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Compound for treating cerebral infarction and application thereof

A compound and a technology for cerebral infarction, used in the field of preparing medicines for treating cerebral infarction

Inactive Publication Date: 2014-04-09
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present inventors unexpectedly discovered that a group of compounds and their analogous compounds or their pharmaceutically acceptable salts have unexpected effects in the preparation of drugs for the treatment of cerebral infarction. At present, there is no report on the treatment of cerebral infarction with this type of compounds

Method used

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  • Compound for treating cerebral infarction and application thereof
  • Compound for treating cerebral infarction and application thereof
  • Compound for treating cerebral infarction and application thereof

Examples

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preparation example Construction

[0021] Preparation of lyophilized powder injection containing compound A:

[0022] ① Take mannitol, phospholipids, glycerol, cyclodextrin derivatives, dimethyl sulfoxide and poloxamer in total of 100 mg and 200-900 mg of the compound of formula (A), mix them in water for injection and dissolve them;

[0023] ②After mixing and dissolving to stabilize, first filter with 0.45um microporous membrane, and then filter with 0.2um microporous membrane;

[0024] ③Put them into small vials, and add other freeze-drying protective agents and auxiliary materials;

[0025] ④Procedural freeze-drying;

[0026] ⑤ Carry out corresponding inspections for pyrogen, sterility, visible foreign bodies, insoluble particles, etc., and wait until they meet the requirements. Preparation of lyophilized powder injection containing compound B:

[0027] ① Take mannitol, phospholipids, glycerol, cyclodextrin derivatives, dimethyl sulfoxide and poloxamer in a total of 100 mg and 200-900 mg of the compound o...

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Abstract

The invention discloses a compound, a pharmaceutical composition thereof and new application, wherein the new application is the application for preparing medicaments for treating cerebral infarction. The compound can reach very substantial effect for treating cerebral infarction.

Description

technical field [0001] The present invention relates to a class of compounds for treating cerebral infarction, pharmaceutically acceptable salts and analogs thereof, pharmaceutical compositions prepared from the above-mentioned compounds, pharmaceutically acceptable salts and analogs thereof, and said compounds or pharmaceutically acceptable salts thereof Use of the analogs thereof in the preparation of medicines for treating cerebral infarction. Background technique [0002] Cerebral infarction is a common clinical disease. The disease is characterized by many causes and many clinically used drugs. However, most of the drugs have weak therapeutic effects. Therefore, a very effective drug for the treatment of cerebral infarction is urgently needed. . [0003] Cerebral infarction can be roughly divided into cerebral embolism, cerebral thrombosis, cerebral cavity infarction and other cerebral infarction diseases. These diseases have high morbidity, morbidity and mortality in...

Claims

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Application Information

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IPC IPC(8): A61K31/5383A61K31/5377A61K31/506A61K31/496A61P9/10A61P7/02
Inventor 韩冰王浩天
Owner 韩冰
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