroke clinical detection, and a therapeutic target is provided for prevention of the disease. The miR-106b-5p has the advantages of being good in treatment effect, easy to operate, free of toxic and side effects and the like.

An acute ischemia monitor is disclosed. The monitor, which includes an analog to digital convertor and a processor that performs beat detection, monitors the time course of a heart signal parameter, namely ST segment deviation, computed from an electrocardiogram. The device stores ST deviation statistics for multiple leads. For each lead, upper and lower ST deviation boundaries are computed. For each lead, current ST deviation values are compared with the statistical values to determine a metric indicative of the degree of abnormality of a current ST deviation value. The metric is equal to the difference between the current ST deviation value and the upper or lower boundary, normalized according to the dispersion of the ST deviation. Metrics from different leads are summed and compared to a threshold to determine whether the combined metric is indicative of a cardiac event.

The invention discloses an acute ischemic stroke focus automatic segmentation method and system. The method comprises the following steps of: registering a head CT (Computed Tomography) image; removing the skull to obtain a brain parenchyma three-dimensional mask; performing ellipse fitting on the brain parenchyma three-dimensional mask through PCA feature dimension reduction to obtain median sagittal plane data; calculating left and right symmetric parameter diagrams of the brain; setting different window widths and window levels for the median sagittal plane data to obtain multi-level window width and window level image data; marking training data; training a segmentation convolutional neural network model; inputting test data into the trained segmentation model for segmentation to obtain a segmentation probability graph of the brain parenchyma, the cerebrospinal fluid and the stroke focus of the corresponding voxel and a prediction probability of whether the stroke focus exists in the corresponding two-dimensional image; and outputting different segmentation results according to different prediction probabilities. According to the method, multi-task training is carried out in combination with brain anatomy priori knowledge, the performance of the convolutional neural network in the NCCT stroke focus automatic segmentation method is improved, and the acute ischemic stroke focus can be accurately segmented.

The present invention relates to an in vitro method for the diagnosis and treatment guidance of a bacterial infection in patients suffering from an acute ischemic or hemorrhagic stroke, comprising the determination of the level of Procalcitonin (PCT) or a fragment thereof having at least 12 amino acid residues in a sample of a bodily fluid from said patient and the correlation of the determined level to the diagnosis of a bacterial infection in said patient.

The present invention relates to microRNA (miRNA) compounds for use in the treatment of consequences of acute ischemia/reperfusion, a method for preparing miRNA compounds by using test ischemic-reperfusion, test preconditioning and test postconditioning of biological samples, use of the miRNA compounds in the preparation of pharmaceutical compositions having cytoprotective and/or anti-ischemic effect in ischemic cardiac diseases.

The invention discloses a son-mother extending catheter and a son catheter thereof. The son catheter comprises a catheter body and a catheter seat, wherein an opening is formed in the end part, far away from the catheter seat, of the catheter body; side holes are formed in the side walls of the catheter body. The son catheter moves along a guide wire in a mother catheter until the son catheter stretches out of the mother catheter, at the moment, the outer wall of the son catheter is in contact with the inner wall of the blood vessel to cause the blockage of the blood vessel, when the contact part of the son catheter and the blood vessel is positioned between each side hole and the end part, far away from the catheter seat, of the catheter body, blood can flow into the catheter body from the side holes in the side walls of the catheter body, and then the blood in the catheter body can bleed from the end part, far away from the catheter seat, of the son catheter to realize the circulation of the blood, so that the condition that the blood vessel is blocked by the son catheter is avoided, the condition of causing acute ischemia is prevented, and the surgical risk is reduced.

The invention discloses application of serum inflammatory biomarkers in prevention and treatment of acute ischemic cerebral infarction. The biomarkers include at least one cytokine of IL-4, IL-5, IL-6, IL-9, MDC, MIP-1 alpha, sLOX-1, IL-33, Trx and YKL-40. The application of the serum inflammatory biomarkers in the prevention and treatment of the acute ischemic cerebral infarction verifies that the cytokines IL-4, IL-5, IL-6, IL-9, MDC, MIP-1 alpha, sLOX-1, IL-33, Trx and YKL-40 are associated with functional prognosis of the cerebral infarction, the reject ratio of the prognosis of patients with the cerebral infarction can be reduced through the regulation of the cytokines, especially levels of IL-4, IL-5 and MDC, and the application can be used for preventing and treating the acute ischemic cerebral infarction by regulating the serum cytokines and related pathways thereof to predict neural functional prognosis of the patients with the cerebral infarction.

