72 results about "Arterial flow" patented technology

An apparatus and method for the determination of the flow, the coronary reserve and relative coronary reserve of a specific coronary artery. The apparatus and method employ a three-dimensional model (50) providing the volume of a segment of the artery at a plurality of points in time, and disclose various options (56) for determining the arterial flow through the artery segment during one or more heart beat cycles or parts thereof. The determination of the coronary reserve (62) and relative coronary reserve (64) follow from the volume (54) and the flow through the artery. Alternatively, the coronary reserve is determined directly from a velocity profile relating to one or more fixed artery segments and the three-dimensional model.

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

Disclosed herein are exemplary embodiments of an impulse therapy garment for use in pump therapy for enhancing venous and arterial blood flow. The garment may be advantageously fitted to a human foot, and may include a rotationally positionable heel-strap, an air inlet connector, separate dorsum straps, or other features. For example, other garments may include a washer having a center hole locatable around the stem and configured to be forcibly retained against the outer surface of the fabric by snap-fit using annular stem protrusions extending from an external surface of the stem. In further embodiments, a garment may include a bladder retention fastener configured to retain an end of the bladder to the fabric to allow substantially differential movement between the fabric and non-retained portions of the bladder during inflation and deflation of the bladder.

The present invention provides compositions and methods for protecting tissues and organs from damage during transplantation or from acute ischemia due to, e.g., injury or surgery. The compositions protect the tissue or organ from acidosis, oxidative damage, ischemia and repurfusion injury while the organ is isolated from the normal circulation or receives inadequate arterial flow.

Devices, systems, and methods for providing retroperfusion to at least one ischemic tissue in a minimally invasive manner are disclosed. At least some of the embodiments disclosed herein enable an anastomosis to be formed between a vein and an artery without the use of sutures and through a non-invasive procedure. In addition, various disclosed embodiments provide a cannula device comprising a Y-configuration for bifurcating arterial flow between an anastomosis and the underlying artery. The devices, systems and methods herein can further provide simultaneous autoretroperfusion therapy to more than one area of an ischemic tissue.

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and / or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.

The present invention is TAH system for auto-regulating blood flow and maintaining the asymmetric pressure balance in the mammalian cardiovascular system by decreasing the resistance in blood flow and minimizing the pressure gradients to exploit the in-flow pressure sensitivities of continuous flow pumps. The system further includes laminar flow generating manifolds connected to the atrium at one end and attached to pumps linked to the great vessels at the other, such that the in-let flow sensitivities of the pumps are maximized to auto-regulate blood flow, providing adequate pulmonary and systemic arterial flow to support normal metabolism and end-organ function and maintain the appropriate asymmetric physiologic pressure balance between the systemic and pulmonary systems of the mammalian cardiovascular system.

The invention provides a simple and convenient method and a simple and convenient system for evaluating hemodynamic indexes and characteristic parameters of a blood signal of a carotid arterial system through non-invasive detection on blood pressure of brachial arteries and an axial blood velocity signal of a common carotid artery. The method comprises the following steps: detecting the waveform and a numerical value of an axial blood velocity of the common carotid artery by using a continuous Doppler blood velocity waveform detecting module, detecting diastolic pressure and systolic pressure of a human body by using an arm-type electronic blood pressure detecting module, and then calculating hemodynamic parameters of the carotid arterial system by a simplified method; and selecting Morlet mother wavelet for wavelet analysis on the waveform of the blood velocity of the common carotid artery, and calculating the characteristic parameters of the blood signal. The method is an analysis method which combines the hemodynamic principle and wavelet transformation; compared with the method adopted by the conventional cerebral hemodynamic analysis device, the signal acquisition and analysis method is simpler; and to a great extent, the defects that the conventional analysis device is complicated in structure, huge in volume, complex in operation, high in price and the like are overcome.

The invention relates to acquiring information concerning the hemodynamic status of the brain (or any other organ) by measuring and analysing the pulsatile properties of blood flow (velocities) in the organ's feeding vessels in relation to the pulsatile properties of the systemic arterial blood pressure. Provided is a system for the analysis of arterial blood flow velocity measurements, comprising means for receiving input signals delivered by an arterial blood flow velocity (FV) sensor and by an arterial blood pressure (BP) sensor, wherein said FV and BP signals are recorded simulataneously and continuously, further comprising means for processing and outputting signals, wherein said processing comprises calculating the pulsatile apparent resistance (PaR) or the Pulse Flow Velocity Mismatch (PFVM). Plotting PAR or PVFM against mean arterial blood pressure and / or end tidal CO2 levels can serve as an indicator for the effectiveness of imposed therapy.

