Application of circular RNA circ-FoxO3 in preparation of products for preventing and treating cerebral arterial thrombosis

A circ-foxo3, rnacirc-foxo3 technology, applied in the field of biotechnology and ischemic stroke, can solve the problems of lack of reliable therapeutic target sites, limited patient prognosis, complex pathological mechanisms, etc., to protect the integrity of the blood-brain barrier , the effect of reducing the probability of hemorrhagic transformation
CN112156103AActive Publication Date: 2021-01-01THE FIRST AFFILIATED HOSPITAL OF JINAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF JINAN UNIV
Publication Date
2021-01-01

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Abstract

The invention belongs to the field of biotechnology and cerebral arterial thrombosis, and particularly relates to application of circular RNA circ-FoxO3 in preparation of products for preventing and treating cerebral arterial thrombosis. The circular RNA is highly conservative and has the same reverse shearing site in human-derived or mouse-derived species. The application proves that the circ-FoxO3 is highly expressed in cerebrovascular endothelial cells of a MCAO / R mouse and the cerebrovascular endothelial cell line subjected to OGD / R treatment; A certain effect of the circ-FoxO3 in the endothelial barrier treated by OGD / R is shown by knockdown or over-expression of the circFoxO3. The application of the circular RNA circ-FoxO3 provides a new thought for prevention of hemorrhagic transformation after acute ischemic stroke, and provides a new target for development of a neurovascular protective agent.
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Description

technical field

[0001] The invention belongs to the fields of biotechnology and ischemic stroke, and specifically relates to the application of a circular RNA circ-FoxO3 in the preparation of products for the prevention and treatment of ischemic stroke. Background technique

[0002] Ischemic stroke is a multiple disease in which intracranial vascular stenosis or occlusion and blood supply disturbance are induced by various factors, eventually leading to brain tissue necrosis and nervous system dysfunction. Blood-brain barrier injury is a common symptom of acute ischemic stroke, and it is also one of the causes of hemorrhagic transformation in ischemic stroke. Hemorrhagic transformation of ischemic stroke refers to the phenomenon of intracranial hemorrhage in patients with no hemorrhage in the early diagnosis but with the natural course of the disease or after treatment. A large number of studies have confirmed that the ischemic and hypoxic microenvironment formed by ischemi...

Claims

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