The invention relates to a Chinese medicinal preparation for treating acute ischemic stroke with a good treatment effect and high safety. The Chinese medicinal preparation is prepared from the following raw materials in parts by weight: 15 parts of red paeony roots, 9 parts of szechuan lovage rhizome, 15 parts of earthworms, 20 parts of danshen roots, 30 parts of siegesbeckia herb, 30 parts of roots of kudzuvine roots, 15 parts of tree peony root bark, 15 parts of twotooth achyranthes roots, 30 parts of suberect spatholobus stems, 15 parts of ground beetles, 9 parts of peach seeds, 6 parts of leeches and 3 parts of safflowers. The Chinese medicinal preparation provided by the invention is effective in treatment of both symptoms and root causes and has the efficacies of combining warming and heat clearing, promoting the circulation of qi and blood, dispersing blood stasis, dredging collaterals, relaxing muscles and relieving muscular spasm. The Chinese medicinal preparation has a significant effect of improving the neurological impairment of a patient with the acute ischemic stroke due to qi deficiency and blood stasis without causing adverse effects on liver and kidney functions, urine and blood routine, and in addition, the Chinese medicinal preparation can be used for treating acute ischemic stroke safely.

A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

The invention discloses application of compound 5-bromo-2-(alpha-hydroxy amyl) sodium benzoate (BZP) in medicine for curing cardiovascular disease, and belongs to the field of medicinal chemistry. Experiments prove that BZP has a protective effect for acute and chronic myocardial ischemia reperfusion injuries of a mouse, so that the overall animal acute myocardial infarction area is reduced through BZP oral administration and intravenous injection, the myocardial infarction area of the acute ischemia reperfusion injury of the isolated perfusion heart of the mouse is reduced through BZP, the function of myocardial contraction is improved, and the haematological myocardial injury markers are reduced; moreover, the invention also relates to application for delaying a process of the conversionfrom myocardial hypertrophy to cardiac failure after chronic orally taken administration of BZP for acute myocardial infarction of the mouse and reducing ventricular remodeling caused by ischemic heart disease of the mouse, the therapeutic action of the cardiac function is improved obviously; moreover, the invention also relates to the transient effect of the compound BZP for reducing the blood pressure of the hypertension mouse (SHR mouse), and these results indicate that the BZP has effective research and development prospects of myocardial damage protection medicine for clinically acute and chronic myocardial infarctions.

The invention discloses an image processing method based on a CT (computed tomography) flat scanning image. The method assists in evaluating the CT early ischemic change degree of the head of an AIS (acute ischemic stroke) patient. According to the invention, the risk assessment of the automatic zoning and quantitative treatment of the acute ischemic stroke from the CT flat scanning images is realized, and an effective assessment method is provided for the early screening, early diagnosis and early treatment of patients with the acute ischemic stroke (AIS).

The invention discloses a fiber chronic embolization device capable of preventing ectopic embolism. The fiber chronic embolization device comprises a linear embolization agent, a delivery pipe and aninjection pipe, wherein the linear embolization agent is arranged in the delivery pipe, the back end of the delivery pipe is connected with an outlet of the injection pipe, the delivery pipe comprisesa connecting part, a storage part and an output part, closing caps are arranged at front and back ends of the delivery pipe, two ends of the storage part are connected with the output part and the connecting part respectively, the connecting part is connected with an output end of the injection pipe, and a pressurization device is arranged at the back end of the injection pipe; and the linear embolization agent is arranged in the delivery pipe, and the pressurization device pressurizes the delivery pipe to input the linear embolization agent in a blood vessel. The embolization agent is designed into a filament-shaped structure, the blood vessel is filled with filaments after the embolization agent is injected into the blood vessel, blood flow still passes through the blood vessel in a short period, the blood flow is gradually completely blocked with gradual formation of filament attached thrombus to form a chronic embolization effect; and the filaments are connected with one another and the filament fibers intertwine one another to prevent ectopic embolism and avoid acute ischemic necrosis of tissue.