Embodiments relate to non-invasively determining coronary circulation parameters during a rest state and a hyperemic state for a patient. The blood flow in the coronary arteries during a hyperemic state provides a functional assessment of the patient's coronary vessel tree. Imaging techniques are used to obtain an anatomical model of the patient's coronary tree. Rest boundary conditions are computed based on non-invasive measurements taken at a rest state, and estimated hyperemic boundary conditions are computed. A feedback control system performs a simulation matching the rest state utilizing a model based on the anatomical model and a plurality of controllers, each controller relating to respective output variables of the coronary tree. The model parameters are adjusted for the output variables to be in agreement with the rest state measurements, and the hyperemic boundary conditions are accordingly adjusted. The hyperemic boundary conditions are used to compute coronary flow and coronary pressure variables.

A technique is disclosed for determining blood flow in a living body by changing the thermal energy level in the venous blood flow path and determining temperatures in both the venous and arterial blood flow paths. Blood flow is calculated as a function of the change in energy level and the temperature differences in the venous and arterial blood flow paths.

Matrix metalloproteases (MMPs) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention relates to the activation of protease-activated receptor-1 (PAR-1) by endogenous platelet MMP-1 collagenase on the surface of platelets. Exposure of platelets to fibrillar collagen converts the surface-bound pro-MMP-1 zymogen to active MMP-1, which promotes aggregation through PAR-1, MMP-1 is shown to cleave the PAR-1 extracellular domain at a novel site, which then strongly activates Rho-GTP signaling pathways, cell shape change and motility, and MAPK signaling. Blockade of MMP-PAR 1 suppresses thrombogenesis under arterial flow conditions and inhibited thrombosis in animals. These studies provide a link between matrix-dependent activation of metalloproteases and platelet-G protein signaling and identify MMP-1 / PAR-1 as a new target for the treatment and prevention of arterial thrombosis and other thrombotic diseases.

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

The invention discloses a traditional Chinese medicine composition for treating decrease of ovarian reserve functions. The traditional Chinese medicine composition is prepared from effective components and medicine excipients. The effective components comprise, by weight, 5-30 parts of radix rehmanniae preparata, 6-30 parts of fructus lycii, 9-30 parts of caulis spatholobi, 9-35 parts of herba epimedii, 5-30 parts of semen cuscutae, 5-30 parts of herba cistanches, 3-30 parts of rhizoma cyperi and 3-15 parts of fructus crataegi. The traditional Chinese medicine composition has the advantages that menstrual amount decrease symptoms related to the decrease of the ovarian reserve functions can be obviously relieved by the traditional Chinese medicine composition, and effective up-regulation effects can be realized for related hormone AMH (anti-mullerian hormone) which can reflect the decrease of the ovarian reserve functions; MRS scores and traditional Chinese medicine symptom scores which can reflect the life quality of patients can be improved by the traditional Chinese medicine composition; effects of the traditional Chinese medicine composition for improving the decrease of the ovarian reserve functions are possibly relevant to improvement of ovarian blood supply and reduction of artery blood resistance indexes; the traditional Chinese medicine composition is free of obvious side effects when used within short time.

Optical Coherence Tomography (OCT) is a high-resolution, non-invasive technique to image subsurface tissue and tissue functions. A broadband light source illuminates an object and the reflected photons are processed using an interferometer, demodulated into inphase and quadrature components and then digitized. The captured data contains information about the velocity of the moving scatterers but current Doppler estimation algorithms have a limited velocity detection range. Using a two dimensional velocity estimation, Doppler OCT (DOCT) can be used for the detection of in vivo aortic blood flow rates of over 1 m / s peak velocity through an esophageal DOCT probe. Previous methods have used a transverse Kasai (TK) autocorrelation estimation to estimate the velocity which is good for slow velocities, such as in the microvasculature. By calculating the Kasai autocorrelation with a lag in the depth or axial direction, backscattered frequency information is obtained which yields high velocity rate information. Through subtraction with stationary backscattered information, the Doppler shift is obtained by the axial Kasai (AK) technique. Through utilizing information from two dimensions, velocities can be resolved which spans rates from the microcirculation to cardiac blood flow velocities.

