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Application of serum inflammatory biomarkers in prevention and treatment of acute ischemic cerebral infarction

A biomarker, ischemic brain technology, applied in the application field of serum inflammatory biomarkers in the prevention and treatment of acute ischemic cerebral infarction, can solve problems such as less cerebral infarction, predict neurological function prognosis, reduce prognosis The effect of bad rate

Inactive Publication Date: 2018-12-21
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fms-like tyrosine kinase-3 ligand (Flt-3L) is a growth factor, and there are few studies on Flt-3L and ischemic cerebral infarction

Method used

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  • Application of serum inflammatory biomarkers in prevention and treatment of acute ischemic cerebral infarction
  • Application of serum inflammatory biomarkers in prevention and treatment of acute ischemic cerebral infarction
  • Application of serum inflammatory biomarkers in prevention and treatment of acute ischemic cerebral infarction

Examples

Experimental program
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Embodiment 1

[0020] In this study, a total of 167 patients with acute cerebral infarction were hospitalized in the Neurology Department of the First Affiliated Hospital of Wenzhou Medical University from April 2014 to September 2016. All patients were admitted within 72 hours of onset and met the diagnostic criteria of the World Health Organization. The etiological subtypes of ischemic cerebral infarction were classified according to the TOAST etiological classification criteria. The exclusion criteria for patients with first acute ischemic cerebral infarction were as follows: (i) medical history of any serious central nervous system disease, such as Parkinson's disease, craniocerebral trauma, dementia, cerebral hemorrhage, cerebral infarction or subarachnoid hemorrhage, etc. (ii) vital organ failure, such as heart failure, severe hepatic or renal insufficiency; (iii) autoimmune disease, use of steroids or immunosuppressants; (iv) history of malignancy; (v) severe History of infection, tra...

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Abstract

The invention discloses application of serum inflammatory biomarkers in prevention and treatment of acute ischemic cerebral infarction. The biomarkers include at least one cytokine of IL-4, IL-5, IL-6, IL-9, MDC, MIP-1 alpha, sLOX-1, IL-33, Trx and YKL-40. The application of the serum inflammatory biomarkers in the prevention and treatment of the acute ischemic cerebral infarction verifies that the cytokines IL-4, IL-5, IL-6, IL-9, MDC, MIP-1 alpha, sLOX-1, IL-33, Trx and YKL-40 are associated with functional prognosis of the cerebral infarction, the reject ratio of the prognosis of patients with the cerebral infarction can be reduced through the regulation of the cytokines, especially levels of IL-4, IL-5 and MDC, and the application can be used for preventing and treating the acute ischemic cerebral infarction by regulating the serum cytokines and related pathways thereof to predict neural functional prognosis of the patients with the cerebral infarction.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of a serum inflammatory biomarker in the prevention and treatment of acute ischemic cerebral infarction. Background technique [0002] Cerebrovascular disease is a threatening global health problem. According to statistics, in 2016, cerebrovascular disease has become one of the leading causes of death and disability in adults, second only to ischemic heart disease. It is known as the biggest killer in middle-income countries and one of the five most common causes of death in low-income countries. Acute Ischemic Stroke (AIS) is mostly caused by cerebral embolism or arterial thrombosis, accounting for 80%-85% of all cerebrovascular diseases, and is the main subtype of all stroke types. The inflammatory response after acute cerebral infarction is an inevitable pathological process in the injury of brain cells after ischemia. Immediately after the in...

Claims

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Application Information

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IPC IPC(8): G01N33/543
CPCG01N33/54326
Inventor 邵蓓金坤林张万里李贤美林思阳陈洁
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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