The present invention relates to novel analogs of
choline and methods of use or treatment of neurodegenerative disorders and / or conditions such as Parkinson's
disease, Huntington
disease, Alzheimer's
disease and related disorders such as
amyotrophic lateral sclerosis,
spinal muscular atrophy, Friedrich's
ataxia, Pick's disease, Bassen-Kornzweig syndrome, Refsom's disease,
retinal degeneration, Cruetzfelt-Jacob syndrome or prion disease (mad cow disease),
dementia with Lewy bodies,
schizophrenia, paraneoplastic cerebellar degeneration and neurodegenerative conditions caused by
stroke. The present compounds are effective to treat any neurological condition where
acetylcholine transmission neurons and their target cells are affected. Compounds according to the present invention are effective to alleviate and / or reverse the effects of a neurodegenerative condition, prevent further deterioration and / or enhance
cognition and memory in patients suffering from neurodegenerative disorders, especially Alzheimer's disease.