Medicine for treating acute ischemic cerebral apoplexy and its preparing method

Abstract

The medicine for treating acute ischemic cerebral apoplexy is prepared with butyl benzene phthalein, emulsifier, co-emulsifier, excipient and water for injection in certain proportion. The preparation process includes weighing materials in certain proportion; mixing butyl benzene phthalein, emulsifier and co-emulsifier in partial water for injection via high speed stirring; dissolving the excipient in other water for injection, adding active carbon, heating at 100 deg.c for 15 min before eliminating carbon; mixing two kinds of solution, adding active carbon, filtering and eliminating carbon; adding water for injection to full amount, measuring pH value and content; fine filtering, bottling and freeze drying to obtain the powder for injection. The present invention provides medicine for salvage of serious cerebral apoplexy patient clinically.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a medicine for treating acute ischemic stroke and a preparation method thereof. Background technique [0002] The chemical name of butylphthalide is dl-3-n-butylphthalide. Butylphthalide is the left-handed form extracted from celery seeds, which is then artificially synthesized into a racemic form. Butylphthalide has pharmacological effects against cerebral ischemia. At present, the oral preparation of butylphthalide - butylphthalide soft capsules is listed. The indication of butylphthalide soft capsules is the treatment of acute ischemic stroke. Stroke is a neurological disorder caused by reduced blood flow in a specific blood vessel supplying the brain lasting more than 24 hours, and the final result is cerebral infarction. The morbidity, mortality, and disability rates of stroke are high, which imposes a great burden on families and society. With th...

AI Technical Summary

Problems solved by technology

The morbidity, mortality, and disability rates of stroke are high, causing a great burden on families and society. With the aging of my country's population and the increase in the prevalence of hypertension, stroke patients have also increased. Butylphthalide Soft Capsules are not suitable for stroke patients, as their effect is slow, and it is not conducive to the rescue of critically ill patients

And because butylphthalide is an oily liquid with poor water solubility, clinical injections that are directly used to rescue critically ill patients have not been seen so far.