Traditional Chinese medicine composition for treating decrease of ovarian reserve functions and application of traditional Chinese medicine composition

A technology of ovarian reserve and composition, applied in the field of traditional Chinese medicine composition, can solve the problems of recurrence, abnormal liver and kidney function, increase the incidence of cardiovascular events and the like

Inactive Publication Date: 2017-09-26
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine treats DOR mainly according to different ages and different treatment purposes, mainly hormone replacement therapy, ovulation induction, egg donation, and immunosuppressant application. Adverse rea

Method used

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  • Traditional Chinese medicine composition for treating decrease of ovarian reserve functions and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating decrease of ovarian reserve functions and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating decrease of ovarian reserve functions and application of traditional Chinese medicine composition

Examples

Experimental program
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Effect test

Embodiment 1-5

[0011] The following examples 1-5 of the present invention are made into granules (hereinafter referred to as Guiyuan decoction) according to the following process steps:

[0012] ① Weigh each medicinal material according to the weight of the prescription, soak for 1 hour, decoct for 1 to 3 times, decoct for 0.5 to 1.5 hours each time, add 10 to 14 times the amount of water for the first decoction, add 6 to 10 times the amount of water for the second and third decoctions, and decoct together Boil the liquid, filter it, and concentrate the filtrate to an extract with a relative density of 1.05-1.30 at a temperature of 60-70°C. Among them, it is preferred to decoct twice, each decocting for 1 hour, add 14 times of water for the first decoction, and 10 times for the second decoction, combine the decoction liquid, filter, and preferably concentrate the filtrate to an extract with a relative density of 1.05-1.07 liquid;

[0013] ②Add ethanol to the above-mentioned ①extract solutio...

Embodiment 1

[0018] Prescription weight: Rehmannia glutinosa 15g, Lycium barbarum 15g, Rhizoma Cyperi 12g, Caulis Spatholobus 30g, Lingpi 30g, Cuscuta 15g, Cistanche 15g, Hawthorn 12g.

Embodiment 2

[0020] Prescription weight: Rehmannia glutinosa 12g, Lycium barbarum 12g, Rhizoma Cyperi 9g, Caulis Spatholobus 15g, Lingpi 15g, Cuscuta 15g, Cistanche 15g, Hawthorn 6g.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating decrease of ovarian reserve functions. The traditional Chinese medicine composition is prepared from effective components and medicine excipients. The effective components comprise, by weight, 5-30 parts of radix rehmanniae preparata, 6-30 parts of fructus lycii, 9-30 parts of caulis spatholobi, 9-35 parts of herba epimedii, 5-30 parts of semen cuscutae, 5-30 parts of herba cistanches, 3-30 parts of rhizoma cyperi and 3-15 parts of fructus crataegi. The traditional Chinese medicine composition has the advantages that menstrual amount decrease symptoms related to the decrease of the ovarian reserve functions can be obviously relieved by the traditional Chinese medicine composition, and effective up-regulation effects can be realized for related hormone AMH (anti-mullerian hormone) which can reflect the decrease of the ovarian reserve functions; MRS scores and traditional Chinese medicine symptom scores which can reflect the life quality of patients can be improved by the traditional Chinese medicine composition; effects of the traditional Chinese medicine composition for improving the decrease of the ovarian reserve functions are possibly relevant to improvement of ovarian blood supply and reduction of artery blood resistance indexes; the traditional Chinese medicine composition is free of obvious side effects when used within short time.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating decreased ovarian reserve function, and furthermore, the invention also relates to the application of the traditional Chinese medicine composition. Background technique [0002] "Ovarian reserve function" is an important indicator to measure a woman's ovarian function and fertility, which includes the quality and quantity of eggs [1，2] , is also an important indicator for predicting female fertility potential and early detection of ovarian failure tendency. When the ovarian reserve function declines (DOS), the ovary's ability to produce dominant and mature eggs is weakened, the quality of the follicles is reduced, and the sex hormones secreted by the ovary are insufficient. [0003] At present, Western medicine treats DOR mainly according to different ages and different treatment purposes, mainly hormone replacement therapy, ovulation induction, egg donation, and immunosu...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/00A61P15/08
CPCA61K36/296A61K36/39A61K36/486A61K36/64A61K36/734A61K36/804A61K36/815A61K36/8905A61K2300/00
Inventor 李祥云徐莲薇李俊菁赵莉刘敛韩虹宇刘慧聪
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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