The invention discloses an electrical impedance detector for artery endothelial functions of arteries and a method, which belong to the technical field of medical instruments. The electrical impedance detector comprises a front arm upper electrode, a front arm lower electrode, a high-frequency low-amplitude constant-current-source generator, an alternating-current voltage detecting circuit, a signal amplifier, a filter circuit, an A / D (analog / digital) conversion circuit and a computer. The alternating-current voltage detecting circuit detects voltage change, analog voltage signals of alternating-current voltage are converted into digital signals by the amplifier, the filter circuit and the A / D conversion circuit, and the digital signals are inputted to the computer. An electrical impedance changing curve along with time and brachial artery blood flow-mediated dilation are calculated, and the curve and a brachial artery dilation analysis result are displayed on a display finally. Compared with the prior art, the method has the advantages that instruments are simple, cost is low, miniaturization is realized, popularization is easy, and market prospect is wide.

The invention discloses a method for calculating a sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) sequence signal. The method comprises the following steps of: setting blood flow speed as laminar flow distribution; calculating an accumulated phase of an SPACE sequence according to the blood flow speed of the laminar flow distribution; calculating a rotation matrix of the SPACE sequence; calculating a relaxation matrix of the SPACE sequence according to the accumulated phase; calculating the evolution process of a spinning magnetization vector according to the rotation matrix and the relaxation matrix; and according to the evolution process of the spinning magnetization vector, calculating the signal strength of each flow layer, averaging, and thus obtaining the signal strength of blood flow. The blood flow speed is set as the laminar flow distribution, blood flow speed-magnetic resonance imaging (MRI) signal strength distribution which is obtained by calculation according to the Bloch equation can be well matched with experiment data, and a calculation result is accurate. Moreover, the invention also provides a system for calculating the SPACE sequence signal and a method for fitting an aorta blood flow signal according to an SPACE sequence signal accurate calculation method and sampling the aorta blood flow signal. By the invention, optimization of sequence parameters is facilitated.

The invention discloses an auxiliary diagnosis system and method for a Parkinson's disease based on multimodal transcranial ultrasonography. The system comprises an input module, a feature extractionmodule, a feature selection module and a diagnosis module. The input module passes through the feature extraction module and the feature selection module and then is connected with the diagnosis module; the input module reads an ultrasound image and an ultrasound colorful Doppler image, the feature extraction module extracts image features of a substantia nigra area of the ultrasound image, and division is conducted to obtain an arterial blood flow frequency spectrum curve in the Doppler image; the feature selection module selects features of the ultrasound module; the diagnosis module classifies multimodal features through a multimodal learning algorithm to obtain an auxiliary diagnosis result as an auxiliary reference for doctors to carry out diagnosis.

The invention provides a use of angiotensin-(1-7), or a functional part, derivative and / or analogue thereof, for the preparation of a medicament for enhancing cardiac function. For instance, left ventricular diastolic pressure, coronary flow, endothelial function and / or myocyte hypertrophy can he enhanced by a medicament of the invention. By enhancing cardiac function, the development of heart failure can he attenuated or prevented. The invention further comprises a pharmaceutical composition comprising angiotensin-(1-7), or a functional part, derivative and / or analogue thereof, and a carrier. A method for treating an animal suffering from, or at risk of suffering from, heart failure comprising administering to the animal a pharmaceutical composition of the present invention is also provided herein.

The invention discloses a reflective infrared arteriogram collector and sensor, belonging to a field of medical apparatus. The reflective infrared arteriogram collector comprises a shell with a detecting window, a circuit board, an infrared transmitting tube, an infrared receiving tube and a resistance. The infrared transmitting tube and the infrared receiving tube are arranged at the same side of the circuit board. The infrared transmitting tube and / or the infrared receiving tube are connected with a resistance. The invention has the advantages of low production cost, that the infrared reflex sensor for artery and blood stream can accurately collect the blood blow waves of a plurality of parts of a human body like a digital artery, a radial artery, a cerebral artery, a temple and even a palm and a lip part and has an extremely wide application, is a major human evangel for controlling and quickly diagnosing the human cardiocerebriovascular diseases.

A Doppler sensor for non-invasive continuous Doppler monitoring for arterial blood flow to a distal body part of a patient that employs a Doppler transducer holder for placement at the distal body part of the patient. The holder is adapted to allow the sensor to be inserted and removed, enabling a sterile sensor for each new use. The holder may be disposable after each use, may be provided with a cover for disposal of the cover after each use and re-use of the holder, and the sensor may be provided with a cover for sterile placement against the patient's body.