Traditional Chinese medicine preparation for treating liver cancer and preparation method thereof
A traditional Chinese medicine preparation and a technology for treating liver cancer, which are applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of traditional Chinese medicine preparations and measures that do not appear to have therapeutic effects on liver cancer, and achieve the enhancement of immune function and side effects of the body. Small, the effect of keeping the whole body in good condition
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preparation example Construction
[0058] The preparation method of the enema of the present invention comprises: Acanthopanax 1500g, Hedyotis diffusa 1500g, Astragalus 1500g, Garcinia cambogia 1500g, Ligustrum lucidum 1500g, Atractylodes macrocephala 1500g, Shouwu 1500g, capillary wormwood 1500g, turmeric 1500g, Prunella vulgaris 1500g, Polyporus 1500g, Schisandra 1500g, Curcuma 1500g, Poria 1500g, Eclipta 1500g, Salvia 1500g, Paeoniae Alba 1500g, Scutellaria barbata 1500g, Scutellaria baicalensis 1500g, Epimedium 1500g, Buad 150g, Scorpion 150g. Add 5-10 times the amount of 60-90% ethanol to soak for 1-2 hours, extract twice; heat and extract for 1-2 hours, extract the active ingredient, concentrate it into a liquid paste, and become component 1; soak the remaining medicinal residues in water for 0.5 -1.5 hours, extract twice, 1-2 hours each time, combine the extracts, filter, concentrate, filter through 80-160 mesh and concentrate under reduced pressure to concentrate the filtrate with a relative density of 1...
experiment example 3
[0076] Experimental example 3: Cumulative toxicity test:
[0077] Chinese medicine preparation oral administration capsule of the present invention is to mice by 7.69,19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine preparation of the present invention The hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of the rats were not significantly affected. After 3 weeks of drug withdrawal, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.
[0078] Skin and in vivo irritation test:
[0079] 1. get the rabbit to sh...
experiment example 1
[0083] Experimental example 1 the influence of Chinese medicine preparation of the present invention on S180 sarcoma transplantation tumor suppression rate
[0084] Experimental method: Extract the ascites cancer cell suspension grown in the peritoneal cavity of KM mice for 8 days under sterile conditions, dilute the cancer cell suspension and sterilized saline at 1:3, and take 50 KM mice (provided by the Department of Biology, Shandong University) Cultivate), inoculate 0.2ml of diluted cancer cell suspension subcutaneously in the armpit. After 24 hours, they were randomly divided into 7 groups, i.e. model group, 5-Fu group (25mg / kg) and the present invention 1, 2, 3 groups (1mg / kg, 4mg / kg, 16mg / kg), 10 in every group, respectively The corresponding drugs were given by intragastric administration (the model group was given an equal volume of distilled water by intragastric administration), and the mice were sacrificed 8 days later, the tumors were stripped, weighed, and the tu...
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